653
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE708804301074392139212266313373416475534555599
A13288043010753
FARMACIE1402804301074292139211266317337381
/18048043010757
Klin1880804301077091109157
Farmakol2057804301074278105179220258305325
Farm2402804301074178104179
2020;2601804301074386128171187
34(4):2807804301074489113155176191
152–1573017804301074482124167206243285
/33228043010757
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
1521328026012657110166
ORIGINÁLNÍ341207012673138172244278352422476549582
PRÁCE944207012661125197257315
Comparison34136501063271125160197232250282323365
of72036501063970
DOS80536501063980112
and93236501063980120
Windows106736501065876117156197256289
version137136501063768104139155196238
of162436501065384
the172236501063172104
MwPharm1841365010653111146187227262317
–2173365010646
a2234365010639
pharmacokinetic228836501063374114149204244278317353370412443477495529
software283236501063272103137199236271303
for315036501064385120
PK/PD32853650106346997132171
monitoring347136501065393135152184223259277318357
of384336501063970
digoxin39283650106385695136171188229
Comparison3409300298143276481624749839902100511421282
of16709300298139220
DOS19389300298167339465
and24519300298127266408
Windows29079300298214278417559696875976
version39319300298127248340443508645785
of34011900298138219
the6081190029888229355
MwPharm1011119002982033835216587838731077
–213711900298120
a230511900298127
pharmacokinetic24801190029814428440949970382993610721201126814081533162116871794
software432211900298104242322414599723813939
for3401450029882219309
PK/PD69814500298139282367505668
monitoring14141450029820734448454863577286292510641203
of266614500298138219
digoxin293414500298143207347484604669808
Tibor340184801376091157221263
Porubän1,6251848013764126168231298356421103818570803610731848013729
Blanka1124184801376697155220280338
Kořístková1,14841848013768129171201249290350413469527200318570803651
2,206718570803621051848013729
Milan21561848013793124154213277
Grundmann1,24551848013776118182247313408466531595304318570803630771848013729
Ivana3128184801373189147212270
Kacířová1,34201848013768126176207251315372429384218570803651
23906185708036
1340200907833
Department3962002013373129191244280319410465526561
of980200201336192
Clinical1095200201336489114174199248301326
Pharmacology,14442002013359118171206298350399458483544606658675
Faculty21422002013354102151211236272326
of2492200201336092
Medicine,26072002013388144206231280305365420442
University30722002013371131156209262298342367403457
of3552200201336192
Ostrava,36682002013376119156191244294347370
Czech40612002013364113168217277
Republic43622002013359114176237299325350398
2340215907833
Department3872152013373129191244280319410465526561
of971215201336192
Clinical1086215201336489114174199248301326
Pharmacology,14352152013359118171206298350399458483544606658675
Department21332152013373129191245280319410465526561
of2717215201336192
Laboratory28332152013352106168228264317352411447502
Diagnostics,3359215201337398151212272332375412437485530552
University3402302013371131156209262298342367403457
Hospital8202302013372133176237263299352377
Ostrava,12212302013375118155191244294347370
Czech16142302013364113167217277
Republic19152302013359114176237299325349398
Background3402810012357110155207264300358416474533
and8942810012349107166
objectives:10812810012354114141193240278304356407450474
Digoxin1575281201216691147203249274330
is1927281201212161
the2010281201213086137
oldest2169281201215378135186226261
drug2452281201215487143200
indicated2674281201212177134158204253286336394
for3090281201212783117
the3229281201213086137
treatment3388281201213164115164197281332388422
of3832281201215282
systolic3936281201213786126161216241264310
heart42682812012153104153186223
failure4513281201212776100124180213264
(HF).4799281201212690140170189
It5010281201212155
is5087281201212161
also5170281201214670110166
useful5358281201215393144174231255
in340295201212378
controlling440295201214195151183216270295318341397453
excessive914295201214794138187226266289337386
ventricular1322295201214594149182215239283338362410442
rate1786295201213078111160
in1968295201212075
the2065295201213085135
presence2222295201215387136176226282327376
of2619295201215281
atrial2722295201214578110134182206
arrhythmias.2949295201214578111167212249304387410458497519
Therapeutic34892952012147103154187235292343398431455499
drug4010295201215386141197
monitoring42292952012179135190214247301334358413469
(TDM)4719295201212678145225252
has49932952012152100139
become51542952012153104150203287337
an55132952012145100
integral340309201212379113163220254303328
part6903092012154104137174
of886309201215383
its99130920121215597
prescription,1110309201215488139179225259283341375398454511533
allowing166530920121467094150224248304361
to2049309201213085
optimize21563092012153111145169253277321372
therapy2550309201213086138172221278326
and28983092012146102159
to3079309201213186
reduce3187309201213182140195241291
the3500309201213187138
incidence3660309201212278124147205256313358408
of4090309201215383
toxicity.4195309201213186132157202226260311328
Since4545309201214771127173223
1991,4790309201214995148196213
the5025309201213187138
MwPharm51853092012178152206261310344428
software340323201214096126163240290323374
package7363232012157107152200250307358
(Mediware,11173232012128107159218242316366399450471
Groningen,1610323201216599155211235292349400457478
The21113232012149107158
Netherlands22913232012166118152208260294318367424481522
/28353232012134
Prague,2891323201215386136193248300321
Czech32343232012158104155201257
Republic)35143232012153105163219277302326372400
has39363232012156105145
been41033232012157109161217
used4343323201215595146205
for4570323201212985119
pharmacokinetic47113232012157114163197281330376431479505561613647671717
and54503232012148105162
pharmacodynamic3403372012157114162196280329375429487536593642726750795
(PK/PD)1157337201212680133173227293320
modelling14993372012181137195246271295319375432
in1953337201212177
TDM,20523372012148116197220
including2294337201212177123147202260284340397
digoxin.2713337201215478134190236261317339
First3074337201214670103144179
Windows32753372012182107163220276350390
version3687337201214696130171195250307
with4016337201217196130186
a42243372012145
broader4292337201215488143193250301335
spectrum4649337201213795147193229263319403
was50743372012171120160
released5256337201213181106157206246297355
in340351201212379
2014,4413512012149100147193214
as677351201214686
a7853512012145
reaction852351201213081129175211235290347
of1221351201215282
worse13253512012171126159200251
support1598351201213792150207264297334
of1954351201215282
the2058351201213187138
DOS22183512012163134183
background24233512012154103149196251284340396451509
on29543512012152108
later3084351201212170103153187
versions3293351201214595128169193249305345
of3660351201215282
Windows.37643512012182107162220275349389411
After4197351201215888125175208
its442735120121215596
release,4545351201213081105156205245296317
the4883351201213187138
company5043351201214296181238287343389
had54543512012153102159
decided3403652012156108154178236287346
to708365201213287
not8183652012155111145
develop9853652012156107156206231287345
DOS13523652012166137187
versions1561365201214797131173197253309349
anymore,19333652012147104150235292325376397
even2352365201215099149205
though2580365201213288144201258314
they2916365201213389141188
are3126365201214882132
globally3281365201215579136194244268292341
used3644365201215495146204
with3871365201217397132188
success.4081365201213994140185235276316338
The44413652012149107158
aim4622365201214771155
of4800365201215484
this4906365201213389113153
study5082365201213974130187236
was53403652012173123163
to5525365201213388
compare3403792012145100184242292325376
the738379201213490142
usefulness902379201215696148179235260316367408448
of1372379201215686
DOS14803792012168139188
and16903792012149106163
Windows18763792012185110166224280354395
version2293379201214999133174198254311
(WIN)26263792012129117142209237
of2886379201215586
the2994379201213490141
MwPharm,31583792012181155209265314347432454
and36343792012149105163
their3819379201213490142166200
prediction4041379201215892143201225271307331387444
quality45073792012157113162187211245296
in4825379201212480
TDM49283792012150119200
of5150379201215686
digoxin.5258379201215882139195241266322344
Materials3403930012383135171223260286338365407
and7693930012348106166
methods:9563930012383136172230288348390414
2913913932012151102
patients15153932012155105138162213270303344
(231882393201212676128
with2032393201217196130186
multidrug22403932012181137161195219276310366423
treated2685393201213164115164197248306
systolic3013393201213786127161216241265311
HF,33463932012163113125
434933932012149
with3564393201217296130186
atrial3772393201214680113138186211
fibrillation,4005393201212754111145170194218267300324380437458
144853932012149
pregnant4557393201215488139196253301358391
woman49703932012171126211260316
treated5308393201213164115164197248306
due3404072012156110160
to521407201213084
fetus626407201212676110164203
tachycardia,851407201213078123177223266315347403426474495
113684072012147
infant1437407201212075104153207240
with1698407201217094127182
Tetralogy1901407201214690123156204228282339386
of2309407201215180
Fallot)2410407201214690114137192224252
who26834072012170125180
were28844072012170119152202
treated3107407201213062112160192241298
for3426407201212681114
>35614072012156
136394072012148
month37084072012179134190222277
with4006407201217094127181
digoxin4209407201215376131186231255310
were45404072012170119152202
eligible476340720121477194149173229253303
for5087407201212681114
inclusion.5222407201212176120144198237260315370391
Patients3404212012153100133157208264297338
received699421201213181127176200249299356
digoxin1077421201215477134189235259315
(Digoxin1414421201212591116172227273297353
Léčiva®️,1789421201214494141164213262280301316
Zentiva,21274212012153102158191215264313334
Prague,2483421201215083132188243294314
Czech28194212012155101151197252
Republic)30934212012151102160215273297321366393
in3508421201212177
a36074212012145
median36744212012180131189213261316
dose40124212012154109149200
0.1254234421201214869114159210
mg44664212012182139
(range4627421201212556105160217267
0.063–0.2504916421201214970121174224276331352406457508
mg)54464212012183139166
once3404352012155112158208
daily.5704352012158107132156204222
The8144352012152109161
therapeutic997435201213591143176226284336392426450496
range1515435201213584141198249
for1786435201213288122
digoxin1930435201215882139195242267323
was22754352012176125165
established2462435201215393128178235261285325381432491
at2975435201215084
0.5–2.03081435201215374129182229252304
μg/l,34074352012156113149175196
according3625435201215196141196230287311367424
to4072435201213590
manufacturer41844352012186135191247277327373409465498549583
requirements.4789435201213586144200224258308393445501535576598
Both54104352012156112146202
MwPharm3404492012180155209264313347431
versions7934492012150100134175199255312352
(DOS1167449201213096167216
version1406449201214999133174198254311
–17394492012151
MwPharm18134492012181155209265314347432
3.30,2267449201215374129180201
Windows24914492012185111167224280354395
version2908449201214999133175199255311
–32414492012152
MwPharm++33154492012181156210265314348432492553
1.3.5)3890449201215370125146200228
were41404492012175125159210
used4372449201215697148206
to4601449201213489
parameterize47124492012158108142191275327361411445470514565
the5299449201213490142
po‑54634492012158115149
pulation3404632012157113138187220244300357
PK7194632012158112
model.8534632012189145203254279301
Serum11764632012155106140197281
digoxin1479463201216186142199245270326
concentrations18274632012150104161207257314347381430464488544601641
(SDC)2490463201213381148207238
were27504632012179129163214
repeatedly2986463201213889147199248281332390414463
examined34714632012155103153237261317369427
and39204632012153110167
the4109463201213995146
differences4277463201216286116150201235286343389439479
between47784632012162114149226276328385
measured51854632012188140189229284318369427
and3404772012148104162
calculated524477201214696120166222246295329379437
values984477201214998123178230270
predicted1276477201215892143201225271307358416
by17144772012158106
both18424772012158114148204
versions,20684772012150100134175199255312352374
including2464477201212481126151206264288344401
the2888477201213490141
percentage30524772012157110143189239295329379435487
prediction3561477201215892143201225271307331387444
error4027477201215185119175209
(%PE),42584772012129107161210239259
were45394772012175125159210
compared.47714772012146101185243293326377435457
Results:3404910012357110153210237273317341
SDC7094912012149116176
were9074912012179129163214
obtained11434912012160118152202226283334392
from1557491201213569125209
2917894912012156107
patients19184912012162112146170221278311353
(mean22934912012133115166215272
age25874912012153110161
67±2027714912012156105161213264
years,30584912012152102151185226248
body33284912012162119177226
weight35764912012179129154211267300
72±2738994912012156107168220270
kg).41914912012148103131151
WIN,43644912012189115182204
compared45904912012150105189247297330381439
to5051491201213994
DOS,51674912012172142192213
used54034912012160100152210
lower340505201212480154204238
constants6005052012147102159199234284340373415
for1037505201213288121
absorption11815052012150108148205238297331355411468
rate1671505201213584118168
constant18615052012148102159199234284340373
(ka)2257505201213078128155
(0.612434505201213182103156202
vs2659505201215091
2.5),2772505201215376130158177
absolute29725052012150108148204229285319370
bioavailability3364505201215984140190237286311335384442466490514548599
(F)3986505201213079109
(0.654117505201213181103155206
vs4345505201215191
0.7),4458505201215475127156175
total4656505201213590124174198
plasma4877505201215984133173257306
clearance5205505201214772123172205255311357407
(CL)340519201212885132161
(6.11523519201212878100146188
vs733519201214888
6.45843519201215173125176
L/h),1041519201214684142168188
and12515192012147104161
extrarenal1435519201214997134168217251301358407432
fraction1889519201212863112158194218274331
(fe)2242519201212856107134
(0.7712398519201212878100151203252
vs2672519201214788
0.783).2782519201215172123173224251270
Individual3074519201212480138162211236293349398423
parameters35195192012156106139189273325359409443485
calculated4026519201214494118164220244293327377435
by44835192012157104
WIN46095192012184109176
were48075192012173124157208
consequently5038519201214498155195247305361412469502526574
also340533201214873113169
lower531533201212582155206240
–7935332012152
volume8675332012150105130186270321
of1211533201215686
distribution1320533201215882122157190215273329363387443500
(V)1842533201213089122
(3171986533201213080127171
vs2180533201215090
35422925332012153103155
l),247053320121245372
renal2565533201213485142191215
fraction2802533201213166115161197221277334
(fr)315853320121315993120
(0.623301533201213081102155205
vs3528533201215090
0.88),3641533201215374128181208228
extrarenal38915332012152100137171220254304361410435
fraction4348533201213165115161197221277334
(fe)4704533201213058109136
(0.554862533201213081102157206
vs5090533201215090
0.63),5202533201215475128178205224
and54485332012150107164
elimination34054720121507599183207264313346370426483
half‑life8455472012156105130160190216240271322
(t1/2)11895472012129611247554507130488013285472012128
(59.41379547201212979128146199
vs1600547201214989
62.717115472012152103125176
h).1909547201215783102
All2034547201216286110
values2166547201214999123179230270
predicted2459547201215791142200224270307357415
by28965472012158105
WIN30235472012186111178
were32235472012174125159210
slightly345554720121406488145201235259307
lower3785547201212480154204238
but40455472012158114149
not42165472012156112146
significant.4384547201214064121177202232259305355411444466
There48735472012150107159193244
was51395472012174123164
a53255472012149
close5396547201214569126166217
correlation340561201214499132166216240289322345401457
between8195612012154105139215265316372
predicted1213561201215488138195219264300350407
and16425612012146101158
measured18225612012180131180219274307357415
concentrations2259561201214296152198247303336369418451474530586625
(Pearson’s2906561201212679127176209250305361382418
correlation3346561201214296130163214238286319343398455
coefficient:3822561201214297148178211238283307357413446468
0.0084312561201214869121174227
vs4560561201214686
0.314,4667561201214970124170216237
both49265612012154110143199
P51465612012151
<52195612012156
0.0001),5297561201214969121175228275297316
and3405752012148104162
between5245752012158110145221272324381
SDCs9275752012150117177218
predicted1167575201215892143201225271308358416
by16055752012158106
both17335752012158114148204
models19605752012184140198250275315
(0.013,2297575201212980101154202247268
P25875752012154
<26635752012161
0.0001).2746575201217596148202256304326346
Their31145752012151108160184218
%PE33545752012180134183
was35595752012175124164
comparable37455752012146101185243293326376434459510
(-0.43),4277575201213059115136188238265284
too.4583575201213590146167
Conclusions:3405890012359115174220247304347374431490532556
Actually9235892012161106142198247272296344
used12895892012159100151209
Windows15215892012188113169227283357397
version19415892012151102135177201257313
of2277589201215888
the2388589201213793144
MwPharm25545892012185159213268317351435
software3012589201214399129167244293326377
can3411589201214999155
be35885892012161113
used3723589201215999151209
for3954589201213389123
TDM40995892012154122203
interchangeably4325589201212783116167200246302351407464515565622647696
with50435892012177102136192
popular,52575892012161118176233257306339357
long‑term340603201212480136194226261311345430
used,792603201215696148206228
but10426032012158114148
in1212603201212581
these1315603201213490142182234
times1571603201213458142194234
unsupported18276032012156113153208266324381415452502560
DOS24106032012167138187
version.2620603201214999133174198254311333
Key3406198012461113164
words:5256198012475133171232276302
MwPharm,8476202012180154207261309342425446
therapeutic1314620201213388139172220277328383416439484
drug1819620201215789145201
monitoring,20416202012184139194218251305338361416472493
digoxin,2555620201215780136191236260315336
software.2912620201214095124160236285317367387
Porovnání3406478012458115153212264323377436464
DOS8246478012469142196
a10406478012453
Windows11136478012489117176236294369413
verze15466478012453105144192245
MwPharm18116478012485161219278331369456
–22876478012450
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