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KLINICKÁ341804301074588109168189242288347
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A13288043010753
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TÉMA732207012658115205275
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u678365010640
diabetikov7333650106385695131163197214250289326
v1074365010637
štúdii112636501063164105145163180
LEADER132136501062962103143175211
–1546365010646
nachádzame160736501064080113154194234265306361392
benefit201436501063567108140171189221
u2250365010639
chorých230436501063475115151188220261
so258036501063272
srdcovým266736501063267107142181218257311
zlyhávaním?29933650106316295137176211248289306360386
cardiovascular340554083316485123139177208241268300338353385407
and7625540833674113
renal890554083255997129145
events10505540833870105143164192
in12575540831957
type13295540832660100135
2147955408339
diabets.1533554083425789128164186214228
N177655408349
Engl18405540833774113129
J198455408328
Med3406540835490129
2017;4846540833569100130140
377:6396540833466101111
644–657.7656540833471108145182216249256
6.3407530853651
Wiviott4107540835873105120158179203
SD,628754083378192
Raz7357540833972101
I,8517540831931
Bonaca8977540834078116147179212
MP,1123754083599599
et12367540833961
al.1311754083375264
Dapagliflozin13907540835081120153191206220237254292320335372
and17777540833674112
car‑1904754083366889108
diovascular340854083385390121153179211248262294314
outcomes669854083387597127163221255281
in9658540831552
type1032854083225595130
2117685408335
diabetes.1226854083385384123157179212238251
N149285408345
Engl15528540833370108123
J168985408325
Med17298540835589128
2019;1872854083356899129141
380:3409540833468102115
347–357.4699540833469100132163196228234
7.34010530853645
Sun40310540833270108
F,52610540833541
Wu58210540836096
S,69410540833547
Guo75710540834684122
S,89410540833548
et95710540833658
al.10311054083344962
Effect11081054083355473108140164
of128810540833958
GLP-1136210540834678114135165
receptor15431054083235789123162184221243
agonis‑180110540833473111150165191212
ts34011540832249
on40511540833977
waist49711540835386101127150
circumference6621154083334869101138196215250271305343375409
among108611540833491130168207
type13091154083235797132
21457115408335
diabetes15081154083405587126161184218244
patients:17681154083407395110145183204232245
a340125408332
systematic3871254083306289112146204236258273305
review7081254083245890106140192
and91512540833573112
network10421254083417699152189211242
meta‑analysis.129912540836196118151173206244276291323350365391405
Endocrine171912540833674113151184205221258293
2015;34013540833468100130141
48:4961354083347083
794–803.59413540833467103141177212245258
8.34014530853653
Holman41414540834583100158191229
RR,6591454083417892
Bethel76614540834177100138174190
MA,971145408361103117
Mentz110414540836096134156187
RJ130714540834168
et139114540833962
al.14691454083375366
Effects15501454083395877112145169198
of176314540834363
once­184114540834382115149172
‑weekly34015540832174109146177194227
exenatide58315540833972107146179201217257293
on89115540834483
cardiovascular9901554083377193132147186219253280313352368401423
outcomes142915540834382105137174234270298
in174215540832159
type181715540832862103140
21973155408340
diabetes3401654083385385124160182216243
N598165408345
Engl65816540833371110125
J798165408324
Med83816540835489129
2017;98216540833468100130139
377:113716540833466100110
1228–1239.12631654083346499132169200230265298309
9.34017530853649
Marso40417540835487108135174
SP,5931754083316671
Bain6791754083346782120
SC,8151754083317285
Consoli91517540833976114141179195210
A,114017540834054
et120917540833356
al.12801754083314659
Semaglutide135417540833267125157196211249272287326361
and173017540833169108
cardi‑18531754083306384122137160
ovascular34018540833769102129161199214246267
outcomes6231854083357395126163221256283
in92218540831250
patients9871854083377091107141180201229
with12311854083486487125
type13711854083205393129
21515185408332
diabetes.15621854083365183123158180214241255
N1832185408342
Engl189018540833068107122
J340195408324
Med37919540835590130
2016;52419540833468100131143
375:6831954083346699110
1834–1844.8081954083346599134172203234270307320
10.3402053085367085
Husain44020540834482108141156194
M,65020540835467
Birkenfeld7332054083355071102136174193227243282
AL,10302054083417387
Donsmark113220540834584122149206239260290
M,143820540835467
et152120540833456
al.15922054083324760
Oral166720540834769102117
semag‑180020540832661119151190213
lutide340215408315527590129164
and51921540833371110
cardiovascular6452154083326586124139177209242269301339354386407
outcomes10682154083387699130167225260287
in137021540831654
patients14392154083407395110145183204232
with16862154083526890128
type18302154083225696132
21977215408335
diabetes.3402254083385385124160182216243256
N612225408344
Engl67222540833270109124
J812225408324
Med85122540835590129
2019;99622540833468100130143
381:115422540833469101109
841–851.127822540833571101134170204235245
11.3402353085366780
Hernandez43623540834480102141174213253288318
AF,7702354083427582
Green86823540834467101138176
JB,10602354083256275
Janmohamed11512354083255896155194233266325360401
S,156823540833346
et163023540833558
al.17042354083324862
Albiglu‑17822354083415897113153169207230
tide3402454083223877113
and46924540833574114
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outcomes103424540834180104135173232267295
in134524540831857
patients14182454083427698114150189211239
with16732454083557194133
type182224540832560100137
21975245408338
diabetes3402554083385486126162185220247
and60325540833069109
cardiovascular7282554083296385123139178210244271304342358391413
disease11572554083365279115147174210
(Harmony13832554083176295117176215254285
Outcomes):168425540834584107139176235271298316329
a340265408332
double‑blind,38826540833978116156173208232273290305344384397
randomised8012654083225594134173232247274310350
placebo‑controlled11672654083405689122157196236260294332371393416454470486521562
trial.1745265408322446193110123
Lan‑188426540833267105128
cet3402754083316689
2018;44527540833469102133146
392:60727540833569103116
1519–1529.7392754083356698129167198229263298309
12.3402853085366884
Marso44428540835487108135174
SP,6332854083387277
Daniels72528540835183121136171186213
GH,95328540834993106
Brown‑Frandsen10752854083406199150188211245265298336375401436475
K,156528540834055
et163528540833961
al.17122854083365265
Liraglu‑17922854083365273106145160198220
tide3402954083223776111
and46629540833371110
cardiovascular5922954083326586124139177209242269301339354386407
outcomes10152954083387699130167225260287
in131729540831654
type13862954083235797133
21534295408335
diabets.15852954083395486125161183211225
N1825295408346
Engl188629540833472111126
J340305408324
Med37930540835590130
2016;52430540833468100131143
375:6833054083346699110
311–322.8083054083346593126158190225238
13.3403153085366883
Pfeffer4413154083355590110129163184
MA,64031540835799113
Claggett7683154083435890129168203225249
B,103331540833750
Diaz10983154083486395125
R,123831540833852
et130531540833658
al.13793154083344962
Lixisenatide1456315408334498096122157195227249265303338
in181031540831654
pati‑18803154083407395110133
ents3403254083347294121
with4773254083526790128
type6203254083235797133
2768325408336
diabetes8193254083405587126162184218244
and107932540833371110
acute120432540833466104126160
coronary13793254083337092129167200221255
syndrome.16493254083286099138159197255290302
N1966325408347
Engl21405540833370109125
J228055408324
Med23205540835489129
2015;24645540833468100130141
373:26205540833466101112
2247–2257.27475540833469101133165197232267300306
14.2140653085366883
Gerstein2236654083437899126148182196234
HC,2485654083418194
Colhoun2594654083377389126164201239
HM,28476540834296109
Dagenais29716540834274112147184216231256
GR,3242654083417790
et33476540833153
al.3415654083294457
Dulaglutide3487654083428095126165180217239254292326
and21407540833270109
cardiovascular2264754083346788126142180211244271303341356389410
outcomes26897540834078101131168227262289
in29937540831755
type3064754083245898133
2321375408337
diabetes3265754083415688127163185219246
(REWIND):3526754083215791150166211257275286
a214085408332
double‑blind,21878540834482121160176212235275291307345384397
randomised2599854083266098137176235250276312351
placebo‑controlled2966854083446093125159199238261295332371393415452468484519559
trial.354085408327496497112125
Lan‑36818540833770109131
cet2140954083316587
2019;22439540833468100130143
394:24019540833467103115
121–130.2532954083346495128159189223236
15.21401053085377085
Kristensen22461054083355975102125160199226262301
sL,25631054083326579
Rorth265810540834180102128167
R,284110540834156
Jhund291210540833069108147187
PS.31151054083417588
et321910540834063
al.32981054083385467
Cardiovascular338110540834680101141156195228262289322361377410432
mortality,214011540835796117142175190205227261271
and242611540833169108
kidney25501154083284584122157188
outcomes27541154083367497127164223258285
with30541154083506588126
GLP-1319511540834375111132163
receptor33731154083205487120160182219240
agoni‑362911540833170108146161183
sts21401254083264977
in223212540831351
patients22981254083377092107142180201229
with25421254083496587125
type26821254083205494129
22827125408332
diabetes:28741254083365284123158181214241254
a3143125408330
systematic31881254083245784107141199231253268300
review35041254083185285100135186
and370612540832967106
meta‑analysis214013540835792115147170202240272288320347361388
of254313540834060
cardiovascular26181354083346788126142180212244271303341356389410
outcome304313540834078101132169227262
trials.3320135408325476294110136149
Lancet348413540833568106139172195
Dia‑36941354083486496118
betes21401454083397496130157
Endocrinol231214540833371110148181202218255294310
2019;263714540833468100130143
7:279514540833545
776–785.285514540833469101138170203237249
16.21401553085366985
Zhang224015540833876108146185
JY,24401554083246068
Wang252315540835789127166
XY,27041554083377583
Wang280315540835688126165
X.298315540833852
Effects30501554083325170104137161189
of325415540833756
liraglutide3325155408314295083123138175198213252287
on362715540833775
he‑37181554083377295
modynamic214016540835795135166205237295310341
parameters24971654083366990122180215237270292319
in283116540831250
patients28961654083366990106140178199227
with31381654083486486124
heart327716540833570102123147
failure.3439165408316496479117138172184
Onco‑363816540834483115151174
target21401754083225476114149171
2017;232617540833468100130139
8:248117540833446
62693–62702.254317540833467101135167204241274307340373386
17.21401853085366876
Arturi22371854083416287125146162
F,241418540833743
Succurro247318540833775107138175197218256
E,274418540833851
Miceli281018540835975107141156171
S,299618540833851
et306218540833961
al.31391854083375265
Liraglutide32191854083375273106145161198221236275310
improves354418540832077117138175207242268
cardiac21401954083316485123139171203
function23581954083205896128153168206244
in261819540831653
patients26871954083407394110144182204232
with29341954083526790128
type30771954083235797133
23225195408335
diabetes32761954083395486125161183217244
and353519540833371110
chro‑36611954083327091128151
nic21402054083385385
heart224020540833772104125150
failure.2405205408319526782120141175187
Endocrine260820540833270109147180201217255290
2017;291320540833468100129139
57:30682054083346777
464–473.316020540833571107144181213248260
18.21402153085366985
Margulies224421540835487108146184199214249276
KB,25352154083397688
Hernandez263921540834883104142175213252287316
AF,29712154083447783
Redfield306921540833974114132149184199238
MM,3322215408359114127
et346421540833860
al.35402154083355164
Effects36192154083365574109141165193
of214022540833757
liraglutide2212225408314285083122137174197212251286
on251322540833675
clinical2603225408330466098113145178194
stability28122254083254881120136151166188222
among304922540833189127166205
patients32692254083377092107142180202229
with35142254083496587125
adva‑365522540833069102135157
ced214023540833165104
heart226023540833974106127151
failure2427235408320536883121142176
and261823540833472111
reduced27442354083225696133166199239
ejection29982354083365186118142158196234
fraction:32472354083204275108132147185223236
a3498235408333
randomi‑35462354083235694133171229244266
zed214024540832862102
clinical22572454083314762100115147179195
trial.2467245408322435991106119
JAMA260124540832565120162
2016;277824540833569100132144
316:29372454083346596109
500–508.306124540833468105143177211246260
19.21402553085367085
Jorsal22492554083246487116151168
A,243425540834763
Kistorp25142554083426087112151174215
C,274625540834761
Holmager282425540835191108168202242279302
P,314325540834147
et320725540834165
al.32892554083385570
Ef337525540834060
fect34402554083185489114
of357125540834465
lirag‑3653255408321386195136160
lutide,2140265408315547894135171184
a2341265408338
glucagon‑like239626540834562100134168209248288312330346378413
peptide-1282626540834582123146163203240264297
analogue,313926540833878112128168209248284298
on345426540834383
left35542654083215778104
ven‑367526540833874114137
tricular2140275408322456296135152186209
function236627540832565105139165182221262
in264527540832161
stable27222754083335893134151188
chronic292727540833877100139179196230
heart317427540834481114137163
failure3354275408325607794133156192
patients356327540834580103120157197220249
with21402854083516891131
and228828540833373113
without24182854083526993133173212236
diabetes26712854083405690130167191226254
((LIVE)-a2942285408321397289127162184208241
multicentre,320028540835998115139155189224263286309345358
double­357528540834079119159177213237
‑blind,2140295408321628096135176190
randomised,234629540832761101141181240257284321362376
placebo‑controlled27392954083446195129164204244269304343382405428467484501537578
trial.33342954083275067100117131
Eur34822954083387699
J3598295408330
Heart364429540835087120142168
Fail2140305408332638096
2017;225330540833671104135146
19:24163054083366782
69–77.251430540833671110143179187
20.21403153085367390
Marso224731540835488111140179
SP,24433154083336975
Baeres253531540833569106128164192
FNM,274431540833278135149
Bain29103154083367087126
SC,30533154083327489
et315831540833558
al.32333154083324963
Ef331331540833352
fects33703154083195589114143
of353031540833758
liraglu‑3605315408315315488129145184208
tide21403254083223879115
on227232540834181
cardiovascular23693254083357092132148188221255283317356373407429
outcomes281532540834181104137175235271299
in313132540831958
patients320632540834277100116152192215244
with34673254083547195135
diabe‑36183254083425992133170194
tes3940554083225785
with4042554083557295135
or41945540834164
without4275554083557296135175214238
heart45305540834278111134160
failure.470755408322577490129152187201
J492555408328
Am497055408345104
Coll50915540834483100116
Cardiol52245540834479101141157197214
2020;54555540833874108143158
75:3940654083346881
1128–1141.4037654083366596131170202231264295306
21.3940753085367082
Cosentino40417540834077104139177198214251290
F,43467540833642
Grant44037540834769101140161
PJ,4579754083395870
Aboyans46647540834584123154187225252
V,49317540833948
et49947540833760
al.5069754083355063
201951487540833771103133
ESC52967540833670111
guide‑5422754083417994133168191
lines3940854083153069104132
on40878540834382
diabetes,4185854083445992132168191225252266
pre‑diabetes,44668540834567101125166182214254290313347375388
and48708540833776115
cardiovascular5001854083377092131146185217251278311349365397419
disea‑5436854083445986121154176
ses3940954083266188
developed40449540834378110145160198238274313
in43739540832057
collaboration4446954083367389104137176215237270291307345383
with4845954083567194132
the49929540832765101
EASD.51089540833880115160171
Eur5294954083387596
Heart54059540834985117138163
J558395408329
2020;394010540833468101135148
41:41031054083356573
255–323.419210540833469101138170202237250
22.39401153085367288
Fitchett40471154083324770100138173196220
D,428211540834960
Butler435711540833977100115150171
J,454311540832840
van459811540833568106
de472011540834176
Borne48111154083397899138173
P,499911540833943
et505811540833759
al.51331154083355063
Effects52111154083375574109142166193
of542011540834060
em‑549511540833795118
pagliflozin394012540833972111126141159176214242257295
on425112540834180
risk4346125408325416797
for44581254083236183
cardiovascular45561254083366990128143181213246272305342358390411
death498212540834378110132170
and516712540833674113
heart529612540834277109130155
failu‑5466125408323567186124146
re394013540832155
hospitalization401013540833675101140156178211226241271304326341379418
across44431354083306384121148174
the46331354083205893
spectrum47421354083256499132156177216273
of503113540833655
heart510113540833772104125149
failure5266135408317506581118139173
risk5455135408319356191
in556113540831451
the39401454083226095
EMPA‑REG405014540833388124161183220253297
OUTCME436314540834791125164220253
trial.4631145408322435991106119
Eur47661454083326990
Heart487114540834479111132157
J5043145408325
2018;508314540833468100131143
39:52411454083356881
363–370.533714540833469103139171203236249
23.39401553085357083
RadholmK,403215540833565102138173187242286299
FigtreeG,4344155408328417798117149182234245
Perkovic46031554083306181109144174187217
V,483315540833138
et488515540832949
al.49481554083274051
Canagliflozin501215540833666102132168182195210227263289302338
andheart536315540832763100146179208227250
failure3940165408318496376111130162
in411616540831046
type41751654083184987120
24309165408329
diabetesmellitus.43521654083334776113147167199223289322336349362383418443454
Circulation4820165408335496897132146176195209245281
2018;51141654083306292120131
138:52581654083305890100
458–468.53721654083296092127162196229240
24.39401753085367186
Kato40451754083356890127
ET,41881754083367180
Silverman4283175408336516698133154212245283
MG,4581175408358103116
Mosenzon471217540835897123158197226263302
O,502917540835062
et510617540833760
al.51811754083355164
Effect52601754083365574108141165
of544117540834060
da‑55161754083427496
pagliflozin394018540833972111126141159176214242257295
on425118540833876
heart434318540833873105126151
failure4509185408319536883121142176
and470018540833371110
mortality482518540835897118143176191206229262
in510318540831553
type51711854083235797132
25318185408336
diabetes53691854083395486125161183217244
mellitus.394019540835792108123138160198225238
Circulation41941954083405576107145160192214229267306
2019;451519540833468100130143
139:46731954083356598111
2528–2536.479919540833469102136173205240273307320
25.39402053085357288
Scirica40432054083326581102119151185
BM,424420540833388103
Braunwald43632054083335589127165216249266305
E,468420540833145
Raz47452054083336797
I,485820540831327
et490120540833255
al.49722054083304660
Heart504820540834278110132157
failure,5221205408317516783121143177190
saxag‑54272054083245890123163186
liptin,3940215408315307092108146160
and411621540833068107
diabetes42392154083365284124160183217244
mellitus:449921540835590107122138161199226239
observations475421540833575102138160195228250266304343370
from51402154083173977135
the52912154083205894
SAVOR­540121540833071105152189211
‑TIMI5339402254083215269125141176210
randomized41662254083195392132171230246276311351
trial.4534225408320425992108122
Circulation46732254083385476108147163196219235274313
2014;500322540833368100132145
130:51642254083336499113
1579–1588.52942254083336398132170202233268304319
26.39402353085367186
Verma40392354083356889147179
S,423323540833043
Goldenberg42912354083417995134168206245280301339
RM,464523540833388101
Bhatt476123540833371103125149
DL,49252354083437588
et502823540833254
al.50972354083294457
Dipeptidyl51692354083435897132171193208247278294
pep‑547823540833672111134
tidase-439402454083223776108135170193229
inhibitors41852454083165492107146161184221242270
and447024540833371110
the45962454083236196
risk4707245408322386494
of481624540833958
heart489024540833974106127151
failure:5057245408319536883121142176188
a5261245408333
systematic53092454083286087111144202235256272304
review39402554083215587103137189
and414425540833270109
meta‑analysis.426825540835792115148170202240273288320347362388401
CMAJ468525540834095137164
Open486425540834787122161
2017;504025540833468100129139
5:519425540833545
E152–E177.52552554083326494127161196227257291297
27.39402653085367180
Green40342654083446599135173
JB,42222654083235972
Bethel43092654083346991130165180
MA,450526540835395109
Armstrong462926540834061119146169190228266305
PW,494926540833492102
et506626540833355
al.51362654083314659
Effect52102654083325170104137161
of538626540833655
sitag‑5457265408324396294133156
liptin3940275408315306991106144
on409927540833574
cardiovascular41882754083296283121136174206239266298336351383404
outcomes46082754083357395126163221256283
in490627540831351
type49722754083195393128
25116275408332
diabetes.51632754083365183122158180214240254
N5432275408343
Engl549027540833068107122
J3940285408324
Med397928540835590130
2015;412428540833468100130141
373:428028540833466100112
232–242.440728540833469102136167199232244
28.39402953085367288
McGuire404529540835487132170185206240
DK,43012954083468296
Alexander44132954083425792124156194234268290
JH,47182954083257083
Johansen481629540832664102135173199234272
OE,51042954083488194
et521429540833557
al.52862954083334962
Linaglip‑53632954083334886118157173188227250
tin39403054083223775
effects40303054083395978112145169197
on424230540834281
heart433830540834378109131155
failure4509305408323567287124145179
and470430540833775114
related48333054083266075108129163203
outcomes505130540834280103134171229264291
in535730540832058
indivi‑54303054083205897112144160182
duals394031540833876109124150
with41063154083567194132
type425431540832761101137
24406315408340
diabetes44613154083435991130166189223250
mellitus472631540836398114129144167205231
at497331540833759
high50473154083435897136
cardiovascular51983154083367091129145183215248275307345361393414
and394032540833270109
renal40643254083215593125141
risk4220325408321366292
in432832540831452
CARMELINA.439532540834083119174208239254300341355
Circulation47663254083405576107145160192214229267306
2019;508732540833468100130143
139:52463254083346497110
351–361.53713254083356899131164198228238