671
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE709804301074291138211265312372415474533554598
A13288043010753
FARMACIE1403804301074191138210265316336380
/18298043010732
Klin190680430107446583131
Farmakol2057804301074278105179220258305325
Farm2402804301074178104179
2023;37(3):89-922601804301074386128172186230270290333354368412456485529571
/32178043010732
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
921858026012657113
PŮVODNÍ341207012660132201274348422456
PRÁCE818207012661124196256314
Assay34136501063872104143176
of53236501063970
colistin61736501063372103121153186204245
A,87836501063754
B947365010634
and99636501063879119
colistin113136501063271103120153185203244
methanesulfonate139136501065284117158198239271306346377408449491531559591
in199836501061556
human207036501063980133174215
plasma230136501063263105139193233
by255036501063470
LC-MS/MS26363650106286180134167193245278
and293036501063879119
short-term306436501063172112148180204233265301355
plasma343536501063364106140193234
stability368436501063164100136153184202234273
components34362101094089165216267317363414443480
after84662101094470103148178
30104762101094793
min.116362101097596146166
After135262101095581115159189
31565621010946
hours,1634621010950100150180217236
the189462101092979125
average34376101094385129158202252298
conversion65676101094088138180224254290311360410
of108276101094975
CMS1172761010952124168
is135676101092155
about142776101094394144194224
13%166676101094686156
at183876101094372
RT192676101094893
and34390101094392143
19%50190101094686158
at67490101094372
3776290101094588
°C860903010725886901010952
(Table95390101092572109160181226
3).11959010109466885
The129590101094495140
stability145090101093666109160181202222252296
of176290101094975
CMS1852901010952123167
in343104101092171
a4311041010944
matrix4921041010975119148178199242
other751104101094979129175205
than973104101093080123173
plasma1163104101095274117153228272
was14521041010966110145
not16141041010950100130
tested.1761104101093075111142186238257
However,3431181010958106171214256299328342
as700118101094277
there792118101092977122150194
is1001118101092155
evidence1071118101094486107156200249289332
of1418118101094874
lower1507118101092069133177206
stability1727118101093565108158179199219248292
of343132101094976
CMS4361321010952125169
in622132101092171
aqueous710132101094395144190240291326
solutions1053132101093686108157187209258309344
or1414132101095080
infusion151013210109227298149184205255305
solutions,1832132101093686108158343146101093051101151186206
this569146101093080101136
stability725146101093666111162184205226256301
needs1046146101095096142194230
to1296146101093079
be1395146101095197
studied1512146101093667116168189234286
more18181461010975125155201
closely343160101094062112147193215258
before620160101095198125175205250
further889160101092677107139189235265
measurement11731601010975121164200249279324400446496526
(7,171816010109257181
12).1818160101094686110127
This483174101094698119155
analytical668174101094595140161204238259300345366
method10641741010978124155205256309
for1403174101092778108
determining1541174101095399130175205282304354375426478
both3431881010953105136187
COL5701881010953115159
and769188101094596149
CMS9571881010954129174
in1171188101092273
plasma1284188101095275120156234279
samples1602188101093782160213235282319
is1961188101092258
applied343202101094596148169190235287
in653202101092272
the749202101093080126
ongoing8982021010951102153203223274325
phase12462021010952103147182228
IV1497202101092273
clinical159320210109426283133153193237258
trial187520210109305980123144
„Pharmacokinetics343216101093384135180211289334376427471495546594625647689727
of1113216101095178
Colistin12342161010953104127148185217239291
in1567216101092273
Critically1683216101095484106137159201247269291336
Ill34323010109224465
Patients440230101095093123144191242272309
With7822301010978100131182
Extracorporeal996230101094691124154199240289320373424455501545566
Membrane15952301010974121199251281326377424
Oxygenation3432441010964109157209257310355387409462514
(COL-ECMO2022)”908244101092780142187210258313388454500547594642667700
(EudraCT1659244101092672123177208255310360
Number2138621010958106178226270297
2022-000291-19;244762101094588130173197244289334376419459481520558575
NCT05542446)3033621010959109154197240281325365407452498519
(13,356462101092564102118
14).369362101094685106121
This213876101094594113147
study229776101093665113162203
is251376101092154
designed258076101095094128147196245288339
to293176101093077
assess302176101094377110154188222
the325576101093078122
influence33907610109216993116163207256295337
of374076101094974
extracorporeal213890101094586117145187226273301351400428472514533
membrane2686901010975119193242271313361405
oxygenation310690101094988132180224273315343362410459
on357990101095098
the369290101093078122
pharmacokinetics21381041010951100142170244285324371412433482525554573612647
of2801104101094974
colistin2890104101094188108127161190209257
and3163104101094391141
CMS.33191041010953123166183
Conclusion21381290014771137206261292361411442510580
A22781461010956
rapid2363146101093076130153207
method25981461010976125157209262316
for2942146101092779111
measuring30811461010977125171208260292315367421
colistin3530146101094192116139176209231284
in2138160101092172
human22361601010950100176221272
plasma2534160101095174119155231275
has2835160101095095131
been2992160101095198146197
introduced3215160101092172102133183236286328374426
and3667160101094495147
validated.2138174101094388110131183227257302355374
The2530174101094496142
described2690174101095096133174204226278325377
method30851741010975121152202253305
is3408174101092156
sensitive3482174101093582133168190221242287332
and2138188101094496150
selective2316188101093684107155198232255301347
for2691188101092779111
the2830188101093082130
analysis2988188101094496142165209247270307
of3323188101095078
colistin3429188101094192116138175208231283
in3740188101092173
plasma2138202101095174119155231276
and2441202101094495147
it2615202101092153
was26952021010966111148
applied2870202101094396148171193240293
to3190202101093080
the3297202101093081128
measurement3452202101097512216720325328433021382161010975122173204
of2362216101094977
patient2459216101095196126148195246277
samples.2756216101093581157209232279315336
The3112216101094597143
presented3275216101095283129166212264294340392
paper36872161010952972138230101095096126
is2281230101092156
part2354230101095094124156
of2527230101094975
the2619230101092979124
Pharmacokinetics2760230101094796139169244287328376419442491537567588629665
of3442230101094975
Colistin35342301010952100122143178209230280
in2138244101092172
Critically2238244101095282105136158200245268290334
Ill260024410109214466
Patients2694244101094892122145191243273311
With3033244101097699131182
Extracorporeal3242244101094590123154199241291322375427458505549572
Membrane3934621010974122201255287334386434
Oxygenation4397621010963108156209257310356387410462515
(COL-ECMO2022)494162101092679141187210259313389454500548595643669
study393476101093669121175221
in418376101092274
which4286761010967120143186239
further455376101092780112146199247279
results486076101093078116168191223262
will515076101096892115138
be5316761010952101
presented.544676101095284132393490101093582133163208261281
The423290101094597143
study439390101093567117169213
has462490101094993130
been477190101095198145196
approved498590101094395147178228272317369
by537290101095194
the548490101092980126
Ethics3934104101094578130153197236
Committee41991041010953104184262286318352400449
of4676104101095180
St.478410410109467798
Anne’s49111041010956109162210232267
University52061041010960113136182229262301324356404
Hospital39341181010960115154209233267315339
Brno4312118101095184138192
(Number4543118101092789143223278328361
10ML/2022-AM).4944118101094793171218255305354402452481541618646666
EudraCT3934132101094391142171214266313
Number42621321010958108181232278307
of4585132101094874
the4674132101093079124
study4813132101093565114165207
is5036132101092055
2022-00029119,51061321010946901341792052543013493924374793934146101094586102
registered4052146101092974124145180211255284329380
on4448146101094998
June4563146101093281131176
21,4755146101094587102
2022.4873146101094590133179198
The5087146101094495140
study5243146101093565114165207
was54671461010964108143
registered3934160101093076129151187219265296343396
at4357160101094474
the4459160101093081128
Clinical461416010109537597148170212257280
Trials492116010109457194138161197
register5145160101093076129151188220266297
https://clinicaltrials.gov/ct2/show/NCT0554244654691601010950811143934174101095086104136162198219240290311351394416445475496539560595615664714756784821852899931963101310621127115612151267131413591405144814941537158016281676
on39341881010949101
September4056188101094491143174220297349396427
15,4504188101094688106
2022.4631188101094693138185205
Podpořeno4460216101094692140188235264305353400
ze4877216101093777
státního4970216101093462108136184204254301
rozpočtu5287216101092975112160207246276323
prostřednictvím3941230101094776123156184213253301349370408437481501574
MŠMT45322301010970111181224
projektem4772230101094776123144185227257297370
VVI51582301010949100121
CZECRIN5296230101094998140189236257314
(LM2023049)4381244101092664135179222264308352397440465
a48622441010947
IGA_LF_2023_004.4925244101092178129178221263305353397439482528574620666685
REFERENCES3442680012357112167220281336407470524579
1.34328400853648
Rychlíčková40928410833568100138153168200230267299332
J,75928410832437
Kubíčková81428410833572111127158188226258291
V.112328410833645
Fyzikálně-chemické11862841083336394110140173189226261284318356391449464496526560
vlastnosti1765284108331477910612916720623234329410832237
kolistinu400294108330678398124147162200238
a658294108332
jejich710294108315496580112150
dopady88029410833876116149188220
do112029410833876
klinické1216294108329466199114146176210
praxe.14462941083396093125159171
Klin16372941083355267104
Farmakol17622941083326182141173203241257
Farm.3433041083326283141155
2022;36(1):29-33.51330410833468101136148183218237268283295330364388420453465
2.34331400853652
Qi41631410834763
B,50031410833649
Gijsen5703141083446075102137176
M,76731410835568
Van85631410833668106
Brantegem9833141083365891130151186226261320
P,132431410833540
et138531410833457
al.14623141083334861
Quantitative154431410834886119158180195218251273289322357
determination1922314108338733433241083225678137152191224246261300339
of70332410833757
colistin7813241083316985100127150166204
A/B100632410834270107
and113432410833271110
colistin12653241083326985100127151166205
methanesulfonate149032410835894117155188227262289327343362401440472495529
in34333410831554
biological4183341083405695111151191207240274290
samples72933410832761120160177213240
using9913341083386580119159
hydrophilic117233410833869109131169210249265281297329
interaction15233341083155476111133167200225241280319
chromatography1863334108332719313134334410835892114152192214248288327359
tandem7233441083225695135170230
mass97434410835891119146
spectrometry.114134410832767103137161183222281317340362397407
Drug157034410834668107147
Test17393441083336492116
Anal.187634410834181114130143
2020;12(8):1183-1195.34335410833468101135148178208225259277289319347378412433464492522556568
3.34336400853651
Rychlíčková41036410833568100138153168200230267299332
J,75836410832436
Kubíčková81136410833472111126158188225257290
V.111736410833645
Farmakologické11783641083336283142174204242258296335351383413447
vlastnosti16413641083324880106130168206233256271
kolistinu.19293641083296734337410831530567994132170183
Klin5413741083355267105
Mikrobiol66137410835470100122160199215253269
Inf9453741083155372
Lék.10323741083316596110
2022;28(2):59-64.115837410833468101135148183217236270287299335367390428464477
4.34338400853651
Gikas4093841083445989123149
E,57438410833246
Bazoti6353841083356898135157172
FN,8233841083327790
Katsimardou9283841083356990118133191223244282321359
M,130238410835568
at138638410833253
al.14553841083324760
Determination153138410834580103136158216231269301323338376415
of196138410833857
colistin343394108331688499125148164201
A561394108341
and61939410833270109
colistin745394108331688499125148164202
B963394108336
in101639410831452
human108539410833875133165204
plasma13053941083395587114171204
by152639410833870
UPLC–ESI161339410834379110149177211245260
high18903941083375291129
resolution3434041083205480118133170192207244282
tandem6374041083225491129164221
MS:8704041083548697
Application98040410834079118133148179211232247284322
to131540410832157
a1385404108331
pharmacokinetic142840410833876108129186218249286316332369403425440471
study.191140410832649863434141083387080
J438414108325
Pharm47841410833572105126184
Biomed6784141083355088147182221
Anal.91441410834180112127140
2013;83:228-236.106941410833569101130142177211222258292326349380414449462
5.34342400853650
Mercier40642410835489110141156190211
T,63042410833241
Tissot6844241083324975101139161
F,85842410833238
Gardiol9084241083447697135150188204
C,112442410834053
et119042410833355
al.12584241083324760
High-throughput13314241083435897135157179217238275313352389428466488
hydrophilic1832424108337681061271643434341083397792107122154
interaction5104341083145273107128161193217232270308
chromatography8314341083316990127185218239276316337369408447477
coupled132143410833168106145161195235
to156943410832158
tandem16404341083225492131166223
mass187643410835890116143
spectrometry34344410832665101134158180217276311333355389
for7534441083185677
the8514441083226095
optimized9674441083377799114172188217251291
quantification127844410833876109147169184202219251284306321359398
of169744410833756
the17744441083226095
anti-18904441083327091107129
-Gram-negatives3434541083216789122180202241276316348370385418452479
antibiotic8364541083316991106145161199221236268
colistin1118454108331688499125148163201
A/B133345410834169105
and145245410833270109
its15754541083153765
pro-drug16544541083386097120161182220259
colistimethate.192745410833168213828410831530567994152187209248280302335348
J2501284108324
Chromatogr25402841083407899136195227249286325346
A.290228410834155
2014;1369:52-53.297328410833468100131143173203237271284320353373407440453
6.213829400853652
Gobin220829410834482122138175
P,240229410833539
Lemaitre245929410833266124156171195216250
F,272829410833238
Marchand278429410835487108139177209247286
S,308929410833245
Couet315229410834077115150172
W,334229410835867
et342829410833356
al.35022941083324760
Assay35802941083416996129159
of375829410833756
Colistin21383041083407793108134157172210
and236530410833270109
Colistin24903041083407793108134157172210
Methanesulfonate271730410835489112150182220255282319335354391430462484518
in325130410831553
Plasma33203041083355082109166199
and353530410833270109
Urine36613041083446480118153
by213831410833869
Liquid22203141083314685122137175
Chromatography-Tandem24083141083407798135192224246282322342375414452482504534561599638672729
Mass315031410835486113139
Spectrometry.330231410833270105138162183220277312334355389399
Antimicrob37133141083417921383241083223795110142163200240
Agents239332410834179114152174202
Chemother.261032410834078113171209231269304325336
2010;54(5):1941-1948.296132410833468100131144179215234268286298328358394424443473504539575589
7.213833400853544
Jansson21953341083245592118144182219
B,242733410833447
Karvanen24863341083346788122154191225263
M,276133410835467
Cars28403341083397192119
O,297133410834657
et304033410833455
al.31083341083314658
Quantitative317933410834683115152173188210242263278310343
analysis353433410833269101116147173187213
of375933410833756
colistin2138344108331688499125148163201
A2352344108341
and240634410833169108
colistin2527344108331688499125148163201
B2741344108335
in278934410831553
plasma28553441083385486113170203
and307134410833169108
culture31923441083316984107144166199
medium340434410835893132147185242
using36593441083376478116155
a2138354108332
simple21863541083264198138154188
precipitation23903541083396195127142182197220252274289327366
step27723541083264983122
followed2910354108319567287125176211250
by317635410833970
LC/MS/MS.32623541083327097152185210265298311
J3589354108324
Pharm362935410833573105126185
Biomed21383641083355189147182221
Anal.237536410834179111127139
2009;49(3):760-767.253036410833468104139152187220239273290302335367403426458490522529
8.213837400853651
Zabidi220337410833870109124163178
MS,23943741083548699
Abu250637410834079117
Bakar26363741083356898131152
R,280137410833548
Musa286237410835492118151
N,302537410834557
et309537410833456
al.31643741083314659
Analytical323637410834078110125157181197228261276
methodologies35253741083579111315118922826621383841083155393108142169
for23253841083195678
measuring242138410835792124151188209225262301
colistin2740384108332698499126149164202
levels29603841083155082116132158
in313638410831452
pharmacokinetic320638410833977110131189222254291321338376411433448480
studies3704384108326498721383941083375286112
J.226239410832436
Liq.2310394108330458395
Chromatogr.24183941083397696132189221242278316337347
Relat.27773941083346984115136149
Technol.29383941083326293130167205220232
2020;43(15-16):671-686.31823941083346799132145178210228258288309339369387398432464496514550585619632
9.213840400853649
Dagla220140410834577116132164
I,237840410831527
Karkoula24184041083356990120158196211243
E,267440410833346
Baira27334041083356883105138
E,288440410833245
et294240410833456
al.30114041083324860
Analytical308440410834180112127159184199231264279
methodologies337640410835792115153191231269285323362377412439
used21384141083376398138
for22944141083185677
the23894141083226095
determination25024141083387395129150208224261294315331369407
of292741410833757
colistin3001414108332688499125149164202
in322141410831452
biological32914141083395492108146186201233266281
fluids.3590414108317347186125151165
Is377341410831541
it213842410831537
still219042410832750658095
a2301424108331
challenge?234842410833169101117132167205244279303
J2667424108324
Pharm270642410833573105126185
Biomed29064241083355189147182221
Anal.314342410834179111127139
2019;164:777-788.329842410833468100130143173204241253286321355374405438474487
10.21384340085366984
Karvanen22354341083356889123155193228265
M,251343410835467
Malmberg259343410835486101158197232253290
C,289643410834052
Lagerbäck296143410833164103137158197230261291
P,326543410833539
et331643410833456
al.33854341083314659
Colistin34574341083397691106132155170207
Is367743410831440
Extensively37304341083326421384441083225593120135167201217249
Lost24024441083326996119
during25364441083397697113151190
Standard27414441083335487125164196217255
In301244410831553
Vitro3080444108336527596133
Experimental322944410833365105140161177235270308329362378
Conditions.36224441083407711615517021384541083223775113140153
Antimicrob230745410834179100116173188220242279318
Agents264145410834179114152174201
Chemother.285845410833977112170209230269304325335
2017;61(11):e00857-17.320945410833468100129139174205220251279294305340376412447481515533564593599
11.39342840085377084
Certificate405628410834178101128146167185220255279316
of440928410833960
Analysis450728410834283118135170199216245
–4789284108336
Colistin48632841083418199116144170187228
sulfate51292841083266684105141165202
(version53682841083195390114143160201242
LRAC9149.02).393429410833166108146179210240273283317350367377
Merck432329410835488109139168
(Sigma-Aldrich)45032941083195064102158190212252267305325340372409425
[online].49412941083185391105120157191207219
[cit.517229410831847628497
19-07-2023].52812941083336386122154172202235267301318329
https://www.sigmaaldrich.com/CZ/en/product/sial/phr1605.39343041083375881120146158184204253306358368395409447503535566581619639654686723735766802859885923961988101910561081111811391175121412501281130513321355136914011415144014771515153515661597163116641676
12.39343140085366884
Mercier403231410835490111142157192213
T,425931410833341
Tissot43153141083324975102140162
F,449131410833238
Gardiol45443141083437697135150188204
C,476331410833952
et483031410833456
al.49003141083324760
High-throughput49743141083446098136159181220241278316355393432470493
hydrophilic548131410833868107393432410832160100140156172187220
interaction41763241083155476111133167200225241280320
chromatography45183241083317193131191224247285326348382422462493
coupled503332410833270109150166202243
to529732410832260
tandem53793241083225695135171231
mass393433410835790116143
spectrometry409633410832665101134158179216275310332353387
for45033341083185678
the46003341083226095
optimized47143341083387799115172187216251290
quantification502433410833875108146167182200217249282304319357395
of543933410833756
the55153341083226095
anti-Gram-negatives39343441083327091107129175197230288310349384424456478493526560587
antibiotic45383441083327092107146161199221237269
colistin4824344108331688499125148164202
A/B504334410834169105
and516634410833270109
its52923441083153765
prodrug53743441083396198137159197236
colistimethate.3934354108331688499125148164221256279317349371405417
J4366354108324
Chromatogr44063541083397798136194226248285325346
A.476735410834156
2014;1369:52-63.483835410833468100131143173203237271284320353373410444457
13.39343640085366780
Pharmacokinetics402636410833571102122179210241276305320357390411425456482
of452036410833755
Colistin45873641083407590103128150164200
in479936410831551
Critically4862364108340607495109139171185198229
Ill51033641083142842
Patients51573641083356586100133170190216
With53853641083577293130
Extracorporeal55273641083326339343741083224273104140160198236256289319333
Membrane428537410835588145183203235271305
Oxygenation460837410834777109146180217248268282319356
(COL-ECMO2022).498137410831957101132146179218271318349382413447463473
ClinicalTrials.gov5471374108340546810411839343841083316377109125139170184209221258295326
identifier:42743841083145285122142156172189223242255
NCT05542446.454338410834584118151184215249280310346381392
Updated495038410834381119150170203241
28.12.202252053841083346678108136147182215246279
[online].549938410831853903934394108315286396111121
[cit.406539410831846597991
19.7.2023].41653941083346271103107141173203236251261
https://clinicaltrials.gov/study/NCT05542446.443639410833656781151401511751942202342472822953253563693904094234524664905015385746046256476687047417707928358749079399711001103410641094112911631174
14.39344040085366984
Suk403640410833270100
P,415440410833540
Rychlíčková42124041083356899137153168199229267299331
J,456140410832537
Součková461640410833270109141171208240273
L,490740410833145
et497040410833456
al.50444041083324760
Changes512240410834078110148187222249
of538940410833757
colistin546440410833168849912539344141083223775
pharmacokinetics402941410833977110131189221254291321338375410433448480508
in455741410831552
critically4630414108331526890105137170186201233
ill48834141083143045
patients49484141083397293109143181203231
due519941410833876110
to533041410832158
the54084141083226095
extracorporeal55234141083346639344241083224376108145167206245267301333348
membrane429842410835792150189211244282317
oxygenation:463042410833868102140175213245267282320359371
protocol50164241083396198120157189226242
for52744241083185677
the53674241083216095
COL-547742410834085118133
-ECMO202239344341083215697153202235270303339
trial4294434108322446092108
–4423434108335
a4479434108333
prospective,45334341083396199126166202235260276309344356
non-randomised,491043410833877116139162195234274312372387414450490503
open-543443410833878114153176
-label39344441083213972113150166
phase412244410834080113141177
IV432144410831553
pharmacokinetic439644410834080113136196230263302334351390427450466499
clinical49174441083324864103119153187203
trial.5142444108322446194110124
BMJ528844410833693120
Open.543044410834889126166180
2023;13(7):e071649.393445410833468101136147177207225260280292326362394427458494528539