599
KLINICKÁ341804001074588109168189242288347
FARMAKOLOGIE709804001074291138211265312372415474533554598
A13288040010753
FARMACIE1403804001074191138210265316336380
/18298040010732
Klin190680400107446583131
Farmakol2057804001074278105179220258305325
Farm.2402804001074178104179195
2025;39(1):14-212617804001074487128172185229271295335352367404443472511550
/32128040010732
www.klinickafarmakologie.cz4568804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
141888020012657110
PŮVODNÍ341200012660132201274348422456
PRÁCE818200012661124196256314
Lipid341360010629478199138
lowering49536001062968127158194212253293
with80336001065875107149
inclisiran:9673600106165791123141173190225267308324
a1306360010638
single-center13593600106314889128159192220256288329362394430
experience180436001063068103135171188220261296328
from214836001062864105159
Slovakia232336001063061100137174209227267
Lipid3409200298123185327391533
lowering921920029866203381503594657796934
with19049200298182246333474
inclisiran:24269200298662043113764405426066968199581016
a34011800298127
single-center515118002981041683074465106357168299521092117713021393
experience19561180029812725139452061167479993910451169
from31731180029882172309514
Slovakia373511800298130194331453578706773898
Stefan340158001375999157195253317
Toth1,67915800137611171572238941590080369291580013729
Marianna9801580013793152193223281345410467
Barbierik14701580013766124166231262320362392451
Vachalcova2,19441580013769124173238296326376439496553249615900803625341580013729
Adriana25851580013772137178208266330388
Jarolimkova1,29961580013745103144208238268363423485542599358715900803636221580013729
Martin36731580013793152193236266331
Sevcik3,40261580013759118175223253313434115900803643771580013729
Tibor4428158001376090156220262
Poruban2471215800137641261682312973564205130159008036
1Gerontology3401740078333711740013371127163222283318377403463525578
and9721740013353113175
Geriatrics11701740013371128163189241276311337386430
Clinic1623174001336489114174199247
and18941740013353113175
School20921740013354104164224285311
of2426174001336092
Medicine,25411740013389144207232280305365420442
Pavol30061740013359110161220246
Jozef32751740013341101147201233
Safarik35321740013354107138192227253303
University,38591740013371131156208262298341366402457474
Kosice,43561740013360118161186234288309
Slovakia4689174001335479139191243294321373
2East3401890078333731890013354106148183
Slovak577189001335579138188240290
Institute888189001332686127162186221280315367
of1276189001336191
Cardiovascular13881890013364116150210234293343395436485543567619653
Diseases2062189001337398139193244285339381
and24641890013353113173
School26591890013354102161220280304
of2985189001336090
Medicine,30971890013388142204228275299358412432
Pavol35511890013358109158216241
Jozef38131890013340100144198229
Safarik40631890013354106136189223247297
University,43811890013371130154205258292335359394447463
Kosice,48651890013360117159182230282303
Slovakia5189189001335478137188239289315366
3Department3402040078333742040013373129191244280319410465526561
of958204001336192
Infectious1074204001332686118172222261285345406448
diseases,1546204001336287129184236279334377400
Faculty19692040013353102151210236272326
hospital23182040013361121164226251287341366
of2707204001336192
Jan2823204001334092153
Adam29992040013367128181272
Rayman,32942040013359112162254306367389
Presov,3706204001335993148191251302319
Slovakia4049204001335479139191244294321373
Background:3402540012461116163219279319379439500561589
Inhibiting960255001212481138163221246280305362420
proprotein1410255001215892148207242298332383408465
convertase19052550012146101158206257291329379420472
subtilisin/kexin2408255001214096154189213238262302327384420469520569594651
type3090255001213384144196
933172550012152
activity3400255001214895132156206231266317
is3748255001212364
an3402690012148104
effective472269001215081115166213249273322372
strategy872269001214075108158191241299348
to1248269001213388
lower1364269001212379153204238
LDL16292690012148115163
cholesterol18202690012145101157182234274309359393449474
(LDL-C),2321269001212976143192215278308328
a26772690012148
major27532690012183132157213247
cardiovascular3028269001214594128185209265313363403449504529578611
risk366726900121335797145
factor.340283001212979125161216250268
Inclisiran,632283001212481127151175215238272321378399
the1056283001213389141
first122228300121295689131166
small14122830012140124173198222
interfering1658283001212480113164198231282316340397454
RNA21362830012154122183
targeting2344283001213383116173224259283339396
PCSK9,27652830012153112163217270288
has30782830012156105145
shown3248283001213995151225282
a35552830012148
50%36282830012151103184
LDL-C3402970012147114163187249
reduction612297001213384142198244280304360417
in1052297001212380
clinical115529700121456993149173219268293
trials.147129700121336791140164204227
Aims:340310001246694181226253
The6223110012150107159
aim810311001214872156
of995311001215585
this1109311001213389113153
study1291311001214075131188237
was15573110012174123163
to1749311001213388
describe18663110012157108149195228253310362
the2258311001213389140
effects2427311001215081115166213249290
of2747311001215485
inclisiran2861311001212379125149173213237270320376
in3266311001212480
real-world3375311001213384133157190265320354379437
clinical34032500121456993149173219268293
settings,656325001214091126162186242299339361
along1041325001214872128185242
with1306325001217499133189
the1518325001213389141
first168232500121295690131166
clinical187132500121456993149173219269293
experiences2187325001215099157209243267319375421471512
of2722325001215585
its283032500121245899
use2952325001215595147
in3122325001212480
Slovakia.3225325001214974130178227275301350372
Methods:3403380012484138176235293354397423
In781339001212479
this878339001213388111150
observational10463390012155112151201234285333366389444499547571
study,1634339001214074129185233249
3619013390012151101
patients20203390012157106138161211267299339
were23773390012174123156206
selected2601339001213990114164209245294351
for2970339001212984117
inclisiran3105339001212378123146169208230263311366
therapy3489339001213388139171220276323
as340353001214887
part4453530012157105138173
of636353001215584
standard738353001213973122177233281313369
clinical112535300121456891146169213262285
assessments,1428353001214887126176215254337388443475516537
procedures,1983353001215689144189238295349382431471492
and24933530012148103159
reimbursement2670353001213382106189245301333373424507557613645
from3333353001212962117200
public35513530012157112169193215260
health3403670012156107155179212268
insurance.636367001212479118173206255311356405426
Each1090367001215099144199
patient13183670012157106139162213269302
underwent16483670012156111168219252329379435468
a21443670012149
standard2221367001214074124179236285317374
lipid2624367001212346104127184
profile2837367001215790145175201225275
assessment3141367001214888127178218257341392448481
and36503670012149104161
high-sensitivity340381001215579134190222262312368407429463486534558591641
C-reactive999381001215883117167215260295318366415
protein1433381001215790144177226250305
(hsCRP)1756381001212984123180233287313
testing2087381001213383122156179234290
before23963810012157108137192225275
submitting2690381001213994150234257290326349404460
applications31683810012149105162187210254303335358413469508
for3694381001212984117
therapy340395001213388139172220277323
approval,6893950012148105162195250297345369389
and11043950012148104160
again12903950012148105153176231
one15473950012155111161
month17343950012183139194227282
after2042395001214877113163195
receiving2263395001213383129178201249273329385
two26743950012133109163
doses28633950012156111151201241
of3130395001215484
inclisiran.3240395001212378123146169208231263312367388
The36543950012150106157
average340409001214895144177225281332
change6904090012145100148203259310
in1018409001212379
lipid1115409001212447103127183
profile1317409001215790144173200223273
levels1609409001212374121170194233
was18604090012174122161
calculated2040409001214593117162216240288320369427
for2485409001212984117
each2621409001215098143198
patient28374090012157106138161211267299
who31554090012173129184
completed3358409001214598182239263313346396453
the340423001213388139
third500423001213388111144200
dose7214230012156111151201
of943423001215584
inclisiran.1049423001212378123146169208231263312367388
Results:3404360012459113158218247285331357
Inclisiran719437001212480126150174214238271321377
therapy1118437001213389141175224282329
was14694370012174123163
approved16544370012148106164198254302352410
for2086437001212985119
3622274370012151103
patients,23524370012157106140164215272305347369
including2743437001212379125149205263287343400
2731654370012151101
with3288437001217398132188
atherosclerotic3498437001214882138189223279340451001214086110162196251285309355
coronary726451001214599133189246295329380
artery1137451001214881118169203254
disease1422451001215680120172221261313
and17654510012149105163
919584510012152
with2040451001217498133189
prior2259451001215791116172206
strokes.2496451001213974108164212262303325
The28514510012150108159
cohort3041451001214599157213247284
included3355451001212480126150206264316374
137594510012152
statin-intolerant340465001214075125159183240273299356389445470522556606663696
patient,10674650012157107141165217274308330
2814284650012151103
on15624650012155112
maximum17054650012183133182207291348433
statin2168465001214075125159183240
doses,24394650012156113154205246269
and27384650012149105163
729324650012152
on30144650012155113
reduced3157465001213384143199245296355
doses.35424650012157113154206247269
After340479001216190127177211
35714790012151
months,6424790012183139195228284323345
LDL-C10074790012147114162186248
dropped1275479001215689144202260312370
by16644790012157104
57.517884790012151101113167
%,19694790012179102
hsCRP2090479001215695153207261
to2371479001213388
1.22479479001215168122
mg/dL,26154790012183140176229276299
and29344790012148104161
lipoprotein(a)3115479001212347104161219253308341391416472500546573
by37074790012157104
14.3340493001215198119174
±5414930012159
6.4627493001215173126
%.7674930012179102
Safety896493001214999129180215265
outcomes11884930012155111145190245329381422
mirrored16364930012184108141175231265316374
clinical203649300121456993150174219269293
trials,235649300121336791140164204226
with2609493001217398132188
mild28244930012183108132190
injection-site3040493001212480104155202238262318375408449473507557
pain36244930012157107131187
in340507001212380
264435070012151102
cases568507001214594134186226
and8175070012149105162
flu-like1003507001212956112145171195242292
symptoms1318507001214089174232266321406446
in1787507001212379
3.1890507001215172
Conclusions:3405200012459117177224253313357386445505550577
Inclisiran946521001212480126150174214238271321377
demonstrated13535210012156108192248305345380413463496546605
an19875210012149105
effective2121521001215181115166213249273322372
reduction2523521001213384142198244280304360417
in2969521001212480
LDL-C30785210012148115163187250
and33575210012148105162
hsCRP3549521001215595154207262
levels,340535001212374122171195234256
slightly61553500121396387143198231254302
exceeding936535001215097141190241299322378434
clinical138953500121446891147170215264288
trial169653500121336690138162
outcomes,18775350012154109143187241324375415436
but23325350012157112146
lipoprotein(a)2497535001212347104160217250305338387411467495540566
reductions3083535001213282139194239275299354409449
varied3551535001214796129153203261
among3405490012148131186242298
patients.6585490012156105138161212267300341363
Safety1040549001214998127178211261
was13215490012173121161
consistent1501549001214498154193216255290339395428
with1948549001217397130186
expectations,2153549001214997154206252287336369393448504543564
confirming2737549001214498154183210243326350405462
inclisiran‘s3218549001212378124147171210233266315370390428
potential36655490012156113340563001213383140173197246271
for634563001212985119
broader776563001215791146196254305339
clinical113856300121456993149173219269293
use.1454563001215595147168
Key3405790012461113164
words:5255790012476133171231275301
inclisiran,847580001212379124147170208231264312368388
LDL-C,12565800012148114161184245268
hsCRP,1545580001215694152205259268
lipoprotein(a),1834580001212447103159216249304337386409465492537563582
target2437580001213382114170220254
values.2712580001214897120175225265286
Hypolipidemická3406050012469122183241269297357385445498585613658713767
liečba1127605001242755108154215268
inklisiranom:1415605001242887141170198242269308360419477564589
skúsenosti340617001244398157201254314372415452481
jedného841617001242982143202255315373
slovenského1234617001244371129181233292336391443502560
pracoviska1814617001246099151197254306334378433486
Úvod:3406340012469123180241267
Inhibícia634635001212480136159216240285308357
aktivity1019635001214996132155204228262312
proproteín1360635001215790145203236291324374398454
konvertázy18426350012148102158205254288324373417467
subtilizín/kexín2338635001214095152185209232255299322378413462511559583639
typu3005635001213384142198
932316350012152
predstavuje3312635001215791141199238272321368424449499
účinnú3406490012155101124179235290
stratégiu659649001213974106155188238295319373
na10616490012156104
zníženie1194649001214399122165216272295346
LDL15686490012148114162
cholesterolu17596490012145100156180231271305354388443467522
(LDL-C),2310649001212875141189212274304323
ktorý2661649001214783138171222
je2911649001212576
jedným3015649001212475133189234319
z33636490012143
hlavných3434649001215680128175232277322377
kardiovaskulárnych340663001214695127182205259305353391437492515562594649693737791
rizikových114866300121335698121166219266316359413
faktorov.1578663001212977123159212244298344360
Inklisiran,1955663001212478124149171209232263311366386
prvá2358663001215689139187
malá25626630012183130153200
interferujúca2780663001212377109157190221271303358381435479527
RNA33246630012153119179
cielená3520663001214467116140189244291
na3406770012155103
PCSK9,4656770012153111161214265283
preukázal769677001215790140195242291334384408
v11986770012148
klinických126767700121477295150173218264315359414
štúdiách1702677001213973128185208256300355
zníženie2079677001214298121164214270293343
LDL-C24436770012147113161184245
o27096770012155
5027856770012152102
%.29006770012179101
Ciele:340690001246087140169222248
Cieľom616691001215881131156210294
tejto938691001213383107140194
štúdie1160691001214073128185208258
bolo14466910012157113137193
opísať16676910012155112136174223256
účinky19526910012155100123178225275
inklisiranu2255691001212379125151173212235268316371426
v27096910012148
reálnych2786691001213282130154209254298353
klinických316769100121477295151174218265315359414
podmienkach360969100121571131703407050012183107157213259308353408
spolu769705001214097153177231
s10217050012140
prvými1082705001215790141192276299
klinickými140370500121467294150173217264314398422
skúsenosťami1846705001213986141180231286341381415464547570
s24377050012140
jeho2498705001212475130186
používaním27057050012157113168211234282331386409492
na32197050012155103
Slovensku.3343705001215073128175224280319365421442
Metódy:3407180012483137175233293346372
V7327190012155
tejto806719001213382106139193
observačnej10187190012154111150201234285333378433483507
štúdii1544719001213973128184208231
bolo17947190012156112136191
na20047190012155103
liečbu212671900121234696142198253
inklisiranom2398719001212378125150173212235268316371426509
vybraných2926719001214898156189237292338382437
3633817190012151102
pacientov35017190012157105150173223279340733001213388136
v5007330012148
rámci572733001213382167213237
štandardných832733001214075125181239288321378434481526582
klinických143873300121477397153177222270321366422
vyšetrení,18847330012148100140192226259310367391412
postupov23207330012157114154189245303360408
a27527330012148
úhrady28247330012155111145194252301
zo3148733001214399
zdravotného32717330012143100133183230285319375427484540
poistenia.3407470012157114138178213263320344392415
U7757470012164
každého859747001214797142199250307363
pacienta12427470012157107152176227284317367
sa1629747001214090
pred1739747001215791141200
podaním19597470012157113172221277301385
žiadosti2364747001214367116174230270305329
o27137470012155
schválenie2788747001213985141189238263314371395446
terapie3254747001213383117166224249300
vykonalo357474700121481001482033407610012155104129185
štandardné554761001214075124181238287321378434486
hodnotenie10697610012155111170226282316366423447498
lipidového1596761001212448105130187244292342399455
profilu2080761001215791146176204228284
a23937610012148
stanovenie2470761001214075124181237285335392416467
vysokosenzitívneho29667610012148100140197245300340391448492516550574624681732789845
C-reaktívneho340775001215783117167215262298322370426477533588
proteínu947775001215790145178227251307362
(hsCRP),1328775001212883122180233287313332
ktoré1680775001214682136170219
sa1919775001213988
zopakovalo2026775001214397155204250304352400424479
mesiac25257750012182133173196244289
po28337750012157113
podaní29657750012156112170218273297
dvoch32817750012156104158204259
dávok35607750012155104150204252
DECLARATIONS:4068257008648871301662142563043393604124625014570257008514
Ethics406827000873764107127160192
approval427427000873780123150192229267288
and457627000873779122
consent471227000873172115146184227253
to497927000872667
participate:506027000874281108136157189210253291318356375
All40682820085446281
procedures417028200854167107142178221262287324354
followed4546282008521628199140194231274
were484228200855390115152
in501628200851758
accordance509628200853569102142167209245286320357
with54752820085537197138
the40682930085236399
ethical41872930085355999116148183200
standards44072930085275287127167202225266294
of472129300853859
the48002930085236399
responsible49192930085235887127167207235252293311347
committee528529300853270130189206230256291328
on406830400853981
human417030400853980141177218
experimentation440930400853571113151176194255293334358395419437478519
and494930400853576117
with50873040085537196137
the524530400852465102
Helsinki536830400854785103132150191226245
Declaration406831500854783116133168191226250267306346
of442931500853860
1975,450331500853669104139153
as467131500853462
revised47483150085235993110138175216
in497831500851756
2008.504931500853672110148163
Consent406832800874282124156194236263
for43453280087246693
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All40684500085436077
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