www.klinickafarmakologie.cz / Klin Farmakol Farm 2022;36(3):85-92 / KLINICKÁ FARMAKOLOGIE A FARMACIE 85 https://doi.org/10.36290/far.2022.014 ORIGINÁLNÍ PRÁCE COMPARISON OF MW\PHARM 3.30 (DOS) AND MW\PHARM ++ (WINDOWS) VERSIONS OF PHARMACOKINETIC SOFTWARE FOR PK/PD MODELLING OF VANCOMYCIN IN CONTINUOUS ADMINISTRATION Comparison of Mw\Pharm 3.30 (DOS) and Mw\Pharm ++ (Windows) Versions of Pharmacokinetic Software for PK/PD Modelling of Vancomycin in Continuous Administration Marcela Hricova1, Blanka Koristkova1, 2, Eliska Vavreckova1, Ivana Kacirova1, 2, Hana Brozmanova1, 2, Milan Grundmann1 1Department of Clinical Pharmacology, Faculty of Medicine, University of Ostrava, Ostrava 2Department of Clinical Pharmacology, Institute of Laboratory Medicine, University Hospital Ostrava, Ostrava Objective: For a long time, the Mw\Pharm software suite (MEDI\WARE, Prague, Czech Republic/Groningen, Netherlands) has been used for PK/PD modelling in therapeutic drug monitoring (TDM). The aim of this study was to find the best model in the newer Windows version of Mw\Pharm++ 1.3.5.558 (WIN) for continuous administration of vancomycin. Patients: Twenty adult patients with a mean age of 66 ± 12 years, body weight 85 ± 16 kg, and median dose 1,625 g/24 h were repeatedly examined for vancomycin. Methods: Concentrations predicted by “#vancomycin_adult_k_C2”, “#vancomycin_adult_C2”, “vancomycin_adult_C2”, “vancomycin_C1” WIN models and “vancomycin (cont.inf.) %ahz” (DOS1) and “vancomycin adult” DOS models were compared with the measured values and with the DOS1 model. Statistics: Percentage prediction error (%PE) calculated as (predicted-measured)/measured or (predicted-DOS1)/DOS1, RMSE, Bland-Altman bias, Pearson’s coefficient of rank correlation (R), Student’s t-test. Statistical analysis was performed using the GraphPad Prism version 5.00 for Windows. Results: %PE values varied between −3.2 ± 33.0% and −7.4 ± 36.7%, with the exception of “vancomycin_C1”, the only one- -compartment model, where it was −20.8 ± 39.4%. The best outcomes were achieved with “vancomycin adult”. The “#vancomycin_adult_k_C2” model produced the lowest %PE, RMSE, and Bland-Altman bias among the WIN models, but its correlation (Pearson’s R) was less tight. RMSE was the same in “vancomycin_adult_C2” while %PE and Bland-Altman bias were similar, with slightly better correlation when compared to “#vancomycin_adult_k_C2”. The %PE value between the two DOS models was 4.1 ± 13.9% (NS); “vancomycin adult” produced slightly better outcomes than DOS1. Conclusion: “vancomycin_adult_C2” and “#vancomycin_adult_k_C2” produced the best outcomes between WIN models. Both DOS models produced lower bias and their prediction was comparable. Key words: PK/PD modelling, vancomycin, Mw\Pharm, therapeutic drug monitoring, continuous administration. Porovnání Mw\Pharm 3.30 (DOS) a Mw\Pharm ++ (Windows) verze farmakokinetického softwaru pro PK/PD modelování hladin vankomycinu aplikovaného v kontinuální infuzi Účel studie: Mw\Pharm software (MEDI\WARE, Prague, Czech Republic / Groningen, Netherlands) je dlouhodobě používán pro PK/PD modelování pro terapeutické monitorování hladin léčiv (TDM). Cílem práce bylo najít nejvhodnější model pro kontinuální aplikaci vankomycinu v novější Windows verzi Mw\Pharm++ 1.3.5.558 (WIN). Pacienti: 20 dospělých pacientů (průměrný věk 66 ± 12 let, hmotnost 85 ± 16 kg), bylo opakovaně vyšetřeno na hladinu vankomycinu. Medián dávky byl 1625g/24h. Koncentrace vankomycinu predikované pomocí WINmodelů „#vancomycin_adult_k_C2“, „#vancomycin_adult_C2“, „vancomycin_adult_C2“, „vancomycin_C1“ a DOS modelů „vancomycin (cont.inf.) %ahz“ (DOS1) a „vancomycin adult“ byly porovnány s naměřenou hodnotou a DOS1 modelem. KORESPONDENČNÍ ADRESA AUTORKY: PharmDr. Blanka Kořístková, Ph.D., blanka.koristkova@osu.cz Oddělení klinické farmakologie, Ústav laboratorní medicíny, FN Ostrava 17. listopadu 1 790, 708 52 Ostrava Cit. zkr: Klin Farmakol Farm 2022;36(3):85-92 Článek přijat redakcí: 13. 5. 2022 Článek přijat k publikaci: 15. 7. 2022
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