811
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE709804301074291138211265312372415474533554598
A13288043010753
FARMACIE1403804301074191138210265316336380
/18298043010732
Klin190680430107446583131
Farmakol2057804301074278105179220258305325
Farm.2402804301074178104179195
2024;38(3):100-1062617804301074487128168183227270294336357372409449494524563602648
/33108043010731
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
1041288026012657111170
HLAVNÍ341207012670127198263336370
TÉMA733207012657114204274
Importance34136501061569104145181212249290324356
and71336501063879119
safety84736501063171101133167206
of106936501063869
magnesium115336501065293131172204238255296349
supplementation151836501063171106141171204258290332364400428446487529
in206236501061556
pregnancy.213436501063368100140181221262297335347
To249636501063069
supplement258136501063071105140171203258290331363
or296036501063874
not?305036501063980110139
For343328101094596128
this500328101093083106143
purpose,6723281010952105137192245283331351
Table1052327801125195153180231
313103278011252
was13903281010968114152
developed.15713281010951100145192216269323372427448
The343342101094597143
table505342101092975127150196
does7203421010950101148185
not9233421010950101132
represent1073342101093076128159205242289340371
all146134210109436688
possible15673421010951103139176198250273320
clinical190534210109406284343356101094970110153175
manifestations.5343561010973116166187213258294324368397418467517552571
The1120356101094494139
frequency1275356101092656101152201246295336380
of1671356101094975
clinical176235610109396081131152192235256
manifestations3433701010974118168190217262298329374404425475526561
was9213701010966110146
derived1084370101095096126148192236288
from1389370101092657107182
the1588370101093080125
general1731370101094995146192222266288
population3433841010951103156207229274304326377428
of792384101094977
adult890384101094395146168199
patients1110384101095196127149195247277315
(5,144638410109257189
11,1556384101094685100
14,1677384101094689108
32).1806384101094691116134
Hypermagnesaemia34340900147811412132763204224845536226857357988609639941055
in3434230014731100
pregnancy4704230014770114176246315377446500564
Hypermagnesaemia4834401010960104156203234310355406457503540584631707729773
belongs12804401010953100122172223275311
to1615440101093180
uncommon172044010109511021431922693434541010977127178
medical5464541010976123175196237281303
conditions873454101094291142193215245266316367402
(11),1300454101092669106126143
usually1468454101095086136179201222265
having1758454101095195137159210261
iatrogenic34346810109216392121169219264313333373
causes.730468101094083132166211246264
Other1008468101096293142186215
causes1237468101094184132166211246
are1497468101094372116
worsening16274681010966114143179224273293342392
kidney343482101094263112160203244
function,600482101092674122161191211258307324
bowel937482101095199163206226
disorders,1176482101095070103151179228271299334352
and1541482101094391140
age-related1694482101094392135164193236256297343496101092972122
conditions478496101094087135185204233252300349382
(11).873496101092666102120135
In1021496101092270
pregnancy,1104496101095179122172220261310349392405
hypermagnesaemia1522496101095089139184212285327376424468343510101093679124198219261
may6185101010975118158
occur791510101094990128177206
in1011510101092170
pre-eclamptic1095510101095281125154201241262304378429458478518
women16275101010966114189234283
after1925510101094368343524101092972100
magnesium4565241010974115164212255289308356428
therapy897524101093077121149191240280
(2).119052410109256890105
Overtreatment13085241010961104146174205233275317345417461509537
with1858524101096585113161
magnesium3435381010975118168217262297317366440
can806538101094083132
result961538101093074109157178207
in1191538101092170
magnesium12845381010975117167217262297317365440
toxicity1746538101093078118139179199228273
(5,34355210109256985
16).442552101094687109125
Hypermagnesaemia5815521010959100151197225300342391440485519563607681701743
is1338552101092155
absent1407552101094393128172222250
in1671552101092170
normal1754552101095099128202244265
renal343566101092974123166186
magnesium5475661010975118168217262297317365440
excretory1004566101094587126155199228277306350
processes1372566101095180129169213248282327362
(14).1752566101092566107130146
Magnesium3435910014799161231300362413444512614
use9855910014768118181
may119359100147102164222
lower1442591001473199189250294
the17635910014742111174
risk343605001474374124186
of5566050014768107
pregnancy6906050014770114176246315377445500563
complications12816050014754121223294325356411473515545614683733
Magnesium4836221010973117167217262298318367442
therapy949622101093080125155198249291
with1264622101096788118167
off-label1455622101095076105131154197248294315
usage1794622101095085129180225
is343636101092157
used425636101095086132184
in634636101092172
adult731636101094496146167197
non-pregnant9536361010951101152181234264310362412456507536
patients1514636101095297126147193244274311
with1849636101096889120170
migraine343650101097595145174217238287332
(38),691650101092670115138154
status862650101093666109138187221
asthmaticus1100650101094378108157231274303323363411446
(38),1563650101092569114137154
and1733650101094493143
arrhythmias1893650101094472101343664101095091123172246267309344
(38).711664101092569114137154
In888664101092271
pregnancy,983664101095180125175225267317357401415
magnesium14216641010976118168218263298318367441
can1886664101094083133
be343678101095197
indicated454678101092171121141181224253297348
in816678101092171
the901678101093079124
case1039678101094184119164
of1217678101094975
eclampsia1307678101094585106148223273308328371
or1692678101095079
preeclampsia1785678101095281125170211343692101092164138189224244286
(38),646692101092669114138154
where8176921010966116161190234
it1068692101092150
is1135692101092156
capable1208692101094083134177228249293
of1518692101095075
preventing1610692101095281125167211261289309359408
seizures343706101093681102141190219264300
or667706101095079
lowering770706101092171137181211232281332
the1126706101093080125
strength127570610109366695140190241271320
of1619706101095076
seizures1719706101093682103141191220264300
(38).343720101092670116140156
In524720101092171
a6207201010943
study688720101093666116167210
by922720101095294
Zarean1040720101095094124169212262
et1326720101094676
al.142672010109446583
(2017),1534720101092570115158197223239
it1797720101092252
was18737201010967110146
also343734101094466102152
confirmed520734101094191142169193222300346399
that,944734101093081125155174
in1143734101092272
the1240734101093181128
oral1393734101095081125147
magnesium15657341010976121172223270306327377454
supplement343748101093686139191213260336383434464
group,832748101095181131182234252
there1109748101093081127158203
was13377481010968112148
a15107481010945
decrease1579748101095299141170216260296343
in1946748101092273
preeclampsia343762101095078121165205224266338387421440481
rates83776210109297199141175
(9).102576210109266790105
Magnesium11437621010971113162210253287306354426
supplementation1582762101093582132181201245318361409343776101093072101121169218
can575776101094083132
lower720776101092270134178207
the941776101092978122
risk107777610109295083124
of1215776101094975
induced1303776101092170120168208251301
high1618776101095069119167
blood1799776101095172121170220
pressure2138328101095383129166202252282328
(49).2491328101092771117142159
The2675328101094698145
use2845328101095187134
of3004328101095077
magnesium31063281010978122174225272308329380457
in3588328101092273
the3686328101093182128
setting2138342101093681110141162211261
of2416342101095075
preterm2509342101095180125154198227302
labour2829342101092163114164213242
belongs3088342101095297118167217267301
to3407342101093078
off-label3502342101095076104130152195245291312
indications2138356101092170120141180223252272321370405
(38).2557356101092569114137153
Magnesium27253561010972115165214259294314362436
supplementation3175356101093684135186207251326371420448492520541589639
can2138370101094082131
be2282370101095196
helpful2391370101095094114164189238258
in2662370101092170
preventing2745370101095179123164207256284304352401
leg3160370101092165114
cramps3288370101094068110183233267
(9)356937010109256790
and3673370101094391141
in2138384101092168
women22193841010965112185229277
with2509384101096585113160
gestational2682384101095093127156198226245292340382401
diabetes3096384101095070111160204232275309
mellitus34183841010973117137156176204251285
(1).37163841010925658298
Foetal21384090014761128191234297328
hypomagnesaemia249340900147691271992683704315015706326837458089109411003
and21384230014761130200
overview23654230014768128189233297329391481
of28734230014768107
increased30074230014731100154197260321372434505
risk3540423001474274124185
for21384370014738107150
foetal23154370014739107170213276307
complications26494370014754121223294326357411473515546614683733
A22784541010955
foetus2357454101092676121151200235
is2616454101092155
dependent2695454101095196147193243293338388417
on3136454101094999
maternal32594541010975118147191221271313334
magnesium361745410109751181682138468101095095130150199273
levels2432468101092166108152173208
(50).2661468101092569114137154
Table2827467801124991145169217
430644678011250
describes3135468101095195131171199220270316351
possible35074681010951101136171191241262307
foetal2138482101092674118147189209
complications2360482101094087160209230249288330358377425474507
that2880482101093078119147
can3041482101093982130
arise318448210109437191124168
due3365482101095098141
to3520482101092976
lowered36094821010921691331762138496101092973123
maternal22754961010975117146189218267309329
magnesium26184961010975117166215260294314362436
levels3068496101092165107150171205
or3287496101094977
magnesium33784961010975117167215260294314362436
restrictions.2138510101092972106135163183222252272320368402420
Some2571510101094492165209
of2794510101094873
the2880510101093078122
conditions3015510101094086135184204232252300348382
mentioned34105101010974118166194214262310354404
in2138524101092170
the2223524101092978123
table2361524101092973123144189
are2565524101094371116
the2695524101093079124
subject2833524101093684135156200241272
of3119524101095075
further3209524101092676104136185230259
research.3482524101093074109154197225264313332
The2138538101094595140
summary2295538101093684159233276305349
of2662538101094975
foetal2754538101092776121150194214
complications2986538101094088163213234254294337366386435485519
was35235381010966109144
obtained36845381010949100213855210109307494143189240
from2402552101092656105180
sources2606552101093685134163203247282
describing2912552101095196131171200221272293342393
hypomagnesaemia33285521010951911431932683113624114562138566101093679124199219261
primarily2423566101095180101175218247267288330
from2776566101092656105179
animal2979566101094392112187229250
data,3252566101095194122166184
as3460566101094378
well35615661010966110131151
as3736566101094378
from2138580101092656104179
human2334580101095099173216265
data2617580101095193122165
or2800580101094978
theoretical2895580101093079124174203247277297337380400
data.3313580101095093122165184
Magnesium21386050014799160228296358407437504605
safety27686050014750111148209251313
in3106605001473199
pregnancy32306050014770112173242310370438491554
and21386190014761129198
relationship23616190014742104134195236265332400449517547616
with30026190014790120161229
pharmaceutical21386330014770139199240342402455515583624654707768798
dosage29616330014769136185246314376
form33626330014738105147249
Magnesium22786501010972115165214258293313361435
supplementation2728650101093583133184205250324369418446489518538587636
seems3378650101093680125200234
to3626650101093077
be3718650101095196
safe2138664101093681107153
for2316664101092777107
maternal24486641010976120150195225276320341
and2814664101094495146
infant298566410109217298143194223
health3233664101095197141162192242
(55),3500664101092671115139156
but36816641010952103133
patient2138678101095398128150196248278
compliance2441678101094191169221244265309361402448
is2914678101092258
required.2997678101093076129180202232278331350
Severe3373678101094592136182212259
side3657678101093658110157
effects2138692101094571100145185216252
may24096921010975118158
occur2586692101094990129177206
in2811692101092170
patients2899692101095295124144189238267303
with3220692101096687116166
renal3404692101093074123166187
insufficiency3609692101092170105153179213870610109264887106149198237280
(56).2431706101092567111133149
Oral2593706101096190132151
administration2758706101094291164184232251284313341383411430478527
of3298706101094873
magnesium33847061010974116165213256290310357430
is2138720101092155
recommended2207720101093074114161236310354404454498549
as2770720101094378
a28627201010943
prophylactic2919720101095180128179228269290332371402422462
strategy339572010109366594137165209259301
for3710720101092675104
pregnant2138734101095079122171220261309337
patients2488734101095193121140184232260295
without2796734101096686114162210258287
clinical309673410109405979127146185227247
symptoms;3356734101093577151200228275349382399
if3768734101092146
clinical213874810109406080128148187230250
symptoms2402748101093678152202231279353387
are2803748101094371115
present,2932748101095079123157202251279297
it3243748101092150
is3307748101092154
advisable3375748101094393136156190233283304348
to3737748101093077
increase2138762101092169108135179220254298
the2449762101092977121
dosing,2583762101095098132151199248266
and2862762101094391140
the3015762101092977121
health3149762101095093135155183231
care3393762101094082110153
professional35597621010951791261511952292138776101093554102150191211
should2362776101093583130178198247
consider2622776101093986134167186235279307
each2942776101094485124172
patient3127776101095092120139182230258
individually3398776101092168117137178199247295336356375416
taking3934328101092972112134182231
into417832810109216997144
account4335328101094382120167215263291
the4639328101093078122
cause4774328101094082130163207
of4995328101094974
deficiency5082328101095094119142180200244292331374
and5470328101094291140
the3934342101093079124
health4076342101095095138158188237
status4331342101093666109138187222
of4571342101095075
the4665342101093079124
pregnant4807342101095281125176225268317345
patient5171342101095195123144188238266
(56).5456342101092669114137153
In3934356101092272
more40303561010976126156201
severe4255356101093682125169199244
cases,4523356101094185120166201220
parenteral4767356101095296126171221250295324368389
administration5180356101094495171192242262297328357401393437010109304997146
of4094370101094974
magnesium41823701010974116166214258293312360434
is4630370101092054
possible46983701010951100134168188237258302
(56).5014370101092568112135151
Magnesium51783701010972115164212257291311358432
sulphate3934384101093685106158208252281326
is4284384101092156
used4365384101095085131183
in4572384101092272
obstetric46683841010950102137168213243272293334
practice,5026384101095282126166198219259304322
where53723841010967118163193238
the3934398101093081128
benefits40863981010953100151197225249279316
should4427398101093787138189210262
outweigh47143981010951102132202248269321372
the5110398101093182128
potential52633981010952104134179230260281325347
risks393441210109295084126163
(54).4118412101092669115138154
During42934121010960110138159208258
MgSO4457241210109721221652274800418706427
therapy,4848412101093079124153196246288302
magnesium51704121010975118168217262297317366440
levels3934426101092165106149169203
should4151426101093583131179199248
be4413426101095195
carefully4522426101093982110153179227247267308
checked4844426101094088132171212254304
(56)5162426101092568112134
and5310426101094291140
safe5464426101093577102146
practice3934440101095282127168200221261306
procedures4265440101095282132174219271321351396432
and4722440101094495146
monitoring48934401010976127178199229278308330380432
should5349440101093787137188209261
be3934454101095299
followed405845410109267799120170237282335
(54,4417454101092671118137
56).4578454101094794118134
The4737454101094697143
only49054541010950101123166
indication5096454101092172124145186230260281331382
for5503454101092777107
intravenous393446810109217098127170211254304352401436
administration4384468101094393167188237257291321349392421441489539
of4937468101094975
magnesium50264681010975117167216260295315364438
sulphate547846810109358310439344821010951101143172216
in4164482101092170
obstetrics42494821010949100135165208238266287327363
is4626482101092155
prophylaxis4696482101095180129179229269291333375396430
of5141482101094975
seizures5230482101093680101139188216261296
in5540482101092170
pre-eclampsia3934496101095180125154201242262304379429464484527
and4478496101094393143
eclampsia4638496101094586106149223274309329371
(56,5027496101092569114132
57,517649610109469099
58).5292496101094791115131
The4074510101094596142
use4238510101095085131
of4392510101094976
magnesium44915101010975118169220265301322372447
sulphate4961510101093585106157208252281326
for5310510101092676106
inhibition54395101010921711211423934524101095274104126176227
of4187524101095077
preterm4290524101095182127158203234310
birth4626524101095274104137187
is,483952410109215777
according4942524101094385125174204256277328379
to5347524101093080
FDA54535241010944103157
20133934538101094895140182
(U.S.4143538101092787105154174
Food4344538101094697149203
and4574538101094597151
Drug4752538101096294146199
Administration),49785381010957110188210262285322354385431462484536589613632
off-label3934552101095077107134157201253300322
usage,4282552101095086130182228247
and4554552101094495147
it4726552101092252
is4804552101092157
not48875521010950100131
recommended5043552101093076118167243319366417468514567
to3934566101092977
use4026566101094984128
magnesium41695661010974117167216260295315364438
sulphate4622566101093583104154203246274318
injection495556610109217090135175207227276325
for5295566101092675104
more54145661010974123152196
than3934580101093080123173
5–74131580101094693135
days4290580101095195136172
to4486580101093079
stop4588580101093667116168
preterm4780580101095181126157201231307
birth5111580101095173102135185
(56,5320580101092570116135
59),5479580101094689114131
because3934594101095198139183233268314
it4271594101092152
can4346594101094085135
cause4504594101094085134170215
low4743594101092171137
calcium4903594101094185106147168218293
levels5219594101092267111155177212
(59),5455594101092570113138155
osteopenia3934608101094985116161211263309360381424
or4379608101094979
pathologic4479608101095196125175225247297349370410
fractures4910608101092657101142174224253298334
in5265608101092171
the5357608101093080125
foetus55036081010926763934622101094576127162
(56).4122622101092671117141159
Parenteral4306622101094992122168219248294324368390
administration4722622101094495171193244265301332362406436458508559
of5307622101095076
magnesium540962210109761201713934636101095096132153202277
suphate4228636101093685136187231260305
can4550636101094084134
contribute4701636101094089140169199220272322352397
to5115636101092978
increase5210636101092171112142187231266312
in5539636101092171
maternal39346501010975118148192222272316337
magnesium42876501010975118169219264300321370445
levels4748650101092167110154176211
above4975650101094395145188232
normative52236501010950100129205248278299342387
levels,3934664101092168111156179214234
if4194664101092148
not42686641010950101131
monitored,44256641010976126177199229279309355407427
which48786641010966117139180230
can5134664101094185136
possibly52966641010952103139175196248270314
lead3934678101092165107157
to4106678101092977
neonatal4198678101094993142191234262305326
complications4538678101094087161211232252292334363383431481515
(60).5067678101092669115138154
The5236678101094494138
safety5389678101093578104148177221
of3934692101094976
the4028692101092979125
magnesium41716921010975119170220265301322372447
unfolds46366921010949100126176198249285
based4938692101095296131177229
on51856921010949100
oral5302692101095080124145
and5465692101094394145
parenteral3934706101095195125170221250295325369390
administration4343706101094495170192242263298329358403432453503554
during49167061010950100130151201252
pregnancy.5187706101095181127178228272322363408423
Allen393472010109547595140189
et4138720101094574
al.422772010109436482
(2023),4324720101092669114157202224241
Calda4580720101095194115165208
(2013),4803720101092569113155194217233
and5051720101094392142
FDA52087201010943101153
report5376720101092973123173202234
that3934734101093183128159
magnesium41207341010977123176228275313335387464
sulphate4612734101093688110163216261292339
was49787341010968114151
changed5156734101094193139191244291345
to5528734101093182
safety3934748101093578104148177221
class4170748101094060102137171
D43567481010959
(59)4430748101092568110134
and4579748101094291141
is4735748101092054
not4804748101094998127
recommended4946748101092972113160234307352401451495546
for5506748101092675104
use3934762101095085131
in4085762101092171
the4176762101093080125
setting4321762101093682112144165215266
of4607762101095076
preterm4703762101095181126157202232307
birth5030762101095173103135185
for5235762101092676106
longer5361762101092171122173219248
than3934776101093079123173
541237761010946
to4185776101092978
742797761010946
days4341776101095194135171
(38,4528776101092670116135
56).4679776101094692116133
Therefore,4827776101094596141171216243293323368386
there5229776101092979125155199
is5444776101092157
an5517776101094393
Tab.34058201124993148172
3.53258201125075
List6545870107375787114
of78658701074569
possible87358701074592123154172218238277
consequences116858701073781129159198244290329377415452484
of167058701074569
lowered175758701071964128166193231277
maternal2052587010771117144182208255301321
magnesium2391587010771117163211250282300346418
levels28275870107185897135154184
manifested3029587010772118165184207246278305342389
in343658701071865
maternal3519587010772118144182208256302321
body385858701074592139177
systems405358701073169101128166238268
Anatomical3717240985197139167213281302339381402
maternal79072409868109137179208255296318
body11247240984794141182
systems13237240983375109138180248282
Clinical1895724098476889136157193235256
manifestation216872409868109156177203245279309350379400446492
Frequency42377240984168110158204246293330373
of46267240984572
clinical4714724098365879125146183225246
manifestations497772409867109155176203245279308350379400445492526
exocrine3718440984182127164193215261303
or6918440984574
integumentary782844098206795137184230299341388416458487530
systems13298440983374108138179248282
skin1895847095306482125
aging46203784709537819814118522238520562347
skeletal3719640983375116138180209251272
system6609640983375109138179248
risk1895967095244170104
for2017967095216388
osteoporosis14212296709543739913718122627029433736738341325309720562344
muscular371108409868114148185231252294323
system71110840983374108138179248
muscle1895108709566108138174191231
spasms214310870953074112142207237
and239710870953780124
cramps,25391087095355996162207237251
tingling,28081087095254285129146163205250264
numbness11,3090108709542851511952392783093393424109205623423463108709514
tetany1434941087095256388126169203369510920562344
frequently42371087095214684129172211255279296332
mentioned4587108709565105148172189232276315360
nervous37112040984688117161206252286
system67412040983375109138179248
agitation,18951207095368198123160184201245288302
change221512070953579115158202242
in247412070951760
behaviour,255212070954484127164200217260303327338
tremor11,290812070952448871531962203126121205623423165120709514
headache14,3196120709543831191632002362793193510121205623443554120709514
depression5,35851207095448312815219122125126831135439391212056233961120709514
anxiety43,1895130709536791151321711972352130131205623452175130709514
vertigo32,2206130709537759912714418823124361312056234553
43,2499131205623452544130709514
fatigue1425751307095215984101145187227279613120562344
frequently42371207095214684129172211255279296332
mentioned4587120709565105148172189232276315360
respiratory37114240982871105152174203244273318347390
system77814240983375109138179248
worsened1895142709558101125156195238278323
lung223514270951760103147
functions240014270952164108144171188231275305
in272214270951760
respiratory27991427095246293137154178215240282306344
diseases1131611427095436090130166196235265342214320562342
asthma3218951527095366692136201238213315320562345
gastrointestinal37116440984687121151179225247293322363397427448494535557
and94416440984187135
excretory109516440984182118147189218264293336
systems144816440983375108138179248282
change189516470953679115158203242
in215516470951659
appetite,223216470953680125166191208233271285
nausea11253416470954379122152191227275616520562342
endocrine37117640984188135181219248269315358
system74517640983375109138180249
(metabolic)101017640982491133162204252298320341377401
hypokalaemia5,189517670954378123167201239257293333398415451234717720562331
11238817720562341
and244617670953679124
hypocalcaemia5,258717670954378123167204241258295332371437454490307817720562331
11311917720562341
altered18951867095365479117141179224
glucose213718670954360103139181211251
homeostasis14240518670954387153192236266293330360376406280618720562344
frequently42371767095214684129172211255279296332
mentioned4587176709565105148172189232276315360
(more423718670952185128153191
prevalent444618670954468107143181198237280305
in476818670951760
inpatient484518670951760104142166183222266290
care)51521867095367397136155
circulatory3711984098365786123169190232260306335378
and76619840984087134
cardiovascular91719840983577106154175221261303337374420441483512
systems144519840983475109138180249283
different18951987095446082107146170208251276
types218819870952563108149179
of238419870954365
cardiac24661987095367397140157193230
arrhythmia1127131987095366085128163191234300317353306119920562342
hypertension14189520870954377123163187215253296326342385429231920920562344
ECG189521870953783130
changes5,204321870953679115158202242272231621920562331
11235721920562341
atherosclerotic189522870953661104144168210240276294333357399424441477
vascular238922870953774104140183200237260
disease3226672287095436090129165195235290222920562345
myocardial1895238709566100143180217241284301337354
infarction3222672387095175981118142177205222265308257523920562345
frequently42371987095214684129172211255279296332
mentioned4587198709565105148172189232276315360
immune37125040982089158204250292
and68025040984187134
lymphatic83125040982061131178225266295316352
systems120025040983375109138180248282
depressed189525070954481124147184213241279322
activity22322507095367196112147163187223
of247025070954262
innate25472507095165899134157194
and275525070953678120
adaptive289025070953679114156180195230268
immune317225070951781145186227265
system4734512507095306694119156220367025120562343
renal37126240982871117159180
and56826240984087134
urinary7192624098457496142183212255
systems99126240983375109138179248282
nephrolithiasis14189526270954383127171194237254271296340356393423439469235926320562344
reproductive37127440982871118148194242288325355376417458
system84627440983375109138180248
narrowing189527470954379103128170228245288333
of224527470954364
human232727470954385151188231
uterine257527470954368106130148190230
arteries4828232747095366088126150167206237306227520562347
may1895284709566102137
worsen2050284709557100124155195238
uteroplacental230528470954368107130173218235272308346389414451468
perfusion48279128470954484108132176206222265309310128520562347
Note:37129670954989113146160
In54529670951758
the6182967095236499
case73129670953373100134
of87929670954061
muscular954296709564104131164204221261284
and125329670954082122
nervous13892967095427699136175216243
systems,16472967095276188112145209235250
the19122967095236498
clinical20252967095334966107124157197213
manifestation2253296709563104145161182215243267306329345386428
may2695296709564104137
overlap284729670954073107130146187228
between30892967095407599156190224266
these33692967095246599127161
two354429670952481121
anatomical367929670954182122146185249265299338355
systems.40482967095286189113146209236252
Frequency3713067095355689130170205246280314
was70030670955595122
derived8363067095407598114149182223
from10733067095204483147
data123530670954081104143
of139230670954061
non-pregnant146730670954282124148190213246287328368410433
patients191430670954081105121155197219247
and217630670954081122
can231230670953473115
vary24413067095347396131
from25873067095204483147
asymptomatic274930670954067100164205228267331371395411445
to320830670952363
life-threatening5,3285306709516335387112136177200233273297330371387429469375330720562230
11,37913072056223946
14,38453072056224150
32.3903307205622423945306709514