1023
www.klinickafarmakologie.cz340804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/27098040010732
Klin278680400107446583131
Farmakol2937804001074279105179220258305325
Farm.3282804001074178105179195
2025;39(1):14-213497804001074487128172185229271295335352367404443472511550
/40928040010732
KLINICKÁ4170804001074588109168189242288346
FARMAKOLOGIE4538804001074191138210265312372414474533554598
A51578040010753
FARMACIE5231804001074292139211266317337381
2156558020012657111
PŮVODNÍ4821200012660132201274348422456
PRÁCE5298200012661124196256314
Lipid3363360010629478199138
lowering351736001062968127158194212253293
with382536001065875107149
inclisiran:39893600106165791123141173190225267308324
a4328360010638
single-center43813600106314889128159192220256288329362394430
experience482636001063068103135171188220261296328
from517036001062864105159
Slovakia534536001063061100137174209227267
Conclusions343590014771137206261292361411442510580630
Based48376001094994131177230
on740760010950101
the86976001092980127
results102376001093076113163185216254
of130476001095077
this140976001092980102139
observational157576001094910213918621626430933936141234390001095198121
study49390001093770122177222
describing744900010952101139183215238292316369423
experiences119690001094692146196228251300353396444482
with170790001096892124177
inclisiran19139000109217434310400109426589128151184231285
from664104001092760113193
a8931040010945
single974104001093761114169193242
center,1252104001094189143176224257274
we15621040010968117
assume1715104001094583122175254304
a3431180010943
comparable412118001094090166218264294339391414461
effect898118001094573104150193226
of1149118001094977
administration1251118001094496172194245267303335366410441463514565
as1841118001094480
in1947118001092172
clinical34313200109406284135157199244266
studies630132001093667118170193239276
with927132001096689120170
nearly1118132001095097141172195239
100%1377132001094790139212
adherence1610132001094396147193224270322363409
and343146001094394147
without509146001096688119170221272303
significant831146001093658109161183210235276322372403
adverse1253146001094395140186217254301
effects.1573146001094573103150192225263283
The1875146001094597144
overall343160001095095142173220243265
management6371600010976122174220273320399447499530
of1196160001095078
patients1302160001095399130153201253285323
receiving1654160001093077120167190236259312365
inclisiran343174001092172115137159195217248293345
therapy715174001093081128160205257301
is1043174001092158
straightforward,112817400109366899144166218270300330381413483528559611631
requiring1787174001092975129179202343188001093053106159
no5301880010951103
complex662188001094192170224247295340
administration;1031188001094497175198251273311343375421453475527580599
the1659188001093082130
costs1818188001094192129162201
for343202001092677107
ordering468202001094980132178209231282333
the819202001093080127
therapy964202001092980126157202254297
arise127820200109447496132179
in1475202001092171
the1564202001093080127
outpatient17092020010949100131183228258280213862001094596127
setting228362001093683114147169220272
only2573620010949101123167
after275962001094370104150181
reimbursement29586200109297698174226278308346392469516567598
by357462001095194
the368762001092980127
health213876001095097141164195245
insurance241176001092172108158189234285327372
company281076001094190167219264315358
(with319576001092691114145196
an341876001094394
invoice353976001092173116165188229275
maturity2138900010977123155207239262295342
of250990001095179
60–75261790001094797148193239
days).288490001095298142180205224
Due3137900010961114162
to332890001093082
favorable343990001092773118170202248302326375
indication2138104001092173126148190236267289341393
criteria,255810400109417295126173204227272292
the2878104001093081129
therapy3034104001093082129160206259303
is3364104001092158
generally3450104001095198150197228274297319364
accessible,2138118001094385126171208244266318341388407
and2565118001094394146
administration2731118001094395171194245266303334365410440462513565
is3315118001092157
not33921180010950100131
limited3543118001092143119141172218271
to2138132001093080
specialized2242132001093688135178200244266288328374427
centers.2694132001094086137167213244281302
The3021132001094496143
therapy3189132001092980127158203255298
guarantees351213200109501011451762212722138146001093178127166
the2333146001093184132
achievement2495146001094488141164212258306385434487519
of3044146001095079
target3153146001093077109163211244
LDL-C34271460010943107153176234
values36911460010944912138160001092172118155
in2313160001092172
over2405160001094993138169
63.42594160001094692112159
%27661600010972
of2857160001095077
patients,2954160001095196127149195247277315335
for3309160001092677108
whom34371600010966117168245
we37021600010966112
would21381740010966116167189241
not23971740010950100131
have2546174001095094137182
reached2746174001093076120161212259311
target3075174001093075105156203234
LDL-C33271740010942103147169225
values3570174001094388110160207244
without2138188001096689120171222273304
this2464188001092980102138
therapy.2624188001093081128158203256299315
We29611880010976120
anticipate3103188001094394125147188210262308338384
that3509188001092980125155
the3686188001093081127
availability2138202001094386131153175219271294316337368414
and2570202001094394146
potential27332020010951103133179230260282326348
widespread3099202001096688140187223275306352396448
implementation35652020010921961491712183934620010976124177208254285308360412
of437462001095179
this448162001093082105142
therapy465162001093082130161207261305
in498462001092173
patients508562001095298130152200252284322
with543562001096891123175
very393476001094389120166
high411976001095072124175
CV4313760010952106
risk44387600109305288131
could458976001094089140163215
lead482376001092168113165
to500776001093080
better510676001095198130163208239
management53647600109751201712153934900010951100178227280311
of427490001095079
hyperlipidemia438190001095195150199231255277331355409457535559604
and501490001094497151
significant519390001093760113166189217243286333385417
reductions3934104001093077131183226260283335388425
in4387104001092274
CV44891040010954109
morbidity46261040010976129161215238291314346394
and5048104001094496150
mortality.52261040010977129161196242265288320367384
Since3934118001094466117159204
this4158118001093081103139
is4317118001092157
a43941180010943
pilot445711800109517496147178
observational46551180010949102139185216263308339361412463507530
study5205118001093567118170214
with5439118001096689120171
limitations3934132001092143118140171215245267317368404
regarding4355132001092975127171201252274324376
sample4748132001093580156207230276
size,504213200109355796142160
we52201320010966111
expect5349132001094488140187228261
the3934146001093081127
contribution4080146001094190142172203225277329360382433484
of4583146001094977
additional4679146001094396148170201223274325370392
larger509014600109216696148194225
studies5334146001093667118170192239276
that3934160001092978121151
would41001600010965113163184234
examine4350160001094486130203224274319
the4684160001093079124
more48231600010974123153197
comprehensive5036160001094087162212242287336381431466486530574
effects3934174001094572102148190222260
of4211174001094976
hypolipidemic4304174001095091144195217239290313364410486507548
therapy4870174001092979125156200252294
with5181174001096688119169
inclisiran,53671740010921721131351561922133934188001092973123142
involving4093188001092171113162185228250300351
multiple44611880010974124146176197249271316
centers4795188001093984134164209239275
and5088188001094292144
a52491880010942
broader5309188001095080130174225271301
patient3934202001095196127149195247277
group.4232202001095081131182235254
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Society180924200833371104119154176210
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cardiovascular7532520083326486124139177209242268300338354386407
disease11752520083385379114146172207
statistics13972520083264982104119145168184216243
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Eur18122520083326990
Heart1917252008344793432620083325378
J.43626200832437
2022;43(8):716-799.48826200833468101136148183215233267285297330363394417449482517528
2.34327200853652
Štatistický4092720083325386108123149172188220250284
úrad7072720083375891131
SR.8522720083326782
Najčastejšie9482720083457793125157184207241256282297332
príčiny12942720083396076108123160191
úmrtia149927200833895117141157189
obyvateľov170227200833777108143176198231247285317
SR34328200833368
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https://18092820083385984123150162189210
statdat.statistics.sk/.3432920083264982104142174196209236259292314329355379394426454467494524553559
3.34330200853651
Český40630200834073100130163
statistický5823020083264982103118144167182214244278
úřad.8733020083375790129142
Smrt102830200833289110135
v1175302008332
datech12203020083387091125157195
[Internet].1428302008318347293127148186221243260272
2023171330200833468100135
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25-01-02].3433120083346991128160179216249266278
Available63731200834171104119134167206222257
from:9093120083184078136148
https://statistikaamy.csu.gov.cz/.10723120083385984123150162189210234257290312327353376392422455487545576586618646683696735773805815847877905911
4.34332200853651
Baigent4113220083356883122157195217
C,64532200834053
Blackwell7153220083355183115145199233249264
L,99632200833145
Emberson105832200833390130165186214252290
J,136632200832436
et141932200833456
al.14923220083324760
Cholesterol156932200834078117132167194217251272309325
Treatment1912322008332498334333200833254112147185207
Trialists’571332008332506597113128154177205218
(CTT)8103320083185893131153
Collaboration.9833320083407793109141180219241274296311349388401
Efficacy1405332008332506886118151184217
and164333200833270109
safety17733320083265978113135169
of196233200833857
more34334200835896118152
intensive5163420083145274108146172187220255
lowering79134200831553105139160176214253
of106534200833757
LDL114234200833278110
cholesterol:127334200833169108124159186209243264302318330
a1624342008331
meta-analysis1676342008357931151481712032412742893213433520083264167
of42435200833757
data4953520083387092125
from6343520083184077136
170,0007843520083346396109144180216
participants10143520083397293118133165180219252290312339
in136735200831553
26143435200833468
randomised15163520083215492131169227242268303343
trials.1873352008322435991106132146
Lancet.34336200833165103135169191204
2010;376(9753):1670-1681.56336200833468100131144179211243262295327360393410422452483516549573604635670702712
5.34337200853650
Nicholls4133720083456092130168184199225
SJ,6583720083325769
Kataoka7463720083356990123161192225
Y,99137200833543
Nissen10543720083446086112147185
SE,12593720083326578
et135637200833456
al.14323720083324760
Effect15113720083335271105138162
of169237200833857
evolocumab17683720083346710412015819122934338200835790129
on49138200833775
coronary5853820083316890127166198219253
plaque8573820083395587126163198
phenotype107438200833977112150189210244284320
and141338200833169108
burden15403820083397798136171209
in176838200831553
statin-18403820083264982103119157179
-treated343392008321436599131152186226
patients5853920083387193108143181203230
following832392008318567287125176191229268
myocardial111639200835888126159192213251266298313
infarction.14453920083155372105126157182197235273287
JACC174839200832464103141
Cardiovasc190539200834073943434020083385391123156183215
Imaging.57340200831573105144159197236249
2022;15(7):1308-1321.83840200833468101136148178208226260280292322351386421444475505537569578
6.34341200853652
Khvorova41141200833574106143165202234267
A.69541200834155
Oligonucleotide7674120083476378117155194231263279314352374389428463
Therapeutics124741200833372107128161200236273296311343371
-1635412008321
A1672412008341
New173041200834580131
Class18784120083405587114140
of34342200833756
Cholesterol-Lowering41242200833977115130165191214248269306321343376413464498519534572610
Drugs.103542200834566104143169182
N1230422008344
Engl128742200833270108123
J1423422008324
Med.146042200835489128141
2017;376(1):4-7.161342200833468100129138173205236255286300312346369400406
7.34343200853645
Raal40243200833568100116
FJ,5324320083325264
Kallend610432008335698499134172211
D,83543200834657
Ray9064320083356899
KK,10194320083357286
et112043200833456
al.11904320083324760
Inclisiran12654320083145284100115141156177210248
for15274320083195678
the16194320083226095
Treatment17284320083335084116138196231269291
of34344200833755
Heterozygous4104420083437799131152188215248285322359384
Familial80644200833261117131146160191206
Hypercholesterolemia.102344200834474113148168198235272287321347369402422458474507564578609622
N1656442008344
Engl171244200833269107121
J1845442008324
Med.188144200835387125138
2020;382(16):1520-1530.34345200833468101135148183218251268300331349361391421454488512543573606641653
8.34346200853652
Alonso4154620083415795133160198
R,63446200833549
Arroyo-Olivares7044620083416284121153190214264280295328361382416443
R,116846200833549
Muñiz-Grijalvo123846200835492130146175196243265280296328343376414
O,167246200834758
et175146200833456
al.18284620083324760
Persistence19094620083356890343472008326416891125163196230
with5934720083516789128
long-term7414720083155492132154177211232291
PCSK9105247200833677111146181
inhibitor12544720083145291106145161184221243
treatment15174720083224478110132190226264286
and182347200833271110
its19544720083143765
effectiveness3434820083345473108141166181214249287323350377
in74148200831453
familial81448200831953111126142157190205
hypercholesterolaemia:104048200833869109145167198237275291327354377411433471487519555613629661673
data17344820083397193127
from18814820083194179138
the3434920083226095
SAFEHEART45249200833273106138182216258294328
study.7944920083264987126158168
Eur9764920083336990
J1080492008325
Prev11184920083365690123
Cardiol.12544920083407394133148186202215
2023;30(4):320-328.148249200833569102136148183217237270287299334367401425457490523537
9.34350200853548
A403502008340
Randomized45550200833567104142180237251279313351
Trial818502008332496495110
Assessing9405020083406793127153179193230268
the12205020083225993
Effects13255020083325169103135158185
of152250200833755
Inclisiran1589502008315528398112138152172205242
on184350200833674
Clinical192950200833954683435120083375284117132
Outcomes48851200834785108138175233268295
Among79551200834199137175214
People102251200833568107146162197
With12325120083577395133
Cardiovascular13785120083407394132147185216249276308345360393414
Disease18045120083466187122154180215
(ORION-4).3435220083186499115162207229265282292
Available64852200834070102117132163202217251
from:9125220083183976133145
https://clinicaltrials.gov/ct2/show/10695220083375882121147159185205233248263300314346378393415436451482497523536574611643665693717752778802839876927950
NCT03705234.34353200834586121155188221254288321356391404
Accessed:76253200834172103137164190225265277
November105453200834583115150208247282304
16,13735320083346578
2024.146653200833468101133146
10.3435420085367085
Ray4455420083356899
KK,5625420083357186
Stoekenbroek6665420083325390126156190228268289326362392
RM,107654200833591104
Kallend1198542008335698499134172211
D,142754200834556
et150154200833456
al.15755420083324860
Effect16535420083335271105138162
of183354200833757
11907542008335
or196054200833758
2343552008334
doses39555200833977103138165
of57955200833756
inclisiran6545520083145284100114141155177210248
on92055200833776
low-density101455200831553104126167202240266281303337
lipoprotein13695520083153069108148169206228262277315
cholesterol170255200833270108124159186209242264301317
levels:3435620083155082116132158170
one-year52756200833776111134166200232253
follow-up794562008318567287125176199237276
of108456200833857
the11555620083215994
ORION-112635620083478499147193216247
randomized15235620083215492131169228243272306345
clinical188256200833147621001153435720083316479
trial.438572008321435890106119
JAMA57257200832464120162
Cardiol.7495720083407394132147185201214
2019;4(11):1067-1075.97857200833569100131143178198229257271283313344380413432462494527559571
11.3435820085366678
Ray4395820083356899
KK,5565820083347186
Troquay6595820083335087127165197228
RP,9045820083367276
Visseren9985820083365278105140161195233
FI,12495820083324760
et132658200833457
al.14005820083324760
Long-term147858200833169107146169191225246304
efficacy1800582008334527088120153185219
and34359200833270109
safety4705920083266079113135169
of65759200833857
inclisiran733592008314528499114141155176209248
in99959200831553
patients10705920083397293109143181203231
with13195920083516689127
high14645920083385392130
cardiovascular16125920083326486124139177209242268300338354386407
risk2138242008321366292
and224324200833169108
elevated23642420083344984116149170204243
LDL262024200833177109
cholesterol274224200833169107123157184207241262299315
(ORION-3):306924200831965101117164210232265282293
results33752420083215581118134156183
from35712420083194178136
the37192420083226095
4-year21382520083345788122154175
open-label232525200833776112149172188220258294309
extension26472520083336589122160186200238276
of293625200833756
the30042520083226094
ORION-131112520083478398146191213244
trial.3368252008321425889104117
Lancet349825200833164102134167189
Diabetes3700252008345609221382620083397496130157
Endocrinol.231026200833371110148181202218255294310323
2023;11:109-119.264826200833468101136147177205214243275310334364392422433
12.21382720085366783
Raal223427200833568100115
FJ,23622720083325163
Kallend2437272008335688498133171209
D,265927200834556
Ray27282720083356798
KK,28382720083357186
et293727200833355
al.30052720083324760
Inclisiran30772720083155385100114140155176209246
for33362720083185677
the34262720083215994
treatment35322720083224377108130188222260282
of213828200833756
heterozygous22062820083377193126147184211245282320357383
familial260128200831851108123138152184199
hypercholesterolemia.281228200833767106141162192230267283317343366399420456472506563578609622
N3446282008344
Engl350328200833269107122
J3638282008324
Med.367428200835488127140
2020;382(16):1520-1530.213829200833468101135148183218251268300331349361391421454488512543573606641653
13.21383020085366883
Katsiki22363020083356890118133163179
N,242930200834558
Vrablik25013020083365689128144159189
M,270430200835568
Banach278730200833568106138170208
M,301030200835467
et309230200833456
al.31623020083324760
Inclisiran,32363020083155385101116142157178211249261
low-density351230200831453104126166201239266280213831200832255
lipoprotein22113120083153069108148169206228262277315
cholesterol254431200833169107123158185208242263300316
and287831200833270109
lipoprotein30053120083153069108147169206228262277315
(a).3338312008318496777
Pharmaceuticals34333120083367310512618521724928332134335921383220083316479105
(Basel).22593220083185487114149164184195
2023;16(4):577.246932200833468101136147177209228260278290325358393399
14.21383320085366984
Padam223733200833567106138196
P,244833200833539
Barton25023320083356889114151189
L,270633200833145
Wilson27653320083587489115153192
S,297133200833346
et303133200833456
al.31023320083324760
Lipid31763320083324786102141
lowering333133200831553104139160175213252
with35983320083506688127
inclisiran:3739332008315532138342008331476188102124157195207
a2364342008331
real-world24143420083215587102125176214236252290
single-centre27233420083274179118134168192225259297319340374
experience.311634200833466105141162177212250282316328
Open346334200834787123161
Heart.364334200834479111132377734200852237
2022;9(2):e002184.213835200833468101136148184203237255267301337373406437468505517
15.21383620085366883
Basile22343620083356895109125159
C,240636200834053
Gargiulo24723620083437697135150188203241
P,272636200833539
Merlini277836200835590111126141179194
PA,29853620083357286
et308436200833456
al.31533620083324760
Efficacy3226362008333506886118151183216
and345536200833270109
safety35763620083276078113135169
of375836200833756
inclisiran2138372008314528398113138153174206243
in239437200831452
real-world24583720083205485100122173210231247285
practice:27553720083396092124148162194227239
insights3007372008314517792130167188215
from32353720083184076134
the33813720083225994
Cholinet348737200834077114130145182216238
registry.37373720083215421383820083385379102124158168
Eur23213820083336991
Heart242738200834479111132157
J.259938200832437
2023;44(Suppl265138200833468101136147182219238270308347386402
2):ehad655-2812.3068382008335536499137169208244278310332363397429459471
16.21383920085356680
Wright22283920083567588125160180
RS,24173920083356677
Raal25033920083356696109
FJ,26213920083324959
Koenig268939200833570103139152188
W,288739200835664
et296039200833354
al.30233920083314455
Inclisiran3088392008314508093106130143162192228
administration332539200833168123136172185209230249280300313348384
potently37193920083387421384020083225490110124154
and230240200833268106
durably24184020083387393124162176206
lowers263540200831451100133153178
LDL-C282340200833176106120161
over299440200833768100120
an312440200833168
extended-term32024020083346486118155192226263284305337357413
follow-3626402008318546882118167188
-up:21384120083215896107
the22574120083225992
ORION-823624120083478296143187208243
trial.2617412008322425687101112
Cardiovasc27424120083407191128141178209240265296
Res.30514120083356994106
2024;31704120083346798129139
120(12):1400-1410.33224120083346295113143172188199227257291326349378408437467478
17.21384220085366876
Makhmudova222842200835487117156214252291329361394
U,263542200834455
Schatz270442200833264102135156187
U,290542200834354
Perakakis29734220083356889122153186216233259
N,324542200834558
et331642200833457
al.33864220083324760
High34594220083456099137
interindividual3609422008315537410812914518321384320083385385101139177209224
variability23754320083316485100132171187202216239272
in266043200831552
LDL-cholesterol272543200833177109124157195233249283310333366387424440
reductions31784320083215494131163187202240278304
after34954320083325075109130
inclisiran363843200831452849911414015421384420083215391
administration224244200833271128143181196222245266299321336374412
in266744200831452
a2732442008332
real-world27764420083215587102124176213235250289
multicenter307844200835794110132147179212250272305326
setting34174420083266183107123160199
in362944200831552
Germany.369444200834479100213845200835790128158168
Clin23224520083405570108
Res24454520083357097
Cardiol.25574520083407394132148186202214
2023;112(11):1639-1649.278745200833468101136147177205235252284311326338368399432466489520551588621632
18.21384620085366985
Mulder224046200835492108147181203
JWCM,245946200832482122177191
Galema-Boers26664620083437692126184217239276315350371399
AMH,308146200834196141154
Roeters325146200833573109131165186213
van348046200833265103
Lennep359946200833165103141176216
JE.21384720083245972
First2231472008333487098122
clinical23744720083314762101117149183199
experiences259447200833466107143165181216255288322350
with29654720083516790129
inclisiran31154720083155386102117144159181215254
in339047200831453
a3464472008332
real-world35174720083215689104127180218241257297
setting.21384820083266183108123161200213
J2366482008324
Clin24064820083405570108
Lipidol.25294820083314786101140179194207
2023;17(6):818-827.275248200833468101136147177206223256274286321353384407442476509515
19.21384920085377185
Lagace224649200833267108142175210
TA.24794920083337287
PCSK9258849200833779114150187
and279749200833373113
LDLR293249200833380114152
degradation:310649200833975117139173214248271287326367380
regulatory35084920083215698137153187210248271306
mechanisms213850200835894128167200239254281340367
in252650200831554
circulation26015020083324769101139155188211226265305
and292750200833271111
in305950200831554
cells.3134502008332668298124138
Curr32945020083407899122
Opin343750200834888104143
Lipidol.36015020083324888104144183200213
2014;25(5):387-393.213851200833468100131143178213230264282294329364397415448481514526
20.21385220085367186
Dong223752200834583121160
B,241052200833547
Wu247052200835793
M,257652200835467
Li265652200833146
H,271552200834356
et278452200833355
al.28525220083324759
Strong29245220083325374111149188
induction31245220083155291128160184199236274
of341152200833756
PCSK9348052200833575108142177
gene367052200833872110145
expression213853200833465105127161187214229267305
through24595320083216081118156195233
HNF1alpha270753200834590123154183198237276308
and303053200833270109
SREBP2:315453200833368102137173207219
mechanism338953200835792125163195233248274332
for37365320083195678
the21385420083226095
resistance2253542008321558296122146178216249282
to255554200832259
LDL-cholesterol263454200833277110125158196235251285312335369390428444
lowering309854200831553104138159175213252
effect33705420083345473107140164
of355454200833756
statins36315420083264982103119157183
in213855200831553
dyslipidemic22065520083387097112127166182221255313329360
hamsters.258255200833770127154177211232259273
J2870552008324
Lipid29105520083314686101140
Res.30655520083367197111
2010;51(6):1486-1495.319155200833569100132145180211226259277289319350386421445476507540574586
21.21385620085367082
Bao223656200833568107
X,235856200833852
Liang24265620083314678116155
Y,259756200833544
Chang265656200834078110148187
H,285956200834457
et293256200833456
al.30045620083324760
Targeting30805620083326081119154177192230269
proprotein33655620083386097137158195217251266304
convertase36855620083316810621385720083326687112145171206
subtilisin/kexin236157200832764103125140155170197211249275306341372388425
type28045720083215595131
92952572008334
(PCSK9):30035720083195595129164199217229
from32495720083184078136
bench340257200833974113145183
to360257200832259
bedside.36785720083387411421385820083264180115127
Signal22805820083334786124157172
Transduct24675820083335083121147186224256280
Target27635820083326081119154177
Ther.295558200833372107128138
2024;9(1):13.310958200833468101133144180199231245257287317329
22.21385920085367288
Patnaik22405920083356789127159174204
S,245859200833345
Pollevick25175920083357288103138170186218248
ME,277859200835588101
Lara-Breitinger28935920083316586119141178200234249271287325364399420
KM,332659200833592105
et344559200833456
al.35155920083324760
Inter-individual3589592008315527410812914916520339342420083385386102140178210226
variability41782420083326586102134173188204218241275
in447124200831553
lipid4542242008315306985124
response:46842420083215582121159198224259272
a4974242008332
narrative50252420083376991112145167182215249
review.52932420083205487102137188199
Am551124200834199
J3934252008324
Med.397325200835590130143
2022;135(12):1427-1433.e7.413125200833468101136148178208241259291320338350380411444477495526557590623635670703709
23.39342620085367287
Ray40342620083356898
KK,41452620083347185
Bruckert42432620083355694126156189210235
E,449026200833346
Peronne-Filardi45482620083356889126164202237260293308323355376414429
P,498926200833540
et504126200833456
al.51102620083314759
Long-term518226200833168106145167189223244301
persistence549626200833974953934272008326416891126164197231
with41862720083516789128
evolocumab433527200833467105121160193231289322362
treatment47182720083214378110132191226265287
and502627200833270110
sustained51572720083266490114147162201236276
reductions5454272008321559513339342820083315571109147173
in412628200831452
LDL-cholesterol419728200833177109124158196234250285312335369390427443
levels46582820083155082117132158
over483528200833769103124
30497828200833468
months:506528200835795134155193220232
final53162820083163371104119
results54532820083215582119134393429200832249
from40002920083194178136
the41532920083226095
European42652920083337091128167203235273
observational455529200833777104139160195227249264302341373389
HEYMANS496129200834477114169211256288
study.52662920083264987126158168
Atherosclerosis.54512920083416310113639343020083215885117132167188225252267293307
2023;366:14-21.425630200833468101136147182217252265295326349380411421
24.39343120085367186
Vonbank403631200833672110149182220250
A,430231200834155
Drexel437331200834567101132166182
H,457131200834456
Agewall464331200834179114165198214229
S,488731200833346
et494831200833456
al.50203120083324760
Reasons509631200833570102128167205231
for53433120083185678
disparity543631200833854801191523934322008321365992
in403932200831553
statin41053220083264982104119157
adherence427532200833271109144165199237270303
rates45913220083215476109136
between47403220083397497150184220258
clinical5011322008331466199114146179195
trials5219322008321435890106132
and536432200833170109
real-54863220083205486102124
-world393433200832173110132148187
observations:414033200833777103138159194227249264302341367379
a4538332008332
review.45893320083215587103138189200
Eur48083320083326990
Heart491733200834479111132157
J5093332008324
Cardiovasc51363320083407394132147185217250277309
Pharmacother.546433200833573105126393434200835790122159181219254275285
2018;4(4):230-236.423534200833468100131143178197230247259295329364388419453488501
25.39343520085367286
Arnold403335200834162100138154193
N,423835200834557
Koenig430835200833572107145160199
W.451935200835867
PCSK9459935200833575109143178
Inhibitor47903520083155290105144159182218240
Wars:504235200835789109136149
How520435200834381132
Does534935200834583119145
Inclisiran55073520083155284393436200831529556990122160
Fit41063620083324769
in418736200831552
with42513620083506587125
Current43883620083407697118151189210
Monoclonal461036200835492130167200214252290322337
Antibody49593620083407899114152191230261
Inhibitor52323620083155290104143158180216238
Therapy?54823620083327110539343720083215493124148
Considerations409737200834077115142156195230251284306321359398424
for45363720083195678
Patient46293720083356789104139177198
Selection.48423720083336883118151175190228267280
Curr51373720083407798119
Cardiol52723720083407294132147185201
Rep.548837200833570109122
2022;24(11):1657-1667.393438200833468101136148183215235266294308320350381415448467498529564597603
26.39343920085367187
Sabatine403839200833265105138159175213248
MS,430239200835588100
Giugliano44193920083445997136151166198236274
RP,47103920083357276
Keech480339200833569104137175
AC,49953920083418093
et510439200833457
al.51773920083324860
Evolocumab525439200833365102118156189227284317356
and393440200833270109
clinical40574020083324762100115147180195
outcomes42664020083387698129166224259286
in456740200831452
patients46344020083387193108143181203230
with48794020083506688127
cardiovascular50204020083316485124139177209242268300338353386407
disease.5441402008338548011514639344120083266173
N4023412008344
Engl408341200833270109124
J4223412008324
Med.426241200835590129142
2017;376(18):1713-1722.442041200833468100129139174206238257288320338350379409441471493524553588622635
27.39344220085367180
Schwartz403542200833365103154187208233263
GG,431942200834488102
Steg44414220083335488127
PG,45894220083358093
Szarek47034220083326195116150180
M,490442200835468
et499242200833457
al.50694220083324861
Alirocumab5150422008341577293130163201259292331
and550142200833270110
cardiovascular39344320083326587126142181213247274307346362395417
outcomes437243200833877100131169228264292
after46854320083325277112134
acute484043200833265104127162
coronary50234320083316991130169202224259
syndrome.53034320083266099139161199258294307
N3934442008345
Engl399444200833370109125
J4134442008324
Med.417444200835489129142
2018;379(22):2097-2107.433144200833468100131143178210244263297332349361397431466499517548580611644650
28.39344520085367288
Bittner4037452008335517397136171192
VA,42434520083367589
Schwartz434645200833365103153186207232263
GG,462345200834489102
Bhatt474045200833573106127152
DL,49064520083457891
et501245200833456
al.50834520083314760
Alirocumab5157452008341577293130163201258291330
and550245200833169108
cardiovascular39344620083316484122137175206239265297334349381402
outcomes43494620083377497127163221256282
according46444620083326394130152189204242280
to493746200832158
sex50084620083266091
and511246200833269108
lipoprotein(a)52324620083153069107146167204226259274312330360378
after39344720083325176109131
acute408147200833264102124158
coronary42554720083326990127166198219253
syndrome:45254720083265897136157194253288300
a4842472008331
report48904720083205494132154179
from50854720083184178136
the52374720083226095
ODYSSEY534847200834794128160192225262
OUTCOMES393448200834792126165210265299332
study.42824820083264987126158168
J4465482008324
Clin45054820083405570108
Lipidol.46284820083314786101140178194207
2024;18(4):e548-e561.485148200833468101133144175206225258275287321356391427450486521555585594
29.39344920085367285
Ying40364920083355189128
Q,418149200834760
Chan425849200834078110148
DC,442249200834687100
Watts453949200835788110134162
GF.47184920083437683
New481749200834580131
Insights4965492008314527994132170192220
Into52014920083155374111
the53294920083216095
Regulation5440492008336711101483934502008315476985123162
of411750200833757
Lipoprotein41945020083324787126166188225247281297335
Metabolism455050200835490112145185224240255282340
by491050200833971
PCSK9:500150200833677111146181195
Lessons52165020083326693120159198224
From54615020083325290149
Stable39345120083325486126141176
Isotope41255120083144179101138177213
Tracer43525120083335083115149170
Studies45365120083335492131146181208
in475851200831552
Human482551200834482139172210
Subjects.504951200833370109125159192216244258
Front53215120083325289128149
Physiol.5485512008335721033934522008326417995108
2021;12:603910.405752200833468101133141171201213249284318351383414427
30.39345320085377490
Libby40455320083324888129161
P,422753200833641
Ridker42895320083365393124159181
PM.449153200833691105
Inflammation4618532008315547289122182241274297313352391
and503153200833271111
atherosclerosis:51635320083335595131153191218252268303325364391407434447
role39345420083215874108
of405554200833756
C-reactive41245420083405475109141173197212245279
protein44165420083386097119152167205
in463454200831552
risk4699542008321366292
assessment.48045420083325885119146173230265303325338
Am515554200834198
J5266542008324
Med.530354200835589129142
2004;545854200833468104140152
116(Suppl39345520083346293112144181220260276
6A):S9-S16.42255520083347594106140172196227258289302
31.39345620085366981
Landmesser403556200833165103142200235262288323344
U,439856200834455
Conde447256200834077115154189
LG,46805620083317487
Wright47865620083577893132170192
RS,49975620083356982
et509756200833457
al.51735620083314760
Effect52525620083325170104137161
of543256200833757
inclisiran55085620083145284393457200831530577293127165
on412057200833776
haematological421757200833871106164197219257273311352367399433448
and468657200833270110
immunological481757200831573131169208247263301341357389422438
biomarkers:52765720083395593152185206237272293321334
a3934582008332
pooled398758200833878117133168208
analysis421558200833270103118150178193219
of445558200833757
ORION-9,453258200834784100148194217252263
-10,4815582008321528496
and493258200833270110
-1150625820083215280
trial5163582008321435991107
data.52905820083387193126140
Atherosclerosis.54505820083416310113639345920083215885117132167188225252267293307
2021;331:E37.425659200833468101133141176209240248282317349355