766
KLINICKÁ341804001074588109168189242288347
FARMAKOLOGIE709804001074291138211265312372415474533554598
A13288040010753
FARMACIE1403804001074191138210265316336380
/18298040010732
Klin190680400107446583131
Farmakol2057804001074278105179220258305325
Farm.2402804001074178104179195
2025;39(1):14-212617804001074487128172185229271295335352367404443472511550
/32128040010732
www.klinickafarmakologie.cz4568804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
161878020012657111
PŮVODNÍ341200012660132201274348422456
PRÁCE818200012661124196256314
Lipid341360010629478199138
lowering49536001062968127158194212253293
with80336001065875107149
inclisiran:9673600106165791123141173190225267308324
a1306360010638
single-center13593600106314889128159192220256288329362394430
experience180436001063068103135171188220261296328
from214836001062864105159
Slovakia232336001063061100137174209227267
were343620010968115146193
selected56362001093784107155198231278332
for92262001092779110
inclisiran105962001092274116138161197219250296348
therapy143462001093183130162207261304
by176562001095397
the188962001093183130
cardiologist.34376001094187117170192243266318371393429461481
All85176001095679101
participating97876001095398129163185226248301347378400451503
patients150876001095298129151198250280318
provided18537600109528313434390001094365117162214
informed5839000109217198148178254300352
consent96090001094189140176221272302
for128790001092676106
the141990001093080126
anonymous157090001094494144195236312363413449
use343104001094984129
of488104001094975
their579104001093079124145175
clinical76910400109406182131152192236257
data1042104001095093122166
for1224104001092675105
statistical1344104001093666110139160194225246286329350
analysis.1710104001094393136157199235255290309
The483118001094596142
data642118001095194124168
analyzed827118001094494137159202243288340
in1184118001092172
this1273118001093080101136
study1426118001093667116168211
were16541180010966111141186
processed1858118001095181130343132001094084120155201252
and611132001094393144
evaluated771132001094588132153202245275319371
using1158132001094984105155205
SPSS1379132001094491135179
version1574132001094387117153174223273
20.01863132001094692110156
for343146001092676106
Windows470146001097698148199249315351
(IBM84214600109254696168
Corp,10311460010952101131183201
2011.1252146001094692135172187
IBM1460146001092171143
SPSS,1624146001094492136180199
20.0,1844146001094691110157175
Armonk,343160001095585160211261303325
NY:6871600010960109123
IBM830160001092271144
Corp.).9931600010952101131183201226243
Continuous12561600010952101151181202252302352402437
data1713160001095194124168
are1901160001094373118
presented343174001095384131169217269300346400
as771174001094481
median8791740010978125179202247299
[25th1205174001092674122152204
percentile;14361740010952101132174220273304326349396415
75th1878174001094893197017400641849
percentile]3431880010953101133175221274305327350398422
and794188001094497150
categorical973188001094187118165219271303326368414437
data1438188001095298129176
as1642188001094582
counts1752188001094292145197228267
(%).343202001092594117134
Lipid493202001094263114135186
levels694202001092167109153175210
are920202001094372117
reported1052202001093074125175205237282333
in1401202001092170
mmol/L,14872020010974149198220251294314
while18162020010966116137158203
Lp(a)343216001094294120161185
values548216001094388109159204240
are809216001094373118
given947216001095172116160211
in1178216001092272
mg/dL.12702160010975126158205248269
The1560216001094496141
primary1722216001095181103178222251297
outcomes3432300010949100130169218294340376
were7412300010966111141186
efficacy,950230001094572101125166210251296311
defined1283230001095196123147197243295
as1600230001094479
the1702230001092979125
relative18492300010930759714134324400109305094138
reduction496244001092974125174215246267316366
in878244001092170
LDL-C,9642440010942102144165220240
and1220244001094392143
safety,1378244001093680106151181225240
defined1634244001095095122145195240291
as1941244001094378
any343258001094393135
adverse497258001094495139184213250296
effects812258001094673102148189221258
identified1090258001092172118168198219246269315367
during14762580010951101130152202253
regular1748258001093075127176198241271
check-ups.343272001094294142185230257311365402423
Secondary797272001094694137188241295341372420
outcomes12472720010951104136178229307355393
included1671272001092274117140192246293348
absolute343286001094598136188211263295341
reduction712286001093077131183226260282334387
in1126286001092274
LDL-C,12282860010943106151173231253
achievement1508286001094588140162209255301379427480511
of343300001095076
target445300001093074104154200231
LDL-C7023000010942102146167223
levels950300001092167111155178213
according1189300001094384124173203254275325377
to1591300001093079
ESC/EAS1696300001094489142175220277323
guidelines,3433140010950100121173218240261311357393412
specific780314001093687133175196223247287
side1092314001093657108154
effects,1270314001094573102148189221258278
and1572314001094494145
discontinuation1742314001095172107148197247343328001093051101151194224245295345
of707328001095076
PCSK98023280010948101146194241
siRNA1062328001093657105166221
(inclisiran)130232800109254696137158179214235265309359382
therapy.1703328001093080126156200251293308
Results3433530014768131181249281323375
Clinical343381001436893117181205259314339
characteristics7113810014353117171206261315356412447473516554579633679
of1419381001436496
patients15443810014366121157182240304340386
During4833980010960111140162212263
the767398001093080126
observation9143980010950102137183213259304333354404455
period,1390398001095198128149199251270
a16823980010943
total1747398001092978108153174
of1943398001094976
36343412001094794
patients464412001095297128150196248279317
in807412001092273
our9064120010951102133
clinic106541200109416385137158200
were12924120010967113144190
approved1509412001094497150181232276321375
for1910412001092778109
inclisiran343426001092169109129150184204232275324
therapy682426001092978122151194244285
covered981426001094087129172201245296
by1291426001095192
health1398426001094993135156185234
insurance.1646426001092170104152181223272312355373
Of343440001096291
the460440001093080127
36612440001094793
patients,731440001095297127148194245275312332
271089440001094691
were12054400010967113143189
diagnosed1419440001095273117168219270306352404
with1849440001096789119170
ASCAD343454001095498149204262
(75620454001092569112
%),742454001097092108
including865454001092169109129177227247296345
151225454001094585
patients1324454001095194122142186235264299
with1638454001096586115163
acute1816454001094382130159203
coronary343468001094190121171222266296343
syndrome712468001093680132184214264341387
(ACS)1125468001092682133179204
(41.671355468001092670112127175219
%),1586468001097296113
101725468001094790
patients1841468001095297127148343482001094596125162
who5214820010966117167
underwent7044820010950100151197227296341391421
percutaneous1141482001095198127168217248292342388438488524
coronary1681482001094089119169219263292338
intervention343496001092274105151183231277330361383435488
(PCI)858496001092676130152179
(27.771064496001092673119130178225
%),1302496001097498116
and1445496001094597151
216234960010947
patients1697496001095399130152200252283322
who3435100010966115165
had523510001095093143
coronary682510001094088117166216258287332
artery1030510001094372104148177222
bypass1268510001095192144187222257
graft1541510001094979122148180
surgery1737510001093584113163208237282
(CABG)343524001092678137187247273
(5.5564352400109267291141186
%)842524001097397
due9665240010951103150
to1143524001093081
significant1250524001093759111163185213238280325377408
stenosis.1684524001093769115167219256278314335
Additionally,3435380010955106158179210231281332376398419462477
98465380010946
patients918538001095296126147193244274311
had1255538001095094145
ischemic142653800109215798148194270292333
stroke178453800109366797147190235
(25343552001092570116
%).470552001097194111
In597552001092272
terms685552001093074104179214
of915552001095076
risk100755200109295186128
factors,1151552001092670111143191221258277
291444552001094691
patients1551552001095196125146191241271307
had1874552001095094145
arterial343566001094473106151181203247268
hypertension637566001095092144191221254299350385406456507
(80.61170566001092570118137184
%),1365566001097295113
915035660010947
were15755660010967112142188
obese17885660010950102149185231
(25343580001092670117
%),471580001097195112
45995800010947
had662580001095094145
type824580001092975127173
210145800010946
diabetes1077580001095172115167213243288324
mellitus14185800010975121143164185215265300
(11.11735580001092568105120161
%),1907580001097195112
and343594001094597151
16524594001094892
patients646594001095399131153201254285324
were10005940010968115147194
smokers12255940010936114167212258290329
(44.41584594001092672123144192
%),1790594001097398116
as1937594001094482
shown343608001093686136201252
in614608001092171
Table705608001094482134156201
1.925608001094762
Regarding483622001094892141183211259279327376
lipid-lowering87262200109214190110159186208255319362390410458507
therapy,1393622001092977121149191240280294
117006220010946
patient1759622001095093121140184232260
was3436360010966109144
included504636001092171111131180230275326
due8476360010951100145
to1009636001093078
statin1104636001093666109138158207
intolerance132963600109217099147168213242285334374418
(2.8176463600109267088135
%),1909636001097194110
28343650001094691
patients457650001095195123143188238266302
were7826500010966111140184
on989650001094999
the1111650001093079124
maximum12586500010975118160180255304378
statin1659650001093666109138158207
dose18896500010951100343664001093681
(77.8%,444664001092570115125172253272
atorvastatin736664001094372120149195238272302346374395444
80mg),1200664001094692177227251267
and1487664001094393143
716506640010946
patients1717664001095194123143188237266302
were3436780010968114144190
on5586780010950102
a6856780010944
reduced754678001093076129180221266319
dose10986780010952103139186
(19.41309678001092669110127174
%):1494678001097396114
316336780010947
patients1705678001095398128149195247276314
on3436920010950101
atorvastatin469692001094474123153200244280311356385406457
40950692001094795
mg10706920010977128
(8.3%),122369200109267191140223246263
215106920010948
patients1582692001095297127148194244274311
on19186920010950101
atorvastatin343706001094474124154201246282313358388409460
20828706001094793
mg9327060010977129
(5.6108670600109267189136
%),1233706001097397114
and1372706001094495147
115447060010947
patient1616706001095398127149195246276
on19177060010950102
lovastatin343720001092170112155190220263292312361
20720720001094691
mg8217200010975125
(2.896272000109256988135
%).1106720001097294110
Six1232720001094464106
patients1354720001095194123143188237266302
were16727200010966110139183
also187172000109446499148
taking343734001093073115137186236
ezetimibe602734001094684129158178253273324369
as995734001094378
a10977340010943
co-medication1164734001094088117193238289309349392421441490540
(16.7%).1728734001092567108126171252275291
The343748001094699146
low516748001092274141
percentage6857480010953100131172218270300346398445
is1157748001092258
due12437480010952103150
to1421748001093181
the1530748001093082129
fact1686748001092873115148
that1862748001093082126157
ezetimibe343762001094685131162182258280331378
use746762001095086132
is902762001092257
not9847620010951101131
a11397620010944
criterion120876200109417192122167197218269320
for1552762001092777107
inclisiran1684762001092172113134154190211240284335
approval343776001094496149179229273317339
in707776001092172
Slovakia,804776001094567117161205248271315334
and1163776001094495147
for1335776001092777108
most14677760010977128164195
patients,1687776001095297127148194245275312332
LDL-C21382440010942102144164219
reduction2380244001093074125174214245265314364
with2767244001096687116165
ezetimibe2956244001094584128158178252273323368
alone3348244001094364113163208
would35792440010966115164184235
not2138258001095099128
be2288258001095197
sufficient2406258001093685110139162202222267316345
to2773258001093078
reach2872258001093074117157206
target3100258001092973101151196225
LDL-C33472580010943102144164219
levels,3588258001092166108152173207226
but21382720010951101130
its228927200109215086
use2397272001094984129
could2547272001094088137158208
disqualify2776272001095171106156205248268289314359
patients3157272001095194123143188237266302
from3480272001092656105179
inclisiran368127200109217011021382860010921417696125168217
therapy2373286001093079124153196246288
for2679286001092675104
failing280228600109266990110130179229
to3050286001092978
reach3146286001092974116156205
LDL-C33692860010943102144164219
levels3606286001092266109152173208
>21383000010953
2.62199300001094563107
mmol/L.23153000010973146193214243284303
There2631300001094493136164207
was28513000010965107140
no3004300001094997
significant3114300001093554102150169194216255296344372
variation3499300001094284111131172200219267315
in2138314001092169
the2220314001092977121
sample2354314001093678151200221264
characteristics2632314001093987129157199237268310339359392421441479514
between3160314001095094123189232277325
genders.3498314001095094142191235263298316
The2278328001094493138
baseline2431328001095093127171192212261305
characteristics2751328001094088130159202241272315344365399428448488523
of3289328001094974
the3378328001092978122
patients3515328001095093121141186235263299
and2138342001094393145
their2299342001093080126147177
initial249334200109217192122143186208
lipid271734200109224394116167
profile2900342001095282131158182203249
levels,3165342001092167110155177212232
along3413342001094365115165216
with3646342001096688118168
hsCRP2138356001095085137185234
values,2391356001094488109159204240260
are2670356001094373118
shown2807356001093685135201252
in3078356001092171
Table3168356001094583135157202
1.3389356001094761
Therapy21383810014763133195239300371430
effectiveness25953810014762100138200255300331393453523586636686
During22783980010961112142164215266
inclisiran2570398001092172114135157193214244289339
administration,2935398001094496172194245266302333364408438460510562581
we35423980010967112
observed368039800109501032138412001093579108153196246
a23994120010943
variable2456412001094386114135177226247292
response2762412001092973108157207256290334
in3111412001092069
terms3195412001092972101175209
of3418412001094974
changes3507412001094088130179228272307
in3934244001092274
selected4035244001093684107155198232278332
lipid439424400109224498120174
parameters4595244001095299130175253301333380411449
and5071244001094597150
hsCRP,5248244001095289143193244253
as5528244001094582
shown3934258001093583132196245
in4193258001092170
Table4277258001094481130151196
2.4487258001094664
The4566258001094393137
reduction4718258001092972123171210241261309358
in5091258001092169
LDL-C5175258001094199141161215
levels5405258001092165106150171205
ranged3934272001093074124176222274
from4234272001092657107183
41.88%4443272001094687102151198281
to4750272001093079
86.25%,4855272001094794114162209292313
with5193272001096789119170
a53882720010944
median545827200109751213934286001095173117167
of4127286001095077
57.54229286001094792102151
±44062860010954
7.54486286001094757106
%46042860010972
(Figure470228600109256990141191221267
2).499528600109467188
Patients5109286001094891121143189240270307
who54422860010966117168
were39343000010966111141186
on41363000010949100
the4252300001092979125
maximum43933000010975119161183258308383
dose47923000010950100136182
of4990300001094975
high-intensity5082300001094970121171200223272302346397432453483528
statins3934314001093666111140161212247
as4198314001094378
concurrent4293314001094189140181230260290335386415
therapy4725314001093080125155199251293
and5035314001094393144
had5196314001095094145
undergone5358314001094910015119622639343280010950100151196
a41463280010944
third4206328001092979100130181
blood4403328001095173123173225
draw4644328001095180124189
(n4850328001092573
=49393280010953
28)5008328001094692116
experienced5140328001094588140186216237283333374418470
a39343420010943
greater3997342001095080125169199243273
median42903420010975121173194237287
reduction4597342001093075127176217249270320371
in4987342001092172
LDL-C50783420010943103146167222
compared53203420010940891652162613934356001092975127
to4080356001093079
those4178356001093080130165211
on44083560010950100
a45273560010944
reduced4590356001093075127176217262314
statin4923356001093566111140161211
dose51543560010950100136182
(n5355356001092673
=54483560010953
7):552035600109477290
61.53934370001094789105155
±41153700010955
12.34196370001094788108158
%43663700010973
vs.4465370001094481101
53.24592370001094792111161
±47793700010955
5.94860370001094766112
%.4984370001097293
The5104370001094597144
absolute5275370001094496133184207258289335
reduction3934384001092973123171210241261310359
in4307384001092169
LDL-C43913840010942100142161215
levels4621384001092165107150171205
was48413840010964107141
2.14997384001094564103
±51153840010952
0.55182384001094563110
mmol/L.53023840010973146195216246288308
The3934398001094598144
reduction4104398001093076129180222255276327379
in4509398001092172
Lp(a)4608398001094395122164188
levels4822398001092269113158181217
was50653980010967112148
highly5240398001095072124175197241
individual,55073980010922733934412001095173117140192242286308327
ranging4287412001093075126177199250301
from4614412001092758108185
048254120010946
%48834120010972
to4981412001093080
58.335087412001094793113163208
%,5321412001097292
with5439412001096789120171
Tab.2140438001124990143164
1.2319438001125068
Summarized2429439001073982152221264288305338373416
characteristics2858439001073782125149190225251286310326354378394430460
of3330439001074566
participants3409439001074589113140156191208251295339363392
Determinant217145300985597126168197266287334375421450
Patients217146500954076101118157200224256
(n)244446500952124664650095412505465009521
36479346500953978
Age217147700954790130
(years)23184770095215695131155186205
60.246844770095397993134
±4836477009547
7.149014770095394580
Male217148900956299116156
(n)234448900952123664890095412405489009521
25466648900953979
(69.447624890095215997109148
%)492048900955979
Female217150100953775141178195235
(n)242350100952124445010095412484501009521
11466850100953970
(30.647565010095215998112152
%)491850100955978
BMI2171513009540103120
(kg/m2)2309513009521569912819225015130056232524513009521
27.346835130095397683123
±4824513009547
3.648895130095395393
ASCAD217152500954785131180232
(n)242052500952124425250095412481525009521
27469352500953976
(7547875250095216097
%)489452500955979
ACS217153700954791130
(n)231853700952123395370095412379537009521
15467253700953973
(41.747625370095225993103142
%)491453700955978
PCI217154900954086103
(n)229154900952223135490095412352549009521
10467054900953975
(27.847625490095216097103144
%)491654900955979
CABG217156100954694135185
(n)237456100952123955610095412435561009521
24704561009539
(5.547615610095215972112
%)488356100955978
Stroke21715730095376185127162200
(n)238957300952124105730095412450573009521
94710573009539
(2547675730095215999
%)487657300955978
Arterial21715850095477199137161178214232
hypertension242058500954378123163187215253296326342385429
(n)286758500952128885850095412928585009521
29466458500953978
(80.647595850095215999113153
%)492258500955979
Type217159700953768114154
22342597009540
diabetes23995970095446097141181206245275
(n)269159700952227135970095412752597009521
44693597009539
(11.14750597009521578898133
%)489359700955978
Obesity217160900955499139169186211249
(n)243860900952124596090095412499609009521
94710609009539
(2547676090095215999
%)487660900955978
Smoking2171621009537102146181199242286
(n)247562100952124966210095412536621009521
16466662100953974
(44.4475862100952158100114153
%)492162100955978
Statin21716330095375995118133174
–2360633009540
the241463300952566104
highest253363300954358100142180208233
tolerated27806330095256581119142177200237280
dose307463300954485114152
(n)324063300952232606330095413298633009521
28466863300953977
(77.847636330095216099106146
%)491963300955979
Statin21716450095376198122140182
–2371645009540
reduced242864500952463107150186224269
dose271564500954387117156
(n)288964500952129106450095412950645009521
74689645009539
(19.447466450095215791103142
%)489864500955978
Statin21716570095376198122140182
intolerance23716570095176084126143183207244287324362
(n)275065700952127726570095412811657009521
14703657009539
(2.847606570095215973114
%)488465700955978
Ezetimibe217166900953772110136153218235279320
(n)250866900952125306690095412569669009521
64687669009539
(16.747446690095215792107145
%)489966900955979
LDL217168100953688124
cholesterol231368100953679122140179210236274298340358
(mmol/L)268868100952285151194212241278300
3.5646606810095395393132
±4809681009548
0.5348746810095405494131
HDL2171693009550102139
cholesterol232769300953679123140180210236274298341358
(mmol/L)270369300952185151194212241278299
1.3246626930095394990126
±4806693009548
0.3948716930095395393131
Total217170500953776100137155
cholesterol234370500953679122140179210236274298340358
(mmol/L)271970500952184150194211240277299
5.3646597050095395293132
±4808705009548
0.5848737050095395393132
Triacylglyeroles21717170095375674110146184202247264300338362405422462492
(mmol/L)268171700952185150194212241277299
1.646817170095394989
±4788717009548
0.3248537170095395393130
Lp(a)217172900953681102137157
(mg/dL)234572900952285130159199236257
142.8463472900953972108120159
±4807729009548
45.6248697290095397587125161
hsCRP217174100954373118158199
(mg/L)238874100952185129159196217
0.3546607410095395393131
±4808741009548
0.0948737410095395393133
ACS217175300954384119
–2300753009540
acute235175300954073112135167
coronary25287530095347294133174213236270
syndrome,280975300952760101140163201265298312
ASCAD313175300954378119163212
–3354753009540
atherosclerotic340475300954163103137159198224256272305328366389404437
coronary38527530095337193132173213235270
artery41327530095406387119142176
disease,43197530095405682115154181213227
BMI455675300953998114
–4681753009540
body473175300954181122154
mass4895753009564104130156
index,50627530095165797130164178
CABG525075300954387125172
–5434753009540
coronary548575300953371217176300952362102142164199
artery23827630095406287119142176
bypass257076300954072112152178205
graft,278676300954163100120145159
HDL295776300954898131
–3099763009540
high31517630095425797137
density330076300954174115141155178212
lipoprotein,35247630095173272112153175214236268284325338
hsCRP387476300954167109146184
–4070763009540
high41217630095425797138
sensitive427176300952760101127141164179213245
C-reactive45287630095435578110150183207223256288
protein,482876300954063102124156172213226
LDL506676300953382115
–5194763009540
low524676300951756111
density536976300954074114140155177212
lipoprotein,21717730095163272112153175214236268284325338
Lp(a)25227730095337394131150
–2685773009540
lipoprotein27387730095163272112152175213236268284324
a,307577300954054
PCI31427730095388196
–3251773009540
percutaneous33047730095407496128167190227268302341382408
coronary37257730095337193132173212235269
intervention40077730095175779111133169201242264280319360
Fig.212861001124770121144
1.228661001125069
Indication239662001071963107123159201225241285329
criteria27386200107376177101136160176220
of297062001074566
inclisiran30496200107196398115131159174197238283
in334462001071963
Slovakia34206200107395598134176211228271
ACD216920900954386137
–2323209009540
acute238020900954075116141175
coronary25712090095347498139182223248284
disease,28722090095405886121163191226241
CABG313020900954389128177
–3324209009540
coronary33812090095337398138181223247284
artery36812090095416592126150187
bypass388520900954073115157186214
graft411620900954064104126153
surgery,42862090095276892133168193229242
LDL-C454520900953385119138185
–4747209009540
low480420900951658115
density493520900954176119147163188224
lipoprotein,51762090095173476118161185226250284302345360
PCI21692190095388299
–2284219009540
percutaneous234021900954176100133174198238280315356398426
coronary27822190095337397137180221245281
intervention30792190095165882116140177211253277294335378