918
www.klinickafarmakologie.cz340804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/26358043010757
Klin2711804301077091109157
Farmakol2888804301074279105179220258305325
Farm3233804301074178105179
2021;3432804301074487128167177
35(3):3629804301074485107149171185
87–953834804301074485126170213
/40678043010756
KLINICKÁ41438043010771115135194215269315373
FARMAKOLOGIE4536804301074392140212267313373416476535556599
A51568043010753
FARMACIE5230804301074292139211266318338381
9556558026012657114
ABSTRAKTA5033207012668132191250313385452514578
9.390336501063245
ČESKO‑SLOVENSKÁ396236501063365100135174203233263302340372413446481523
KONFERENCIA450036501063473114145177213245287321339379
KLINICKEJ48933650106356684125143177213245272
FARMAKOLÓGIE518036501062967103157198233272304343383400432
some34062301073381154198
patients,55762301074687114132175223249283299
dysfunctional87562301074585118143191238278308326374422462480
immune137462301071688161208255299
response16926230107236598147195243276319
plays203062301074666106144177
a2226623010738
crucial228362301073662110150168208226
role25296230107236988132
during268062301074592118137184233
the34076301072876120
second48076301073478119166214264
stage76376301073463104154198
of98076301074872
the107276301072876120
disease.121276301074968100144185218262277
Expert48089801124795148195228262
opinion:759898011247100124176200251302325
The109790301074189132
pharmacological124790301074592131155228267306350369415463480519559576
treatment18419030107244990128154226268315340
is219990301071446
considered226390301073580127158175222265289331379
as266090301073668
a2746903010736
key280190301073374112
part340104301075090116146
of505104301074770
management5941043010774114161201249292365408456481
strategies109410430107346288128154196245263306339
and1452104301074087136
needs1607104301074891135184216
to1842104301072773
be1934104301074993
tailored204610430107286886104151177219268
according2333104301074180118164190237255302350
to2702104301072873
the2794104301072875118
stage340118301073462102151194
and553118301074694142
disease714118301075572104148187219263
severity.995118301074083123165191209236278289
Numerous13031183010763110183226252298345378
pharmacotherapeutics16991183010756104143169242282322368394442485511551600644691718736776810
have2528118301075493132175
been27211183010756100144191
introduced34013230107196793120167217264304346396
into75613230107247299145
the920132301073482127
clinical106613230107466582130148188230248
practice1333132301075683124165195213253295
despite1648132301075599132181200228270
low1937132301072574138
level2095132301072569109152171
of2285132301075478
evidence2382132301075091110159203251291333
from2734132301073057104179
well‑designed3401463010766109128146173224268301319368416459509
clinical86914630107466482130148188229247
studies1136146301073968116165183226260
or1415146301075481
systematic1515146301074080114142185258299325344384
reviews/meta‑analyses.1918146301073375116135178243277309380424451492520560608649667707740784818834
The2771146301074898141
strongest34016030107346288135183231275308336
recommendations695160301073275115161235308352399448488514533580628660
assume1374160301074780112159232275
the1668160301073482125
use1812160301075486130
of1961160301075477
new2057160301075498162
antiviral2238160301074794120138179197223264282
drugs2539160301075581129177209
(i.276716030107304863
e.2849160301074963
remdesivir),340174301072668139187229261278317335360381393
systemic752174301072968100128169240257296
corticosteroids,1066174301073681106135153191236268296337362407424472503518
neutralizing1602174301074386132159184224241258293311357405
antibodies2025174301073683108125173220269286328360
targeted240317430107246388135177203244292
to2714174301072368
the2800174301072370112
viral34018830107415985125143
S‑protein.502188301073966116142188215256274321336
In857188301071663
patients939188301074788114132175222248282
with1240188301076280107155
systemic1413188301073171104132174247264304
hyperinflammation1736188301074583132176202220267290311351424496536562580627675
the2430188301072572116
indication2564188301071663112130169209236254301348
of340202301074770
anti‑IL6monoclonal429202301073682108125152171210251339386433480520537584631670688
antibodies,1135202301073783109126174222270287330362377
JAK/STAT1530202301072776119154194236281316
inhibitors1864202301071561107125173190217262288321
and2203202301073683131
anakinra2352202301073783122159178224249289
may26602023010769108145
be2824202301074588
justified.34021630107196698126144167186229278293
To652216301074182
achieve753216301074080127145187227270
a10412163010740
more11002163010773120146188
efficient130721630107436692111151168211258284
immune1610216301071890163210257300
response,1929216301072568100149197245277320334
multiple22812163010773120138165183231250293
methods25932163010773116143190238287319
could340230301074085131149196
be555230301074588
applied,661230301073784133151168210259273
including952230301071561100117163211228274322
regulation1292230301072264112158176214240258304351
of1661230301074466
the1745230301072470113
immune1876230301071586158204250293
response,218723030107226496143191238269312325
augmenta‑2530230301073782130202244291316356382
tion34024430107284592139
of498244301074366
the582244301072471114
immune714244301071587159205251294
system1027244301072969101129170242
against1288244301073785124141188219247
the1554244301072370113
virus,168524430107375580127159174
inhibition1877244301071561108125173191218236282330
of2225244301074466
the2310244301072470113
dysfunctional2442244301074483116140187234273302320366413453471
immune340258301071991164211258301
response,660258301072567100149197245277320334
and1012258301074088136
inhibition1167258301071865112130178196224241289336
of1522258301074770
the1611258301072774118
viral174725830107405984125143
replication/infection.1909258301072567116135152192232259276324371403422469492534574604622669717732
Conclusion:4802718011254104157197223275314339391443466
Pharmacological966272301074592131157230270310355374422471488528568586
research1571272301072971104147187212250297
represents1887272301072971120146188221264311337371
a22772723010743
major23392723010777116134182208
challenge2565272301074390130148166209256305348
and340286301074188137
unmet495286301075098170213240
need754286301075194138187
for96028630107267298
the1077286301073078121
entire1217286301074693119137162204
scientific144028630107367593136183209227250269308
and1767286301074391139
clinical192528630107426078125142182222240
community,2184286301074288161234281328345373414425
as2628286301074375
it2722286301072148
has2789286301075190123
the340300301072875118
potential477300301074997124165213239256296314
to810300301072772
get901300301074891118
through1038300301072774100146193242289
the1346300301072674117
ongoing1482300301074795143190209256304
pandemic.1805300301074989137185228301319358373
Analysis3403255014370134188213267312336379
of747325501436597
Reported8713255014362121187252288329386452
Adverse13513255014371136190248283328387
Events17663255014357110167231267313
Following21073255014356119145170234320345409474
Covid3403395014368130184210275
196423395014360110
Vaccination7803395014362114168220244308362398422486551
in1358339501432790
the14763395014338103161
Slovak1665339501435782146199254305
Republic19973395014362121187251317343367421
Monika3403550012383141199226278330
Laššánová1,6923550012351104146189242300358408460114735570723111773550012324
Monika12223550012384142201227279332
Čičová2,1576355001235986132189240292186835570723148
31928355707232
1Institute340370706427366370101092273109141163194245276322
of708370101095078
Pharmacology806370101094999143174251295337387410461513557
and1383370101094596148
Clinical155137010109537597148170212257279
Pharmacology1851370101094899143174250295337386409460513557
of2428370101095078
Faculty2526370101094586128179201232278
of340384101094977
Medicine4373841010973120173195237259310357
Comenius8143841010953103179226277299350387
University12213841010959110132177222253291313344390
in1631384101092273
Bratislava,1724384101095081126156178215237282325370390
Slovak2134384101094568119162207251
Republic2405384101094996149200252275297339
2SIDC,340398706427368398101094466128182203
Pharmacovigilance5913981010949100144175251296338387431454505528550594646687733
and1344398101094495148
Clinical151239810109537597148170211257279
Trial181139810109467194138161
Section,1992398101094592134167189240292312
Slovak2324398101094567118162207251
Republic340412101094895148199251274296338
3Department3404267064273684261010960107160205235269345392444474
of862426101095078
Organisation960426101096394146190241264300346376398449501
and1481426101094495147
Management16484261010974119170214266313389436487518
of2186426101095078
Pharmacy,2284426101094999144174251295337383399
Faculty340440101094485127178200231277
of637440101095178
Pharmacy735440101094999144174251296337383
Comenius11384401010954103180227278300351387
University15454401010959110132177223254291313344390
in1956440101092272
Bratislava,2049440101094980125156178214237281324369389
Slovak2458440101094668119163208251
Republic340454101094895148199251274296338
Introduction:480481801122581115152207263317360397424478533558
The1060482301074091136
COVID-1912184823010749108154176235266306346
pandemic1585482301074891140191236311331373
has1979482301074688123
resulted2123482301072570105153173203247298
in2442482301071867
more25304823010772122150194
than2745482301072776118168
4.5340496301074360105
million466496301077291111131151199249
deaths736496301074792133161210244
worldwide.10014963010762111139160210276296346391407
Vaccination1429496301074384125165185233275303323372421
against1871496301073989131151200234264
the2156496301072575120
SARS‑CoV-22296496301074093139183212267314359386426
virus274349630107385986136169
is340510301071953
the415510301073383129
only5665103010754104125167
way7545103010771114155
out9305103010754104134
of1085510301075480
the1186510301073484130
pandemic,1337510301075699149200246322342384402
however,17605103010754105171216259304332346
reaches2127510301073277119162211257293
only24415103010754104125167
392629510301075094
%27445103010772
in2838510301072574
the340524301072878124
Slovak485524301074869119161204244
Republic.750524301075298149200251272292335353
Concerns11245243010758106157199243271322357
about1502524301074799150200230
side1753524301074060111157
effects1931524301075075105150193225262
(ADRs)2214524301073084144192228251
of2486524301075480
vaccines2588524301074790132173193243289324
are340538301074169114
the475538301073080126
one6225383010750101147
of790538301075076
the887538301073080126
reasons1034538301072973115150201251286
for1341538301072675104
low1466538301072171138
vaccination1625538301074386128169189239282311331381431
rate.2078538301072872101145162
Objective:4805518011265123151202247284312363413439
The9415523010751103150
aim1112552301075071147
of1281552301075783
this1386552301073787108143
presentation1551552301075988133169216267296339369390440491
is2064552301072863
to2149552301073686
analyse22565523010750101144165207244290
reported2568552301073681133185214247292345
suspicions340566301073586122176198243264317369406
of769566301076289
adverse8815663010755109154201231269317
reactions1221566301074087131176210232284337373
of1618566301076189
registered1730566301074087141163199232278308355410
COVID-1921635663010765127176200262296338380
vaccines25665663010754100144187209261309347
(Comirnaty,340580301072474122197217245295336365409422
Vaxzevria,783580301074484125165210251280301342359
Spikevax),1163580301074090111150194236279320345360
which15445803010763112132174223
State1788580301074067110138182
Institute1991580301071767101131151180230259303
for231558030107227099
Drug2435580301075684134184
Control2640580301075097147175203252273
received340594301072670113156176218263314
from67559430107225199174
healthcare870594301074691133153182231273316343387
professionals1278594301074876124150194229264283332382424444478
and1777594301073988138
patients1936594301074891119139184234262298
in2255594301071766
the2342594301072675121
time2484594301072646120165
period2670594301074894122143192243
from340608301072453102178
1st539608301074675106
January667608301073275125174216245289
2021978608301074690134175
to1174608301073078
31st1274608301074686116146
May14426083010772114155
2021.1619608301074590133175187
Methods:4806218011275124158213266321362386
The887622301074090134
program1042622301074774121172199241314
R,1377622301074260
language1458622301071758106156204245294339
and1817622301073887136
environment1974622301074189129149176224273346391439466
for246162230107216997
statistical2578622301073161103131150183213233273315335
calculations,340636301074084104147196217260289309359410445463
version824636301074994123159179229280
3.1125636301075370
6.1216636301075371
3,1308636301075369
R13996363010754
Foundation1474636301075099149199251293322343393444
for1939636301073282111
Statistical2071636301075078122151171206237258300343364
Computing,24576363010759108184236286316337386438455
Vienna,340650301074668114164213256273
Austria,6356503010754103138169197218260278
GNU9346503010758118176
GPL11316503010758105146
license129965030107214183127177212258
was15786503010767110145
used1745650301075084130182
for1949650301072574103
data2074650301075093122165
analysis.2261650301074292135155197233253287306
Results:4806638011253101142196223258299324
During8246643010756105133153201251
the1096664301072675120
evaluation1236664301074283125145193235263283331380
period,1637664301074893121141189240257
57631914664301074285126169
reported2104664301072468118168196227271321
suspicions2446664301073279113163183224244292341375
of2842664301074671
ADRs3406783010752110156191
were5526783010762106133176
analysed,749678301073886127147188222267317333
overall1103678301074586129157199218238
there1361678301072674119146189
was15716783010762104138
a17296783010738
significant1788678301073150100148167192213253295344371
(p2180678301072172
<22726783010751
0.0001)2344678301074157102148194234253
increase2617678301071765106133177217251296
in340692301071968
the429692301072675120
number570692301074795170220267294
of885692301074672
reported978692301072569119170198230274325
ADRs13246923010751110157193
fivefold.153869230107224385129154203224274292
931851692301074284
%19566923010765
of2042692301074671
ADRs21346923010751110157193
(n2348692301072269
=24386923010752
5346)2511692301074285130177201
were27336923010763108135179
reported340706301072771123174202235280331
for693706301072675104
COVID-198187063010754113160182242274314354
vaccines.1193706301074387129170190240286321340
No15547063010760110
statistically1686706301073667110139159194225245287330351372413
significant2121706301073656107157177203224266310359388
difference253170630107517197126172200245295337381
(p340720301072475
≤4357203010752
0.238)508720301074258105150194218
was7477203010762105139
identified907720301071767112161189209234255300351
between1279720301074793122190235281330
Spikevax1629720301074090111149193235278318
and1968720301073988138
Comirnaty2127720301074997172192219269311339382
in2530720301071766
the2617720301072675120
pro‑2758720301074876124154
portion3407343010750101129162183233283
of645734301074773
serious740734301073379108129179229263
ADRs.10257343010753112160197215
However,12627343010756107173218261306334348
a16317343010741
significantly1694734301073353104154174200222264307357386406448
higher2164734301074868119169215243
(p2429734301072476
≤25267343010754
0.00001)2601734301074462108155203250292311
proportion340748301075079128180231260293313363414
of776748301075682
reported880748301073580131182211244289341
suspicions1242748301074291126177198241261311362397
of1660748301075783
severe1764748301074289131176205250
NU20357483010766124
was21817483010774117152
observed23557483010756108144190218264309361
with2738748301077495125175
Vaxzevria.340762301074687128170214257286307349367
There7297623010749100146175219
is970762301072661
a10527623010748
statistically1122762301074071114143164198229250292335356376418
significant1561762301074161112162182208230272315365394
difference1976762301075677102132177205250300342386
in2384762301072676
the2481762301073585131
ratio2634762301073377106126176
of2832762301075581
serious340776301073378105125174222256
ADRs6167763010750109155190
between827776301074793121189233278326
the1174776301072674119
sexes1314776301073176116159193
for152877630107227097
all164677630107385878
COVID-1917447763010749107152173232262302340
vaccines2105776301073880121160180228273307
(p2433776301072272
<25267763010751
0.00001);2597776301074258103149195241282300316
in304062301071968
woman3130623010765115191233283
this34356230107287898133
ratio358962301072771100120170
is378162301071953
in385662301071969
all39466230107426283
cases405062301074184119165201
statistically427262301073465108137158192223244286329350370412
significantly470562301073455105155176201223265308358387408449
higher517662301074969120170216244
than544162301072979121171
in304076301071968
men3130763010777123173
(p332476301072880
<3425763010757
0.0001),350376301074865111158206248267282
whereas3807763010768119165193238280315
the414376301073181127
most4292763010777127162193
often450776301075177110154204
were4733763010768113141186
ADRs4941763010756115163200
reported516276301073075126177206239283335
by551876301075394
patients304090301075093122143188238267303
(p336590301072678
<3464903010755
0.0001),354190301074663109157204246265281
of384390301075076
which3940903010767117138180230
up4191903010750101
to431390301073078
66441390301074693
%4527903010768
were4617903010766112140185
women.4823903010767117192239289307
Conclusion:31801038011254107162206233288330358412468493
In3695104301072373
the3789104301073282128
Slovak3939104301074666116158202242
Republic,4202104301075096147197249270290332350
the4574104301073282128
rate4723104301073174103148
of4892104301075278
spontaneous4992104301073788139190218262311357408458493
re‑5506104301073176107
porting30401183010749100128161181230281
of3342118301074772
suspected3435118301073281115166212255286330382
ARDs3838118301075198158193
has4052118301074789124
been4197118301074894141190
low4408118301071867134
for456311830107227199
a46831183010740
long4744118301071867117168
time;4933118301072647121167183
in5138118301071766
the5225118301072776122
period5368118301074894122143193244
January3040132301073173123172215243288
–33491323010750
May34201323010774117158
20213599132301074893136178
rate3798132301073174103147
increased3967132301072373115143188230265311363
as4351132301074580
a44531323010745
result4519132301073176111160181211
of4751132301075278
active4850132301074588120140183228
calls5100132301074487108129163
for5284132301072878106
ADRs54121323010757116164201
reporting,3040146301072771123174202235256305357374
patients3436146301075598127147193243272308
reported3766146301073276128179207240285336
the4124146301073383129
most42751463010778129164195
often.4491146301075379113157207225
According47371463010758100140189217267288337389
to5147146301073382
European5250146301074795123172224271313363
data,3040160301074890118161178
Vaxzevria3239160301074384124165209250279299341
has3601160301074687122
a37441603010739
significantly3803160301073252102151170195216258300349377397438
higher4262160301074666116165210238
ratio452116030107246795115164
of4706160301074671
reported4798160301072569119169197229273324
suspicions5143160301073179113163184225245294343377
of5541160301074671
serious3040174301073378105125174222256
ADRs.33171743010750108154190207
For3545174301073987115
all368017430107395978
vaccines,3779174301073880121161180228273308325
the4124174301072675119
incidence4264174301071765106126175220268309352
of4637174301074570
severe4728174301073176117161188232
NUs49801743010755112144
is5145174301071750
statistically5216174301073161103131150184214233274316336356396
significantly3040188301073454104154175200222264307357386407449
higher3510188301075070121171217245
in3777188301072170
women.38691883010767116192238288306
Analýza30402135014370137193221276330389
nežiaducich34592135014368129181208264332398454481537603
účinkov40922135014367123150216269334390
hlásených4512213501436895152198259326379434500
po50422135014370138
vakcinácii30402275014354112165219246312369425452479
COVID-1935492275014372150213242322364417469
vakcínami40482275014358116169223250316373473500
v45782275014358
Slovenskej4666227501435987153209269335381433493520
republike3040241501433595163230298326353405465
Monika30402570012383143203232286340
Laššánová1,34042570012353108152197252312372424478387925770723139102570012324
Monika39572570012386146207235289344
Čičová2,4325257001236190138197250304463125770723149
34694257707233
1Ústav30402727064273067272101095896129177222
farmakológie3310272101092977109187234279331355408462486535
a38662721010947
klinickej393427210109457195147171215260307332
farmakológie4287272101092977109187234279331355408462486534
Lekárskej4843272101094694139187219258303351375
fakulty5240272101092976121174199231279
Univerzity30402861010958111135181229261305329362410
Komenského34722861010951103181230283321366413467519
v40132861010946
Bratislave,4081286101095284131164187226250296341388409
Slovenská4512286101094872124170217271309354401
republika4935286101093280135188242267291336383
2ŠÚKL,304030070642730693001010944105157203226
Sekcia3317300101094795141183207253
farmakovigilancie3592300101092976109187234279330376401454478502548601645669717
a43313001010946
klinického439930010109457094147171214259306360412
skúšania,4833300101093984137175222275299345367
Slovenská3040314101094468121167214267306351398
republika3460314101093280135188242267290335383
3Katedra30403287064273069328101094996129176231263310
organizácie3401328101095285138184237261303351394418466
a38893281010946
riadenia3957328101093257103157206259283329
farmácie,4308328101092976108187233277301349370
Farmaceutická4700328101094690122200247290338390423447491536583
fakulta5305328101092976121174198231278
Univerzity30403421010958111135181229261305329362410
Komenského34723421010951103181230283321366413467519
v40133421010946
Bratislave,4081342101095284131164187226250296341388409
Slovenská4512342101094872124170217271309354401
republika4935342101093280135188242267291336383
Úvod:31803698011261110162218243
Pandémia3441370301074586135185230304324365
ochorenia3827370301074688137186214258307327368
COVID-1942163703010749108154175234265304343
si4580370301073251
celosvetovo4652370301073882102151186228273302349390439
vyžiadala5112370301073882122142184234276296337
viac5470370301073959101142
ako3040384301074180129
4,53190384301074258104
milióna3315384301077292113133182232274
úmrtí.36103843010746121149181202219
Jediným3850384301073075127147196236312
východiskom4183384301073984125174224275296330369417493
z46973843010735
pandémie4753384301074891140191236311331377
je5151384301071863
vakcinácia5235384301073982121162182231274315336377
proti3040398301075078127156177
vírusu323939830107476997147182230
SARS‑CoV-2,34913983010749102149194224280329374402443460
ktorá3972398301074578126155198
však4192398301074883127166
v43803983010748
SR4449398301074995
dosahuje45663983010756106141185235284305350
iba4938398301072677120
395080398301075194
%.5196398301077392
Jedným5310398301073884136186226302
z30404123010737
dôvodov30994123010758109152202255307350
nízkej3471412301075778117158204225
zaočkovanosti3719412301074590141185225275318362413465501532553
je4295412301072874
aj4391412301075072
obava44854123010757110154197241
z47484123010745
nežiaducich48154123010758105145166209261312355376419470
účinkov53074123010757100121171212262305
(NÚ)3040426301072483141166
vakcín.3228426301074285125166187237255
Cieľ:3180439801125480131159187
Cieľom3392440301075172117139188264
práce3677440301075685128170215
je3913440301072571
analýza4005440301074797139160202243287
hlásených4313440301075475117153199249289330380
podozrení47154403010755106158208245274319369389
na5126440301075496
NÚ52444403010763121
v53864403010747
tom5454440301073483158
čase3040454301074184120166
registrovaných3228454301073681134154189221250299342386436477519570
COVID‑vakcín38204543010760120168190251283326370411452473524
(Comirnaty,4365454301073385134211232261312355384429443
Vaxzevria,4830454301075596139180226269298320362380
Spikevax),52324543010751103124164210253297339365381
ktoré3040468301073871119148193
Štátny3254468301074169112141191232
ústav3507468301074782113156198
pre3726468301074978123
kontrolu3870468301073887137166195244265314
liečiv420646830107183884127147190
prijal441746830107507899120162183
od46214683010748100
zdravotníckych4742468301073686114157199248277328348390429474516565
pracov‑5329468301074978121163212254283
níkov3040482301074869110159201
a32634823010742
pacientov3327482301075195137158203253282330372
v37214823010742
období37854823010749101153203255276
od40834823010749101
1.4206482301074558
1.4286482301074658
20214366482301074690134175
do45624823010751101
31.468548230107468699
5.4806482301074562
2021.4889482301074691134175188
Metodika:31804958011275125160214269296347396421
Pre3621496301074470114
vyhodnotenie3756496301073983133182233282331360403452472517
súboru4293496301073280130180208258
bol4572496301074797118
použitý4711496301074898147184205234277
program5009496301074876124175202245319
R,5349496301074362
jazyk543149630107185997141181
a30405103010741
prostredie3103510301075887137172203232277330350396
pre3521510301075887133
štatistické3675510301074273117146167202233254296336381
výpočty,4078510301075095148199242275319333
verzia4433510301074994123164185228
3.4682510301075370
6.4774510301075371
3,4867510301075269
R49585103010754
Foundation50335103010751100150201252295324345396446
for5501510301073282111
Statistical3040524301074270113142163197228248290334354
Computing,34165243010753102178229279309330379430448
Viedeň,3885524301074870116168213263280
Rakúsko,4187524301074790130180215254303320
licencia452852430107214184128178220240283
GNU48325243010758117175
GPL.50295243010758105146165
Výsledky:31805378011257107148176226283335387413
Za3615538301075498
dané3734538301075698148194
obdobie39495383010754106158208260281327
sa4297538301074084
analyzovalo4402538301074797140160202243292334377398448
57634871538301075194136181
hlásených5073538301075575118153199249289331380
po‑54755383010756107138
dozrení3040552301074999136165210260280
na3342552301075396
NÚ,34595523010763121136
celkovo3616552301074690111150199241291
došlo39285523010754104140160210
k41605523010743
signifikantnému4224552301073959110160180206228267311361390440486562611
(p4856552301072981
<49595523010759
0,0001)5039552301074966113160208249269
nárastu5329552301075496124168203234283
počtu3040566301074999141173221
hlásených3282566301074767108143188237276317366
NÚ36695663010755112
päťnásobne.3802566301074890120168210244294345394439456
Z42785663010747
celkového4346566301073881102141189230274323373
počtu4740566301074797139171220
hlásení4981566301074666107142187236256
sa5258566301073174
935353566301074284
%54585663010764
(n5543566301072269
=30405803010754
5346)3115580301074588134182206
týkalo3343580301072872113157178228
COVID‑vakcín.35925803010752111158180240272315358398439460509527
V41415803010746
zastúpení4209580301073680116146196247294344364
závažných4595580301073781122166204255295337386
NÚ50035803010758116
nebol5140580301074995146197219
medzi53805803010775121172211232
vakcínami3040594301074184124165185235278353373
Spikevax3435594301074798119159203246289331
a37875943010747
Comirnaty38555943010757105181202230280323352396
identifikovaný4273594301072475121171199220246267307356398441491531
štatisticky4826594301073970113142162197228248290330375
významný5222594301074691132183225300350390
rozdiel3040608301072775113163183229250
(p3311608301072678
≤34116083010756
0,238).3488608301074663110156201225240
Signifikantne3750608301074464114164185210232272316366394444490
vyšší4262608301074388123158178
(p4462608301072678
≤45616083010756
0,00001)4639608301074662109156204251293312
podiel49736083010752103155175221242
hlásených5236608301075171114149195245285327376
podozrení30406223010750101153203240269313363384
na3445622301074890
závažné3557622301073680121164203254300
NÚ38786223010757115
bol40156223010749100121
ale4158622301074061106
zaznamenaný4286622301073580119169212287333383426475516
pri482362230107497899
vakcíne4944622301074083123164184234280
Vaxzevria.5246622301074586127169213256285306348366
V30406363010746
zastúpení3107636301074387122153203254301351371
závažných3500636301074286128171210261301342392
NÚ39146363010764122
medzi40576363010780126178217238
pohlaviami43166363010757108158179221263284326401422
je4759636301072672
pri4852636301075685106
všetkých4980636301074782128158198242284334
COVID­53356363010758117164186246277
‑vakcínach3040650301072770113153194215264307349399
signifikantný3461650301074161111161182207229269313363391441482
rozdiel3964650301073483120170191236257
(p4243650301073183
<43486503010761
0,00001),4430650301075168114162210257299318334
u47856503010755
žien4862650301074364110160
je5043650301072773
tento5137650301073580130158207
podiel53656503010757108160181226247
vo3040664301074190
všetkých3151664301074580126156195240282331
prípadoch3504664301075382103154198249299342392
štatisticky3917664301073768111140161195226247289328373
významne4312664301074489129180222298348394
vyšší,4727664301074489125160180197
než4946664301075197136
u51046643010751
mužov51776643010777126165213256
(p5454664301072779
<55556643010757
0,0001),3040678301074359104150196236255269
pričom333067830107477495135182256
signifikantne3606678301073151100148168192213251294342370418463
najčastejšie4090678301074586106147188222252295314347367411
hlásili4521678301074666107140160179198
NÚ47406783010754111
pacienti4871678301074789130150194242270290
(p5181678301072272
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0,0001),5345678301074157102148194235253268
z30406923010736
toho3098692301072978128179
až3298692301074382
663401692301074693
%35156923010768
tvorili3605692301072975124153174194215
ženy.3841692301073883133173187
Záver:31807058011253106157207246274
V34837063010747
SR3553706301075299
je3675706301072976
miera37747063010785106153183228
spontánneho4025706301074396149202232277328380428480532
hlásenia4580706301075880124161209261282326
podozrení49297063010760112166218257287334386407
na53597063010758103
NÚ54847063010768128
dlhodobo3040720301074969118168219269321371
nízka.3432720301074767105145189207
Za3660720301074790
obdobie3771720301074698149199250271316
1–5/20214108720301074385130161206251294334
sa4464720301073275
zvýšila4560720301073580125160180200242
v48237203010739
dôsledku4884720301074797132152197249288338
aktívneho5243720301073979111131174224270319369
vyzývania3040734301074186126171217261310331373
na3434734301075396
hlásenie3551734301075374116152198248268313
NÚ,38867343010762120135
ktoré4043734301074275123152197
najčastejšie4261734301075396117159202237268312333367387433
hlásili4715734301075374116151171192212
pacienti.4949734301075497140160206256284305323
V52937343010751
súlade5365734301073987108150202248
s30407483010733
európskymi3093748301074189116164214248286329404423
dátami3537748301074687115157230249
má38077483010770111
signifikantne393974830107315099148167192212250293341369418462
vyšší4422748301073881116149168
podiel4611748301074796146166210230
hlásených4862748301074565106140184233272312360
podozrení5242748301074797147196231259303351370
na3040762301074891
závažné3152762301073983125168207257303
NÚ34777623010760118
Vaxzevria.3617762301074889131172217259288309352370
Pri400876230107487697
všetkých4126762301074479125154194239281330
vakcínach4478762301074387126167188238280323372
je4872762301072267
výskyt4961762301074388124164208241
závažných5224762301073983124168207257297339389
NÚ30407763010757115
štatisticky3177776301073566109138159193224245287326371
významne3569776301074388129179222297347393
vyšší3983776301074388123158178
u41837763010750
žien.4254776301073859105155173