498
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE709804301074291138211265312372415474533554598
A13288043010753
FARMACIE1403804301074191138210265316336380
/18298043010732
Klin190680430107446583131
Farmakol2057804301074278105179220258305325
Farm.2402804301074178104179195
2024;38(3):100-1062617804301074487128168183227270294336357372409449494524563602648
/33108043010731
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
1021308026012657111168
HLAVNÍ341207012670127198263336370
TÉMA733207012657114204274
Importance34136501061569104145181212249290324356
and71336501063879119
safety84736501063171101133167206
of106936501063869
magnesium115336501065293131172204238255296349
supplementation151836501063171106141171204258290332364400428446487529
in206236501061556
pregnancy.213436501063368100140181221262297335347
To249636501063069
supplement258136501063071105140171203258290331363
or296036501063874
not?305036501063980110139
Assessment3436890014776128178241291341443506576618
of9886890014767106
magnesium112268900147101163232301364414445514616
status343703001475093156198266316
in687703001473099
pregnancy8147030014770113176246315376445500563
To483720101094693
evaluate608720101094792139162214260291338
magnesium9797201010977123176229277315338390468
status,1480720101093770116148200237258
serum1771720101093785117169248
magnesium3437341010976121173225272309331381458
concentration828734101094191143185230282313343388419441492544
(5)139873410109267297
can1521734101094287138
be1686734101095299
used,1812734101095087134187207
or343748101094979
other439748101095080129175205
methods6617481010975121151201251303339
such1016748101093685126176
as1209748101094379
measuring13057481010975120164200249279300350401
magnesium17237481010975119169220265343762101093555103176
concentration533762101094087136175218267295324366395415463512
in1060762101092069
erythrocytes,1143762101094473117149197226273313357389432466485
saliva,164276210109357899119161203222
and1878762101094391141
urine.34377610109497798147191209
Laboratory567776101094185135184213256285332361406
tests988776101092972107137173
and1175776101094392142
clinical133277610109396080128149188231251
assessment1598776101094377112156191225299343392421
are2138692101094373118
recommended2272692101093075116165241316362412464509561
for2850692101092676106
overall2972692101094992137167211232253
evaluation3242692101094588132154203247276297347398
(22).3656692101092671117140158
According2138706101095595135183213264285335386
to2547706101092978
Morton,26487061010972122152185234284303
A.,297470610109557695
(2018),3092706101092570116158200225242
serum3356706101093681111162237
magnesium361570610109751191702138720101095096132153202277
concentrations2436720101094089139180225275305334378408429479529565
in3021720101092171
the3112720101093080126
preconception3258720101095181126168217267308352404434455505556
time2138734101093051126172
range2329734101093074124175220
from2568734101092757107182
0.622769734101094765112157
to2945734101093079
0.953043734101094665110155
(mmol/l),3217734101092699174224246277300326343
and3579734101094393145
in3743734101092171
the2138748101092978123
first,227674810109264978114144163
second,2454748101093580121168218268286
and2756748101094392142
third291374810109307899128178
trimesters,310674810109295879153198233263307336372390
their3512748101092978123144172
values37007481010942862138762101092171117152
are2309762101094372118
0.65–0.92445762101094664111157203253272316
(mmol/l),2780762101092598173223245277299325342
0.62–0.93140762101094665112157200250268313
(mmol/l),3471762101092699174224246277300325343
and2138776101094393145
0.45–0.92302776101094665111156203252271316
(mmol/l),2637776101092698174224246277300325342
respectively2998776101093075111162209250282303347392414457
(3).347477610109257093110
Maternal39346890014799161203265309378439470
hypomagnesaemia443268900147681271982673694315005696326827458079109411002
and39347030014761130200
clinical4162703001475385116185216270332363
manifestations455270300147102164233264302365415459521563594662731781
The4074720101094699147
deficiency,4249720101095199128153196219266319362409425
depending47027201010952100153202254308331383436
on51667201010950103
the5297720101093183130
rate5456720101093076107154
and3934734101094394147
factors4101734101092671113146196227264
contributing4386734101094090141171202224277328359381432484
to4890734101093080
magnesium49907341010975120171222269306328378454
loss5465734101092172108145
(11),3934748101092672112134153
can4119748101094289142
manifest42947481010977124177200230278317351
as4677748101094483
nonspecific47927481010951104158196251300345368397424467
(11)5291748101092772112134
and5457748101094598153
can3934762101094085136
be4094762101095198
similar4215762101093658134156179223253
to4492762101093079
other4595762101094980131178208
electrolyte4827762101094568114157190220271293337371417
imbalances52677621010921971501952172623133934776101094188125
(11),4088776101092670109131149
but42667761010952104136
can4430776101094288140
also4598776101094467105157
manifest47837761010977122174197226273311344
specifically.5155776101093690138182204233258301347370393438455
Tab.34061701124993148172
2.53261701125076
Overview65562201075898136162204223262325
of99862201074569
the108562201072673112
aetiology121562201074685112131177197242289327
of156062201074569
magnesium1647622010771117164211250282300346418
deficiency208362201074585109129167186225272310349
in245062201071966
pregnancy253462201074572110156203249296334374
or292662201074572
in301662201071865
the309962201072673112
preconception322962201074672110149193240278316362389408454501
period374862201074685112131177224
Aetiology3717600985192121142188210256303344
General19267600985396143185215256277
population22207600984793141187208250278299345392
and18898600984187134
pregnant20408600984776118165212253300328
women238586009860105174216263
Detailed27657600985597126168189211253301
information3082760098216793139169237279307328374421
genetic3719800984688135177206227264
aetiology6519800984183112133179201247294335
G224498309550
G2244108309550
G2244118309550
G2244128309550
hypercalciuric27659830954378123163187222259277313330372396413449
hypomagnesaemias403232983095437712316723327031435739742746450457058762365338879870562347
Gitelman-like27651083095506793131148214250293319337354388426
hypomagnesaemias40320910830954377123167233269314357396427464504570587623653386410870562347
mitochondrial276511830956682108150187230273317361385402438455
hypomagneasemias40323811830954377123167233270314357396433462502568585621651389111870562347
other276512830954367110150174
genetic295712830954383126165190208244
hypomagnesaemias40321812830954378123167233270314357397427465504570587623653387312870562347
aetiology37114000984183112133179200246293335
of72214000984572
use81014000984680122
of94914000984571
addictive103714000984088135156193223244286327
substances138014000983480127161191233279316357391
G2244140309550
addictive276514030953681125142178205222259298
substance308014030953072117147173210253290328
use342514030954372112
(heroin,355514030952164104128170187230244
morphine,3817140309565109133178222239282321334
cocaine,416914030953677114152169211251264
nicotine,44511403095436096138162179222262275
alcohol,47441403095365389131175218236250
caffeine,50111403095367394119158175218257271
or529914030954367
other538414030954267110150174
addictive276515030953681125142178205222259298
substances)41308015030953072117147173210253290328358377345915070562343
nutritional37116200984692121150171199220266313354376
deficiency76316200984789116138175196238285322364
or114416200984574
overnutrition123516200984586127156203249278307328357378423470
G2244162309550
G2244172309550
P2249182309540
G2244192309550
G2244202309550
unmet276516230954286151191216
nutritional299916230954285110134152177194237281318335
or335116230954367
dietary34361623095436099124162185224
requirements14367716230952463107150167191229295335378402433410616270562344
parenteral276517230954481105144187211249273311328
nutrition14,31101723095438611113515317819523828233871727056234452
42344917270562345
malnutrition327651823095661021191622052302542722973143574013166182705623
starvation4227651923095305693117156194218235278322308819270562345
diet276520230954460100125
high290720230954360104147
in307220230951659
fat31492023095215883
or324920230954367
sugar43333420230953072116153176350820270562345
gastrointestinal37121400984687121151179225247293322363397427448494535557
aetiology94421400984183112133179201247294335
G2244214309550
G,220722430955065
P2289224309541
G,220723430955065
P2289234309541
G2244244309550
G2244254309550
G2244264309550
G2244274309550
fistulas14,27652143095213968941371551912212981214705623443025214309514
vomiting14305621430953779145162188205248292334321470562344
diarrhoea3,27652243095446097120145189232272308307422470562331
14,31152247056234452
42317722470562345
malabsorption3,2765234309566102119156200230274298343368385428472323723470562331
14327823470562344
acute276524430953673116141179
pancreatitis14,29662443095458212516118522426028430132734437333352447056234452
42340024470562345
(Note:346724430952172116140178192
can368224430953573116
also38202443095365383126
be396824430954585
classified40752443095365389119149166188206245290
into43872443095176084126
section-453524430953069106134151194237263
transfer48202443095254986129159181220244
from50872443095214688154
the526324430952568108
extracellular53932443095397510212616427652543095367491108151168204228
to301025430952567
the309525430952468107
intracellular32202543095165983108145181219237254296313350374
compartment)361125430953678144188226249277343383426450472
gastric276526430954480110136160178214
bypass299626430954580125163193223
surgery4232362643095307296139178202241347726470562345
liver27652743095173471109133
disorders4329162743095436090133157200240264295321327470562345
renal37128600982871117159180
losses56828600982066100134176210
G2244286309550
G2244296309550
G2244306309550
„2765288306745
familial:284528630952159124141158175211228242
genetic310428630954484127166191209245
aetiology14336628630953776101118161179222267303366728670562344
„2765298306745
acquired:284529630953673115158175199237282296
from31582963095214688155
therapeutic333029630952568108132169213254296322339375
agents14372329630953680120163187218393729670562344
„2765308306745
other284530630954367110150174
acquired303630630953773116159176199238283
tubular333630630952568112156173209233
dysfunctions358730630954379110132176219255283300343386416
and402130630953679123
diseases42,4162306309543609012916519523526544293067056234553
44449230670562348
endocrine37131800984188135181219248269315358
aetiology74531800984183112133179200246294335
G,220731830955065
P2289318309541
G2244328309550
G2244338309550
G2244348309550
G,220735830955065
P2289358309541
G,220736830955065
P2289368309541
hypercalcaemia3,276531830954378123163187222259277313350389455472508327431870562331
14,33153187056234452
44337731870562348
(reduced34423183095214382126169205243288
NaCl374831830955187134151
reabsorption)39163183095246299143173216241286311328371414434
„2765330306745
primary28453283095446886152188212250
hyperparathyroidism44311332830954377123163187232269293330355398433458500517561578607673378732870562348
„2765340306745
malignant2845338309566102119136180223260303327
hypercalcaemia44318933830954378123164187223260277313350390456473509369933870562348
hyperthyroidism44276534830954378123163187215258293317360377421438467533329934870562348
hyperaldosteronism276535830954377123163187224242286329359385423447489533550579645
(reduced34273583095224382127169206244289
NaCl373335830955188134151
reabsorption)3,39023583095236298142172216240285310327370414433433435870562331
44437535870562348
osmotic276536830954373138182206223260
polyuria304236830954488106142186209227263
–3323368309540
poorly338036830954488132156174210
controlled360836830953577121145169211229246285330
diabetes39563683095436096141181206244275
mellitus3,4248368309566105123140156182225254450336870562331
44454436870562348
transfer3713800098285798145179206248277
from66538000982555101170
the85138000982875117
extracellular98438000984282113142184220262283305351372414443
to37139000982874
the46139000982875117
intracellular5943900098216796125166203244266287333354396425
compartment103639000983581149197239268298367409456484
G2244380309550
G2244390309550
G2244400309550
G2244410309550
G2244420309550
G2244430309550
G2244440309550
treatment27653803095254987123148214254297321
of310438030954264
diabetic31853803095446197141182207224260
ketoacidosis34633803095337297139176213230274317347364393
with387438030955775100143
insulin4240353803095175989131148165208424538070562345
refeeding27653903095246284123163208225267312
syndrome14,30943903095306711115517922128732734163907056234452
42,34783907056234553
44354239070562247
correction276540030953677102126165202229246289333
of311540030954365
metabolic3197400309566105130168212256274291327
acidosis42,3541400309537739013417720722425337964007056234553
44385940070562348
ethanol276541030953964107144187230248
withdrawal303141030955775100143188211249306343361
syndrome42340941030953067111155179221287327373941070562345
hungry276542030954385129173197235
bone301842030954488131171
syndrome42320742030952966110154178220287326353642070562345
–3598420309540
a3656420309536
state37094203095305693118156
of388342030954264
profound396442030954569111133175219262306
hypocalcaemia14428742030954378123167204241259295332372437454490477242070562344
catecholamine27654303095367397136173216259277313379396439478
excess44326143030953974110148178208347143070562348
significant27654403095304690133150172190226263306331
blood311344030954462105149194
transfusion4433244403095254987130159182226255272315359368444070562348
use37145200984680122
of51045200984571
therapeutic59845200982874116146187235277324352373410
agents102545200984087129176204239
G2244452309550
G2244462309550
G,220747230955065
P2289472309541
G2244482309550
G2244492309550
G,220750230955065
P2289502309541
G2244512309550
G2244522309550
G2244532309550
G2244542309550
G2244552309550
proton276545230954468111135177221
pump300345230954488153198
inhibitors14,32184523095176010312016418220724927330435174527056234452
42357945270562345
aminoglycoside2765462309536102119162205250267303339380411427471511
antibiotics14,32934623095378010412116518322625026730433536234627056234452
42,36854627056234553
44374946270562247
loop276547230951760104149
and293147230953780124
thiazide30734723095246884121154172216255
diuretics3,334647230954360102126165190207243274362147270562331
14,36624727056234452
42372447270562345
,443779472705683257
monoclonal2765482309566109153196233250293337373391
antibodies317348230953680104121165209254271310341
–3531482309540
cetuximab35894823095357398141177194260296341
and394748230953780124
others42408948230954267110150174204429648270562345
amphotericin2765492309536102146190233258296320338374391434
B14,321649230954032544927056234452
42331649270562345
cytotoxic276550230953674102143168210244262298
drugs:308050230954468111155185199
cisplatin3,32965023095365382126144180205222265356150270562331
14,36025027056234452
42,36645027056234554
44372850270562347
certain27655123095367498126163180222
antitubercular300551230953679104121146189233274298333375393429453
drugs44347551230954468111155185366251270562348
beta-adrenergic276552230954484110147172208253277315358398422465482518
agonists:330152230953680123167184213239271285
theophylline,360352230952568108152196240275293310326369409422
salbutamol4440435223095296784128172197234300343361440552270562348
digitalis42276553230954460104121147184201218247301453270562345
antacids43276554230953679104141177194238268303554270562345
laxatives4327655523095175389126151168205243274304155270562345
pregnancy37156400984776118166212253300337379
and76756400984087134
puerperal91856400984793135165212255284326347
aetiology128256400984082112133178200246293334
P2249564309540
excessive276556430953974110148178208225262300
lactation3308356430951753901171541781962392823365564705623
other37157630984574120163192
factors58057630982567103134179208243
G2244576609550
G2244586609550
G2244596609550
G2244606609550
G2244616609550
G2244626609550
G2244636609550
stress4527655766095305680119149179294657700562345
sweating43,2765586609530891281641882052482923059587005623453104586609514
exercise43313558660953975113137172189219258339558700562345
oestrogen276559660954383113139163206250290333
therapy43311659660952468107131168213248336459700562345
low276560660951760118
salt29016066095296784109
intake4330286066095176084121155194322460700562345
low276561660951760118
selenium29016166095296987126169186228294
intake4332136166095165984121155193340961700562345
vitamin27656266095365479116182199242
B6302462660954181
deficiency43312262660954483105123159176215258294332345562700562345
vitamin27656366095365479116182199242
D3024636609552
hypervitaminosis309463660954277122163186226243269306372389431475505522551
or366263660954367
hypovitaminosis43374763660954377123167203221246283349366408452482499528427763700562345
Note:37164860954989113146160
endocrine54564860953476116157191214230272306
aetiology8656486095417599115156173213254287
can116764860953372114
overlap129564860954074107130147187228
with15386486095557195136
renal16886486095235698138155
aetiology.18576486095407598115155172213254287299
Sign:3716586095355191133146
G531658609547
indicates5936586095165898115148188211244272
that87965860952465105129
information10226586095165878118141205245269285325367
was140465860955595122
mainly1540658609564104121162178212
retrieved17666586095235680103119153188221262
from20426586095214584148
available220465860954175114131147187228245279
information24986586095165777117141204245268285325367
from28796586095214484148
the30416586095236599
general315465860954175116151174212229
population.339765860954182123164180221244260301343358
Sign:3716686095355191133146
P531668609538
indicates5846686095165798114148187211244272
causes87066860953373114140174202
of108666860954061
hypomagnesaemia116266860954173113155219259300341375403443478541558598
relevant17756686095225572106141180222244
to203466860952362
pregnancy21116686095406396137178219260294328
data.245466860954080104142158