789
www.klinickafarmakologie.cz340804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/27138043010732
Klin279080430107446583131
Farmakol2941804301074279105179220258305325
Farm.3286804301074178105179195
2024;38(1):15-213501804301074487128168183227270294334351366403441468507546
/40928043010732
KLINICKÁ4170804301074588109168189242288346
FARMAKOLOGIE4538804301074291138210265312372415474533554598
A51578043010753
FARMACIE5232804301074191138210265316336380
1756558026012657109
HLAVNÍ4945207012671127198263336370
TÉMA5337207012657114204274
Medication386236501065284123141176217246263304346
adherence422336501063878119151186219260295327
–4566365010645
the462636501063071103
way474536501065794127
to488736501063069
understand497236501063880119151187221254290331371
patients53593650106326997115147188220253
The343621010946100149
topic52162101093082137161204
was754621010968115153
officially93662101095079111137181204250273297342
incorporated130762101092275118170202257311343390422470524
into186062101092275107159
medical343761010975122175198239285307
terminology67776101093076107184206258309332383435480
in118476101092173
1976128476101094689134178
when1490761010966118165216
Sackett173476101094489131174220252285
and34390101094394147
Haynes511901010958103146198244281
introduced81390101092172103133183236287329374427
the126190101093080127
term140990101093076106183
‘compliance’161390101091957107183236258280325376343104101094086106
(40).471104101092671119145163
Then,656104101094597144195215
in894104101092172
1993,988104101094689136182201
the1212104101092980127
discourse1362104101095072109150200251282319366
shifted1750104101093687109137170216269
from343118101092658108185
‘compliance’549118101091957107183236259281325376418463483
to1054118101092979
‘adherence’,1155118101091961113164211241287339381426446460
signifying1636118101093658110161183210257280331383
a3431321010944
more4151321010976128159206
nuanced6491321010951102148200242288342
understanding10191321010950102156203234273305351403456479531584
of1631132101095078
patient1737132101095298129151199251282
engagement343146101094495145189239285360405456485
with845146101096587117167
their1029146101092979125146176
medication12221461010974119171192233277307328377428
regimens1667146101092973125146221266317352
(41).343160101092671113133151
The522160101094597144
term693160101093076107184
‘persistence’905160101091969117148186208244276322374416461482
was14141601010967112148
introduced1590160101092172103134184237288330376429
in343174101092275
2001,454174101094897148194211
further701174101092782114150203253285
expanding1022174101094793149196250305329382437
the1495174101093084133
scope1664174101093781133188238
of1938174101095181
this343188101093184107145
field.517188101092753101125180201
In747188101092275
a8511881010945
significant925188101093760114167190219245289336389421
development13751881010952101147194218271326405454508540
in1944188101092174
2003,343202101094693142188207
the570202101093080127
World7172021010976125156179231
Health9682021010958105150172203254
Organization1242202101096293145189240262302348379401451503
(WHO)17652021010925104165229254
released34321610109307699145190227274326
a6972161010943
comprehensive768216101094090167219250296348395446483505550595
report1390216101093076129181212245
on16632161010949101
medication17912161010975122175198343230101094188120143196250
adherence,622230101094498151200232280334377424445
contributing1096230101094193146178210233288341374397450504
greatly1628230101095284132178210234279
to1936230101093183
the343244101093081127
body4962441010951102155199
of720244101095077
knowledge822244101094395146213236282335387433
(42).1281244101092570114139157
Between1463244101094996127197242290341
20081829244101094693142190
and343258101094394147
2009,515258101094693142190207
the747258101093081128
term900258101093076106183
‘medication1109258101091892139192214256301331353404455
adherence’1590258101094395147193224270321363409429
was3432721010968115153
recognized525272101093078122173228281304345393448
as1002272101094583
a11132721010945
MeSH11872721010974123170231
term,1447272101093178110190211
marking16872721010977123155201225278332
its34328610109215290
significance455286101093557109160182210234276321372414459
in936286101092172
medical10302861010975122175197238283305
research.1357286101093076113159204234276326347
In1725286101092273
2010,1820286101094693136180199
the343300101093184133
International513300101092276108156189243290323347400454501525
Society1075300101094599144168217250299
for1410300101092780113
Medication15603001010974124179203247295327351404459
Adherence3433141010955106157204235281332374419
(ESPACOMP)780314101092570116164215266327400450474
introduced1272314101092172102133183236286328373426
the1716314101093081127
ABC18613141010955105158
taxonomy,343328101093075119168220271347390406
a7673281010944
framework829328101092658103179226293343374417
for1265328101092677108
categorizing1392328101094085116161213264295318358380431483
adherence1893328101094496343342101095097127174225267312
(Fig.67634210109257091143163
1)860342101094666
(41,947342101092670112128
43).1095342101094792116134
Definition3433670014782145180213282313356386454524
and8943670014761130200
significance1121367001475081151220251285319373435504559620
of3433810014768107
adherence4773810014761131200263306369438493554
In483398101092271
order578398101094978129173202
to804398101093078
properly906398101095180129180226255276318
understand1248398101094999149194223259289333382433
the1704398101093079124
concept1852398101094088138343412101094185137167
of535412101095076
medication6354121010976122174195236280309330380431
adherence,1090412101094495146191221266317358402420
it1534412101092252
is1610412101092157
essential1691412101094682117163213243263307328
to343426101093079
grasp446426101095180124159211
the681426101093080125
distinction830426101095273107138159209249281302351402
between1256426101095298128197242288338
adherence1618426101094495145191220265316356401
and343440101094393143
compliance.510440101094088162213234254297346386429447
While9814401010976126146166211
these1216440101092979123158203
terms1443440101093073103177212
are1678440101094472117
often1818440101095075108151201
used343454101095188135189
interchangeably,563454101092273104150181222274319371423470515569591636651
they1246454101093082129173
carry1450454101094287118149196
nuanced16784541010951102147199241287341
yet343468101094389119
significant487468101093657109159180207231272317367397
differences909468101095273100129176206251302344388425
in1358468101092273
their1456468101093081127148178
meaning.16594681010976123167218239289341360
Medication3434821010971116166185224266294314362410
adherence,767482101094392140184213256305344386403
as1184482101094276
defined1274482101095094119141190233283
by1571482101095191
the1675482101093078122
WHO,18104821010975133194209
refers343496101092974100145174209
to567496101093078
“the660496101093262111156
extent831496101094587119163212241
to1086496101093078
which11794961010966116136176225
a14194961010943
person’s1477496101095197126161210260277309
behavior1801496101095197147189343510101094364112141
–4985101010944
taking556510101093073114135184234
medication,8045101010974119169189228271300319368417435
following125351010109267495115164228249297347
a16145101010943
diet,1671510101095070114143162
and/1847510101094391141172
or343524101095079
executing446524101094587131171220250270319370
lifestyle83952410109224268113148178223244289
changes1152524101094089132181232277312
–14875241010946
corresponds1556524101094189118147192227278328377428463
with343538101096789119169
agreed537538101094495125170216269
recommendations830538101093075117166242318364415467511540561611662697
from1552538101092657106183
a17595381010945
health1828538101095197141162343552101093081
care449552101094186116162
provider.”636552101095282132176198250296326341371
Compliance,10325521010953103180232254275319370411456475
on15315521010951102
the1658552101093181128
other1811552101095080131177208
hand,343566101095195145196215
indicates583566101092171123144185229259303339
a9475661010944
more10165661010976126156201
passive1242566101095296132168188232277
and1544566101094494146
authoritarian1714566101094494124174224254276343580101093073102123165214
approach576580101094494145174223266306355
where9505801010966116161190234
patients1203580101095295124144189238267303
simply1525580101093556130180201244
follow178858010109267596116166231
prescribed343594101095281126161202231252302348400
directives767594101095172101145186218238282326361
without1152594101096788117167217266296
active1472594101094484115136179223
involvement17195941010921711131611832262703436081010977124176206
in577608101092173
decision-making.677608101095299142163199221272324354432477521544595647667
Recognizing1371608101095097140190242294315355377429481
this1879608101093182104140
difference34362210109517197126170199244293333377
is737622101092155
fundamental809622101092676125176218292337387416459480
in1305622101092171
promoting1392622101095281129204253282303352402
effective181162210109457110014418534363610109294991133
healthcare489636101095093135155183231270312340383
outcomes885636101094997125163210283327361
and1259636101094391140
patient-centered1412636101095193121140184232260284325367415443486514557607
care343650101094084112157
(42).522650101092568111134150
According694650101095594133181210260280329379
to1095650101093078
the1196650101092978123
20031341650101094791138183
WHO15466501010976135197
report,1765650101092974124174203235254
adherence343664101094496146193223268319360405
is773664101092156
a8546641010944
multidimensional9236641010976127148178199251272348394445480501551602646667
phenomenon16156641010952103150200251327374343678101095099149
influenced50767810109217196119168213262302346397
by919678101095293
five102867810109264992135
key1179678101094286127
dimensions:1322678101095171145190240274294343393427445
health1783678101094994137158187236
system/healthcare343692101093577111140182255285334378420439468515554596624667
team,1023692101093072114187204
social/economic,1240692101093583123142183203233272312358407454527547586603
condition-related,185769210109398613434370610109507099119167216244273317337380408451501519
therapy-related,876706101092978122150193243283310340383404446474517568585
and1475706101094392141
patient-related163070610109519412214218623526328731636034372010109226595140192
factors.560720101092771112144193223260280
This864720101094697118153
challenges1042720101094191135156177223274325371407
the1474720101093080126
traditional1625720101093060104156177207228278329373394
misconception343734101097799135177226278320365418449470521573
that941734101093182127157
adherence1123734101094597148195226272324365411
is1559734101092258
solely1642734101093788110157179223
the1890734101093182129
patient’s343748101095195123143188238266287320
responsibility677748101093074109160209259293313364385405425454499
(42,1191748101092568111129
44).1335748101094693117133
Viewing1483748101095071116181202251301
medication17997481010975120171192343762101094083111131179228
non-adherence585762101094998147175217267315360388432481520563
as1162762101094377
the1253762101092978122
patient’s1389762101095194122142186235263284315
“fault”1718762101093258101149169198232
is1964762101092154
a3437761010943
misinformed399776101097494128147196220268297370414464
and877776101094391141
detrimental1031776101095094123151171244288337365407427
perspective.1472776101095095123158207252292322342384427444
As1929776101095590
Everett213862101094484127155198227257
Koop240862101094895143193
emphasized,2614621010944117167215257290310347390440457
“Drugs308462101093290119167216249
don’t334662101095098146163192
work3551621010965112140181
in374562101092169
patients213876101095195123143188238266302
who2458761010966116165
don’t2640761010951100150167197
take285476101093074115159
them.”303076101093079124199217246
Therefore,329476101094495139168213239288317361379
it369076101092151
is375876101092156
crucial213890101094068116155174216236
for238790101092674102
health250390101094993134154183231
professionals274790101095179126151195229263282330379420440474
to323490101093077
acknowledge332490101094382122171219283303347397446490
that2138104101093079122150
inadequate2311104101092171113164208259308351380423
medication27581041010975120171191231274303323372421
adherence3202104101094494143188217262311351395
leads3620104101092166109159194
to2138118101093079
suboptimal2241118101093685136187238268288364407428
clinical269311810109416182132152193236257
outcomes.29741181010950100130169218293339374393
This3392118101094596116151
is3567118101092156
supported364711810109368513721381321010952103132165209261
by2424132101095294
the2542132101093080126
WHO’s26921321010977137200219252
statement2968132101093667111140185261307357386
that3379132101093080123153
improving35561321010922971491782282138146101094364113163
adherence2317146101094494143188217261311351395
may27281461010975117158
have2902146101095093134178
a30961461010943
greater3155146101095079123166195238268
impact3438146101092296146190229261
on3715146101094999
health2138160101095197141162193243
than2406160101093081124175
enhancing2606160101094697147191242283304354406
specific3036160101093788135177198225249289
medical33501601010977123175196237282303
treatments.36781601010930601052138174101094473149195246275311331
A24931741010956
continuous,2573174101094190140170190241290340391426445
collaborative3042174101094190112132176227278308352381402446491
approach35571741010944951471772272138188101094383132
is2287188101092155
required2359188101093074125174194223267318
to2694188101092977
achieve2788188101094483132153197239283
optimal30881881010949100129150224267287
medication33921881010975120171191231274303323372422
adherence2138202101094394143188217261311351394
and2552202101094392143
fully271420210109267697117159
utilize289320210109497999119139177222
the3134202101093079124
benefits3277202101095197147191218241270306
of3602202101095075
current36972021010940892138216101092957101149177
therapies2329216101092977121149191241261304339
(45).2681216101092567110133148
The2843216101094493137
Medication29932161010972116166186224267295314362411
Adherence34172161010954103151195223267315354397
Reporting2138230101095096149201231264286337389
Guideline25522301010960111132185231253275326372
(EMERGE),2949230101092771145191240300346372389
adopted3364230101094496147200231276329
by3718230101095396
the2138244101093079124
ESPACOMP,2282244101094488135184234293364412420
employs27222441010945120170192241282317
a30592441010943
three-phase3123244101092978107151197226278328370405450
classification3593244101094061103138173193213825810109275192136166187238289
known2452258101094395145212264
as2740258101094581
the2845258101093181128
ABC29972581010957106159
taxonomy3181258101093075119168219269346388
to3594258101093080
categorize36992581010941862138272101093075127178208229268314
medication24762721010977123175196237282311332382433
adherence.2934272101094496146192222268319360404423
The3381272101094697143
phases35492721010952103147183229265
include2138286101092170110131179230274
(a)243328610109266689
initiation,254328610109217090119140182211231280329348
(b)291228610109257698
implementation,3031286101092196146167212287332381410453482502551601619
and3671286101094392143
(c)213830010109266488
persistence.2251300101095299129165186222252297348389434452
Persistence2728300101094892122159180215246291342383427
is3180300101092157
defined3261300101095298125149199245297
as3583300101094480
the3687300101093081127
duration21383141010951100129173202222271321
from2483314101092757106181
initiation268831410109217091120141184213233282332
to3044314101093079
the3147314101093079124
final329531410109275099142163
dose34823141010951101136181
before36873141010951972138328101092675104149
discontinuation.2308328101095171105145193243271292341389432461481530580598
In2927328101092271
each3019328101094588128177
phase,32173281010951101144179223241
there3479328101093079124153197
are3697328101094472117
distinct393462101095171105135156205245276
methodological4228621010975120149198247298348369418468489528572592
challenges483862101094089132153173218267317362397
related52536210109297495137166210261
to553262101093078
defining,393476101095093119141189208256305322
measuring,4270761010973117159192240267287335384401
and468476101094391140
analyzing483776101094391133152193232252300349
medication5199761010974117167187225267295315362411
use393490101094984128
(43).407790101092568111133149
Non-adherence4240901010959109158186229279328373401446495535578
comes483290101094088162207242
in508890101092170
eight517290101094566115164193
forms,537990101092675104178212231
adapted3934104101094393136186215259309
from4257104101092756104179
Arnet4450104101095583133177207
et4671104101094574
al.’s47591041010944648298129
classification,4903104101094060102137171191217239279322350370419469486
including54041041010921701091291783934118101095172122173
primary4131118101095181102177221250296
non-adherence,44511181010950100150179223274324369399444494535579597
drug5072118101095180130181
holidays,52771181010951100122142194237278314333
the3934132101093079124
toothbrush4072132101093078127156205255285334368417
effect,4504132101094571100144185216234
perfect4753132101095196125153198238270
adherence5037132101094394143188217261310350394
with5445132101096687116165
the3934146101093079123
wrong4071146101096696144193243
medication,43281461010975120171191230273302322371420438
dosage47801461010951100134178228272
errors5066146101094574103152181216
(overdose,5296146101092672113157186236284393416010109358096
underdose,4044160101094998148192220269318352396413
erratic4471160101094573102144172192231
dosing),4716160101095099133152201250273289
incorrect5019160101092169109156184213256296327
dosing5360160101095098133152201250
frequency,3934174101092656100151200245294334378392
early4345174101094588117137180
therapy4543174101093079124153196247288
discontinuation,4850174101095171105145193243271292341390432461481530580598
and5467174101094392143
polypharmacy39341881010951101122164216265308337412454494538
(Table4490188101092572109159180225
2)4732188101094769
(46).4819188101092568115138154
Understanding39342130014780149219282325377420482551622653722791
the47522130014743112174
underlying49532130014769138208271315346406438507577
mechanism393422700147102164220289350419450500602
of45632270014768107
non-adherence46972270014769137206246308378447510553616685740801
Our40742441010964117148
comprehension4249244101094293171225256304356404457494516568620
of4897244101095179
non-adherence50032441010952104157187233286339386418465518560607
remains3934258101093076154199221272308
partial,4269258101095298128162184228251270
with4566258101096790121172
some4765258101093687165212
factors5003258101092773115148198229267
and5296258101094596149
treatments54712581010931611083934272101094373148194245274311
not42692721010950100129
fully442227210109267799120163
addressing4608272101094495146176221257293314364415
the5046272101093080126
underlying51952721010950100152197227249292314364415
causes3934286101094085134170216252
of4211286101094976
this4312286101093080101137
behavior.4474286101095198149192235256306336352
Therefore,4851286101094596142172217244294324370388
selecting5264286101093682104150191223245295346
the3934300101093080126
appropriate4079300101094495147177226278308330373403447
treatment4546300101093059105148178253299349379
should4945300101093585135185207258
be5223300101095197
guided53403001010950100121172218270
by3934314101095091
the4041314101092978122
reasons4178314101092973116150199248283
behind4476314101095095145165214264
non-adherent4755314101094998147176218268317362391435484513
behavior5283314101095095145187228249298327
and3934328101094495147
the4107328101093081127
patient’s4260328101095297127148195246276298332
level4618328101092168112157179
of4823328101095077
commitment4926328101094190167243265296372419470500
(47).5452328101092670114140158
Fig.2140358301124771123146
1.2308358301125070
Illustration24213588010719365498127152177218243260305350
of2791358801074567
the2878358801072671108
history300635880107466492117160185224
of3250358801074567
medication33363588010772109154171208251276293337383
adherence3738358801074690136173198233279315351
with4108358801076380105150
significant427835880107314791136153175193229273318342
events4640358801073875112157181211
modified48713588010772116161179200218255300
according5190358801074682117159185227244289334
to5543358801072769
Vrijens214036980107456784101139184213
et2367369801073864
al.244536980107466378
(41)253836980107236196113
Hippocrates22115408084415893129164195220253275309339
stated25645408084315286107141177
that27555408084225891113
physicians224854880843672103134150181197231266296
should255954880843066101137153189
be276254880843669
cautious222155680843165100122138173209239
about247555680843369104140161
patientreported2651556808436699110714117619822615649084255894129154175209245
medication252056490845387122138170203225241276312
use.24875737084366625535738084352589573708417
440247150700913978121
-2518512909126
360242851880913980122
BC256751880913983
1976286243710912465105146
2001399551250914487130154
2003438243710914487130169
1993363043710912465105145
2008474450670914487130170
-4824512509126
2009475251840914487130170
Sackett265039060843670101133167189211
and287539060843470105
Haynes299539060844175107143176207
introduced2646398708416527499134169205237270306
the29673987084215791
term30723987084225681133
COMPLIANCE.272940670843979129165196221261302342376393
Shift34383907084367288107129
from35823907084194479131
the37283907084225791
term38333907084225680133
COMPLIANCE347939870843979128165195221260302341375
to386839870842257
ADHERENCE.352440680843978119153191225266305339356
The394654060843571105
term40655406084225680133
PERSISTENCE387754870843670108144170206241275317356390
was384955670844679110
introduced.3973556708416527498133169205236270305323
The418739070843571105
WHO430639070845496136
released44563907084255875108142172205241
a4712390708433
report41733987084255894129154175
on436339870843571
medication444839870845386122138169203225241276312
adherence.430940670843369105139163197233264297315
ESPACOMP508039070843470106146185225274310
implemented493339870841669105121154207241276298332367
the53153987084225791
ABC542039870844078117
taxonomy.50884067084225587122158193245277294
Medication469754070844983119135166200221238273309
adherence470954870843469105139164197233264298
became4635557608436701014735557708437477255760845386
a4873557608433
MeSH492155760844983119161
term.47765658084225580133150
2010515843710914487111154
1985323051250912465105143
C.308654080843957
Everett31575408084346598123157179200
Koop337254080843873108144
emphasized307054880843487122158192222238266300335
that34205488084225891113
“Drugs30145569084317094130166196
don't322555690843671107123145
work338455690844682106139
in353755690841752
patients29735649084366991107141177199229
who321756490844682117
don't334856490843671107123145
take35085649084225588121
them.”32055730084225891144161192
Tab.2140599301124991145167
2.2323599301125075
Eight2441599801074056100146170
forms262559980107236792162191
of2831599801074567
non-adherence,2912599801074791136163209253299336361397442479514529
modified34555998010772116161179200218255300
and3769599801074691135
adapted3919599801074590134178203239283
from421759980107234891162
Arnet4393599801074974119156182
et4589599801073864
al.'s46675998010746637885116
classification479759980107385599128158174195213250293318335379425
(46)5236599801072461103123
Abbreviation217161360985198146176218259280321350371417463
Form271561360984186116184
Description371561360985597131168197218266295316362408
NON2171625609854112167
Primary27166259095406381146183207245
non-adherence297962590954386130155192236279319342381424461499
Medication3715625909562101145161197233257273315358
is408662590951645
not414462590954385109
obtained426662590954286110147163205244288
or456662590954366
picked46456259095446196129167211
up486962590954286
from49686259095214586152
the513262590952567106
pharmacy.525162590954487123146211247283320330
A2171637609851
Drug271663790955276120164
holidays289763790954387104121165202237267
Patients37156379095407599115154196220250
temporarily397463790952563128171214238274297314330365
stop43496379095305596140
taking44986379095256195112154198
their470563790952567106122145
prescribed485963790954468106135171194211254294338
medication.5206637909566104148165200236260276319361375
D2171654609855
Toothbrush271665490953776120144187232256299329372
effect31056549095396185124161189
Patients371564990954076101118157200224256
start39886499095295693116144
following4149649909521648298142200217260304
doctor's447064990954487124151193217232262
recommendations47496499095236299140207272312355400436461478521564594
shortly536064990953073116140168185221
before371565990954484106149173211
an394465990953679
appointment404165990953681125169187230254320360403427
but448565990954588113
may4616659909565102137
otherwise477065990954367111150174235252282321
ignore510965990951761104147171210
them.533765990952468107173188
H2171676609854
Perfect271667190954078102126165202229
adherence296367190953680123163187226269305343
but332467190954487113
with345467190955875101144
the271668190952568108
wrong284168190955882125168212
medication3071681909565105150167203240265282325368
Patients37156719095407599115154196220250
take39786719095256195133
medication4124671909565104148164200236260276318361
as449867190953766
prescribed,457767190954468106135171194211254294338351
but494167190954487112
it506667190951741
is512067190951746
the517967190952567106
incorrect52986719095175995136159183221257283
medication.3715681909566104148165200236260276319361375
E2171693609841
Dosage271669390955296126163208247
errors,29816939095386287129153184199
overdose319769390954379118141185228258298
Patients371569390954076101118157200224256
take39886939095256296135
more4140693909566109134172
medication4330693909565105150167203240265282325368
than471669390952468104147
prescribed.488169390954468107137174198215259300344359
R2171705609846
Dosage271670590955296126163208247
errors,29817059095386287129153184199
underdose319770590954386130169193237280310350
Patients371570590954076101118157200225256
take39887059095256296135
less41417059095175686116
medication4275705909565105150167203240265282325368
than466170590952568104147
prescribed.482670590954468107137174198215259300345359
E2171717609841
Dosage271671790955296126163208247
errors,29817179095386287129153184199
erratic31977179095396387125149166202
dosing341771790954387117133176221
Patients37157179095407598113151192215245
inconsistently39717179095175893133175203218246271307349371387421
follow4404717909521627893135191
the460771790952466104
prescribed472271790954467104133168190206249287331
dosing506471790954385114129170212
schedule.528871790953065106144187228244282294
N2171734609854
Incorrect27167349095176096138162187225262290
dosing302373490954487117134177221
frequency32617349095214685130172212255291329
Patients37157299095407599115154196220250
take39787299095256194132
medication4123729909565104148165200236260276318361
at449772990953660
the457072990952567106
wrong468972990955781122165209
frequency49107299095214683127169208250286323
(e.52467299095215770
g.,53247299095445871
twice540872990952484101136173
a3715739909536
day376773990954479114
instead38967399095175988113151186230
of414173990954364
the422173990952567106
prescribed434373990954467105135170193210254293337
three46967399095256790128167
times).487973990952541106145174193204
C2171751609847
Early27167519095377598116152
therapy288675190952467107131168213248
discontinuation31527519095436090126168211236253296338375399416459503
Patients371575190954076101118157200225256
discontinue39887519095446190127169212236254296339379
therapy438475190952568108132169213249
prematurely.465075190954469107173210234277301339357393404
E2171768609841
Medication2716763909562102147164200237262279322365
cocktail,309976390953577114148176213230247261
polypharmacy271677390954488106142187231267291358394431469
pattern320277390954482106134172196239
Patients371576390954076101118157200224256
engage398376390953982126162207246
in424176390951760
a4313763909536
pattern436176390954482106134172196239
of461276390954365
taking46897639095246196114157201
multiple4902763909566108125151168212230269
medications5183763909566105150167203241265282325369398
simultaneously.371577390953046112155172197234277317361404433450486497