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Farm2402804301074178104179
2020;2601804301074386128171187
34(4):2807804301074489113155176191
152–1573017804301074482124167206243285
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1541308026012657110168
ORIGINÁLNÍ341207012673138172244278352422476549582
PRÁCE944207012661125197257315
Comparison34136501063271125160197232250282323365
of72036501063970
DOS80536501063980112
and93236501063980120
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version137136501063768104139155196238
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software281836501063272103137199236271303
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PK/PD32573650106346997132171
monitoring344336501065393135152184223259277318357
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digoxin39003650106385695136171189230
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in193461301192678
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The704103301194397145
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in340117301192174
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1801609145301194789138
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Pharmacokinetic3401593011951105151180265311357409453476530580611633678
(PK)1041159301193585135165
models12291593011991146202252274311
include1562159301192984129151204260310
up18951593011961117
to340173301193182
34441733011945
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systems1080173301193479116148194275311
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infusion,731187301192881107162198218272326343
oral1096187301196191137158
and12761873011954107162
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inputs.340201301192173128181212250268
Dosage6302013011961115152197252300
regimen952201301192673128148229278331
selection1305201301193482103151197230250303356
is1683201301191854
imple‑1758201301191899153175223254
mented3402153011982131184213260315
in677215301192376
a7752153011948
unique8452153011955108128182235283
interactive1150215301192376105152181227272305325370418
fashion.1590215301192975111164184237291308
Its192021530119245493
qualities3402293011953104147167186215235281317
were6772293011967114141187
honored8852293011948100152204232277331
as1237229301194075
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best1479229301195098134164
in1664229301191667
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com‑1814229301193989169198
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benchmark674243301195199151195247327371399441
study1136243301193364116170213
[4].137024330119236892108
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of1323257301194974
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DOS3402713011965133178
software,540271301193790117151226271300348363
with925271301197293124177
a11242713011945
broader1191271301195685137183237286315
spectrum1528271301193791141186219248302383
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available676285301195296142162183227282303352
since1050285301194464117162209
201412812853011956103147190
as1493285301195289
a16042853011953
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to340299301193183
the446299301193892142
worse6102993011981134164202252
support884299301194598153209264295329
of1235299301196289
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DOS15102993011973142188
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later648313301193380111160191
versions8633133011957107138178199255311349
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Windows.13533133011995119174231287361401420
After1797313301197199135184215
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the786327301193994144
company9533273011953106190246293347391
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develop4993413011962110155203224277332
DOS8533413011972140185
versions10603413011953101130167187240294330
anymore,14123413011953106148231284314361377
even18113413011955100148201
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they660355301192882130174
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widely1541355301197091145194214258
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phar‑17983693011960114159188214
macology3403833011981125169219240292346390
at751383301194170
University8423833011958110130174220249285305335381
hospital12443833011949102138191211241286306
Ostrava1571383301196399130159204246291
has1883383301195094129
been3403973011956107158213
using576397301196299120174230
DOS8293973011974144191
version10423973011954103133172193248303
since1368397301194566121167215
199716063973011957100151198
(ver‑1827397301193479128158185
sion340411301193859113169
2.0),531411301195875126152167
upgraded7214113011962118175205252308358415
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version12744113011954103133172193247303
3.301599411301195875126176
since1798411301194566120166215
1999.340425301194990139189203
It565425301192252
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used872425301195490139194
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a11934253011946
referential1261425301193178104152181228281310331375396
because16794253011956105151196249285333
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is571439301192763
long‑term656439301192780134188219250297326408
experience1086439301195498153203232253301354399445
with15534393011979100130184
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The18564393011953108156
Windows3404533011980101152205256326361
version722453301194086114150169220272
was10154533011967111146
implemented1182453301191695148168215294341392420465519
into172245330119166795145
the1888453301192677124
department’s3404673011954103158203232266348397450479499533
internal895467301192780109156185239284304
service1221467301194493122170191235282
shortly1525467301194496150179213234278
after1825467301195177112158187
its34048130119215290
first45248130119305180118150
release623481301193481102150195231280
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in340495301192174
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available1017495301194689135155176220275296345
releases.138449530119297697146190226275312330
The4805093011946101150
hypothesis652509301195799155209239293341378398434
underlying11085093011957110164212241263307328381435
the1565509301193588136
current17235093011949101130160207260289
study340523301193872128185232
was5965233011989138177
that7965233011947103150182
actually10025233011962109144200248270292339
used13645233011970109160218
Windows16065233011999123178236292367406
version340537301194593122159179232286
of648537301196086
the756537301193790139
MwPharm9175373011985156206258303332414
software1353537301194497123158233278307354
can1729537301195197150
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TDM6715513011942106182
interchangeably87455130119166896141169211263306357410457500553574617
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long‑term340565301192174128182213244290319402
used,763565301195390138193210
but9955653011955109139
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these1252565301193184132169218
times1492565301193151132181218
unsup‑17325653011953106142194248280
ported3405793011955109139173220275
DOS6375793011965132178
version.837579301194592121159179232285303
Materials3406050014799161203265309340401432482
and8496050014762131201
methods107660500147103166209278346417468
Study340633501435690154220273
population6416335014367133199264289342378403467532
Routine4806493011950105159191212266316
clinical81964930119497192145166212258280
pharmacokinetic11226493011960115160190273319365417461484537587619640685
data18306493011960105136182
were3406633011972121151199
retrospectively562663301193785117147200237293343390424445492540562607
collected11926633011952104126148197243278325382
from1597663301193364117200
pati‑18206633011962109140161192
ents3406773011948103133172
at535677301194778
University6366773011964117139185233263302323354402
hospital10616773011955110148203225257303325
Ostrava14096773011968107139170216261308
and17406773011947101156
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departments.3406913011955104160207237273356406460490530549
459126913011957104
patients10396913011964111142163213267298337
were13996913011981130160209
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for340705301192680110
eligibility,47370530119547697152174229251272293325373386
of882705301195986
whom9917053011978133187270
161284705301195598
were14057053011978127157205
excluded1633705301195599144165218274323379
from340719301192658110193
the556719301193488138
study717719301194072126182227
group.967719301195787140194249267
Finally,1257719301194970123169191212257270
2915507193011952100
subjects1673719301194093148170219266300339
(26340733301192675122
hospitalized,4857333011954108146201223255301323344385433489507
310157333011949
outpatient)10877333011953107139195242272294343397427454
were15647333011972121151199
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ded3407473011954102157
and520747301194295149
all69274730119426383
of798747301194976
them896747301192881130211
supervised1129747301193486141190220268290326374430
by1581747301195295
medical16987473011979127183203248293314
and340761301194599155
nursing5187613011952106135174195249304
staff845761301193669115142173
in1041761301192074
2016.1138761301194796141185203
231364761301194897
patients14847613011954101132153203257287326
with1833761301197193125179
multidrug3407753011982135157188210265295349405
treated768775301193364112157188236292
systolic1083775301194086125157210232253298
HF14047753011966113
were15407753011975124154202
65–9217657753011952100151201247
years2140663301194493138168206
old,2369663301195780135153
425456633011952
patients26206633011959106137158207262292331
with2974663301197698130184
atrial3181663301194980110132177199
fibrillation3403663301193053108139161182203249279301355409
were21406773011972121151199
55–642362677301194995146199251
years2636677301194492138167206
old,2865677301195375131148
130366773011949
pregnant3108677301195485133189243289343374
woman35046773011972126209255309
treated2140691301193163112159190239297
due24616913011964118169
to2654691301194094
fetus2772691301193585118173211
tachycardia3007691301194088135190234280328359414437483
was35146913011982130168
2737066913011959106
years2140705301194595141172212
old2375705301196386143
and25427053011955110167
127337053011958
infant2815705301193085112161216248
with30867053011982105138193
Tetralogy33037053011956101133164212235290348395
of3721705301196391
Fallot2140719301194688109131185216
was23787193011981127165
112566719301195796
months26847193011991145200230284321
old.3028719301196284139158
The32097193011954110160
study3392719301194578132187233
was36487193011980127164
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according26087333011955101145198229284306360416
to3047733301194093
the3164733301193994144
Declaration33327333011974124172193240270318349371425481
of2140747301195380
Helsinki,22437473011964114136173193247290313330
and25967473011947101156
the2775747301193286136
hospital29337473011955109147202224256303324
ethics3280747301194981135156202241
review3544747301193078124146196268
board21407613011956113161192247
approved24117613011954111169200255301351408
the2843761301194096147
protocol.3013761301196597151183236284337361379
Exclusion34167613011956104149171226264285341397
criteria214077530119447394125172201223267
were24297753011969116146193
as2644775301194279
follows:274577530119237697118171242279296
(1)306377530119246787
unavailable31727753011950103147191237257278323377399447
data3641775301195196126172
of3940663301195380
dosage40436633011955109147194249299
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digoxin,4468663301195576131185228250304322
(2)4813663301192674100
only49356633011954108130175
one51336633011953108158
measu‑53146633011982131176214267298
rement.3940677301193078160210264294313
Treatment4080691301194770119164195277327381411
of4514691301195279
systolic4616691301193581120152205227248293
HF49326913011961108
was50636913011970117154
based52406913011954100138188244
on55076913011951106
the3940705301193185135
European40987053011948100130183239289334388
Society45097053011949103150171220251299
of4831705301195683
Cardiology49377053011959105135189210264287341397443
(ESC)5403705301192875123180209
guidelines39407193011954108129184234256277330380418
for4381719301193386117
treatment4521719301193868116161192275324379409
acute4953719301195298151183231
and52077193011952106161
chro‑53917193011952106136188221
nic3940733301195577124
HF40887333011974122
[5].4234733301193686114132
All4390733301196992114
patients45287333011965114146168219275307348
received4900733301193989137186209257307365
digoxin5289733301196587144200245268323
(Digoxin3940747301192793116172227271293348
Léčiva®️,43127473011954103150172219267285305318
Zentiva,46547473011963112167198220267315333
Prague,5011747301195989137193248298316
Czech53507473011966111160207262
Republic)39407613011951102159214271294315361388
as4352761301195493
a44687613011955
part45467613011965113143179
of4748761301196391
their4862761301194095146168198
treatment5084761301194071120166198282333388419
at5526761301195586
a39407753011946
median40097753011991142199220266321
dose43537753011964119157207
of4584775301196289
0.1254697775301195876119162212
mg49337753011979135
(range5092775301193563110165221271
0.0635386775301195876127178226
Fig.213563001124771125149
1.230263001124868
Pharmacokinetic241663601074388133159230275312356393412458496523541578
profile301063601074369113136155173211
of323763601074366
digoxin331963601074462107152188206252
in358863601071662
a)366663601074365
DOS3747636010755113151
model,3914636010770115161199218233
b)416363601074365
Windows424463601077189135180225288319
model.4579636010769114161199217233
Cmax,482963601076048887000634269914980636010716
maximal5012636010770115152170241287305
concentration;53336360107357912516219924521357460107265294120138184230244
Cmin,239674601075224488100634253802528746010716
minimal256074601077694140158229274293
concentration;286974601074185131169205251276302345370389434480495
Ctox,338074601075234308100631542633495746010716
toxic352774601073175111129166
concentration;370974601074285132169205252277302345371389434481495
CL,422074601075389106
total434274601073174100143162
plasma452074601074968113143213258
clearance;47947460107426098143169212258295332347
V1,51587460107485203810063245225746010716
volume525774601074287105151222260
of553374601075073
distribution;21358560107456392118143161206251276294339385399
t1/2,255085601072325689200632439632631856010716
elimination26638560107355371142160205250275293337384
half-life;306285601074488107129154173191213250265
fe,33438560107205773
extrarenal343285601073572100126168193229275320338
fraction;37868560107204688125152170215261275
fu,40778560107206681
free41748560107204683121
fraction43108560107214789126153171215262
of458785601074365
a4668856010742
drug472685601074368113158
(digoxin)49008560107216381126171206224270290
in520685601071662
a5284856010742
plasma;534285601074261105135204249263
ka,21359660107378197
absorption224996601074590120165191236262280325372
rate26379660107266894131
constant;278496601073780127157183226272297314
F,311496601073950
absolute318096601074591121165184229255292
bioavailability348896601074564109155193237255273318364382400419445484