Klinická farmakologie a farmacie – 2/2020

KLINICKÁ FARMAKOLOGIE A FARMACIE / Klin Farmakol Farm 2020; 34(2): 56–62 /  www.klinickafarmakologie.cz 62 HLAVNÍ TÉMA Laboratorní metody v terapeutickém monitorování léků umožnily stanovit více látek různých generací i farmakologicky aktivních metabolitů v jedné analýze. Pro analýzu imunosupresiv, především cyklosporinu A a takrolimu bylo vyvinuto množ­ ství imunoanalytických metod od RIA, EMIT, FPIA a CMIA, ale žádná z těchto metod nedokázala úplně eliminovat možnost zkřížených reakcí s metabolity a tím nadhodnocení parentní látky. Proto dochází k jejich postupnému nahrazová­ ní metodami chromatografickými. U sirolimu a everolimu, které se jako imunsupresiva začaly používat později, už nabídka imunoanalýz ne­ byla tak široká, a proto se především používají metody LC‑MS/MS. Tyto metody se využívají i pro všechny další farmakologické skupiny, které se začaly monitorovat později, jako jsou psycho­ farmaka, beta‑laktamová antibiotika, antivirotika, antihypertenziva a antimykotika. 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