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www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
1581308026012657110168
HLAVNÍ341207012670127198263336370
TÉMA732207012658115205275
Tribute3413650106306683119160192225
Czech58036501063468100135176
Clinical7713650106336582123141176217248
Pharmacology103436501063374114149204245278317349388428465
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE708804301074392139212266313373416475534555599
A13288043010753
FARMACIE1402804301074292139211266317337381
/18048043010751
Klin1875804301076485103151
FarmakolFarm2046804301074178105179220258305325366403429504
2020;2569804301074487129172187
34(4):2776804301074489113154176190
1582986804301074482125
/31308043010752
Tribute3409300298132206269411551638763
Czech11529300298143256381489630
Clinical18309300298143206270410474580706771
Pharmacology2649930029814027640149169582192810641129126714071532
Folke34013140294122253313432550
Sjöqvist’s94013140294124183316454575635732815878964
overall195413140294136252370454573632691
importance2695131402946126240053561870682796110671187
for3401574029477210293
Clinical68315740294141199258392451556677736
Pharmacology14681574029413526738646967179089610261087122013571476
Professor480202301074468112133174205235281305
Folke80220230107368097132172
Sjöqvist99120230107365297144182199229256
passed1264202301074482113143185232
away1513202301073596135171
onMarch1701202301074287168206230266311
30,340216301074589103
2020463216301075397138182
at664216301075077
the760216301073786131
age9102163010750100145
of1074216301075781
861175216301075398
years1292216301075093133160194
in1505216301072876
Stockholm,1600216301075278125166204255303323397412
Sweden.3402303010742103144192234280294
Hewas652230301075294172211242
a9122303010736
true96623030107224794136
pioneer1119230301074562108155197240264
in1401230301071459
clinical147823030107355269114131169209226
pharma‑1721230301074592130155227266291
cologyworld‑wide340244301073983100145192230306351375392438463526542588630
and987244301073580126
the1130244301072268109
founder1256244301071863108153199240264
of1537244301074264
thismedical161824430107226783113198239286302339378394
specialty340258301073481124164180219236262303
both661258301075198124170
in849258301072066
Swedish9332583010743104146194211242288
healthcare1239258301074992130147173220259298323364
and1621258301074288136
acade‑1775258301074281120168210237
mia.340272301077390128142
It499272301071440
is556272301071444
almost618272301073552123169200227
impossible862272301071485132179210241257304322363
to1243272301072267
cover1327272301073579117158182
all152727230107355268
areas1613272301073560100138169
where18002723010759105147171212
Folke340286301074390109146189
made5482863010780121170214
important781286301072599148197224254295343369
contributions1169286301074793142168194213262310338356404452485
so1673286301074088
below17802863010756101119167233
follows34030030107246987104150213245
only603300301075097114153
a7743003010743
selection83530030107357895137177205222269315
of1168300301075173
some1259300301073582154197
true1474300301073055101144
milestones1636300301077692109151183211255302345376
in340314301071965
our423314301074692117
broad558314301074873118158206
discipline.78131430107486495134151199216233279322335
Folke’s480328301074288106142184199228
career727328301074585110152196221
started966328301073966106131161202251
at1235328301074772
Karolinska1326328301075091116162180197244275312353
Institutet1697328301072471103130147174221248289316
with340342301076583109156
an514342301074693
MD‑degree6253423010775132160210253301326367411
in1054342301072370
19591142342301074985127166
followed132634230107287492109156220262310
by1654342301075593
experi‑1765342301074987135179204221247
mental3403563010774116163188227244
research602356301073071103145183208245291
and911356301074490138
a10673563010744
PhD1129356301074893149
on1296356301075198
cholinergic1412356301074389136154170216259283330347385
trans‑181535630107315695142173197
mission340370301077490121152169215261
in619370301071460
1962.697370301073974117157171
As885370301074881
post‑doctoral984370301074592123150173222268308336381406445462
fellow,14643703010719607894140203214
he1696370301074385
joined179937030107146077123165213
the340384301072874116
legendary473384301071456104146191239277301342
Bernard833384301074082106153192216262
B.1112384301074155
Brodie’s1184384301074165110158174216230259
laboratory1460384301071453100147172211236280305346
at1824384301073560
the1902384301072369111
National340398301075694118134179225262278
Institutes63539830107145989115131156201226266296
of948398301074263
Health,1028398301075192129145170215228
Bethesda,1273398301073980105150191222268306319
USA.1609398301075087136151
Hewas1777398301075092167205236
then340412301072874117163
introduced52141230107216792117162210256295335384
to922412301073075
the1015412301073076118
field115141230107264486103151
of1320412301074972
drug1409412301075176122170
metabolism15974123010776118144184231279297313344416
and340426301074187135
novel493426301074895134175192
methods7034263010775117143189236284316
of1036426301074971
drug1125426301074974121168
analysis1311426301074288127144182214231262
in1590426301072066
biological1674426301075067114132178226243282321338
matrices.3404403010775115141166184223265297313
These671440301074897140172216
tools905440301073379127146177
made11004403010780120168212
it1330440301072451
possible13994403010756104136169186234253296
to1713440301073379
study1810440301073967114163202
interindividual34045430107196589130155172218265282321338385431470487
variability844454301073676100117156203220237254280320
in1182454301071460
pharmacokinetics1260454301074491130154226265304348385403449491517534572605
and1883454301073682129
Folke340468301074287105141182
early540468301074179104122160
understood718468301074591139181206238266310358406
this114246830107257288119
would12794683010763109155172219
be1516468301074891
of1625468301074567
significa‑171046830107314895141158180198237276302
nt340482301074873
clinical43148230107446178124141179219236
relevance68548230107317289131170210256295336
as1039482301074476
a11334823010745
guide1196482301075398115162205
for141948230107277398
individualised1535482301072369117133173190238283322339356387429477
dosing340496301075097130147194243
in601496301072471
many6914963010780119167204
therapeutic914496301073380124149190239283330357375414
areas.1346496301074772114154186201
In1566496301072471
Karolinska1656496301075092117163182199246278315356
University3405103010757103120160201226259276302344
Hospital7025103010762109141189206233273290
today,1010510301073378127166204214
our12425103010753100124
laboratory1385510301072463111159184224250295321362
service1766510301073881106148166205246
covers340524301074085123165189222
therapeutic579524301072370112137176224267313339356395
drugmonitoring992524301074468115162249296342359385430455472518566
of1576524301074365
more16595243010769115140182
than1858524301072370109155
150340538301074581124
agents,482538301074695138186212245260
mainly7615383010780119137184202241
immune‑modulating1020538301072497171217265308336410458508554572612638655702751
drugs,1790538301075480127176208222
anti‑epileptics,340552301074188114131158203252269287330378405422461495509
anti‑infectives,868552301074693119136163181228250293333362379419461494508
psychiatric1395552301075587127166213230269295321338378
drugs,1791552301075480127175207222
cardiovascular340566301074080104151168214252292324362408425464489
drugs,847566301074771118166197211
and1076566301073985133
antineoplastic1226566301073986111128174216263312330368400427444483
drugs.1727566301074771118165196211
During4805803010758106132151198247
his74758030107456395
American8625803010749122166192211251292339
post‑doc1221580301074695128157181231279320
period,1561580301074690116135183233248
Folke1828580301073885105142184
also34059430107405889136
studied495594301073057104152170212261
scientific77459430107306987129176201219242261300
approaches1093594301073684133159204245284331373406
to1518594301072369
clinical160559430107365472118136174215233
trials185659430107245068107125157
at340608301074066
Johns425608301072672119166197
Hopkins641608301075198146183203249280
Hospital940608301075198130178196223262280
in1239608301071460
Baltimore,131860830107408098125142213260286327341
under1677608301074389137180205
the1900608301072370112
mentorship3406223010773117165192238265299346365414
of773622301074568
Professor861622301074267114138181215248296322
Louis1203622301073784132150183
Lasagna.1405622301073779112154203250291307
Perhaps1732622301074183110158198247281
he340636301074892
already45263630107375682125165214254
then726636301072472116164
could910636301073783131150199
foresee112863630107216895138171215260
that1407636301072573113140
clinical156763630107375574121140180221240
phar‑1826636301074795136162186
macology3406503010773113153199218266315355
would7156503010761108155174222
develop957650301074588129171190238287
a12636503010738
leadership132065030107165998147191217250298316364
in1704650301071562
critical178665030107366281109127167208226
drug340664301074975123172
evaluation532664301074081122141188228255274322370
and921664301073886135
evidence‑based1076664301074080100149192240281323351402443476520570
medicine,16666643010770114164182222241288332347
including340678301071965105123169217235282330
the689678301072471114
establishment822678301074073101141190208226258305376420467493
of1334678301074367
drug1420678301074470117165
information160467830107166285131157230270296314361409
centers340692301074185135163207235271
with631692301077494124174
individual,826692301072676127146189210260310352372388
case‑based1235692301074891126171202254297332378430
pharma‑16866923010758108150178255297326
cotherapeutic340706301074087114162206233275324369417445464504
advice864706301074695136156196238
and1122706301074694144
the1285706301073381126
evidence‑based1430706301074990109158202251291334363413455488532582
input340720301071967116164193
to552720301072672
Drug644720301075683131181
and845720301073886135
Therapeutics1000720301074089133160202251296344372391431466
Committees1485720301074996170244262290321363408442
at1947720301073865
the340734301072876120
regional480734301072366116134182231271290
or790734301074572
national881734301074586113132180228269287
level.1188734301071660101144163179
Obviously,13867343010758108148167215263296315355366
clinical177273430107375674122140180222241
trial34074830107275371110128
design487748301074487119136184230
remains736748301072364136175193239271
a10257483010737
key1081748301073375113
competence1213748301073681153201244271312359398439
for167074830107206692
clinical178074830107365472118135174214232
pharmacologists340762301074997137163236276316361381428477495527556590
in949762301071562
academia,1030762301073777118166210282300340355
the1404762301072572115
pharmaceuti‑1538762301074694134160233273313354401429447474
cal340776301074082101
industry460776301071967116164197226253296
and775776301074189139
drug933776301074976124173
regulatory1126776301072770120167186227254300327370
agencies.1516776301074190134183223242286319336
Folke2280202301074292114154200
became25022023010759107151195272319
the2843202301073788134
first300020230107325483120151
Swedish31732023010751118164217238273324
chair35192023010749100143164193
in3734202301072878
clinical214021630107406282132153196239261
pharmacology,24222163010759110153182259302345394416466519562575
in3019216301072878
Linköping3119216301074970120161210263284334386
back35272163010759103146186
in3735216301072778
19702140230301074586131176
and23382303010751102155
thereafter2515230301073889137166213256282317363392
at2930230301075080
Karolinska30332303010755100130180203224275311352397
Institutet3453230301072880116148169200252283329360
from2140244301072352101176
19722337244301074281124169
at2527244301073968
the2616244301072676121
newly2758244301074792158179221
established3000244301074277107150201222242276325370421
Huddinge34432443010754103154205225274324370
University21402583010756106126169214242278298328373
Hospital.25342583010763114149200221251294315332
His2888258301076384118
early3028258301075092120141183
academic3233258301074790133184230305326368
work36222583010772121150190
included2140272301071968111131181232278330
pioneering2491272301075576126176222269297318368419
twin29312723010733102123173
studies3126272301073869119170190236271
to3419272301073381
identify3522272301072374120170199219245291
genetic2140286301075097148196226247291
dif2453286301075980106
ferences2565286301072471100146197241286323
in2910286301072879
the3011286301073789136
metabolism31692863010784131162206259311334355390467
and36582863010751102154
pharmacokinetics21403003010751103147176255299343393434458509556587609652690
of2853300301075885
antidepressant29603003010751102132154206254307337383420456501553583
drugs,3565300301075988140193229248
later214031430107196190135163
characterised2324314301074494136164208250282327355376411457508
in2854314301072272
detail2947314301075399128171192212
in3181314301072272
relation327431430107307596138167188238288
to3584314301073179
the3685314301073181127
CYP2D621403283010751100147191249295
polymorphism.2456328301074999120162237287316367417438472546564
Under30413283010755104155200228
his3290328301074767101
leadership,3412328301071863105156201229265314334385401
this214034230107287999134
pharmacogenetic22963423010758109152180257300343392444490541587617638681
field2998342301073254100122173
developed31933423010758104147192213264316363416
rapi‑3630342301073679131152182
dly2140356301074970112
especially2274356301075288139186229250292313333375
through2671356301073686115164214265315
translational,3008356301073665109159194215257286307357408450471488
mecha‑35183563010782128172222264294
nistic2140370301074970105136157200
studies2362370301074374125177198244281
in2665370301072778
collaboration2765370301074998120141184237288318362392413463515
with3302370301077496126177
Magnus35013703010780123175226276312
Ingelman‑Sundberg2140384301071971124172194271316367398441492544597650698728780
at2942384301075181
Karolinska30463843010755101130181203224276312353399
Campus.34673843010762107185238290326345
Today,2140398301074184134175215227
there2388398301072574118145189
are2597398301073865109
several2726398301073176117160187229249
clinical299639830107375776124144184226246
examples3262398301074181123196246266311345
whe‑36273983010762111156185
re2140412301072771
patient2233412301074892121141187237265
genotyping2520412301074893143194223267319340390441
is2983412301071752
recommended3056412301072670113162238313359409460506558
prior363541230107497899148177
to2140426301072775
treatment223642630107265497139167241286335363
as2620426301073973
a27144263010739
basis2774426301074790124144177
for297242630107227199
drug3091426301074775124174
selection328642630107327797142184216236284334
and/3641426301073988138172
or2140440301074876
individualised2237440301071867118138181202252301343364384418464515
starting2773440301073363106134166187236287
dose.3081440301074797132178194
The3296440301074192138
academic3455440301073981124175221296316357
activities2140454301074286119141186208239261308345
initiated2508454301072879101132154197228274327
by28584543010760103
Folke29834543010752103125166213
have32184543010759103146193
remained3433454301073683161205227278326380
high2140468301074869119169
for2331468301073181110
decades24624683010757103146189240286322
with2805468301077394124174
numerous30014683010756105180227255304354388
internatio‑3411468301072776105149178228271300320370401
nal2140482301074891111
guests22734823010754104150185216252
and2547482301074696147
long‑standing2716482301072474125176206241272315365416437486538
collaborations3275482301074694116136178230281309353382402452503537
with2140496301076485114164
Europe2325496301074087115163214260
and2606496301073988139
other2766496301074675124169197
continents,2984496301073886136164184233278328356392409
employing34144963010742117167188237278299348398
both21405103010750101130180
mechanistic‑molecular23415103010780126169219262312332366397418460485561611633679722771792834862
and3225510301074797148
pharmaco­33955103010756106149177253296338386417
‑epidemiological2140524301072775126147198244319340390411461513533575619639
approaches.2801524301074394146174223267309359405440459
Folke’s2280538301074392113153198215248
international2549538301072878107151179230273302322372423466486
commitments3056538301075099176253273302379425476504541
were36185383010776121149194
countless2140552301074087135183210229273307340
and2500552301074492141
included2661552301072270110129177226270320
among30015523010744117166215264
others3285552301075178126171197231
IUPHAR3536552301072278123179231276
(International214056630107254697127172202254298328349400453496518
Union26805663010782133154205257
of2960566301077399
Basic30825663010770115151172215
and33205663010765117170
Clinical3512566301077698119170191234279301
Pharmacology),2140580301074694135162237278320367387436487528551565
the2725580301073583128
WHO,28735803010782140202215
CIOMS3108580301075978139210253
(Council3381580301073181128177226267286305
for3706580301073179106
International214059430107196794136163212252280298346395436455
Organizations2614594301075885133174222241277319347365413462495
of3129594301074569
Medical32175943010767112162180221262281
Science)351859430107397998142190230273294
and2140608301074191141
EACPT23016083010750105155201244
(European2566608301073173120147195246292333382
Association2969608301076096130179221241282310329378428
for3417608301073179107
Clinical354460830107597897146165206249268
Pharmacology2140622301074592133159234275315362381430480520
and2680622301074189138
Therapeutics).2838622301074291136162204253298346374393433468489502
Folke2280636301074393115156202
was25046363010789134170
curious26966363010764115144165217268304
by30226363010773116
nature31606363010772116145197226272
and34546363010764115168
had36446363010772116169
a21406503010740
strong219965030107295783129176224
research244265030107226496139178204241288
mind2749650301076986133181
willing294965030107607896114131178226
to3194650301072369
explore3281650301074078127146192218260
and3560650301073683131
ex‑3710650301073978102
plain2140664301075069110128176
variability2336664301073879106125165215234253271299342
in2697664301071664
the2781664301072573117
effects291866430107416492135176207241
of3179664301074569
drug3268664301074672120170
treatment345866430107245194134161235279328354
on2140678301074897
different225667830107466589116160186229278304
patients.2580678301074789116135178227253288305
He2905678301075498
understood3023678301074593142186213247276323372422
intuitively346467830107166491139158186205246289308348
how2140692301074999165
experimental2326692301075192143189217237312357407434477496
methods28436923010782127156205255307340
and3204692301074898148
drug3373692301075784133184
assays3578692301074882117160199234
could2140706301074087136155204
be23647063010757102
applied2486706301074898148168186230281
clinically278770630107476684133151192234253271312
to3119706301073481
improve3220706301072699149176224264308
patient3548706301075698126145189237264
care.2140720301074082109152167
He23277203010764108
always2455720301074867133174214248
argued2723720301074774123171215266
for3008720301073179106
the3134720301073583128
importance3282720301072599149199226257299347388431
of3733720301075579
clinical214073430107416079128147188230249
pharmacology24097343010757107148175251292334381401450501542
making29727343010781122161182231281
a32737343010748
difference3341734301075776100128173200243292334377
in3738734301072674
healthcare2140748301074790129147174221260301326368
and2527748301073683131
thereby2677748301072471113139181229267
positioned2963748301074593125143170188234282325373
the3355748301072471114
discipline348874830107446294133151199218235282325
well‑integrated21407623010765108128146174194242269311361388429456499549
in2709762301072371
the2800762301073280125
hospital29447623010753102135184204232273292
and3256762301074593143
the3418762301073381125
clinical356376230107456482130149189230249
needs2140776301074892137187220
of2380776301074872
the2472776301072776120
healthcare2611776301074993133152180228269310336379
system.3010776301073475109138180254270
Folke4080440301074392113153198
has42994403010759102137
been44574403010760107154205
a46834403010751
strong4755440301074475103152203255
inspiration5031440301072979113165185213257286306356407
and54594403010751102153
mentor39404543010774118166193240267
for4226454301073077104
us4350454301075386
and4456454301074694144
many46204543010779120168206
other4846454301075481129173200
colleagues.5065454301074693113131175215265312356390407
We54914543010780122
remember3940468301072770143187261311356382
Folke4342468301074491111149192
as4553468301074478
a46504683010744
visionary,471446830107446396114162211251278321332
energizing5066468301074795139165214232269288336385
and5471468301074492141
powerful39404823010750100165209235263312331
leader.4291482301072670111160205232244
He45554823010764108
cared4683482301074789116159209
about4912482301074898148196225
his5157482301075574107
staff5283482301074170112136163
and5466482301074896146
collaborators3940496301074190111131174226278306350379428457493
irrespective445449630107305887132168219267310342362406451
of4926496301076186
background50334963010762106149189239267317367418469
or5524496301076089
position.3940510301075099132151179197245294310
Folke4270510301074794114152195
was44845103010771112146
long4649510301072573122171
active4840510301074687117136177220
and5080510301074694144
dedicated5244510301075498148167207249276318368
to3940524301072876
our40365243010756105133
work41895243010773122149189
and4398524301074998149
development45675243010757102144188208257308384430479506
for5094524301073179107
years5222524301074791132159195
after5437524301074873105149176
retirement.394053830107266895113138180252295342368383
We43425383010770110
keep4471538301073476119168
him4658538301074461133
and4810538301073784132
his496153830107446193
excellent5073538301073978116158176194237283309
achie‑5401538301073776123141184211
vements3940552301074184158202250277312
in4271552301071967
fond4358552301072371120169
memory.45475523010773118191240267310322
Marja‑Liisa50525803010768113139156202229267286304333378
Dahl54465803010756102149167
Professor,4730594301074367111134172203233277303316
Senior5062594301073977124142187213
physician5291594301074592127158175212231275322
Clinical430260830107486685131149186230248
head4567608301074684129175
of4758608301074568
Department4842608301075796142187213241313351397422
of5280608301074568
Clinical536560830107486684130148186230248
Pharmacology5110622301074388133159230275312356374419465502
Erik520665030107406483119
Eliasson534165030107405876121151181225272
Professor4589664301074367111134172203233277303
and4909664301074591136
Senior5062664301073977123141186212
physician5291664301074592127158175212230275321
Medical43916783010768106152170208252270
head4677678301074785130175
of4869678301074568
Laboratory4953678301073782127173199241267311337376
Services5346678301073977103143161199235266
Karolinska4949706301074287113156175193239269304349
Institutet531470630107196595121139165210236272299
and4467720301074592137
Karolinska4620720301074287113156175193239269304349
University49857203010754100118156193218250267293332
Hospital53337203010754100130174193218262280
Laboratory4894734301073782127173199241267311337377
Medicine,52877343010768106152170207225271310325
Clinical483374830107486685131149186230248
Pharmacology,5098748301074287132158229274312355374419465502515
Stockholm5248762301073964107146182229274293364
Sweden53227763010742105148198243291