Klinická farmakologie a farmacie – 1/2025

www.klinickafarmakologie.cz / Klin Farmakol Farm. 2025;39(1):14-21 / KLINICKÁ FARMAKOLOGIE A FARMACIE 21 PŮVODNÍ PRÁCE Lipid lowering with inclisiran: a single-center experience from Slovakia Conclusions Based on the results of this observational study describing experiences with inclisiran from a single center, we assume a comparable effect of administration as in clinical studies with nearly 100% adherence and without significant adverse effects. The overall management of patients receiving inclisiran therapy is straightforward, requiring no complex administration; the costs for ordering the therapy arise in the outpatient setting only after reimbursement by the health insurance company (with an invoice maturity of 60–75 days). Due to favorable indication criteria, the therapy is generally accessible, and administration is not limited to specialized centers. The therapy guarantees the achievement of target LDL-C values in over 63.4 % of patients, for whom we would not have reached target LDL-C values without this therapy. We anticipate that the availability and potential widespread implementation of this therapy in patients with very high CV risk could lead to better management of hyperlipidemia and significant reductions in CV morbidity and mortality. Since this is a pilot observational study with limitations regarding sample size, we expect the contribution of additional larger studies that would examine the more comprehensive effects of hypolipidemic therapy with inclisiran, involving multiple centers and a broader patient group. REFERENCES 1. Vardas P, Townsend N, Torbica A, et al. European Society of Cardiology: cardiovascular disease statistics 2021. Eur Heart J. 2022;43(8):716-799. 2. Štatistický úrad SR. Najčastejšie príčiny úmrtia obyvateľov SR [Internet]. 2023 [cited 25-01-02]. Available from: https:// statdat.statistics.sk/. 3. 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