935
www.klinickafarmakologie.cz340804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/27098040010732
Klin278680400107446583131
Farmakol2937804001074279105179220258305325
Farm.3282804001074178105179195
2025;39(1):14-213497804001074487128172185229271295335352367404443472511550
/40928040010732
KLINICKÁ4170804001074588109168189242288346
FARMAKOLOGIE4538804001074191138210265312372414474533554598
A51578040010753
FARMACIE5231804001074292139211266317337381
1556558020012657110
PŮVODNÍ4821200012660132201274348422456
PRÁCE5298200012661124196256314
Lipid3363360010629478199138
lowering351736001062968127158194212253293
with382536001065875107149
inclisiran:39893600106165791123141173190225267308324
a4328360010638
single-center43813600106314889128159192220256288329362394430
experience482636001063068103135171188220261296328
from517036001062864105159
Slovakia534536001063061100137174209227267
inklisiranu.34354001212380128154178218242276325382438460
Priemerná83354001215487111163247299333390440
zmena1303540012143128179236286
hladín161954001215680129187211268
lipidového191754001212448106131189245293344401457
profilu240454001215792147178205229285
bola2720540012157114139188
vypočítaná2939540012148100159216263286321371427476
u3446540012155
každého353254001214797141199250307364
pacienta,3926540012157107153177229286319369391
ktorý434854001214784139173225
absolvoval4603540012148106147203228278333381431456
tretiu508954001213367118152177232
dávku5352540012156106153202258
inklisiranu.34368001212380127153177217241274324380436458
Výsledky:343820012464117160188241302357412439
Liečba80182001214770121166223271
inklisiranom109282001212378125150173212235267316371426510
bola1621820012157113137185
schválená182582001214085140186235258308364412
pre225682001215790140
362415820012152102
pacientov,2537820012156105150173223279311365412428
z2985820012142
toho304782001213387143198
273264820012151100
s3383820012140
aterosklerotickým344282001214881130163217257303328378411466499522566613663747
ochorením4209820012155100155210243293349372455
koronárnych4683820012147101134188244292324380426470525
artérií522782001214881117166199222245
a5492820012148
95559820012151
po343960012157113
prekonaní47796001215790139187240296344399422
cievnej92096001214568118166222272296
mozgovej1237960012184139181236291338388411
príhody.166996001215790114171226283331347
Súbor2037960012150104161217250
zahŕňal230796001214393148181236284308
12635960012152
pacienta2708960012157105150173223279311360
intolerantného308996001212379111165189239272321376408464514570625
na3735960012155103
statíny,385996001214074123155178234279295
284175960012151102
pacientov4297960012157106151174224280312366413
na4731960012156104
maximálnej4856960012183131178202285333357412462486
dávke5363960012157105151198247
statínov343110001214073122154177233288335
a6951100012149
77621100012151
na8311100012155103
zníženej952110001214398121164214269320343
dávke.13131100012157105151198247267
Po15981100012153106
317221100012151
mesiacoch17911100012183134173196244288342387442
sa2251110001214089
hladina2358110001215578126183206261309
LDL-C26851100012147113160183244
znížila2947110001214398121164187211258
o32231100012155
57,532961100012151100111163
%,34711100012179101
hsCRP3590110001215694152204258
na38661100012155103
1,23987110001215267120
mg/dl41191100012183140174226250
a43871100012148
lipoproteín(a)4453110001212346103158215248303335384408463491536562
o50331100012154
14,35105110001215197117170
±52961100012160
6,45373110001215272124
%.55091100012179102
Bezpečnostné3431240012154104148204255300355410449483538588
výsledky949124001214898138161211268314364
boli13311240012157112136159
v15081240012148
súlade1574124001213993116164221271
s18621240012140
klinickými192012400121467194149172216263313396420
štúdiami2357124001214073128184207255338361
–27361240012149
mierna28031240012183106156189245292
bolesť31131240012157112136186226260
v33911240012148
mieste34571240012183106156195229278
vpichu37521240012148106129174228283
sa4053124001213988
vyskytla4159124001214898137183234270293340
u45171240012155
2645901240012151100
pacientov47081240012157105150173223278310364411
a51361240012149
chrípkové52021240012145100132155212259312359408
príznaky343138001215790113156212260306357
u7211380012155
37971380012151
pacientov.8701380012157105150173223279311365412428
Záver:3431520012458113165217256283
Inklisiran653152001212480127153176215239272321377
preukázal1058152001215891141197245294338389412
účinné14991520012156101124180236287
zníženie1815152001214399123166217273296347
hladín2191152001215680128185209265
LDL-C24851520012147114162185247
a27611520012149
hsCRP,2839152001215695153207261270
pričom3138152001215791115160214299
výsledky34651520012149100140164215273320371
mierne38651520012184107158191248299
prevýšili4193152001215790141189240280303327350
klinické457215200121477396152175221268317
štúdie.4918152001214074130187210261282
Redukcia52281520012155106164219266310334382
lipoproteínu(a)343166001212447103159216249304337386409465520547592618
sa989166001213988
medzi11051660012183134191234257
pacientmi13901660012157105150173223279311395418
líšila.183516600121244788111134182203
Bezpečnostný20661660012154105148205256302357412451485540586
profil2679166001215790145174200223
bol29301660012156112136
v30941660012148
súlade3169166001214094118166222273
s34691660012140
očakávaniami,35361660012155100149196245291340395418466549572593
čo4156166001214599
potvrdzuje42821660012157113146196230286329384408458
potenciál47671660012157113146195251296319367390
inklisiranu5184166001212479126151174213235268316372426
pre343180001215790140
širšie50418000121396295135158208
klinické73318000121477295151174218265314
využitie.1068180001214899155197221254277327347
Kľúčové343194001246191153198256308360
slová:723194001244371129181234260
inklisiran,1004194001212379125150173212235267316371392
LDL-C,14171940012147113161184245268
hsCRP,1706194001215594152204258267
lipoproteín(a),1995194001212346103159216249303336386409465492537563582
cieľové2598194001214568118143197244293
hodnoty.29131940012155110167223278311360377
Introduction3432270014732101143186254325394448493524592661
A4832440010955
significant553244001093657107156177204227267311361390
advancement958244001094394138181231271315390436486515
in1488244001092171
both15752440010950101130180
primary1770244001095181102177220343258001092973
and431258001094391141
secondary587258001093580120167217266309337382
prevention984258001095079123165208257286306354403
of1402258001094974
cardiovascular1491258001094083111161181230271314348388436457499528
(CV)343272001092575127155
diseases,513272001095171106151194229274309328
which8562720010966116136176225
remain1097272001092973148191211261
the1373272001093079124
leading1512272001092166109160181230280
cause1807272001094084132167212
of343286001094976
mortality4432860010975125155188232253275305350
and817286001094393145
morbidity.9862860010975125155206228279300331376391
According1401286001095595134183213264285335386
to1811286001093079
recent1914286001092975343300001094186138168
data,537300001095296127172192
CV7553000010953107
mortality8883000010976127158192237259281312358
in1272300001092172
Europe1371300001094594125175228275
accounts1673300001094485126175227278308346
for343314001092676106
45%475314001094691174
of674314001095076
all77631400109436486
deaths887314001095197140170220256
in1168314001092171
women12653140010966115191237287
and1578314001094393145
391748314001094791
%18513140010971
in1948314001092171
men,3433280010975121171190
respectively551328001092974110161208249281302346391413456
(1).102432800109266888105
In1146328001092172
Slovakia,1235328001094466116158202245268311330
CV15823280010953105
diseases1705328001095072107153196232278314
account343342001094383122169219268297
for655342001092675104
45.3775342001094589107155
%9403420010971
of1026342001094975
all111634200109436484
causes1216342001094083131166211246
of1478342001094874
death,1568342001095095137166215234
while18173420010966115136157202
in343356001092172
the441356001093080127
Czech594356001095293139181232
Republic,852356001094895147198250272294335355
they1232356001093181127170
represent1428356001093076128158204241287338368
381822356001094693
%,1926356001097293
reflecting343370001092975102126171213245266316367
the729370001093080126
European874370001094493122172223270314364
trend1257370001092959104155206
(2,148237000109267189
3).159037000109467087
Hyperlipidemia4833840010958101152198227249269320341392437511532575
is1074384001092055
the1145384001092978124
most12843840010975124159189
significant1489384001093556106155176202226266309359388
risk189238400109295085127
factor343398001092669108139187216
for574398001092574103
the692398001092977122
development828398001095095136180201249300373418467495
and1338398001094391141
progression1494398001095079127177206250284319339387436
of1945398001094874
atherosclerotic343412001094371119164193240275315335379408456484505544
CV9024120010951102
diseases1019412001094970104148190225269304
(ASCVD).1337412001092578122173224284307323
Lowering1675412001094189153197225246295344
LDL3434260010942100142
cholesterol499426001094088136157202236266309338386407
(LDL-C)920426001092566124166185239265
levels1200426001092165107150171205
is1419426001092155
a14884260010943
fundamental1545426001092675124173216289333382410453474
pillar34344000109537598120165196
in566440001092274
the667440001093082130
management8244400010977122174219272319397445497528
of1379440001095179
ASCVD.14854400010956103158212276293
It1805440001092254
has1886440001095196133
long343454001092274126179
been5494540010952100148201
established777454001094683115161215238260297348396450
that1254454001093082127158
each1439454001094692134186
116524540010947
mmol/L17114540010977155207230263308
reduction343468001093075127177219251272323374
in742468001092172
LDL-C8404680010942103146167224
leads1089468001092268112163199
to1314468001093079
a14194680010944
22%1488468001094793165
decrease1679468001095197138168214258294340
in343482001092171
the434482001093080126
relative58048200109297496140169190234279
risk87948200109295186128
of1027482001095076
CV11234820010952105
events1248482001094589133184213250
over1518482001094992137167
a17054820010943
period1768482001095198127149199251
of343496001094976
54394960010946
years506496001094287130160197
(4).72349600109266993110
In854496001092171
patients946496001095195125146191242271308
at1274496001094473
very1368496001094388118163
high1551496001095072122172
CV17444960010952105
risk,186949600109295186128150
rapidly343510001093075127149201223267
achieving636510001094385136157203247270321372
target1034510001093075106157203234
LDL-C12945100010943104148170226
levels,1546510001092268112157180216235
particularly1807510001095297127161182343524001094090111155185206249
in617524001092171
those712524001093080130166211
following94852400109267698119169235257307358
an1330524001094494
acute1448524001094384134164209
coronary1681524001094089119169219263292338
syndrome343538001093680132184214264340386
or755538001095080
revascularization,861538001093076119164200241291313357387409448494524546596647666
is1553538001092157
crucial1636538001094171121163184228250
for1912538001092676107
stabilizing343552001093666111162184205226265287337388
atherosclerotic750552001094373123168198248284324346391421471501522562
plaques1331552001095274117168218264300
(5).165055200109257094111
Inclisiran483566001092170109129149183203232274323
is820566001092155
a8895660010943
new946566001094994158
long-acting1118566001092170119168196238277308328377426
parenteral1558566001095193122165214243286315357378
lipid-lowering1950566001092141343580001095071121149171220284328357378427476
agent.834580001094392137186215233
This1082580001094494114148
small12455800010935109151172192
interfering145258000109217098142171199244273293342392
RNA18595800010947106160
(siRNA)34359400109255979127186240264
inhibits623594001092070119139190211240276
hepatic915594001094994145188217238277
production1208594001095080128179228268299320369418
of1642594001094974
proprotein173259400109508012817920825734360800109297293141
convertase499608001093987135176219248279322356401
subtilisin/kexin914608001093583133162182202222256276324355397440481502550
type1479608001092973123168
916626080010945
(PCSK9).1721608001092672122166213258281298
PCSK93436220010948100146194241
is600622001092156
a6726220010944
protease732622001095181131161205249285330
that,1079622001092979123152172
upon12676220010950101152202
binding1485622001095273123175196246297
to1798622001093079
the1893622001093080126
LDL3436360010942102145
receptor,505636001092974115160211241290320335
induces856636001092171122172213257293
its116563600109215188
degradation1269636001095196147177221272316345366416466
in1752636001092171
lysosomes.1839636001092164100150343650001093686163209245265
By634650001094992
inhibiting752650001092172122144195217248269320371
PCSK911496500010948101146195242
production,1417650001095282132184234275308329379430450
the1892650001093081127
degradation343664001095095146175218268311340360409459
of817664001094975
LDL9076640010942101144
receptors1066664001092974114158209238286316352
is1433664001092155
reduced,1504664001092973124173213256307326
their1845664001093079124145174
recycling343678001092974114158198218239288338
increases,696678001092170111139184227261306342361
and1072678001094392143
this123067800109307999134
results1379678001092974109157178208244
in1638678001092170
a17246780010943
reduction1782678001092974125173214343692001093051101151
in513692001092171
LDL-C6046920010942102145166222
(6).84569200109257094111
The483706001094698145
efficacy655706001094674104129171216258305
and986706001094496149
safety1161706001093782110157188235
of1422706001095078
inclisiran1527706001092172115137158195217247293344
are1898706001094474121
evaluated343720001094588132153203246276321372
in731720001092171
the819720001092979125
ORION9607200010962111134196256
clinical123272000109416283133154194238260
trial150872000109305981124145
program.1669720001095282131182212256331350
Phase343734001094897141176222
II585734001092244
and649734001094393145
III81473400109214365
studies899734001093667117168189235271
have1190734001095093135180
shown1390734001093686136202252
that1663734001092979123152
inclisiran183673400109217111213315434374800109365888133184
reduces553748001093076129180221267304
LDL-C8837480010943104148170226
by1135748001095295
approximately1257748001094496149180230272294371416446491514558
501841748001094794
%19467480010973
with343762001096891123175
dosing5477620010953105142165217270
once8467620010951104147194
every1069762001094691138170217
six1316762001093659103
months14487620010978130183214266303
and1780762001094597151
is1960762001092259
effective343776001094674104151193226248293339
in708776001092273
patients807776001095298128150197248279316
with1150776001096790121172
ASCVD13487760010956103156210273
as1647776001094481
well17547760010967113136158
as1938776001094481
those2138230001093080130165211
at2368230001094373
high2460230001095071122172
CV26512300010952105
risk,277423000109305187129150
including2943230001092171112133183234255305356
patients3318230001095196125146192242272309
with3645230001096788118168
heterozygous2138244001095096127171201251289335385435485521
familial2684244001092671146168189210254275
hypercholesterolemia2985244001095091144190220261311361383429465496540570620642688764785829
(FH)2138258001092568124148
(7,8).230225800109257079127150167
Currently,2484258001095299128157202251280300343357
additional2856258001094393144164194214263313355376
Phase3247258001094896139173218
III348025800109224364
clinical356025800109396081130150190233254
trials213827200109295878120141175
are2328272001094271115
underway2457272001094998148192221288330371
to2842272001093077
provide2934272001095079127169189239283
evidence3232272001094486107157201250290333
on3580272001094897
the3692272001092978122
long-term2138286001092171122173202232277307382
safety2540286001093580106152182228
and2787286001094393145
efficacy2951286001094572102126167211251296
of3267286001094976
inclisiran,3362286001092171112133155190211240284335354
as3735286001094379
well21383000010966111133154
as2313300001094379
the2412300001093080125
ORION-425583000010962111134197257286336
study,2914300001093667117168211226
which31603000010967117138179229
focuses3409300001092676118167203249285
on37143000010949100
evaluating2138314001094690136158209254284306358410
its257431400109225391
impact2691314001092299152197239272
on29903140010950102
CV31183140010954108
morbidity32523140010977128159212235288309341387
and3666314001094495148
mortality.21383280010975125155188232254275305350365
Results2522328001094994130180201231268
are2809328001094473118
expected2946328001094588140187228260305357
in3322328001092171
20263412328001094692136181
(9).361232800109267094111
Despite22783420010960105140191211241284
the2583342001093079124
absence2728342001094394129173223263307
of3055342001095075
these3151342001093079124159204
data,3376342001095093122165184
inclisiran35803420010921711111311511852062138356001092973122
was22763560010967110144
approved2437356001094394145174222264308359
by2812356001095293
the2921356001093079124
European3062356001094492120169220265308357
Medicines34363560010972117168189228249298343378
Agency21383700010955104149198238282
at2436370001094372
the2524370001093079123
end2663370001094595145
of2824370001094975
2020.2915370001094690134178196
It3127370001092150
is3193370001092156
indicated3264370001092170121141181224253297348
as3627370001094478
an3721370001094393
adjunct2138384001094391111159206245275
to2426384001092976
dietary2515384001095069112141183210254
measures27823840010973117158191238266309343
for3138384001092673101
individuals3252384001092168117137178198247294336355388
with3653384001096585113161
heterozygous2138398001095095124168197246283327376426475509
FH26633980010943100
or2778398001095079
non-familial2872398001095099149177203247321342362382425445
hypercholesterolemia33323980010950911421882172563053543754204552138412001093074103151172217292312355
or2515412001095079
mixed2617412001097595137180231
dyslipidemia2871412001095193128149169219240290335410430473
at3366412001094472
very3461412001094387116161
high3645412001095070120169
CV21384260010952104
risk226642600109295084125
with2415426001096687116165
manifest26044260010975118167187213258293323
atherosclerotic2950426001094472121166195244279319339384413461490511550
disease,3524426001095171105150193228272290
where21384400010967118164194239
existing2402440001094689110146176197247299
high-intensity2725440001095172123173202225275304349400435456486531
lipid-lowering328144000109214294115167196218269335380410431482533
therapy2138454001093079124153196246288
has2443454001095092127
proven2587454001095281129171215264
insufficiently2869454001092170104153179208230270290335384413433476
effective.3362454001094571100145185216236279323341
The22784680010946100148
aim2458468001094567146
of2636468001095179
this2748468001093083106143
study2923468001093770122176221
was31764680010969115152
to3361468001093082
describe34754680010952100138182213236290339
the2138482001093082128
effectiveness2293482001094674104151193226248293339390437474511
of2830482001095078
inclisiran2934482001092273115137159195216247292343
in3304482001092172
a34034820010944
group3473482001095282133184237
of3736482001095078
patients2138496001095195125146192242272308
with2472496001096688118168
very2665496001094388118163
high2853496001095072122172
CV30514960010952105
risk318149600109295186128
according3334496001094484124173203254275325376
to3735496001093079
current2138510001094090120150195245275
indication2434510001092171122143184228258279329379
criteria283451000109407092122166196218261
in3116510001092171
Slovakia,3208510001094566116159203245268311331
as3559510001094479
well36595100010966111133155
as2138524001094379
to2240524001093079
highlight2342524001095071122172193214265315345
specific2710524001093586133174195222246287
aspects3020524001094379130176218250287
of3330524001094976
managing34295240010975118168212263284334385
these2138538001093080126161207
patients.2364538001095296125147192243272309328
Methods21385630014799162206275343414465
Between2278580001094894124192236282331
March26255800010972115144184233
20232874580001094690134180
and3069580001094393143
August32285800010955103153202237267
2024,3511580001094691134178196
363722580001094691
patients2138594001095195124145191241270307
(252461594001092570116
men25935940010975120170
and2779594001094493144
112939594001094684
women,30395940010966115190236286305
average3360594001094385129159203253299
age3675594001094393139
60.22138608001094794113162
±23266080010954
7.1240660800109465798
years)2530608001094388132162199222
were27786080010967112142188
included2992608001092172113135185237283335
in3353608001092172
this3451608001093080101137
open36146080010950102149200
cohort2138622001094191143194224258
prospective2422622001095283134170223270312345367412458
registry.2906622001093076129151187218249295311
These3243622001094698145182229
patients3498622001095297128149196248278316
had2138636001095093144
very2298636001094388118163
high2477636001095071121171
CV26646360010952105
risk.278563600109295186128149
Among29506360010954129179230280
them,3246636001093080125201220
753482636001094689
%35826360010972
had3669636001095094145
clinical213865000109406080129149188231252
atherosclerotic2405650001094271120164193241276316336380409457486507546
coronary2966650001093987116164213255284328
artery3309650001094371103146175220
disease3543650001095071105149192226271
(ASCAD).2138664001092680126178235295319336
Inclisiran2278678001092272113134155190211241285335
was26326780010966110146
prescribed2797678001095181126162203233254306352404
to3220678001093079
patients3318678001095196125146192242272309
with3646678001096688118168
FH21386920010944101
or2259692001095080
mixed2359692001097596138183235
dyslipidemia2614692001095093129151172223245296342417439482
who31166920010966117167
had3303692001095093144
a34676920010944
very3531692001094387117163
high371469200109507121387060010951103
CV22687060010953108
risk240370600109305289132
and2562706001094496149
clinical273870600109416385137159201246269
evidence3033706001094791114167214266308354
of3414706001095178
ASCAD,35197060010956103157216277295
and2138720001094597152
whose23257200010968122174212261
LDL-C26217200010944107153176234
levels2891720001092270116163187224
remained3151720001093078157203226279327382
above3569720001094499152197245
2.52138734001094666114
mmol/L22637340010976151201223254298
despite2583734001095096132183205235280
receiving2885734001092975116161182226248298349
intensive3256734001092171100145196231252296340
lipid-361873400109224394116167196
-lowering2138748001092850100166211241263313364
therapy.2521748001093080125155199251293308
It2848748001092252
was29197480010966110146
also3084748001094364100150
recommended3253748001092974116165240316361412463509561
for2138762001092676106
individuals2269762001092171122143187209260310353375410
with2704762001096687118168
heterozygous2896762001095096126171201250288334384434484519
FH34407620010944101
whose35657620010967117167203249
LDL-C21387760010942102146166222
levels2376776001092267110155177212
exceeded2604776001094588128172219270316368
3.12988776001094665106
mmol/L31057760010975150200222253297
despite3418776001095196132183205235280
high371477600109507139342300010950100
intensity4051230001092171101146196231252282328
therapy.4395230001093080126156200251293309
Intensive4720230001092272102146197232253297341
lipid-lowering507823000109214294115167196218268334379409431481532
therapy3934244001093080126155200251293
was42442440010967111146
defined4407244001095197124148198244296
as4720244001094379
the4816244001093080126
maximum49592440010975119162184259308384
tolerated53602440010930791011471762213934258001093074126
dose40772580010950100136182
of4275258001094976
statins4367258001093666111140161211247
(atorvastatin463025800109256696145175221265301331376405426476
or5123258001094979
rosuvastatin)52182580010930791151642082522873183633934272001093051101124
combined4083272001094189165216238288334386
with4494272001096688118168
ezetimibe,4687272001094585130160181257278329376394
or5106272001095080
in5211272001092171
cases5307272001094084120166202
of5534272001094976
statin3934286001093666111140162212
intolerance,4170286001092171100149171217247291341382427445
treatment4639286001093059105148178253299349379
with5042286001096688118168
ezetimibe5234286001094585130161182257278330376
alone.3934300001094364113162207225
Statin4174300001094472115144164213
intolerance440330000109206998146167212241284333373417
was48353000010966109143
identified4993300001092171116165194215241264308359
if5368300001092046
a54303000010942
patient5488300001095093393431400109305196147176
could4130314001094089139160212
not43613140010950100130
tolerate4511314001092978100146176220250294
at4825314001094373
least4917314001092267111147177
two5114314001093098147
different528131400109517299128174204249299329
statins,3934328001093666111140162212247266
resulting4219328001093075111160182212233283334
in4572328001092171
their4662328001093080126147177
discontinuation.4858328001095072107148197247277298348397441471492541592611
Prior407434200109487798148178
to4270342001093079
initiating436734200109217293123144187217238288339
treatment,4724342001093059105148178253299350379398
each5141342001094588129179
patient5338342001095196125146192242272
had3934356001095094145
a41003560010944
lipid416535600109214294115166
profile4353356001095181131157181202248
done46223560010951101152197
(including484135600109254696137158208259280330381
total5243356001093079109153175
cholesterol,54393560010941901403934370001092167102133177207256278297
LDL-C,42473700010942102145166221241
HDL-C,45043700010959119162183238258
triglycerides,477837000109306081132153196235279309331382427463482
and5276370001094393144
lipoprotein5436370001092142931443934384001095181131161205227277
(Lp(a)),4234384001092567119145186209232249
and4506384001094393145
liver467338400109224387131161
parameters4857384001095195125169244290320365395432
(alanine531138400109266788132182203253299
transaminase3934398001093060105156192237313335386430466513
(ALT),4473398001092681125164193211
aspartate4710398001094480132177207240285316361
transaminase5097398001093060105156192237313335386430466513
(AST),3934412001092680126172200217
gamma-glutamyltransferase417641200109519417024528931837139244247251659263365568571575980984487291794799110271073
(GGT),5274412001092582140186214232
as5531412001094379
well39344260010965109130151
as4100426001094377
inflammatory419242600109217095119161235308351380428457501
markers47084260010974117145187230259295
(high-sensitivity501842600109257495144193221257301351385405434455497519548592
C-reactive3934440001095377109155200242275297342388
protein4349440001095283134165211233285
(hsCRP))4660440001092778114168217268292316
assessed,5002440001094581118165202239286339359
along5388440001094466118170222
with3934454001096789120171
screening4131454001093678108154201252274325376
for4533454001092778108
other4667454001095081132178209
modifiable49024540010976127180201229253297350372419
CV53474540010952106
risk547945400109305288131
factors3934468001092772113145195225262
such4222468001093686128178
as4426468001094480
smoking,45324680010935111162205228279331350
hypertension,4908468001095092145192222255301352388409459510530
diabetes,54644680010951721163934482001095198128173209228
and4181482001094494145
obesity.43454820010949101148184205235280295
All407449600109557698
patients4192496001095195125146191242271308
met45204960010975121152
the4692496001092979125
Slovak4837496001094466116159203245
criteria510249600109407091122166196218261
for5383496001092676106
insurance-covered55094960010921713934510001093686116161212253298329373422466511541587640
PCSK946005100010948101147196244
inhibitor4870510001092172123144196218249299329
treatment5225510001093060106151181257304355385
with3934524001096688118168
inclisiran4124524001092171112133154189210240284334
(Figure448052400109256889140189219264
1).476652400109466583
Inclisiran4870524001092272113134155190211241285335
was52275240010966110145
initially539452400109217192122143187393453800109224387
administered4047538001094496173195245267303334380410456509
as4582538001094481
a46895380010944
2844759538001094693142
mg49135380010976127
subcutaneous5067538001093686138180231262307358404456507543
injection,393455200109227496144187221243295348368
followed4329552001092779102124176245292346
by4702552001095296
a48255520010945
second4897552001093784128178231284
dose52085520010953105142190
after5425552001094472107153185
three3934566001093080109154201
months,41555660010975125175205255290310
and4485566001094393144
then4650566001092979125176
a48465660010943
third4909566001093080101131181
dose51115660010950100136182
after5313566001094370103147177
six551156600109355699
months.39345800010975125176205255290310
A42655800010955
lipid434058000109224394116167
profile4528580001095181130157181202248
was47975800010966110145
measured49635800010975121165200249279324376
before5360580001095198125174204250
each3934594001094589129179
injection.413259400109217192138179211233282333352
In4503594001092171
addition,4593594001094394146167197218268319338
at4949594001094373
each5040594001094589130180
visit,5238594001094365100121152171
clinical5427594001094162831331543934608001094084106
information406460800109227298148178254297327348398448
was45376080010966110146
recorded,4707608001093075116165195246292343362
including5094608001092171112133183234255306356
any5475608001094393135
ASCVD3934622001095499150201261
events4210622001094587130179208244
or4469622001094978
side4562622001093555105150
effects.472762200109447199144184215251270
The5012622001094494139
therapy5166622001092978123152195245286
was54676220010965108143
discontinued3934636001095172107148197247277298348398443495
if4448636001092147
patients4514636001095195125146191242271308
were48416360010966111141186
non-compliant50456360010950100151180223272347399421442485535565
or3934650001095081
if4041650001092148
the4116650001093081127
treatment4269650001093061107151181258305356386
was46816500010967112148
ineffective,4855650001092273119147177223266298320365410429
defined5310650001095198125150201247300
as3934664001094379
less4034664001092267103139
than4194664001093080123174
a43896640010943
40%4454664001094694166
reduction4641664001093075127177217250271320371
in5033664001092172
LDL-C51266640010942102146167222
by5370664001095193
the5484664001093080126
sixth393467800109365799132182
to4142678001093079
ninth4247678001095071121151201
month,44746780010975125176206256275
or4774678001095080
failure488067800109267192113163193238
to5144678001093079
reach5249678001092974118159209
the5484678001093080126
LDL-C39346920010942102146167222
target.4175692001093074104154200231250
All407470600109547596
patients4185706001095194123144189238267303
underwent4503706001094999149194223291335385414
standard4932706001093565109158209251280330
cardiology52787060010939831121621822312533023934720001095094
examinations.4044720001094588131206227277321350371421472507526
From4586720001094472121196
an4799720001094393
ethical4908720001094575125146187231252
standpoint,5176720001093667111161212263314335385415434
this393473400109297899133
study4082734001093565114164207
adhered4304734001094293142186216260311
to4630734001092977
standard4722734001093565109158208250279329
treatment5066734001093058103145174248293342371
protocols54527340010950801283934748001092977118165187221
and4170748001094392142
was43287480010965108143
conducted4486748001094087137187235275307350401
as4902748001094378
an4995748001094392
observational51027480010949100135179208254297326346395444487508
study3934762001093666116168211
based4161762001095196131177229
on44067620010950100
anonymous4523762001094393143194235311361411447
processing4986762001095181131172217253288309359410
of5413762001094975
results55057620010929743934776001093584105134170
from4120776001092656104179
routine4314776001093078127157178227272
examinations4601776001094587130204225274317346367416466500
after5117776001094369101145174
patients5307776001095094123143188238267303