498
www.klinickafarmakologie.cz340804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/27098040010732
Klin278680400107446583131
Farmakol2937804001074279105179220258305325
Farm.3282804001074178105179195
2025;39(1):14-213497804001074487128172185229271295335352367404443472511550
/40928040010732
KLINICKÁ4170804001074588109168189242288346
FARMAKOLOGIE4538804001074191138210265312372414474533554598
A51578040010753
FARMACIE5231804001074292139211266317337381
1756558020012657109
PŮVODNÍ4821200012660132201274348422456
PRÁCE5298200012661124196256314
Lipid3363360010629478199138
lowering351736001062968127158194212253293
with382536001065875107149
inclisiran:39893600106165791123141173190225267308324
a4328360010638
single-center43813600106314889128159192220256288329362394430
experience482636001063068103135171188220261296328
from517036001062864105159
Slovakia534536001063061100137174209227267
a343620010943
median402620010975120172193236286
of70462001094975
14.379562001094687106154
±965620010954
6.4103562001094665111
%1157620010971
(Figure12436200109266989140189218263
3).15226200109466986
Regarding162462001094894145188217268289339389
inflammatory34376001092173100125170247324369399450481527
markers,897760010977121152196241272310330
we1254760010967113
observed1394760010950103140187218266312365
a1785760010945
percentage185676001095210013134390001094187139169215267314
decrease68490001095198141172218263300347
in105790001092273
hsCRP115790001095187141190240
levels142490001092168113159182218
of166890001095178
14.8177390001094790109159
±1958900010955
8.7343104001094666112
%.466104001097192
There581104001094596142172217
was8221040010966110146
no9921040010950100
significant1116104001093556107157178205229269314364393
difference153310400109517299128174204249300340385
in1942104001092171
the343118001093182130
characteristics500118001094193138169215257291337368391428460482524562
of1089118001095179
the1195118001093082130
sample1352118001093682160213236284
between16631180010952100132203250298350
genders.343132001095096147198244274311330
Additionally,6991320010955106157178209230280330374396417460475
significant1199132001093657108158180206230271315365395
LDL-C16191320010943103146167223
and1868132001094393145
Lp(a)343146001094395122163188
levels557146001092168112157179215
reduction798146001093076129179221253275326377
was12011460010967112148
observed13751460010950102139185216263308361
also1762146001094466102153
in1941146001092172
patient343160001095195125145191241270
with629160001096688118167
statin812160001093667111140161211
intolerance1039160001092171100149170216246289339380424
and1479160001094393144
ezetimibe1639160001094584129160181255277328374
monotherapy3431740010975125176226256306351381425477519
only.8811740010949100121164179
Adherence3431990014776145215277321383453507569
to9391990014742110
Therapy10761990014763132195239300370430
and15331990014761130200
Prevalence3432130014767109172232294325387457511573
of9432130014768107
Adverse10772130014776145207268312363426
Effects15302130014762100137200255300352
A4832300010955
total563230001092978108153174
of761230001095076
97862230001094690
doses9772300010951101136182218
of1219230001095076
inclisiran1320230001092171112133154189210240284334
were16792300010966111141186
administered,1889230001094495343244001097596146168203234278308353405424
including792244001092171112134183234256306357
the1174244001092979125
first132424400109265080116147
dose14962440010951101137182
(n1703244001092673
=18012440010954
36),1880244001094692116133
second343258001093681123172222273
dose6352580010951101137182
(n836258001092673
=9282580010954
32),1001258001094690114131
third1151258001092979100130181
dose13512580010950100136182
(n1552258001092573
=16442580010953
28),1716258001094692116133
and1868258001094494145
fourth343272001092778130161195246
dose6162720010952103140188
(n830272001092776
=9322720010955
5).101427200109477391
For1131272001094595127
261284272001094894
administrations1405272001094497174197248270307339370415446468519571608
(26.8343286001092671116135183
%),538286001097194112
patients675286001095196125147192243272309
reported1010286001092975126177207240285337
a13722860010944
burning14412860010952102132183204254305
sensation1771286001093682132168212343300001093051101151
during5193000010951101130152202253
the797300001093080125
injection,94830000109217192138179211232282333352
which13253000010966117138178228
did1578300001095172124
not17273000010950100130
last1882300001092164100131
more3433140010976126157202
than571314001093081125176
30773314001094693
minutes891314001097698149199229275311
after1228314001094470104149179
administration.1433314001094496172194244266301333363407437459509560580
In343328001092274
44453280010947
cases519328001094288125173210
(11.1756328001092771110126169
%),937328001097498117
flu-like1081328001092752104134158181225271
symptoms1379328001093782161215247298376413
were18193280010968115147194
reported343342001092974126176206239283335
the694342001093080125
following83534200109277698119169235257307357
day,1208342001095194136150
but13743420010952102132
these1522342001093079125161206
did1745342001095071122
not18833420010950100130
persist3433560010952100131169191227259
for628356001092778109
more7643560010977128159206
than996356001093082127178
241201356001094792
hours.13203560010951102154184222242
Adherence15893560010956108160207238284336378424
to343370001093182
therapy452370001093183131162208262306
was7863700010968114151
nearly965370001095199144175199243
complete,1236370001094292171225248296328374394
with1657370001096992123175
two18603700010931102153
patients343384001095195125146192242272308
refusing671384001092974101152187208258309
the999384001093080126
second1144384001093681123172222273
dose14373840010950100136182
(5.55163838400109257088136180
%).1829384001097295112
Discussion3434090014782114164219287338387418487556
This4834260010946100122159
prospective673426001095385137174228277320354377423470
study1174426001093669121175220
aimed1425426001094567146194248
to1704426001093182
track1817426001093162109151196
the343440001093183131
specifics503440001093790139182204233258301339
of872440001095078
administering980440001094498176199251274311343390421444497550
inclisiran1559440001092274117139162199221252299351
in1939440001092274
Slovakia,343454001094668120165211255279324345
patient715454001095399130153200253284
management,10264540010977123175220273321399447500531551
the1605454001093082130
efficacy1762454001094775106132174220343468001094187
of456468001095077
inclisiran559468001092172114135157193214244289340
administration925468001094496172194245267303334364409439461512563
compared1514468001094190167219264294340393
to1933468001093080
the343482001093183131
documented5014820010952104148199278325378409456510
results1038482001093078115167189221259
of1325482001095179
clinical143148200109426487139161204250272
studies1731482001093769121174197244282
on3434960010950102
reducing471496001093076129180222243294346
LDL-C8444960010943104148170226
and1097496001094495147
Lp(a)1271496001094395122164188
levels,1485496001092269113159181217237
as1748496001094481
well18554960010967113136158
as343510001094480
adherence449510001094497148194225271322364409
and884510001094495148
possible10585100010952103140176198250272319
adverse1403510001094496141186217254301
effects,1730510001094674104150193225263283
based343524001095195131177229
on5915240010949100
experiences710524001094588140186216238283334374419455
from1184524001092657106182
a13855240010943
single1447524001093657107158179225
center.1691524001094185135165210240255
As483538001095591
part588538001095194123154
of756538001095075
the845538001093079124
management,9835380010975117166209258303377422471500518
patients1515538001095194123143187237265301
were18305380010966110139183
enrolled343552001094492120167187206250299
based655552001095092126169218
on886552001094997
the996552001092977120
indication1129552001092168117137175217244264311359
restrictions1501552001092972106134162182220250269317365398
for1912552001092673101
treatment343566001093059103146174249294343372
covered731566001094088130174203247298
by1045566001095293
public11545660010951101151172193232
health1403566001095094137158187236
insurance1655566001092170105153182225274314358
(scheme).34358000109255898147192266311333349
This706580001094595115149
included869580001092170110130178229273324
patients1207580001095194123143187236265301
with1522580001096686116164
a17015800010943
history1758580001095070104134181210255
of343594001095076
ACS,4445940010956106151170
PCI,6385940010949102122142
or804594001095080
CABG9085940010953110159217
on11505940010950100
arteries,1275594001094473105150180201246282301
or1601594001095080
patients1705594001095296125146192242271308
with343608001096891122173
confirmed546608001094191143170195225303351404
stenosis980608001093668114166218254276312
in1322608001092173
arteries1425608001094475108154185207254291
>17466080010955
501812608001094895
%.1919608001097394
These343622001094494139173218
patients,575622001095194122142186235264299317
who9066220010966115164
did1084622001095070120
not1218622001095099127
reach1359622001092973116155204
LDL-C15776220010942100142162216
levels1807622001092166108151172206
≥3436360010953
2.6406636001094664110
mmol/L5256360010975149198219249291
after830636001094469101144173
310176360010946
months10786360010974123173201250284
of1376636001094975
treatment1465636001093058102145173247292341369
with1849636001096686115164
the343650001093078122
maximum4796500010974117158179252300374
tolerated86665000109307798142171213242285335
statin1215650001093565107136155204
(with1433650001092588108137185
or1632650001094978
without1724650001096586114163211260289
ezetimibe),343664001094482125154173246266315360381397
had753664001094991140
documented907664001095098137185257301350378420470
statin1390664001093665107135154202
intolerance160666400109206896143164207235278326365407
as343678001094377
defined,433678001095094120142190234284302
or748678001094977
were8396780010965108137180
already103367800109436290134176225266
receiving1313678001092972112155175217237285334
approved1661678001094392142171218259302352
biological343692001095171119140189238258298340360
hypolipidemic717692001095090140189210230280300350394468488527
therapy,1258692001092978122150193243283297
were15696920010966109138181
indicated1764692001092169119139178221343706001093074125
for485706001092675104
therapy606706001093079124153196247288
with911706001096787117166
inclisiran.1094706001092170110131151185205234277326345
After483720001095580112156186
meeting6847200010975120165195216265315
the1014720001093079124
criteria115472000109406990119163192214256
for1426720001092675104
covered1546720001094087130173203247298
therapy,1860720001092978123343734001092971121162176
a5337340010943
pre-prepared590734001095179123152203232276326369397441491
Excel1096734001094385124167188
file129873400109264969113
was14267340010965107141
used1582734001094883127177
for1774734001092574103
the1891734001092978122
simple343748001093556130180202247
entry605748001094594123152197
of817748001094975
patients,908748001095094123143188238267303322
generating1245748001095095144189218262291311361411
a16717480010943
request1729748001092974125174218254284
for343762001092675104
approval463762001094393144174222264308329
of807762001094975
therapy897762001093079124153197247289
by1201762001095192
the1309762001092978123
insurance1448762001092170104153182225275315358
company,1822762001094088162343776001095094142183197
and555776001094391142
calculating712776001093982103143191212254283303352402
the1129776001092978122
intervals126677600109217099142171216259280314
for1595776001092675104
the1714776001092978122
first,185177600109264978114144162
Tab.213861001124990143164
2.231461001125074
The242961001074085121
effect25616100107385983119155180
of275261001074566
administering282861001074689159175219235263287322346362407450
33288610010742
doses334061001074589117153182
of353261001074567
inclisiran36096100107186398114131158174197238283
on390261001074590
selected40026100107316784120156182216260
biochemical427261001074663106142187223292309344386403
parameters468561001074690114154224260285320344373
compared506961001073778148192236260295338
to541861001072668
baseline54966100107458921387200107316783100144181
values23317200107388097140176206
Determinant21698600985597126168197266287334375421450
Value46528600984887109155197
P-value51928600984569110152173219261
LDL21699800953688124
cholesterol23119800953679122140179210236274298340358
(%26869800952280
change,27839800953679115158203242255
mmol/L)305698009565131175192221258280
57.54605980095397783123
±474698009547
7.54811980095394686
<520998009548
0.0015267980095395392133169
LDL-C216911000953688124141190
–2376110009540
highest243411000954360104147186216243
toleranted26941100095256784124148185228252291335
statin30471100095305693118135177
(%324211000952179
change,333911000953578115158202242255
mmol/L)3612110009565131174192221258279
61.545841100095397383123
±4725110009548
12.347901100095397387127
<5230110009548
0.0152881100095395392128
LDL-C216912200953688124141190
–2376122009540
reduced243412200952362107149186224269
statin27201220095305693118135178
(%291512200952179
change,301212200953679115158203242255
mmol/L)3285122009565131175192221258280
53.245991220095397690131
±4748122009547
5.948131220095395290
<5230122009548
0.0152881220095395392128
Lp(a)216913400953681102137157
(%234313400952280
change,244013400953679115158203242255
g/L)271313400954473110131
14.345911340095397488128
±4737134009547
.6.448021340095145469108
<5228134009548
0.0552861340095395392131
hsCRP216914600954373118158199
(mg/L)238614600952185129159196217
14.845991460095397488129
±4745146009548
8.748101460095395493
<5228146009548
0.0552861460095395392131
hsCRP216915800954168110149187
–2370158009540
high24251580095415898139
sensitive257915800952761103129145168185219252
C-reactive28451580095435680113154187212228263296
protein,315515800954064103127159176217232
LDL340115800953383117
–3532158009540
low358615800951757113
density371415800954074116142158181216
lipoprotein,39451580095163373114155179218242274291332347
Lp(a)43061580095337495134153
–4474158009540
lipoprotein45281580095173374115156179219242275292333
a4875158009540
Fig.2138191001124770121144
2.2295191001125074
Percentage2410192001074377101135170214238279323359
change2781192001073882125169213249
in3042192001071963
LDL-C3117192001073792127144194
levels332319200107185591127143171
in3506192001071863
individual3581192001071862106123159175219262306322
patients3915192001074589114130166210234263
after419019200107456694128152
two4354192001072789132
doses4498192001074588117152182
of4692192001074566
inclisiran477019200107186398114131159174197238283
compared5065192001073779148192236260295338
to5416192001072668
baseline5496192001074589213820300107316783100144181
values233120300107388097140176206
LDL216846600953384119
–2304466009540
low236146600951658115
density249346600954075118146163187224
lipoprotein27334660095173576119161186226251285303345
Change21643609471211254105151202254300
in2164329447121122576
%21643203471211279
LDL21633109471211246107152
Fig.2140499001124770121144
3.2304499001125072
Percentage2417499001074377101135170214238279323359
change2794499001073782125169213249
in3061499001071963
Lp(a)3142499001073781103143164
levels332449900107185491126143171
in3512499001071963
individual3593499001071963106123159175219263306322
patients3933499001074690114130166211234263
after421449900107456694128152
two4384499001072689131
doses4533499001074689117153182
of4733499001074566
inclisiran481749900107196399115131159174198239283
compared5118499001073779149192236260295339
to2140510001072668
baseline2221510001074589117153170186230267
values250051000107388097140177206
Lp(a)21717730095337598137158
–2346773009540
lipoprotein24037730095163476118160185226250284302344
a2764773009541
Change21646872471211254105151202254300
in2164655747121122576
%21646466471211279
L(pa)2163637247121124672124170195