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FARMACIE5232804301074191138210265316336380
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Medication386236501065284123141176217246263304346
adherence422336501063878119151186219260295327
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the462636501063071103
way474536501065794127
to488736501063069
understand497236501063880119151187221254290331371
patients53593650106326997115147188220253
Medication340930029820332947253664376885491910561195
adherence158393002981272684075326227488889941118
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the3401190029888229354
way74211900298182307426
to12161190029888225
understand14901190029813927942054563673982695210911232
patients277111900298143268354419544684769873
Patricia3401588013764121161203233283313371
Schnorrerova1,7331588013760109174239302344385444486550606664139015970803614241588013729
Petra14751588013764120161204261
Matalova2,17581588013794152192251281345401459221615970803622541588013729
Martin23051588013793152193236266331
Wawruch1265815880137981532352773413914563106159708036
1Institute340174907833371174201332687129166191227286322376
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Pharmacology8861742013358118170205297349398457483543605657
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Faculty28111742013354102151211236272326
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Faculty17701892013354102151211236272326
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Medicine22351892013388144206231280305365420
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Dentistry,28771892013373129190225250292328364419436
Palacky33361892013359110136188237287342
University37021892013371131156208262297341366402456
Olomouc41821892013376102162254314375424
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University48271892013372132156209263298342367403457
Hospital3402042013372132175237262298352377
Olomouc,7402042013376102163254315375424447
Czech12102042013364113167217277
Republic15102042013360115177238300326350399
The3402560012149105154
aims511256001214870152190
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this818256001213387110148
review983256001213281128151201273
are1273256001214779128
to1418256001213386
explore1521256001215096152176230262311
the1849256001213387137
critical200325600121447699132154198246268
issue228925600121236199153202
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medication26082560012183132189211255303335357411466
adherence,30912560012148103158207239288343387435455
which35632560012173128150194248
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essential419270001215089128178234266288336359
for796270001212983116
effective929270001215080112162207242265313362
healthcare13082700012156106153176209264308357389438
outcomes17642700012155109142186239322372411
but21932700012157112145
remains2355270001213382165213236291329
a27022700012148
significant2767270001214062118173196225251295343398430
challenge.3215270001214499147170193243298354404423
The36562700012150105156
review340284001213280126149197269
delves6252840012155104126173221259
into900284001212376107160
the1076284001213286134
diverse1226284001215678124172203242291
aspects1533284001214885140189233267306
of1856284001215381
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including2609284001212377120142195250272325380
patient30052840012156103134156204258289
perceptions,33102840012156106137180227283314336390443481501
economic340298001214994146201255336359402
challenges,759298001214498145167190239293348397436456
and12322980012147101157
complex1405298001214497179234257307353
treatment1774298001213365113160192273323377408
regimens.2199298001213281136159240290344382402
It2618298001212355
emphasizes26902980012150131187242288326348390439477
the3184298001213386136
importance33362980012124105160215247282330384427475
of340312001215482
accurate438312001214791133186217264296343
adherence7983120012147102155204236284338382429
assessments,1244312001214785122171209247328377431462501521
particularly17823120012155103134168190234287309356387410455
through2254312001213286117170223278332
self-report2602312001213988111139167199248303357389424
questionnaires30423120012155108157195228250303357411457479510559597
and36553120012148101156
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database9133260012156104136185242291330380
analyses.13153260012148103151174222261312351373
The17093260012149106156
review1886326001213383131154205278
also2185326001214872110166
explores2372326001215097154179234267316356
the2749326001213388139
historical2909326001215579117151205238262306355378
evolution3309326001215097151175230263286341397
of3727326001215584
adherence3403400012147102156204236284338381429
concepts785340001214395149193240295327366
and11673400012147101156
highlights1339340001215476130183206228282335366405
the1760340001213386135
critical191134000121447597129151194241263
role2190340001213285108157
of2363340001215381
pharmacists24603400012156110156188269316359381418450489
in2965340001212377
educating30583400012149104157201248279301354408
patients34823400012156103134156205259290329
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medication9613540012184134192215259308341364419474
regimens.1453354001213383140163246297352391412
The18833540012150106157
importance20583540012123106163219252288337392437486
of2562354001215584
recognizing2664354001213382128182238294317360383438494
and31763540012148104160
addressing33543540012148105162194244283323345401457
medication3403680012183132189211255303335357411466
non-adherence8233680012155109164196243299353403435484539583631
as1471368001214886
a15743680012148
significant1639368001214062117171194223248292340394426
health20823680012155105152175207261
policy23603680012157112135158202250
issue262836800121236199153202
is2847368001212361
underscored,29263680012154109164214246286330383415464520540
advocating34843680012147103151204248296340382001213356110166
for524382001212983116
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measurement10763820012182133180219273305354437487543575
methods16683820012183133166221276332371
and20563820012148103159
interventions2233382001212378110159191242290346378400455510548
such2799382001213993138192
as3009382001214887
multidrug31133820012183137160193216272304359415
punch35453820012157112167211266
cards340396001214593126182221
and5833960012148103160
medication7643960012184134192215260308341364419474
charts.12603960012145100148180216257278
The15603960012150106156
review1738396001213383130154204277
advocates20373960012148105153207253301334383423
for2481396001213085118
a26203960012148
patient-centered26903960012157106138161212267300328375424480512561594644701
approach34133960012148105162195249298343398
and3404100012148103160
multidisciplinary5204100012183138161194217274297336381404460484507563611643693
collaboration1233410001214598122146194250306339388420443498554
in1807410001212378
healthcare,19054100012155106154177210265310359391441461
aiming2386410001214871154177232289
to2694410001213387
enhance28014100012150106161209264309358
healthcare31794100012155106154177210265310359391441
outcomes36404100012155110143340424001214598182232272
and6304240012148103160
medication8084240012183134191214259307340363417473
adherence12994240012148105160210243293348393442
through1759424001213388121175230287342
systemic2119424001213987127161210293317361
changes.24984240012145100148203259309349370
It2886424001212457
also2961424001214871110165
underscores31444240012155110167217250290335389422472511
the3673424001213388139
need3404380012155106156213
for571438001212984117
empowering7064380012150133189245318367400423478534
pharmacists12584380012157112160192276324369391430464504
with1780438001217397130185
expanded1982438001215097154203258314365422
roles2421438001213387111161201
and26404380012148103159
appropriate28174380012148104161194248305338362409442491
tools3325438001213387143167205
within3548438001217397130185208263
healthcare3404520012155106154177210266311359392441
systems803452001213987127161210293332
to1157452001213387
further1265452001212985117153208259292
improve15784520012123107163196251298347
patient19464520012157106138161212267300
outcomes.22674520012155110143187241324375414436
Key3404687012462114165
words:5334687012476133172233277303
medication8654690012184135193216261310343366421477
adherence,13714690012148106161212245295351397446466
adherence18664690012148105161212245295351397446
barriers,23414690012157106139172196246280320342
patient27114690012157107139163213269302
adherence,30414690012149106162212246296352397447467
survey3536469001214095128179229276
and3404830012148103160
questionnaires,5214830012157111162201235258313369424472495527577617638
self-report.1180483001214090114144173206256313369402438459
Adherencia3405147012466125184237276329389434462515
k8765147012454
liečbe950514701242755108154215268
–12395147012450
cesta1309514701244597142179233
k15625147012454
pochopeniu16365147012460118164224282342395455482541
pacienta21975147012460113158186239299335389
Cieľom340532001215779128151203285
tohto640532001213385139170222
prehľadového878532001215688136190212258312366411459513566
článku1459532001214566112166211265
je1739532001212473
problematika1827532001215688140196218267348395426447492540
adherencie23825320012148103156205236284338382403451
k28495320012146
liečbe,291053200121244594138192242260
ktorá3186532001214680133164211
je3412532001212473
kľúčová3500532001214671124167219264311
pre340546001215687134
dosiahnutie4895460012155108145166211264317369400421469
výsledkov972546001214896133154202257302353398
v13845460012147
oblasti14465460012154109131176213245266
zdravotnej1726546001214396127173217269299352400422
starostlivosti.2163546001213970117147199236268289310356408445476498516
Článok2694546001215778123176229274
skúma2982546001213983136216262
rôzne3259546001213284123176224
aspekty3498546001214784138187232265313
non-adherencie,3405600012156110165196243299353403434483538582604653672
ako1039560001214894146
napr.12125600012155102158190205
postoj14445600012157112150183236259
pacienta17295600012157105149171220275306354
k21095600012147
liečbe,218256000121244695140195246265
ekonomické2473560001215096149204258341363407452500
prekážky3000560001215789138184232274320370
a33965600012148
zložitosť3470560001214366120161184216269307341
liečebných34057400121244695139187243298343385439
režimov.799574001213281123146228282328343
Súčasne3405880012149104149197236291342
je701588001212475
kladený795588001214772120176227282328
dôraz11425880012157112145193237
na13985880012155103
hodnotenie15215880012155110167223278311360416439489
adherencie,20295880012148105160211244293349394417467487
predovšetkým2535588001215790140197252300339389423469519604
pomocou31585880012157113196252297351406
sebahodnotiacich35835880012140901481963406020012156111169224279312336384429452497552
dotazníkov9206020012157112145194238294317366420467
a14166020012148
retrospektívnych1492602001213383117150204244301352399435459507564609653709
analýz22296020012148104152176223269
údajov25266020012155112161184240287
z28416020012143
databáz.29136020012156105137186243292336358
Identifikácia3300602001212481131187220243272299345395440463511
non-adherencie3406160012155108162193240295349398430478532576598647
predstavuje1003616001215688136192230263310355409432481
prehliadanú1501616001215587136190213235281336383436490
oblasť20076160012154110133179217251
zdravotnej2274616001214297128176221273305359408431
politiky.27216160012156110134156188210255304319
Využívanie30576160012155101155197220266314367389438
nových35126160012154108154203245299
možností3406300012183139181236291331364387
merania7496300012183134166215270293341
a11116300012148
intervencii,1181630001212378111160193244293349394416440460
ako1662630001214895149
sú1832630001214094
viacdávkové1947630001214872120165220268315362416463512
perforačné24806300012157108141173228261310354409460
karty2961630001214796129164214
a31966300012149
liekové326663000121234696144197245294
karty,3581630001214796128164214230
môžu3406440012184139181236
prispieť605644001215790113152209232283317
k9506440012147
zlepšeniu1025644001214367118175214265320343398
adherencie.14516440012149105161211244294350395418469489
Nevyhnutnosť19686440012166117164215271327382415470526565600
systémových2596644001213988127161211294350397448492547
zmien,31716440012143127150200256277
potreba34766440012157113146179229286335
multidisciplinárnej3406580012182135157189211266288325369391446469491544591622676725748
spolupráce1104658001213994148171224279311358401449
zdravotníckych1569658001214297128175220272304358380423468517559612
pracovníkov2198658001215687134178230275330352399451497
a27116580012147
orientácia2775658001215485108156210241289332354400
na31926580012154101
individuálne3309658001212377131154200223278331378400453502
potreby3406720012157113146178228285331
pacienta6936720012157105150173223279311360
predstavujú1074672001215790140197236270319365421445500
cestu1595672001214594133167222
k18386720012147
lepšej1906672001212474131170221245
adherencii.21726720012148105160210243293349394417440460
Kľúčové340688701246191153198256308360
slová:721688701244371129181234260
adherencia10036890012148105160211243293349394417465
k14906890012147
liečbe,155968900121234697142199250270
bariéry18516890012157105138161212245295
adherencie,21686890012148105160210243293349394417467487
adherencia26776890012148105160211243293349394417465
pacientov,31646890012157105150173223279311365413428
prieskumy3615689001215689113163340703001214086141225270
a6327030012148
dotazníky,7017030012156111144193236292315364414430
sebahodnotiace1152703001214090147196251306364419474507530578622671
dotazníky.18457030012156111144193236292315363414430
Introduction3407450014732101143186254325394448493524592661
Medication4807621010973119171192233278307329379429
adherence935762101094395145191221267318359403
is1364762101092156
a14467621010944
crucial1515762101094170121162183227248
factor1789762101092671112144193223
for340776101092675105
achieving460776101094383132153198240262311361
optimal8377761010949100129150224267288
treatment1141776101092958103146175249295344373
outcomes,1530776101094998128167215290335370389
as1935776101094377
it2140748101092150
directly2206748101095071100144185216237279
impacts2500748101092195146189229261297
patient2812748101095195124144189238267
health3095748101094994137158187236
(1).334774810109256786102
However,34647481010959108173217260303333347
it2140762101092151
is2213762101092156
a22907621010944
persistent2355762101095197127164185220251296346376
challenge2752762101094090134155177222273324369
in3143762101092171
healthcare,3235762101095096139161191241282326355401419
since36757621010936571072140776101094288
many22607761010978124176220
patients2512776101095399131153201254285324
struggle2868776101093770101154207261284332
to3232776101093182
follow3346776101092780103126178247
their3625776101093183132155186
DECLARATIONS:4068257508648871301662142563043393604124625014570257708514
Declaration406827120874987120141179206244271291333375
of445727120874066
originality:45372712087406888130150192230251271298337356
The406828250853473109
manuscript418828250855891130168195227249266306329
is452828250851744
original45832825085386178117133172205222
and481628250853472112
has49392825085387299
not50502825085387699
been516128250853975110149
published532228250853977117134150177216251291
or406829350853862
submitted414529350852867108167184208234269310
elsewhere.44702935085355381117169209245269305320
Ethical406830710873764107127160198218
principles43003071087427090132165185228249287319
compliance:463330710873173134177197218256298330368387
The406831830853678116
authors420531830853475100142183208238
attest44643183085356087124153179
that466431830852465101126
their481131830852465103121146
study49783183085295595138173
was517231830855490119
approved531231830853577120145186221258301
by406832930854073
the41583293085236399
local42743293085175689124141
Ethical44323293085345898115147182199
Committee464832930854179139198215239265300337
and500232930853373113
is513232930851745
in519432930851656
compliance526732930853169129169187204239278311346
with40683403085537298140
human423634030854081143180221
studies44863403085285596139157195226
and474034030853577119
animal48883403085347695156193212
welfare512834030855391110133170196234
regulations53903403085236110414516420140683513085234080120148
of423535130853960
the43153513085236399
authors’44343513085347397136176200229244
institutions46983513085165684109126150189213231270310338
as505635130853462
well513835130855187104122
as527935130853462
with53613513085526993133
the55143513085236299
World406836230856099124142184
Medical427336230855795137155188224242
Association453536230854474104144178196231256273314355
Declaration491136230854785119136172196232257274315356
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Helsinki537036230854684102131149189224243
on406837330853878
Ethical41653733085355898115147182199
Principles43833733085376178117150167207225261290
for46923733085205983
Medical479437330855693134151183218235
Research504837330853874102139173197229268
Involving53353733085175690128146181198238278
Human406838430854685145179219
Subjects430738430853474114132168201227256
adopted458338430853474114155179215256
by485838430854074
the49523843085236399
18th507138430853669514138480501437
WMA5198384308559116160
General537838430854582122158182217235
Assembly406839530854475105143204247266302
in439339530851758
Helsinki,447439530854785104134152193228248264
Finland,47613953085355394113149190232249
in503339530851758
June511539530852667109147
1964,528539530853771110150166
with54743953085537297139
subsequent406840630852867107136172213252288328352
amendments,443740630853493130169210269305345369398414
as486840630853462
well494840630855287105122
as508840630853362
with51674063085526993133
the53184063085236298
ICMJE543440630851759116143179
Recommendations406841730853977112153216278317359402439465483525568598
for46974173085226389
the481841730852466104
Conduct,495441730854283125168210245272290
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