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D.4364146101096179
Roosevelta,44631461010949100151188235279324347378424444
Banská4927146101095095146182226271
Bystrica,5218146101095094131163194216258303323
Slovenská3040160101094467118161207258295338384
republika3444160101093076129180233256278321367
Chronická3180188301075198123168216233272309350
lymfocytová3548188301071554127149195235276306352391431
leukémia3997188301071558104141183255272311
(CLL)4327188301072068106145168
je4513188301071658
najčastejšou4590188301074483101140180212239281298330376423
B‑bunkovouma‑5032188301074169118165212248294333379426514554580
lignitou304020230107193785132150177222270
dospelých3328202301074693126174218236275314361
v37082023010737
západnom3764202301073273122163211258306379
svete.4162202301072971113140181195
Nové43762023010754101141183
liečebné457820230107153275115157205253296
agens4893202301073786129176208
získali512020230107325183119161179196
dôležité5335202301074592111154190209236277
postavenie3040216301074996127154193231272318335376
v34342163010736
liečbe348721630107153173112159202
CLL3707216301074583121
amanažment38462163010736122160206245280351393439464
CLL4328216301074683121
prechádza4467216301074570110150195234281316356
dynamickýmvývojom.4841216301074381128167238254293328369441494535577622640685757771
Dlhé3040230301075776121164
obdobie3222230301074391139185233251293
bola3533230301074592110149
chemoimunoterapia3700230301073581123195241259330375421468493534559598646664702
štandardnou442023030107295695142189228252299345391437
liečbou487523030107153274113160207254
pre5147230301074470111
pacientov5276230301074584123140182228253298336
s30402443010733
CLL.3092244301074786125141
S32522443010738
príchodomnových330824430107467290129176223272319392455503542584622669
–39962443010741
cielených405624430107365396114157204242280327
liekov440224430107153275112158197
sa4618244301073070
rozšírili4707244301072369103137155180198216233
liečebné495924430107153275115156205252295
možnosti,52732443010770117152199247279307325339
ktoré3040258301073868114140182
zlepšili324125830107355497145178195213231
prežívanie3490258301074975117153172212252300317360
predovšetkým3869258301074975117166213253286329356393435508
vysokorizikových4396258301074082115163201247273291327345382429468510549596
pacientov.5011258301074990129147190237263309348359
TP533180272301074288129171
poruchy3370272301074695122170210258296
(zahŕňajúce368527230107215799147173221261280327367409
TP534113272301073985127168
mutáciu43002723010770118146187227245292
a46112723010738
17p4668272301074177123
deléciu)4811272301074589108152193211258279
sú5110272301073077
najsilnejším5206272301074585104136154173220264283315333406
prediktorom3040286301075077120170188226257303330378452
chemorezistencie.3511286301074593137211259286329367386419448490538579597641656
Okrem41872863010765104132175248
uvedených4455286301075294137187231279318357405
genetických4880286301075498146190218237277315358397445
porúch53452863010754104131179220268
aj3040300301074160
mutačný31203003010781129157199239288326
status3466300301074170112139187220
génov37063003010756101149198238
pre3964300301075784127
variabilnú4111300301074889116135176226245264312360
oblasť44913003010755105125166199229
ťažkého4740300301073677114153196245294
reťazca5053300301073477106147184224266
imuno‑5339300301072599147195244273
globulínu3040314301074968116166214233252300347
(IGHV)340731430107254399156203230
pomáha36573143010750100174215263303
klinikom398031430107396078126144182229304
pri430331430107517897
rozhodovaní4420314301072774109158207257305345387435453
o48933143010749
liečebnej496131430107203982124166215264308327
stratégii.530831430107346390132159201251270288304
Medzi30403283010770114165202221
nové32813283010754103143186
cielené3487328301074765109129173221265
lieky,377232830107254488126169180
ktoré3972328301074576122149192
boli41843283010756105125144
schválené4347328301074081129169210229273321366
pre4732328301075784127
pacientov4878328301075798139158201250276323363
s52613283010740
R/R5321328301075287133
CLL5474328301075898138
patria3040342301074990117143162202
inhibítory3261342301071562110128177195223269295338
Brutónovej3618342301074268116143189237285325367385
kinázy4023342301073454101141178220
–42633423010741
ibrutinib,432334230107166491139166185232250299313
akalabrutinib,4655342301073775116135175224250298326344391409458472
zanubrutinib,5147342301073274121168217243291319337384402451465
inhibítory3040356301071966114132181200227273300342
fosfatidylinozitol3402356301072067100125166193212260300320338385433468487514561580
3-kinázy4001356301074168106126174214251293
–43143563010741
idelalisib,4375356301071564107126166185203235253302316
duvelisib,4711356301074592133176195213245263312326
alebo505735630107375699148197
inhibítory5273356301071663111129178197224270297340
BCL23040370301074597137182
–32423703010745
venetoklax.3307370301074084132176204250289310350390407
Relabujúca,3180384301074590109149199247266314354396412
refraktérna361138430107327599126168206237279306355395
CLL4026384301075797137
zostáva4183384301074188122151192232273
nevyliečiteľným4476384301075498138182201220264305323351394413461499574
ochorením5070384301075394142190217260309327400
na‑5490384301075494122
priek304039830107507898142181
liečebným324239830107264589131175225275314390
pokrokom.36523983010757107147176224263311387403
Dlhoročná4076398301076586135184212260302351392
monoterapia44883983010782131181230258302329371422441483
novými49913983010756105146190266285
liekmi529739830107264589128205224
je5541398301072671
asociovaná3040412301074174123164182230271312360401
s34614123010732
prerušením3513412301074976119145194227271319337411
liečby394341230107193781122171211
pre4173412301074976119
rozvoj4312412301072673108152199219
mutácií45504123010773121149190231249268
vedúcich4837412301074084134181222240280329
k51854123010737
rezistencii,5242412301072669106125158187230278318337355371
s30404263010733
finančnou309342630107204087128175215263311359
záťažou,3471426301073375103144181227275290
kumulatívnou3781426301073482155202221261288307348396444492
toxicitou4293426301072471108127167186213260307
aj4620426301073856
s46964263010730
problémom4745426301074774120170189233306354428
s51924263010731
dlhodobej5242426301074665112160210258307352370
adherencie3040440301074293143189217261311354373419
pacienta34804403010758101143163208258286329
k38304403010746
liečbe.389744030107274692134185232248
Tieto4166440301075072117146195
faktory4382440301073175114146195223268
viedli4671440301074869114166186206
k48974403010747
potrebe49644403010758109138166211262309
ďalšieho52944403010758100120153173218268319
rozvoja3040454301072775111155204223264
konceptu3325454301074593142184227277305354
časovo3699454301074890124173214262
limitovanej3981454301072645120139167215256298347392411
inovatívnej4412454301072675124165207235254296346391410
liečby484245430107264590131181222
s50844543010740
dosiahnutím51454543010756105139158199248297345374393468
hlbokých3040468301074867116166204247287335
a33944683010742
dlhotrvajúcich3456468301075068116165192219263304323370411430470518
remisií3994468301072770144162195213232
a42454683010742
s43074683010734
ideálne4361468301071969113153172219264
čo4644468301074188
najdlhším4751468301074990109158177225258276350
obdobím5120468301074999149197248267340
bez5480468301075095132
liečby.304048230107193780121170209220
Odpovede32804823010757106155204244286336380
na3679482301074585
koncept3783482301073582130170212261288
fixnej409148230107204078126170188
liečby429948230107163477118166205
nám4524482301074585158
poskytujú4701482301074695128165208238286305351
výsledky5072482301073780113132175225262305
štúdie5396482301073059106155173217
Murano.30404963010770118144186234282297
Dostupnosť33574963010755104138167215264313361394424
uvedenej3801496301074586129179223271315334
liečby415549630107163478119168208
zlepšila438249630107345397147180198217258
liečebné465949630107163578119162211260304
výsledky4983496301073781115133177227265308
aj5311496301073756
našich5387496301074586119137178226
pacientov,3040510301075091132150194242269316356367
vrátane3427510301073967108135177225269
ťažko3716510301072768105143191
predliečeného3926510301074976119169188206250291333381425474522
pacienta,4468510301074890131149193241268309325
alebo4813510301073958102152201
pacienta5034510301074890130149193241268309
vo5363510301073987
vyš‑5469510301074083117143
šom3040524301073482156
veku3216524301074487125174
a34095243010745
s34735243010738
početnými35305243010754103144186214262301375394
komorbiditami.3944524301074189163211238288308357375404445518537553
Nová45175243010761109149191
dostupná,47285243010752101134163211261309350366
kombinovaná5113524301074289164213232280329369410458499
a30405383010742
fixovaná310253830107315292140182224274316
liečba343853830107274691133184226
venetoklax3685538301074893142188216264304325367408
a41145383010748
rituximab418353830107345483132173192268310361
je4564538301072772
dobre46565383010757107158186230
manažovateľná.49065383010783124174216254302344386414458479527569586
Pri551353830107537999
dostatočnej3040552301074896128157197223269309356400418
hydratácii3477552301074482129155196222263302320338
a38345523010737
antiuratickej3891552301073784110128174200241267285325362404422
liečbe433255230107163376116165209
vieme456055230107375598171214
predchádzať4793552301074672114163203250290338374415443
syndrómu5255552301073070118166192238311358
z30405663010736
nádorového3096566301075394143192219266306349398446
rozpadu3562566301073178114164206255302
buniek.38845663010755103151170214252270
U41745663010761
našich4255566301075394127145185233
pacientov4508566301075596137155199247274321361
sme48895663010738112156
nezaznamenali5065566301075397134177214263303377421469510529547
výraznejšie3040580301074184111153190239283302335353397
cytopénie3456580301074083114161211256304322366
či3842580301074058
infekčné392058030107196790134172211259303
komplikácie.4243580301073885159209229247285327368386430445
Innovative3040605501432589153217271326362387441499
Asthma35666055014372118157221319373
Treatment3966605501435785142195231329388452488
with44816055014388114151215
Fixed4724605501435681133190256
Triple5008605501435784110176202260
Inhaler3040619501432589153207232290326
Combinations33936195014370132230296322385439475500564629672
Štefan3040635001235286139172225283
Laššán33456350012350103146188241299
Department30406501010960107160205235269345392444474
of3534650101095078
pulmonology,36326501010952104126202253304355378429482526542
phthisiology41946501010952104134185207244266316339390443487
and4701650101094596148
functional4869650101092779130172205227278329374396
diagnostics,3040664101095173117169220271308340362403441461
Slovak3521664101094668119163208251
Medical37926641010974121173196237282305
University41176641010959110132177222253291313344390
and4527664101094496148
Bratislava4695664101095081126156178215237281325370
University50856641010959110132177222253291313344390
Hospital,30406781010959110147199221252298320340
Bratislava,3400678101095081126156178215237281325370390
Slovakia3810678101094568119162207251274319
Introduction:3180705801122678110144196249301342375400452504526
Asthma3725706301075386114161233272
is4016706301071950
a40847063010741
serious4144706301073476102119166213245
global4407706301074967113162202220
health4645706301074992130148175221
problem4885706301075075121170188231303
affecting520670630107416490132172201218265313
all553770630107415976
age3040720301074188130
groups3188720301074469114160208240
with3446720301075977103150
increasing361472030107146098123164202234250296344
prevalence3976720301074570111150189207249295334374
and4368720301073682130
still45167203010728567390107
imposes4641720301071485133180212254286
a49457203010736
significant499972030107294592138155177196234273320345
burden5362720301074491115162204250
on3040734301074793
health3151734301074385122139165211
care337973430107357498139
systems.353673430107286798125165236267282
The3835734301073784126
GINA3978734301075168123172
20214168734301073979118155
document4341734301074389128173244286332356
recommends4715734301072162101145216287329374421452
in5184734301071460
the5261734301072369111
field53897343010719367895142
of5548734301074365
pharmacotherapy3040748301074996134159231269308352377423466490530577614
stepwise367274830107295696143206223254296
approachwith3986748301073583131156200240278324402419445491
two4495748301072388133
treatment464674830107234889127152223265311336
tracks500074830107234887126162196
which52147483010759106122161206
differ543874830107446183108150174
in3040762301071964
reliever31227623010722638097139177218243
medication.33837623010768110158175213253278295341387402
Add‑on3802762301074894142168216262
treatments408276230107234889127152223266312337369
for446976230107196590
patients4576762301074585110127168215239272
who48667623010760106153
are5037762301073560101
already515676230107365377118156203241
being5415762301074588104150197
treated304077630107275292130155195243
at3300776301073661
the3378776301072368110
step350677630107285595142
436667763010738
or3722776301074267
538067763010739
include386277630107146098114159206248
long‑actingmuscarinic4127776301071460106153179217255283300345392477522553591630654672717733771
antagonists4916776301073581105144191237283300330357389
(LAMAs).5323776301071956108176226259278289