www.klinickafarmakologie.cz / Klin Farmakol Farm 2023;37(2):64-67 / KLINICKÁ FARMAKOLOGIE A FARMACIE 67 HLAVNÍ TÉMA Trastuzumabem indukovaná kardiotoxicita: přehled během léčby trastuzumabem a po ní, aby se toto riziko minimalizovalo. Všechny pacientky vhodné k léčbě trastuzumabem, a zejména ti, kteří byli dříve léčeni antracykliny a cyklofosfamidem, by měli podstoupit základní kardiologické vyšetření včetně anamnézy a fyzikálního vyšetření, elektrokardiogramu, echokardiogramu a/nebo vyšetření vícenásobné akvizice (MUGA) nebo magnetické rezonance. Hodnocení srdeční činnosti provedené na začátku léčby by se mělo opakovat každé 3 měsíce během léčby a každých 6 měsíců po ukončení léčby až do dosažení 24 měsíců od ukončení léčby. Zdá se, že ostatní terapie zaměřené na HER2 mají mnohem menší riziko kardiotoxicity než trastuzumab a mohou být bezpečně používány u pacientů s vyšším kardiovaskulárním rizikem. Kvůli celé řadě nezodpovězených otázek je však třeba provést další studie s těmito přípravky, protože HER2 léčba má zásadní význam na výsledky léčby pacientek s HER2-pozitivním karcinomem prsu. LITERATURA 1. Slamon D, Eiermann W, Robert N, et al. Breast Cancer International Research Group. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med. 2011;365(14):12731283. doi: 10.1056/NEJMoa0910383. PMID: 21991949; PMCID: PMC3268553. 2. Perez EA, Romond EH, Suman VJ, et al. Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831. J Clin Oncol. 2014;32(33):3744-3752. doi: 10.1200/JCO.2014.55.5730. Epub 2014 Oct 20. PMID: 25332249; PMCID: PMC4226805. 3. Lin M, Xiong W, Wang S, et al. The Research Progress of Trastuzumab-Induced Cardiotoxicity in HER-2-Positive Breast Cancer Treatment. Front Cardiovasc Med. 2022;8:821663. doi: 10.3389/fcvm.2021.821663. PMID: 35097033; PMCID: PMC8789882. 4. Curigliano G, Lenihan D, Fradley M, et al. ESMO Guidelines Committee. Electronic address: clinicalguidelines@ esmo.org. Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol. 2020;31(2):171-190. doi: 10.1016/j. annonc.2019.10.023. PMID: 31959335; PMCID: PMC8019325. 5. Leung HW, Chan AL. Trastuzumab-induced cardiotoxicity in elderly women with HER-2-positive breast cancer: a meta-analysis of real-world data. Expert Opin Drug Saf. 2015;14(11):1661-1671. doi: 10.1517/14740338.2015.1089231. Epub 2015 Oct 13. PMID: 26461271. 6. Ezaz G, Long JB, Gross CP, et al. Risk prediction model for heart failure and cardiomyopathy after adjuvant trastuzumab therapy for breast cancer. J Am Heart Assoc. 2014;3(1):e000472. doi: 10.1161/JAHA.113.000472. PMID: 24584736; PMCID: PMC3959671. 7. Abdel-Qadir H, Thavendiranathan P, Austin PC, et al. Development and validation of a multivariable prediction model for major adverse cardiovascular events after early stage breast cancer: a population-based cohort study. Eur Heart J. 2019;40(48):3913-3920. doi: 10.1093/eurheartj/ehz460. PMID: 31318428. 8. de Azambuja E, Procter MJ, van Veldhuisen DJ, et al. Trastuzumab-associated cardiac events at 8 years of median follow- -up in the Herceptin Adjuvant trial (BIG 1-01). J Clin Oncol. 2014;32(20):2159-2165. doi: 10.1200/JCO.2013.53.9288. Epub 2014 Jun 9. PMID: 24912899. 9. Zardavas D, Suter TM, Van Veldhuisen DJ, et al. Role of Troponins I and T and N-Terminal Prohormone of Brain Natriuretic Peptide in Monitoring Cardiac Safety of Patients With Early-Stage Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Receiving Trastuzumab: A Herceptin Adjuvant Study Cardiac Marker Substudy. J Clin Oncol. 2017;35(8):878-884. doi: 10.1200/JCO.2015.65.7916. Epub 2016 Oct 23. PMID: 28199174. 10. Ponde N, Bradbury I, Lambertini M, et al. Cardiac biomarkers for early detection and prediction of trastuzumab and/ or lapatinib-induced cardiotoxicity in patients with HER2-positive early-stage breast cancer: a NeoALTTO sub-study (BIG 1-06). Breast Cancer Res Treat. 2018;168(3):631-638. doi: 10.1007/s10549-017-4628-3. Epub 2017 Dec 27. PMID: 29280043; PMCID: PMC5843537. 11. Demissei BG, Hubbard RA, Zhang L, et al. Changes in Cardiovascular Biomarkers With Breast Cancer Therapy and Associations With Cardiac Dysfunction. J Am Heart Assoc. 2020;9(2):e014708. doi: 10.1161/JAHA.119.014708. Epub 2020 Jan 21. PMID: 31959034; PMCID: PMC7033834. 12. Tang GH, Acuna SA, Sevick L, et al. Incidence and identification of risk factors for trastuzumab-induced cardiotoxicity in breast cancer patients: an audit of a single „real-world“ setting. Med Oncol. 2017;34(9):154. doi: 10.1007/s12032-0171018-y. Epub 2017 Aug 4. PMID: 28779423. 13. Vaduganathan M, Hirji SA, Qamar A, et al. Efficacy of Neurohormonal Therapies in Preventing Cardiotoxicity in Patients with Cancer Undergoing Chemotherapy. JACC CardioOncol. 2019;1(1):54-65. doi: 10.1016/j.jaccao.2019.08.006. Epub 2019 Sep 24. PMID: 33083790; PMCID: PMC7571368. 14. U.S. National Institutes of Health, National Library of Medicine, ClinicalTrials.gov. Preventing anthracycline cardiovascular toxicity with statins (PREVENT). https://clinicaltrials.gov/ ct2/show/NCT01988571. Staženo 31.01.2023. 15. Obasi M, Abovich A, Vo JB, et al. Statins to mitigate cardiotoxicity in cancer patients treated with anthracyclines and/or trastuzumab: a systematic review and meta-analysis. Cancer Causes Control. 2021;32(12):1395-1405. doi: 10.1007/s10552021-01487-1. Epub 2021 Aug 18. Erratum in: Cancer Causes Control. 2021 Sep 17;: PMID: 34406595; PMCID: PMC8541988. 16. Gilchrist SC, Barac A, Ades PA, et al. American Heart Association Exercise, Cardiac Rehabilitation, and Secondary Prevention Committee of the Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Council on Peripheral Vascular Disease. Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors: A Scientific Statement From the American Heart Association. Circulation. 2019;139(21):e997-e1012. doi: 10.1161/CIR.0000000000000679. PMID: 30955352; PMCID: PMC7603804. 17. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005;353(16):1673-1684. doi: 10.1056/ NEJMoa052122. PMID: 16236738. 18. Jafari L, Akhter N. Heart failure prevention and monitoring strategies in HER2-positive breast cancer: a narrative review. Breast Cancer Res Treat. 2021;186(2):295-303. doi: 10.1007/ s10549-021-06096-9. Epub 2021 Jan 22. PMID: 33481134; PMCID: PMC7820093. 19. Lynce F, Barac A, Geng X, et al. Prospective evaluation of the cardiac safety of HER2-targeted therapies in patients with HER2-positive breast cancer and compromised heart function: the SAFE-HEaRt study. Breast Cancer Res Treat. 2019;175(3):595-603. doi: 10.1007/s10549-019-05191-2. Epub 2019 Mar 9. PMID: 30852761; PMCID: PMC6534513. 20. Dempsey N, Rosenthal A, Dabas N, et al. Trastuzumab-induced cardiotoxicity: a review of clinical risk factors, pharmacologic prevention, and cardiotoxicity of other HER2-directed therapies. Breast Cancer Res Treat. 2021;188(1):21-36. doi: 10.1007/s10549-021-06280-x. Epub 2021 Jun 11. PMID: 34115243. 21. Min J, Wu L, Liu Y, et al. Empagliflozin attenuates trastuzumab-induced cardiotoxicity through suppression of DNA damage and ferroptosis. Life Sci. 2023;312:121207. doi: 10.1016/j. lfs.2022.121207. Epub 2022 Nov 17. PMID: 36403642. 22. von Minckwitz G, Huang CS, Mano MS, et al. KATHERINE Investigators. Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer. N Engl J Med. 2019;380(7):617-628. doi: 10.1056/NEJMoa1814017. Epub 2018 Dec 5. PMID: 30516102. 23. Murthy RK, Loi S, Okines A, et al. Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer. N Engl J Med. 2020;382(7):597-609. doi: 10.1056/ NEJMoa1914609. Epub 2019 Dec 11. Erratum in: N Engl J Med. 2020 Feb 6;382(6):586. PMID: 31825569. 24. Huang W, Xu R, Zhou B, et al. Clinical Manifestations, Monitoring, and Prognosis: A Review of Cardiotoxicity After Antitumor Strategy. Front Cardiovasc Med. 2022;9:912329. doi: 10.3389/fcvm.2022.912329. PMID: 35757327; PMCID: PMC9226336. 25. Choksey A, Timm KN. Cancer Therapy-Induced Cardiotoxicity-A Metabolic Perspective on Pathogenesis, Diagnosis and Therapy. Int J Mol Sci. 2021;23(1):441. doi: 10.3390/ ijms23010441. PMID: 35008867; PMCID: PMC8745714.
RkJQdWJsaXNoZXIy NDA4Mjc=