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www.klinickafarmakologie.cz340804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
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Klin2698804301077091109157
Farmakol2873804301074279105180220258306325
Farm3216804301074279105180
2020;3414804301074487128171187
34(2):3619804301074489113156178192
63–693829804301074487133180223
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KLINICKÁ41488043010771115135194215269315373
FARMAKOLOGIE4541804301074191138210265312372414474533554598
A51588043010753
FARMACIE5231804301074291138211265317337380
6956558026012657115
PŘEHLEDOVÉ4549207012660124182256312369444520587645
ČLÁNKY5216207012660115187259327395
Vliv12153650106366785123
genetických135436501063769110142176194228264303336377
a1746365010638
epigenetických17993650106316683122154195227261278313349388420462
faktorů227536501063068103137176212253
jako25433650106236297136
kovariátů269536501063372110146181199239267308
snášenlivosti301836501063273112146178219250268306346378411429
a3462365010638
léčebné35153650106306297129165207239
odpovědi376936501063979114155192224264281
na406636501063979
olanzapin416136501063870111152185227261279320
v4496365010637
terapii45473650106316399141175193210
psychotických477336501063266103136177218248266300336375408449
onemocnění523836501063880111166206242283315356374
J.3405540832437
Olanzapine‑induced397554083476396134163197236252290325348364402441479511545585
weight10025540835185101140178199
gain1217554083437590128
is13615540832046
associated1422554083376490129161177209231264304
with1747554083506688127
the­18895540832765100123
-759C/T340654083215387120162190227
and-697G/C5836540833877116139177212246289316356
polymorphisms9556540834484100133193232254295334350376435462
of14336540834363
the15126540832766102
HTR2C16356540834580117154194
gene.18456540834480119155167
Pharmacogenomics3407540833573105126184217249286325360398437495510542570
Journal9257540832462101122160193208
2009;11487540833469105140153
9:13167540833447
234–241.13797540833469104141173205235244
61.340853085366981
Gurevich4398540834482103137169185217255
EV,709854083357382
Bordelon809854083357395133168184222260
Y,10848540833846
Shapiro11468540833472104144159180217
RM,13818540833591104
Arnold15038540834162101139155194
SE,1712854083356780
Gur18108540834482103
RE,1931854083356982
Joyce340954083246293124158
JN.513954083226780
Mesolimbic6069540835489115153169184241280295327
dopamine9469540833876115148205220258293
D312519540834678
receptors1344954083185284118157179215237264
and16219540833169108
use1741954083376498
of18529540833756
antipsychotics192195408332693401054083223776103135167205243265280312340
in69510540831856
patients7691054083397294109144182203231
with10181054083516689127
schizophrenia.116010540833062100115144181221259280315353368400413
A1591105408341
postmortem165110540833877104127185224245270304361
study.3401154083264987126158168
Arch5241154083416293131
Gen67011540834479117
Psychiatry8031154083356194125163178210232253287
1997;11061154083346499132142
54:12631154083357082
225–232.136011540833469104140172207239252
62.3401253085367187
Reynolds44512540833570102141179195234260
G,72212540834457
Yao79712540833564102
Z,91712540833750
Zhang98512540833775107145184
X,118712540833851
Sun125312540833572110
J,137812540832639
Zhang143412540833775108146185
Z.163612540833751
Pharmacogenetics17041254083357210512618421724928634013540833873111146168183215243
of59613540833756
treatment6671354083204175107128186221259281
in96313540831250
first‑episode1026135408317345582105125161200216242280319354
schizophrenia:13931354083265896111140177217255276310348363395407
D3181313540834678
and190413540833270109
5-HT2C34014540833456102136172212
receptor5671454083255991125164186223245
polymorphisms8271454083438298130188227248288326342368425452
separately129414540833065104137159192213247263294
associate16041454083366289127160175207229262
with18861454083506688127
positive34015540833978105120142158191225
and58115540833775114
negative71115540834378118150172188221255
symptom98115540833265124163185223281
response.12781554083266087126165204230266278
European15721554083377496133173209241279
Neuropsychopharmacology1872155408345801183401654083215897124157188226265304343375396455487519556572610650682
2005;103716540833468104138149
15:12021654083346475
143–151.12921654083346598134165195226235
63.3401753085367287
Adams44017540834179112169196
D,64917540834556
Close7181754083405694120155
S,88717540833245
Farmen9451754083326283141177215
M,117317540835468
Downing125417540834584135174189227266
A,153317540834155
Breier16011754083355791106141162
A,177617540834155
Houston1844175408345831211473401854083215794
J.44918540832133
Dopamine49418540834482120152208223259293
receptor8021854083175082115153174210231
D3104418540834576
genotype113218540833871108145166199238272
association14161854083315783120151166197218232269306
with17341854083506586123
greater186918540833858911223401954083225577
acute43219540833264102125158
positive60619540833978104119142157189224
symptom84519540832759118157179216274
remission113519540832155113128154180195233272
with14221954083516789127
olanzapine15651954083375385123153186225241279314
therapy189419540832260953402054083215493124
in47920540831351
predominately5442054083386094134172230245283315337371386418
caucasian97620540833164101134167193208240278
patients12672054083397294109144182203231
with15122054083506688127
chronic16522054083316990128166181213
schizophrenia1880205408325579511034021540832865105143164198236251283
or63521540833859
schizoaffective.7072154083265896111140177210229248282315339354386421433
Human115221540834482140172210
Psychopharmacology­13742154083366294125163201241279311332390423455491507545585616638
‑Clinical340225408321647994132147179212227
and58222540833270109
Experimental70722540833265104140161177234269307329362377
2008;109922540833569105140152
23:12672254083346980
267–274.136222540833568101133165198228241
64.3402353085367184
ReynoldsGP,TemplemanLA,ZhangZJ.Theroleof5-HT2Creceptorpolymorphisms433235408335689713316818221824229432732937039845349050353659162165669673674879482985989493197610011011105110881120114911841197123012751292133413541397142914621499152815593402454083316298118152171218254267296352388407444479492516570594
inthepharmacogeneticsofantipsychotic94724540831045741101421892242542733283583874224584915265585785916206456907077477828018148508749049339681004102310361065
drug3402554083385793130
treatment.4832554083234274104123179212248268279
Progress7762554083355388126145177202226
in101525540831651
Neuro‑Psychopharmacology&Biological1080255408345781131321681892242482783083443804174544845035595896206546687047427728198628759113402654083155188101131162175
Psychiatry5262654083366090119155168198218237269
2005;80626540833466100132141
29:9582654083346677
1021–1028.10472654083346394123154183212243274286
65.3402753085367185
Samanaite43827540833265122153191223237259293
R,74327540833549
Gillespie804275408343587388122149187202236
A,105327540834054
Sendt111927540833367105143165
KV,12972754083347381
McQueen139127540835385133170205240277
G,168127540834356
MacCabe174927540835486118158191229264
JH,3402854083246982
Egerton43728540833472107129153190229
A.68228540834156
Biological7552854083355088104143182197229262277
Predictors10492854083355690130145177201238259287
of135228540833857
Clozapine14262854083405593121155194209247282
Response:17252854083357097136175213240275287
A340295408341
Systematic3962954083336390113146204237258274306
Review.71729540833570103118153204215
Front9472954083335290128150
Psychiatry11122954083356194125163178210232254288
2018;141529540833468100131143
9:157429540833447
327.163629540833467100106
66.3403053085367490
Zhang44630540834482115154193
JP,6553054083296671
Malhotra74630540835588104143181204225259
AK.10213054083468298
Recent113430540834177110144183205
Progress135430540834162100140161196223250
in162030540832058
Pharmacogenomics16943054083417911213319222525829534031540833874112151210225257285
of64131540834262
Antipsychotic71831540834785107123162189222254292331353369401
Drug114031540834567106145
Response.130131540834176103143182221247283295
Curr161131540834683104126
Psychiatry17533154083406710013117018521723934032540832155
Rep41032540833570110
2018;53532540833468100131143
20:6933254083356982
24.7903254083346679
67.3403353085367079
Miller4323354083547085100134155
CA,6003354083408296
Sweatt70933540833282116148170194
JD.9183354083226778
Covalent100933540834077109141157191229250
modification127233540835795135150167184216249270286323362
of164633540833757
DNA171533540834691132
regulates186233540831852911293403454083154769103129
memory48534540835792150188210244
formation.7443454083195678136169190206244282295
Neuron105534540834479117138176214
2007;128434540833469105137147
53:14463454083356879
857–869.154034540833468102134170206240251
68.3403553085357287
Miller440355408354698398132152
CA,6043554083408195
Gavin71135540834375106121158
CF,8813554083397177
White97035540835694109131164
JA,11483554083216074
Parrish12343554083356686107123148185
RR,14313554083357084
Honasoge152735540834381118150176213252286
A,182535540834054
Yancey1891355408335631002140554083316596
CR,2252554083407690
Rivera2358554083355083117139172
IM,2545554083157084
et26445540833457
al.2717554083314760
Cortical2793554083397698123138170203218
DNA30275540834591132
methylation31755540835792115153184200232254269307345
maintains35365540835790105143164197212250277
remote21406540832155113151173207
memory.23626540835792150189210244254
Nature2632654083447798136157192
Neuroscience28396540834580117138176202235250284323355388
2010;32436540833468100131144
13:3402654083356576
664–666.34936540833470106144181217252265
69.2140753085367285
Ghadirivasfi22387540834482114153169190205238271297315332
M,25837540835568
Nohesara26647540834583121156183216237270
S,29477540833345
Ahmadkhaniha30057540834179137169208238278310348363401433
HR,3451754083448094
Eskandari355875408332609012316120023221408540832136
MR,21908540835490104
Mostafavi23088540835493120143176194228259275
S,25978540833245
Thiagalingam2656854083327287119158190205220258297329387
S,30578540833245
Abdolmaleky31168540834180120158174231264279314344378
HM.35088540834499113
Hypomethylation3635854083447611515421409540835690112149178193224245260297334
of24869540833655
the2555954083195690
Serotonin2656954083326686122143179216231268
Receptor29359540833569100133171192228249
Type-23195954083325998132154184
AGene33909540834182116153187
(HTR2A)3592954083155891127161202220
at214010540833253
T102C22061054083326596129168
Polymorphic23871054083357187119177215236276314329360
Site27601054083324769102
in287710540831350
DNA294010540834590131
Derived308410540834580101116148182221
From33181054083325289146
the34791054083205792
Saliva3584105408332658095127159
of375610540833756
Patients21401154083356789104139177198226
With23791154083577496134
Schizophrenia252611540833365103118147184224262284318356371403
and294211540833270109
Bipolar30641154083355089128144176197
Disorder.32741154083466187126147185220241252
American353911540834199134155171203235273
Journal214012540832462101122160193208
of236512540833857
Medical243912540835590129144176209225
Genetics268112540834479117152174190222249
Part29481254083356788112
B‑Neuropsychiatric307812540833558104139177198236275302334366404419451473494510542
Genetics3637125408344791171522140135408322376997
2011;225213540833468100128136
15624031354083346499
B:251413540833547
536–545.257713540833467101139173208241253
70.21401453085367186
Kebir224014540833569108124145
O,239914540834758
Chaumette247014540834078110148206241263288321
B,280514540833548
Fatjó‑Vilas2867145408332618399137160196212227260286
M,316714540835468
Ambalavanan324814540834199138171187219251284322354392
A,365414540834055
Ramoz372214540833668214015540835796124
N,228215540834558
Xiong23581554083385391129168
L,254215540833447
Mouaffak260815540835492131163182201235265
F,288815540833541
et294515540833659
al.30191554083355063
Family‑based309715540833565123138153185207247280306341381
association34931554083356188126159174206228243281319
study21401654083264986125157
of230916540833756
common237816540833167125182220258
variants,26491654083316485100132169191218231
rare28951654083185171105
mutation301316540835794116149170185223261
study32861654083264987125157
and345516540833270108
epistatic35761654083347288113136169190205237
interaction21401754083155274108129162194218233271310
detection24631754083387295128161185200238277
in275517540831250
HDAC281817540834490130169
genes300017540833873111146173
in318817540831250
schizophrenia.32511754083265896111140177217255277311349364396409
Schizophr367317540833265103118214018540832865105144165
Res23201854083357097
2014;243318540833468100131142
160:259118540833465101114
97–103.27201854083346799130162195207
71.21401953085367183
Levenson22361954083316598132170196235273
JM,25241954083227790
O‘Riordan26281954083466096112150171209242280
KJ,29211954083356375
Brown30091954083355694145183
KD,32051954083358293
Trinh33111954083325065103141
MA,346519540835596111
Molfese358919540835492108127162189224
DL,21402054083457891
Sweatt224520540833282116148170194
JD.24552054083226879
Regulation254820540833570109147162195216232270308
of287020540833756
histone29402054083375278101138177212
acetylation31652054083326498120154170202224239277316
during34942054083387697112150189
memory369720540835792214021540835796117151
formation23072154083236082140173194210248286
in260821540832057
the26812154083266499
hippocampus.27952154083435897136175208241298338376402416
Journal322621540832967105126165197213
of345421540834261
Biological35302154083405694109148187202234267283
Chemistry214022540834078113171186212235256291
2004;244622540833468104140152
279:261422540833467100113
40545–40559.274322540833470104139172208245281315347380391
72.21402353085367288
Peleg22432354083417490125164
S,242323540833750
Sananbenesi248823540833871109142180219254293328355369
F,287323540833743
Zovoilis293223540834279111149165180195221
A,317323540834156
Burkhardt324423540834078100130170202223261284
S,354323540833851
Bahari­360923540834174112144165181203
‑Javan21402454083214274106139177
S,233224540833548
Agis‑Balboa23982454083417995121142179212227266305338
RC,27512454083387992
Cota28612454083407799132
P,300824540833842
et306624540833659
al.31402454083355063
Altered32212454083415679112134168207
Histone34462454083446086109146184219
Acetylation36832454083417310621402554083225571103125140178216
Is237125540831339
Associated24232554083406895133165180212234267307
with27432554083506688126
Age‑Dependent288225540834179114137184219258293331370405443464
Memory335925540835489147185207241
Impairment361525540831270109142157178214026540835792130152
in230726540831553
Mice.237526540835570102136148
Science25382654083336580115153185219
2010;277226540833468100132144
328:293226540833466100112
753–756.306026540833467100136168200235248
73.21402753085367083
Alarcon22352754083415484104132167204
JM,24512754083247788
Malleret25512754083548598111144163195215
G,277827540834455
Touzani284527540833364101128159195208
K,306527540833547
Vronskaya31242754083365489126150178209238269
S,340527540833243
Ishii346127540831438738699
S,357227540833343
Kandel362727540833567103140172186
ER,21402854083336678
Barco22302854083356685114149
A.239128540834154
Chromatin24572854083407594130186216236249285
acetylation,27542854083316293113145159189209222258294305
memory,307128540835790146182202234241
and332428540833268105
LTP34412854083315893
are35462854083325183
impaired36422854083146910613715021402954083205288
inCBP+/-mice:Amodelforthecognitivedeficit22412954083104592125158195216232297310339370380428493528565597610636671690720755787826860897932944964977100710381084111611311148117711891209
inRubinstein­34632954083104588123159172207231251282295330349
‑Taybisyndromeand21403054083214975103141155190220257294313348405437479515551
itsamelioration.Neuron2004;42:947–959.270530540831031569815318620021324926829931933236840441546950253855759262867270473877278282585686691094397310041036106810991107
74.21403153085366883
Chuang223631540834077115147185224
DM,2473315408345100113
Leng259931540833165103142
Y,275431540833543
Marinova281031540835487108123161199231264
Z,308631540833851
Kim315031540833551109
HJ,32713154083446981
Chiu33653154083407893130
CT.35083154083407584
Multiple360531540835592107130145184214032540831549
roles22043254083185571105132
of234932540833756
HDAC241732540834489129167
inhibition26003254083124987102140156178193230268
in288432540831249
neurodegenerative294632540833772109130167206240280314352386407440461477509543
conditions.350132540833168106144159182197234272298312
Trends21403354083335084122161187
in234333540831452
Neurosciences241033540834580118139176203235250285323355389416
2009;284133540833468105140153
32:30093354083346779
591–601.31033354083356799132169204236246
75.21403453085377390
Weïwer225334540835994111165201224
M,250034540835671
Lewis258834540833874128145173
MC,278434540835699114
Wagner292134540835992133173210233
FF,31713454083407481
Holson326934540835192109137177218
EB.35043454083407792
Therapeutic361334540833981118141176214035540833975114138154187
potential234335540834585108142181204220253269
of262935540834363
isoform27083554083214887107146169228
selective29523554083336985121155180196229265
HDAC323935540834491132172
inhibitors34273554083216099115155171195233255283
for37273554083246385
the3940554083226197
treatment4054554083285085118141201237276299
of43695540834464
schizophrenia.44495540833366105121152190231271293328367383417431
Future48965540833976100139161197
Med51155540835591132
Chem52635540834786122181
2013;54605540834176109140153
5:39406540833446
1491–1508.4003654083346599132166197228263299313
76.3940753085367086
Kebir40397540833569108124145
O,41987540834758
Chaumette42707540833977110147205240262287320
B,46047540833548
Fatjo‑Vilas466675408332628399137160196212228260286
M,49667540835468
Ambalavanan50487540834199138171186218250283321353391
A,54537540834155
Ramoz5522754083356839408540835796124
N,40828540834558
Xiong4158854083385391129168
L,43428540833447
Mouaffak44088540835492131163182201235265
F,46888540833541
et47458540833659
al.4819854083355063
Family‑based48978540833565123138153185207247280306341381
association5293854083356188126159174206228243281319
study3940954083264987126158
of41109540833857
common41809540833167125183221260
variants,4452954083326586101133171192220233
raremutation4700954083185172106164201224256278293331369
study5082954083264987126158
and52529540833270109
epistatic5374954083347388114137170191207238
interaction39401054083155274108129162194218233271310
detection42631054083387295128161185200238277
in455510540831250
HDAC461810540834490130169
genes480010540833873111146173
in498810540831250
schizophrenia.50511054083265896111140177217255277311349364396409
Schizophrenia547310540833265103118394011540832865105144165199237252284
Research42391154083367197132164185216254
2014;450911540833468100131143
160:466711540833465101114
97–103.479611540833467100131162195208
77.39401253085367281
Kim403812540833551109
T,416212540833443
Park42211254083366789119
JK,43561254083256075
Kim444812540833551109
HJ,45731254083446981
Chung467112540834078115153192
JH,48791254083257083
Kim497812540833551109
JW.51031254083258393
Association52131254083416995133166181213235250288327
of555612540833757
histone39401354083375278101138176211
deacetylase416313540833873104136170192225241273299334
genes451013540833772110145171
with46941354083506688126
schizophrenia48321354083265896111140177216254275309347362393
in524013540831350
Korean53031354083357293127159196
population.55121354083387739401454083397792124146161199238251
Psychiatry42061454083366294126164179211233254288
Res45091454083367198
2010;462214540833468100131144
178:47821454083346397109
266–269.490614540833468104141173207240251
78.39401553085356985
Brousse40371554083355591128153179213
G,426215540834255
Meary432915540835387118138171
A,451215540834053
Blanc45771554083355081118149
O,473815540834656
Lancon480615540833163100131166204
C,502215540833951
Llorca50851554083304582103133165
P,526115540833539
Leboyer531215540833063101139169202223
M.554615540835467
Clinical39401654083405570108123155188203
predictors41591654083386094133149180205242263290
of446516540833756
response45371654083205481120159197224259
to481116540832259
olanzapine48851654083375385123153186225241279314
or521416540833759
risperidone52881654083213663101137158174213251289324
during39401754083387697112150189
acute414417540833264102125158
episode43171754083347389115153193228
of456017540833756
schizophrenia.46321754083255795111140177216255276310348363395409
Psychiatry50561754083356193125163178210232253287
Research53581754083357097132164185216254
2010;394018540833468100131144
179:41001854083346397110
12–18.42251854083346498129160174
79.39401953085377387
Cheah404319540834684120153192
SY,42511954083387584
Lawford435119540833771123145184206245
BR,46121954083417893
Young472019540834276115154194
RM,493019540834298112
Morris506319540835695117140156183
CP,52621954083458287
Voisey53641954083427995122158190
J.557019540833043
mRNA394020540835793139180
Expression413620540833366105127161188214229267305
and445720540833270109
DNA458220540834691133
Methylation473120540835489111150180196228250266303342
Analysis508920540834179111127159186200227
of533220540833756
Serotonin5404205408333688912614818539402154083385390
Receptor404421540833570103136176198235256
24313215408335
A(HTR2A)436021540834159103137174210252271
in464621540831250
the47122154083195792
Human481721540834582140172210
Schizophrenic504121540833264102117147184223262283317355370402
Brain.54562154083365790105143156
Genes394022540834479117152179
(Basel)41342254083195588114149165184
2017;433422540833468100129139
8.448822540833448
80.39402353085367388
Ghadirivasfi404123540834482114153168189205237270297315332
M,438623540835467
Nohesara446623540834583121156183216237270
S,474923540833245
Ahmadkhaniha480723540834179136168207237277309347362399432
HR,52512354083458094
Eskandari53582354083336090123161200232394024540832136
MR,399024540835490104
Mostafavi410824540835493120143176194228259275
S,439724540833245
Thiagalingam44562454083327287119158190205220258297329387
S,485724540833245
Abdolmaleky491624540834180120158174231264279314344378
HM.530824540834499113
Hypomethylation543524540834476115154394025540835791113150180196228249264301339
of429125540833756
the43622554083195690
serotonin44652554083266081117139175213227265
receptor47452554083175183116155176212234
type-249932554083195292127149180
AGene518425540834183118155189
(HTR2A)53882554083166093130165206224
at394026540833254
T102C40072654083336798131171
polymorphic41922654083387793125183222243283322337369
site4576265408325396296
in468726540831351
DNA475226540834591132
derived48982654083387394110142177216
from51302654083163976134
the52792654083215994
saliva5388265408325587388121154
of555626540833756
patients39402754083397293109143181203231
with41852754083506688127
schizophrenia43272754083255795110139176216254276310348363395
and473627540833270109
bipolar48592754083385493132148180201
disorder.50742754083385380118139178212234244
Am533227540834199
J5446275408323
Med548327540835590129
Genet394028540834479117152175
B4130285408335
Neuropsychiatr418128540834479117138175215242274306344359391413434
Genet463028540834479118153175
2011;482028540833468100128136
15649712854083356599
B:508228540833548
536–545.514528540833467102139173209241253
81.39402953085366981
Dazzan403429540834577106136169207
P.425329540833540
Neuroimaging430629540834478115136173188245277315330367406
biomarkers47242954083395491149181201231265286313
to505229540831955
predict51192954083396093132147179202
treatment53362954083194074105126184218256277
response39403054083215582120159198224259
in421430540831351
schizophrenia.42783054083265896111140177217255276310349364396409
European47003054083336990127167202234272
Neuropsychopharmacology49853054083458011813917621624227530634438342246149351457360539403154083316884122162194
2016;414931540833468100131144
26:43083154083346880
S140-S140.44033154083336495131155186217248284296
82.39403253085367492
Dazzan404832540835387119152187227
P.429232540834249
Neuroimaging435832540835289129152191208268302343360400441
biomarkers481632540834663103164198221253289312342
to517532540832867
predict525932540834669105147164197223
treatment54993254083295288394033540833256116154194217
response41753354083276392133174215243280
in447333540832161
schizophrenia:455133540833468108125156195237278301337377394428442
the501133540832869106
end513433540834181122
of527433540834465
30535633540834278
years545233540833774108131160
of394034540833758
solitude?40153454083317088104128167208244270
Dialogues43073454083456296113152193232268297
in462034540832059
Clinical46963454083456178117134167201218
Neuroscience493634540834481120143181209243259296335369404
2014;535634540834075108141154
16:55273454083397185
491–503.394035540833469102136172207242256