1606
KLINICKÁ341804001074588109168189242288347
FARMAKOLOGIE709804001074291138211265312372415474533554598
A13288040010753
FARMACIE1403804001074191138210265316336380
/18298040010732
Klin190680400107446583131
Farmakol2057804001074278105179220258305325
Farm.2402804001074178104179195
2025;39(1):22-332617804001074487128172185229271295335352367411455481521563
/32258040010731
www.klinickafarmakologie.cz4568804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
321848020012657113
HLAVNÍ341200012670127198263336370
TÉMA733200012657114204274
Farmakokinetické34136001062867102157197233271307325366398432449484520552
lékové9093600106296197136173205
interakce11303600106155688120156198233266298
přímo14443600106336886139180
působících164036001063273105146182200234252286327
perorálních198336001063264100140176218249291308343384
antikoagulancií238236001063879112129165204242280321352394435469487504
10.343570085377187
Mikkaichi4515700835571102134169184217256272
T,7445700833342
Yoshigae807570083367199137153193226261
Y,10905700833644
Masumoto11555700835689116154214253275313
H,14895700834559
et15695700833457
al.1647570083334962
Edoxaban17305700833473112143176217250289
transport343670083224376114140179218240264
via621670083314779
P-glycoprotein713670083355697112144175212252273311333366381419
is11456700831541
a119967008332
key1244670083306495
factor1352670083195284108145167
for1532670083185678
the1623670083216095
drug‘s1731670083385997136149174
disposition.19186700833854803437700833977104119141157195233246
Drug6057700834567105144
Metab7647700835590112145184
Dispos.964770083456087125164191205
2014;42(4):520-528.11847700833468100131143178210228260278290325358392416450483517530
11.343870085366678
Gnoth4368700834482120142181
MJ,632870083548092
Buetehorn7408700833573108130164202240262301
U,10568700834455
Muenster11268700835593127166192215249270
U,14128700834354
et14828700833456
al.1553870083324860
In16298700831553
vitro169787008332487091129
and18418700833270109
in19658700831553
vivo343970083324780117
P-glycoprotein473970083365797113144176213252274311333367382420
transport906970083214376114140179218239264
characteristics11839700833169102123156188212246267283309332347379407
of16039700833756
rivaroxaban.1672970083213769102123160191223263296334347
J343107008324
Pharmacol38210700833673105126185217249286302
Exp70010700833265104
Ther.82010700833271106128138
2011;338(1):372-380.97310700833469100128136171204239258289304316351383417438470504540552
12.3431170085366884
Jacqueroux4461170083245688126164199220257295327
E,79311700833245
Mercier85811700835590111142157192213
C,109111700834053
Margelidon-Cozzolino116411700835587108146181197212251289327350393430458489526542557595633
V,181711700833645
et188211700833456
al.19581170083324760
In34312700831553
vitro411127008331477091128
assessment5541270083325985120147174231266304326
of89512700833757
P-gp9671270083355696136
and111812700833169108
BCRP124212700833576111147
transporter-mediated14041270083224376114141180219240265299320340398433473488520542575615
drug-drug3431370083385998137159199220259298
interactions6601370083155274108129162194218234272310336
of101613700833756
riociguat10911370083213775107122161199231253
with13631370083516689127
direct15091370083385374108141165
oral16941370083375891107
anticoagulants.1820137008332709110713917534314700833271108124156194216243257
Fundam61514700833269107146178236
Clin8661470083405570108
Pharmacol.99014700833572104126184216249285301314
2020;34(1):109-119.132014700833468101135148183218238269284296325357392416446474504515
13.3431570085377186
Gong45115700834585125166
IY,6391570083155362
Mansell72215700835791130158194211227
SE,9711570083336781
Kim107415700833653113
RB.12091570083367488
Absence131915700834283111148188221256
of159715700833959
both167815700834080103143
MDR11843157008356104142175
(ABCB1)3431670083196096136172204218
and57616700833270109
breast6991670083396195127153176
cancer89016700833164102134168189
resistance1094167008320558196122146178216248282
protein13911670083396097119153168206
(ABCG2)16121670083185995136178213230
transporters185716700832243761141413431770083397799124157179206
significantly5651770083264180118133151168200233271292308340
alters9211770083324770103124152
rivaroxaban10891770083213669102123160191223262295334
disposition14391770083385379118157184199221236274313
and176817700833270109
central189317700833265103343187008322458096
nervous4631870083387597134173213240
system7271870083276190114149210
entry.9601870083357598120156167
Basic11511870083367198114148
Clin13221870083425874113
Pharmacol145918700833675109132192226260299316
Toxicol.179818700833469101118151190207221
2013;112(3):164-170.34319700833468100130141171199229246280297309339370407429460490523535
14.3432070085356782
Sodhi43720700833269108145159
JK,6082070083245872
Liu6922070083314682
S,78620700833244
Benet84220700833569106140162
LZ.10162070083316982
Intestinal11102070083155172105131153168205236251
efflux1373207008333516986123153
transporters15382070083214274111136174212233257289310336
P-gp18862070083355595133
and34321700833270109
BCRP46721700833676112148
are6312170083315387
not7332170083387698
clinically8462170083314762100115147180195210242
relevant11032170083215571105138171209230
in134921700831452
apixaban14172170083317186117150189222260
disposition.16932170083385379118157183198221236274312326
Pharm34322700833573105126184
Res.5432270083357097111
2020;37(10):208.66922700833468101135148183215231263295313325360394430443
15.3432370085366781
Shen43723700833269104141
H,59023700834457
Yao65923700833564101
M,77223700835467
Sinz8522370083324683112
M,97623700835467
et105623700833355
al.11232370083324759
Renal119523700833569106138153
excretion13602370083346596116150172186224262
of163423700833756
dabigatran:170223700833869108123161193214235267305316
the3432470083226095
potential4582470083387799133171193208240255
role7332470083215874109
of86224700833756
multidrug93824700835895110133148187208246285
and124324700833270109
toxin13722470083225989105142
extrusion15342470083346690112150176191229268
(MATE)182224700831872114143177197
proteins.3432570083396097119153168206232246
Mol60425700835593109
Pharm.72825700833673105126185198
2019;16(9):4065-4076.94225700833468100130143173204223255273285320356391425447484520552584597
16.3432670085377187
Kou45126700833674113
W,58626700835869
Sodhi67626700833373113152168
JK,8652670083256277
Wu96326700835997
X,108126700833953
Benet115526700833773112148171
LZ.13472670083327487
Investigating14562670083155486121149173189229262285301340380
intestinal185726700831554771111393432770083223978112128
transporter4932770083234580119147188228251277312334
involvement8502770083155487126143177213273310349372
in124427700831555
rivaroxaban13212770083213872106129168199233274309348
disposition16922770083395582123164192207231247287327
through3432870083226081118156195233
examination5932870083346698156171209242263279317355
of96528700833757
changes103928700833169101139178213240
in129628700831452
absorption.13652870083327198136158198220235273311325
Pharm170728700833572104126184
Res.19082870083357097111
2021;38(5):795-801.34329700833468101133141176210229263281293326360394416452487519528
17.3433070085356675
Xu43030700833873
R,51530700833548
Liu5753070083314683
W,67030700835766
Ge74830700834378
W,83830700835766
et91630700833455
al.9843070083314658
Physiologically-based105430700833572102128142179195232271285317349364378409431470502528562601
pharmacokinetic1667307008338761071281852172482843143303433170083377293108140
pharmacodynamic49531700833876108129187218250286325357395427484498530
parent-metabolite10373170083397192125163184203261295317350388426442457479512
model156131700835795134168183
of175731700833655
edoxaban18253170083337211014017234332700833870107
to46232700832258
predict5323270083385992131145176200
drug-drug-disease7443270083375895133155194215252290312351366391426457482517
interactions:12733270083145172105125157189212227264302327339
M4162432700835488
contribution.1725327008330661041251451601992362582733433370083377588
CPT44333700834074108
Pharmacometrics56333700833572104124182214246282339374396417432464491
Syst10663370083326288111
Pharmacol.118933700833572104125182214246282298310
2023;12(8):103-106.15123370083346799134145174204221254272283312343376397428459494507
18.3433470085366985
Ferri4453470083326688109125
N,58734700834557
Colombo6613470083407793131189229268
E,94534700833346
Tenconi100834700833363101134170209224
M,124934700835468
et133434700833456
al.14073470083314760
Drug-drug148434700834567105144166207228266305
interactions180634700831553741081291621943433570083223776114141
of50535700833757
direct5823570083395475110143167
oral7703570083375992108
anticoagulants8993570083327092107139177210249287303335374396424
(DOACs):134335700831965114154194222239251
from16153570083184078137
pharmacological1772357008339781111321912243433670083316884122162177209242257
to61336700832259
clinical685367008331466199114146179194
practice.8923670083396194126150165197231243
Pharmaceutics.114836700833573105126185217249283321343358390418432
2022;14(6):1120.159336700833468101136148178209229262280292322349379413426
19.3433770085366982
Corsini4383770083407798126141178194
A,64537700834155
Ferri7143770083326688109125
N,85337700834457
Proietti9243770083355693108143165189205
M,114237700835568
Boriani12243770083357495111143181196
G.143437700834357
Edoxaban150537700833371109139172211244282
and180137700833270109
the19233770083226095
issue3433870083154167105139
of50238700833757
drug-drug5793870083385997136158199220258297
interactions:8963870083155374108129162194218234272310336349
from12653870083184078136
pharmacology142138700833877109130189221253290306344384416
to185738700832158
clinical193538700833147613433970083385385117133
practice.4913970083396093126150165197231243
Drugs.74939700834567105144171184
2020;80(11):1065-1083.94839700833569102136149184219239270298312324354386421455477508539575609621
20.3434070085367287
Bashir4454070083356895133148169
B,62940700833548
Stickle6924070083325469101131147182
DF,8894070083467985
Chervoneva98940700834078113134169206245280312345
I,134940700831527
Kraft13914070083355891110135
W.154140700835767
Drug-drug162340700834667106145167207228267306
interaction1944407008314523434170083225577110142166181219258
study6214170083275088127159
of80041700833757
apixaban8774170083327187118151190223261
with11584170083516789127
cyclosporine13064170083316596111150176215254276292329364
and169141700833270109
tacrolimus1820417008322558710814616117634342700835795121
in47842700831452
healthy54342700833873105120143181211
volunteers.7684270083316985122160182216251272299313
Clin10944270083405570108
Transl12164270083324982120147162
Sci.1391427008333658093
2018;11(6):590-596.149742700833569100131144174201216250268280315347383407441473509522
21.3434370085367082
Mansell44243700835487125151186202217
H,67643700834457
Shoker75143700833270108139173194
A,96243700834156
Alcorn10354370083415688125147185
J,123843700832436
et129143700833456
al.13654370083324760
Pharmacokinetics144243700833573105126185217249286317333371406428443475503
of196243700833857
apixaban3434470083327186118150189222260
and61744700833270109
tacrolimus7394470083215486108145161176233271297
or105044700833758
cyclosporine11224470083316496111149176215254275291329364
in149944700831553
kidney15654470083294685123158189
and176744700833270109
lung18904470083145290129
transplant3434570083224376114140179195227265287
recipients.6454570083215588103142158192230252280293
Clin9534570083405670108
Transl10774570083324982120147162
Sci.1254457008333658093
2022;15(7):1687-1697.136345700833468101135148178208226260280292321353388421440470502535568575
22.3434670085357186
Xia4414670083385284
CQ,5374670083398497
Liu6464670083314683
N,74146700834457
Miwa81046700835469119151
GT,9744670083437685
Gan107146700834376113
LS.11964670083316578
Interactions12864670083145273106126159190214229266304329
of162846700833755
cyclosporin16964670083306394109146172211249270285322
A343477008341
with3974770083516789127
breast5384770083386094126152176
cancer72747700833164102134168189
resistance930477008320558196122145178216248282
protein.12264770083386097119153168206219
Drug145947700834567105144
Metab161647700835590112145184
Dispos.18144770083456187126164191205
2007;35(4):576-582.34348700833468104137147182215232265283295330363395419453487520533
23.3434970085377692
Sugimoto46349700833373114131191231255294
H,78549700834560
Matsumoto87349700835690114143182243283307346
S,124749700833348
Tachibana13234970083336397137154195230270304
M,165549700835671
et175449700833559
al.18414970083335064
Establishment1933497008334633435070083215493108123149186243278315337
of69250700833756
in76150700831452
vitro825507008332476990127
P-glycoprotein9655070083355696111142173210249270307328362376414
inhibition13915070083155290105143159181196233271
assay16755070083325884117147
and183550700833169107
its19555070083143764
exclusion3435170083336494109146171185222260
criteria615517008330516688120141156187
to81451700832157
assess8835170083325783117143169
the10645170083215892
risk1168517008321366190
of127051700833755
drug–drug13375170083385896134169209229266304
interaction16535170083155272105126158189212227264302
at196751700833152
the3435270083226094
drug4505270083385997136
discovery5995270083385379111148180214235269
stage.8815270083264981120155167
J1061527008324
Pharm109852700833572104125184
Sci.1294527008333658093
2011;100(9):4013-4023.14005270083346899127135165196232252284302314348384415445467503539572606619
24.3435370085367186
Patil4485370083356789104119
AG,5865370083418497
D‘Souza7025370083455993131169198232
R,95353700833549
Dixit10215370083456192107130
N,117053700834457
Damre124653700834577135156191
A.145553700834156
Validation1530537008335678297136168190205243282
of183053700833857
quinidine190653700833875913435470083385392107145180
as54354700833259
a622547008332
probe6745470083396198138173
substrate86854700832663102129152174207229263
for11515470083185678
the12495470083226095
in136554700831452
vitro1438547008331477091128
P-gp15875470083355697136
inhibition17445470083145290105145160183198236275
assay3435570083325885118149
in51255700831553
Caco-258555700834073105142165196
cell802557008331658095
monolayer.91855700835795134172188220251285307317
Eur12555570083337091
J1366557008324
Drug141155700834567105144
Metab157555700835590112145184
Pharmacokinet.1779557008336731051261852173435670083316899115153188210224
2011;36(3):115-119.58256700833468100128136171205224258275287317344374397427455485496
25.3435770085367388
Lee45157700833266102
CA,5745770083408397
Zhang69257700833876109147187
L,90057700833145
Han96657700834477115
Y,110257700833644
et116757700833457
al.12445770083324861
Breast13265770083355791124151174
cancer152157700833164103135169191
resistance1733577008320558297124147180219251285
protein3435870083396097119153168206
(ABCG2)5655870083185995136178212230
in81158700831452
clinical879587008331466199114146179194
pharmacokinetics108958700833877109130189221253290321337375410432448480507
and161258700833270109
drug17365870083385998137
interactions:188858700831552741083435970083215486110125163202228240
practical6015970083396194126150165197230246
recommendations8645970083215588125183241276314353385407422460499525
for14075970083195678
clinical1503597008331466199114146179194
victim17155970083324880104119177
and191059700833270109
perpetrator3436070083397495135171193214247269306328
drug-drug6916070083385997136159199220258297
interaction10096070083145274107129162194218233271310
study13396070083264987126158
design.151760700833873100115153191205
Drug174260700834567105144
Metab1906607008355903436170083225494
Dispos.4526170083456187126165191205
2015;43(4):490-509.67261700833469100130141176208227260277289323356392416450484519530
26.3436270085367186
Grymonprez4416270083436598156194232271292326355
M,80862700835468
Carnoy8886270083407293131169200
L,110062700833145
Capieu115762700834072111126161198
A,136762700834155
et143462700833456
al.15036270083314659
Impact157562700831471110143174198
of178662700833756
P-glycoprotein1854627008335569611114234363700833166105125161182215229266
and62163700833168106
CYP3A4-interacting73863700833975111143182216238253290310343363395426449464500538
drugs12886370083375895132158
on145763700833774
clinical1543637008330455996110141173187
outcomes17426370083377395125160217251277
in34364700831452
patients4076470083397192107142179200227
with6476470083506587125
atrial784647008332537490121136
fibrillation933647008316337293108123138169191206243281
using12266470083376378115153
non-vitamin139264700833775113135167182204237294309346
K1750647008335
antagonist179764700833269911231611993436570083375277100
oral4566570083365890105
anticoagulants:5736570083326990105137173206244281296328365386413425
a1011657008331
nationwide10556570083376990105142180230245283318
cohort138565700833167105143164188
study.15866570083254885124155165
Eur17636570083326889
Heart186565700834378109130154
J343667008324
Cardiovasc3826670083407394133148186218251277309
Pharmacother.70766700833572104126184216249285307346381402412
2023;9(8):722-730.113466700833569102136148183202236254266299334368389420454489501
27.3436770085367180
Li44067700833147
D,50567700834556
Yan57967700833564102
C,69967700834053
Guo77067700834381120
M,90767700835568
et99367700833456
al.10676770083324760
Evidence11456770083336480119154192224258
of142167700833756
potential14956770083397799133171193208240255
pro-haemorrhagic1768677008339609812116019222734368700835795116137175207245260291
drug6476870083385896135
interactions7946870083155273106127159191215230267305331
between11376870083397496148182217254
CYP3A4140468700833976112145184219
inhibitors16356870083155289104143158180216237264
and191268700833169107
direct3436970083385374108141165
oral5216970083375992107
anticoagulants:6416970083327091107139175208247285300332370392420432
analysis108669700833270102117149176191217
of131669700833757
the13866970083215994
FAERS149369700833371104139173
database.16796970083387092125164197223258270
Br196269700833657
J343707008324
Clin3827070083405671108
Pharmacol.50670700833572105126184217249286302314
2023;89(8):2423-2429.83670700833468101136147182217236269288299335366399434456487518551585596
28.3437170085367288
Frost4437170083325289116139
CE,5957170083397285
Song69371700833270109148
Y,85471700833543
Yu91071700833570
Z,99371700833750
et105671700833456
al.11257170083324760
The119871700833271106
effect13177170083345472107139163
of149371700833757
apixaban15627170083327187118150189222260
on183571700833775
the19237170083226095
pharmacokinetics34372700833876107127185216247283313329366400421436467494
of84972700833755
digoxin9167270083385290127157172209
and113772700833168106
atenolol12557270083315285122160175212227
in149472700831552
healthy155872700833771102116138175205
subjects.177572700832662100115149181204231244
Clin3437370083405570108
Pharmacol.46673700833573105126185217249286302315
2017;9:19-28.79673700833469100130140175188218248272303336350
29.3437470085367285
Shi4477470083327085
J,55174700832436
Wu60574700835895
T,71874700833341
Wu77874700835794
S,89074700833346
et95474700833456
al.10297470083324760
Effect11077470083335271105138162
of128774700833857
genotype136274700833873111150172205245281
on166174700833776
the17557470083226095
pharmacokinetics18697470083387710913034375700835790122159189206244279301316348376
and73575700833169108
bleeding8597570083395590125165180218257
events113175700833467101139161188
of133575700833757
direct14077570083385375109141165
oral15887570083375992107
anticoagulants:171175700833270921071391762092482853437670083154785107134147
a505767008332
systematic5537670083265986109142200233255270302
review8707670083215587103138189
and107576700833170109
meta-analysis.119976700835893115148170202240273288320347362388401
J1616767008324
Clin16567670083405570108
Pharmacol.178076700833572104126184216343777008331688497
2023;63(3):277-287.45577700833469101136148183217235269286298333366401419450484517523
30.2138570085377490
Raymond22505700833670102162201241281
J,25525700832537
Imbert26115700831574114151173198
L,28315700833246
Cousin28985700834179118145161200
T,31195700833342
et31835700833457
al.3262570083324862
Pharmacogenetics33455700833674108129189223256294334370410446213867008322376997
of22516700833756
direct2323670083385374108141165
oral2504670083375992107
anticoagulants:2627670083327092107139176209248286301333371393420433
a307667008332
systematic3123670083275986109143201233255270302
review.3441670083215587103138189200
J365767008324
Pers3697670083356890117
Med.21387700835490129142
2021;11(1):37.22967700833468101132140170198213245259271306338345
31.2138870085366981
Laizure2235870083316580109147168203
SC,2453870083327386
Parker2554870083356788119153174
RB,2743870083367285
Herring28438700834479100122138175215
VL,3073870083356882
Hu31708700834482
ZY.3267870083387584
Identification3366870083155489127148164181198230263285300338377
of37588700833756
carboxylesterase-dependent2138970083316486125164195229245280307330364385418445480503544579618654692731766805826
dabigatran29859700833870110125164197219240273311
etexilate3317970083345690122138153185207241
hydrolysis.357897008338691071291661822142138107008326416781
Drug223410700834567105144
Metab239410700835489111144183
Dispos.25931070083456187126164191205
2014;42(2):201-206.281310700833468100131143178210228262280291327361393411442476512525
32.21381170085367086
Laizure22371170083316479108146167201
SC,24511170083327285
Chen254911700833977112149
F,271111700833238
Farrar27621170083326182104136157
J,293211700832436
et298011700833456
al.30491170083324760
Carboxylesterase-231211170083407393133171201235251285312335368389422448483506537
plays36701170083395486117144
a2138127008331
critical2182127008331526789104135168183
role23771270083205773107
in249612700831552
dabigatran256112700833769108123161193214235267305
etexilate28781270083345689120135150182203236
active31271270083316386101133167
metabolite330612700835792113146184223238253275308
formation.3626127008318557713416621381370083223775113127
Drug228013700834567105144
Metab244013700835489111144183
Pharmacokinet.263913700833572105126184217249286316333370405428441
2022;47:100479.309513700833569102136149183215226255287323359391425436
33.21381470085367186
Blech22441470083355186119157
S,242014700833345
Ebner248514700833272110145166
T,267114700833241
Ludwig-Schwellinger273214700833168107158174213235267299337387422437452467505544579600
E,335214700833346
et341714700833456
al.34931470083324760
The357314700833271106
metabolism36991470083579221381570083225494132148163189247
and240215700833169108
disposition25271570083385379118157184199221236274313
of285615700833757
the29291570083226095
oral30401570083385992108
direct31641570083385374108141165
thrombin33461570083216081118176215231269
inhibitor,363115700831553911061451612138167008322598090
dabigatran,224616700833971110126164197219240273311324
in258816700831553
humans.265916700833875133165203230243
Drug292116700834567105144
Metab308416700835489111144183
Dispos.32861670083456187126165191205
2008;36(2):350916700833569105140152187222241275293305
386-399.213817700833469104127160193228239
34.21381870085367388
Ebner224518700833372110145166
T,243018700833241
Wagner248918700835889128166201222
K,273018700833549
Wienen279818700835773108146181219
W.303518700835868
Dabigatran312118700834578117132171204225247280318
acylglucuronide,3457187008332649811415316820523827529633421381970083375291126137
the22881970083226094
major239519700835789105142164
human257219700833774132164202
metabolite278719700835792114146185224239254277310
of311019700833756
dabigatran:317919700833870109124163195217238271308320
in351219700831552
vitro3577197008332477091128
formation,37181970083185577213820700835790111127165203216
stability,23692070083265082122137152167190224233
and261820700833270109
pharmacological274220700833977110131189221254291306345384399431464480
activity.32372070083326488103136152174208218
Drug347020700834667106145
Metab363020700835590112145184
Dispos.21382170083456187126165191205
2010;38(9):1567-1575.235821700833569100132145180214233266284296325355390423441472502535568580
35.21382270085367186
Shi22372270083327085
J,233622700832436
Wang238522700835789127166
X,256422700833851
Nguyen262822700834584122154188226
JH,28672270083246982
et296222700833456
al.30322270083314760
Dabigatran310522700834577117132171203225246279317
etexilate34362270083345690121137152184206240
activation3689227008331648810321382370083326586102140178
is233023700831541
affected23852370083325170105137162195235
by263423700833970
the27182370083226095
CES1282723700834073107137
genetic297823700833973112147169184216
polymorphism32082370083397894125184222244284322337363421
G143E364323700834475106138171
(rs71647871)2138247008318376495127157193224257289321335
and248524700833168106
gender.260424700833771108147181201211
Biochem28272470083355087119156190247
Pharmacol.308624700833572103124181213244280295308
2016;119:76-84.34062470083346798128140170196226239271302325360396408
36.21382570085367288
Merali224725700835590111144159174
Z,244225700833851
Ross251325700833674101127
S,266125700833245
Paré27272570083356788122
G.286925700834458
The294825700833272107
pharmacogenetics307525700833977110131190222254291331366404439461477509536
of363225700833757
carboxylesterases:37092570083316485213826700833977108141157192219242275296329356391417430
CES1258126700834072106137
and273126700833169108
CES2285226700834073106140
genetic300526700833872110145167183215
variants32322670083326586101133171193220
and346526700833270109
their35872670083215994109130
clinical3730267008331476221382770083385385117133
effect.22862770083345473107140164177
Drug247827700834667106145
Metabol263827700835590112145184223239
Drug289227700834567105144
Interact.30522770083145274108129162194218232
2014;29(3):143-151.329927700833468100131143178212231265282294324355387409440470501510
37.21382870085367079
Ji223328700832439
Q,228728700834761
Zhang236328700833876108146185
C,256328700834053
Xu263128700833974
Q,272128700834760
et279628700833457
al.28682870083324760
The294328700833372107
impact306528700831572112145177201
of328128700833757
ABCB1335328700834177117153185
and355328700833270109
CES1367728700834073106137
polymorphisms21382970083397793125184222244283322337363421447
on260029700833876
dabigatran269129700833870110125164196218240273311
pharmacokinetics301729700833877109130189221253290321337375410432448480507
and353929700833270109
pharmacodynamics366329700833977110131213830700835891124162203236275308368383416444
in260430700831453
patients26793070083397395111146185208236
with29363070083526891130
atrial3087307008333557793126142
fibrillation.3250307008317357497113129144177200215254294307
Br357930700833658
J3658307008324
Clin37043070083405671110
Pharmacol.213831700833573105126184217249286302315
2021;87(5):2247-2255.246831700833468101133141176209225259277289324359391423442473507542575587
38.21383270085367288
Härtter22433270083447698122147180202
S,246132700833345
Sennewald252332700833267106144179230263278317
R,285632700833650
Nehmiz292232700834580118176191220
G,315932700834357
Reilly32333270083357085100115147
P.339732700833540
Oral345432700834768101117
bioavailability3587327008339549212515719020521383370083154786102117132155188
of234733700833756
dabigatran242433700833870110125164196218240273311
etexilate27553370083345690122137153185207240
(Pradaxa)30163370083185475108147179211244261
after32983370083325176109131
co-medication34493370083316892150186225240272305327342213834700833776
with22333470083516689127
verapamil23793470083326688120160193250266281
in267934700831553
healthy275134700833873105120142181211
subjects.298234700832663102118152185209237250
Br325234700833557
J3328347008324
Clin33723470083405570108
Pharmacol.349934700833573105126185217249286302315
2013;75(4):1053-1062.213835700833468100130141174207225258275287317348382415437468499535568581
39.21383670085367185
FDA224136700833277117
Full2376367008332698499
Prescribing24933670083355690117149171186225241279318
Information:28293670083155371109131189221243259297335347
Pradaxa®31943670083355689128160192225252
(dabigatran-34643670083185587127142181213235257290328350
-etexilát),21383770083215779113145160175207229248259
Boehringer241037700833574109147168184222261296317
Ingelheim,27403770083155291126142180214230287300
11/2023.30533770083346283118152185220232
[Internet].3298377008319347294127149187222244262274
Available358537700834171104119134166205213838700831550
from:22043870083184077136148
https://www.accessdata.fda.gov/drugsatfda_docs/2368387008338598312315016218920926031436737841244447550953556260163365568870172175979280584488291493797399410321071109711311152117312121244128213211360139214201446
label/2024/022512s047lbl.pdf.21383970083154786122137163198232265297322356389423458489519546581617649664703719732772811831842
40.21384070085367388
Rohr224040700833573112133
BS,23844070083366880
Foerster247840700833270105126153176210231
KI,27224070083345163
Blank27984070083355183121151
A,296040700834155
et302840700833456
al.30984070083324760
Perpetrator31704070083356990129165187208241263299321
Characteristics3504407008339771091301631952192522732892138417008326496597124
of227641700833756
Azole234641700834172109125160
Antifungal251941700834180101116136174212251284299
Drugs283241700834567105144170
on301641700833775
Three31054170083327293127162
Oral328141700834769102117
Factor34124170083326194118155176
Xa360241700833870
Inhibitors3686417008315539110621384270083395477114135162
Administered231742700834179137152190205231254288309343383
as271642700833258
a2790427008332
Microdosed283842700835570102124161200239265300340
Cocktail.319442700834077110140164197212227240
Clin34504270083405570108
Pharmacokinet.35754270083357210412618421621384370083316899115153188210224
2022;61(1):97-109.237743700833468101136148184214229261275287322355374405436471482
41.21384470085366981
BI223744700833551
Trial2306447008333506597113
No.24374470083458395
1160.10125514470083346192128141171203235
Synopsis.280444700833262101139179205220246260
Boehringer308244700833574109148169184222261296317
Ingelheim,34174470083155392127143180215231288301
report37364470083215521384570083397799124
date22754570083387192126
29241545700833468
October249745700834779103140180215237
2009.274745700833469105140151
[Internet].2911457008319357394128149188223245263274
Available319945700834172105120135167206222257
from:34704570083184077136148
http://36314570083385984123136162183
trials.boehringer-ingelheim.com/content/dam/internet/opu/213846700832142578810212714017921725128830832336039843145247148652356159460964668069475076379482988691193997510121033106511021123114911841215127112971312134913691402142214601494151515411575161416511676
clinicaltrial/com_EN/results/1160/1160.101_U09-1350-01.pdf.2138477008331466198113144177192214235250282297322350387444481516560585604638664701716738765791824851882916941973100010311066107811091140117112041248128313171341137114001433146714901527155815671607164616651676
42.21384870085367086
Kosloski22404870083357299114152179209225
M,248148700835468
Bow256448700833574125
M,270448700835468
Kikuchi27874870083355181120152190205
R,300748700833549
et307248700833356
al.31434870083324760
Translation32184870083335083121147163195217232270308
of354248700833756
In361348700831553
Vitro3681487008336527596134
Transport21384970083335083121147186225246271
Inhibition24254970083145290105144160182198236274
Studies27154970083325391130145180207
to293749700832259
Clinical30114970083405570108123155188203
Drug-Drug323049700834567105144166213235273312
Interactions35584970083155374108129162194218234213850700833776102
for22595070083185677
Glecaprevir23555070083446095127160199221255287303324
and269850700833270109
Pibrentasvir.28265070083354989110144182204237263296312333344
J3188507008325
Pharmacol323150700833673105126185217249286302
Exp355250700833365105
Ther.367650700833271106128138
2019;370(2):278-287.213851700833468100130143178210243263297315327362395428451482515548555
43.21385270085377388
SPC224852700833369110
ČR:23795270083417791
Pradaxa®24925270083355690130163196229257
(dabigatran27705270083195790130146186219241264297336
etexilát),31275270083355893125141157190212231243
Boehringer339152700833676112151173189228268304325
Ingelheim,37385270083155421385370083397491129165181239253
11/2024.24125370083356385121156190222235
[Internet].2668537008319357496131153192228251269281
Available297053700834273107123138171211228263
from:32555370083184179138151
https://www.34275370083386085126153166194215267321376387
ema.europa.eu/documents/product-information/pradaxa-21385470083349212513817321123327031034335639142945649253056360165969473375478280884686890594598310151039105910751114113311701192125112831305132113591398142414621483151715561588162016531676
-epar-product-information_cs.pdf.21385570083215796129151170210232269309346378403422438476495533554613645667682720758796829856870910949969980
44.21385670085367490
Testa22465670083336390113146
S,241056700833245
Prandoni24735670083355588126165204242257
P,274856700833539
Paoletti280556700833567105121156178203218
O,304156700834758
et311656700833457
al.31905670083324760
Direct32685670083456182116149173
oral34585670083385992108
anticoagulant3583567008332709210713917620921385770083397793125164186
plasma23455770083395588115174207
levels‘25735770083155083118134160173
striking2767577008327507288119136174214
increase30025770083155386108142175202237
in326057700831554
severe33355770083266294129151186
COVID-19354257700834086123139186210241272
respiratory21385870083215582120136157190212249270304
syndrome24585870083265897136157195253288
patients27615870083397294109144182203231
treated30075870083224377109131165204
with32265870083516789127
antiviral33685870083327092107140155177210225
agents:360858700833271106144166193206
The213859700833373109
Cremona22685970083416398157196236269
experience.255859700833467107144166182217256289324337
J2916597008324
Thromb29625970083337395133193233
Haemost.321659700834578114173212240264277
2020;18(6):351559700833469103138151182214234268287299
1320-1323.21386070083346497131155185215248283295
45.21386170085367186
Delavenne22406170083458196128160194232270305
X,256161700833852
Ollier2629617008346637893127149
E,279361700833346
Basset28556170083356895121156179
T,304961700833342
et310761700833456
al.31796170083324760
A3255617008341
semi-mechanistic331161700832762119135157215251283321353392407433456471503
absorption21386270083327299138160200222238277315
model247462700835897137173188
to268362700832260
evaluate276362700833567101117155187209244
drug-drug30276270083396099139161202224263302
interaction33506270083155375109131164197222237276315
with36866270083516689128
dabigatran:213863700833871110126165197219241274312324
application248363700833271111127142174207229244282321
with28256370083506689127
clarithromycin.29726370083324780101117139177199236295326357372410424
Br341663700833657
J3494637008324
Clin35396370083405570108
Pharmacol.366863700833572105126213864700835790122159175188
2013;76(1):107-113.234164700833468100130141174206225257271283313344377396426454484496
46.21386570085367489
Härtter22416570083447697122146180201
S,245565700833345
Sennewald251365700833368106144179230263278317
R,284365700833549
Schepers290565700833265103138177212233261
C,317965700833952
et324465700833457
al.33136570083324860
Pharmacokinetic33866570083367310512618521724928631733337140621386670083223769
and222166700833270109
pharmacodynamic234466700833977109131189221254290330362401433491506538
effects28966670083345473107140164192
of310266700833756
comedication317266700833268127162201216248281303318356395
of358166700833756
clopidogrel36526670083314684124139213867700833876116137171187
and234167700833270109
dabigatran246667700833870109125164196218239272310
etexilate27926770083345790122138153185207240
in304967700831452
healthy311767700833873105120142181211
male334467700835890105140
volunteers.35006770083327086123161183216252273300314
Eur21386870083336990
J2244687008324
Clin22836870083405570108
Pharmacol.240668700833573105126185217249286302315
2013;69(3):327-339.273668700833569100130142178211231264281293329361394413445478511522
47.21386970085367079
Kumar223469700833572130162183
P,243469700833540
Gordon249069700834482104142180219
L,272569700833245
Brooks27876970083355794132163192
KM,299569700833592105
et311769700833456
al.31906970083314760
Differential32666970083466181100134155189228249264296312
Influence3594697008315537187125160198213870700833267
of222770700833858
the23077070083226298
Antiretroviral242770700834281104120142178201223262295312334368385
Pharmacokinetic283370700833675109131191225258297329346385422445461494
Enhancers334970700833373112146185219254276304
Ritonavir36757070083365376114213871700833973106123145
and230771700833373114
Cobicistat244571700834180121138171188215240274297
on276671700833979
Intestinal28697170083155578113142166183222256273
P-Glycoprotein316671700833658107124158191229271294333356391407447
Transport36377170083345287127154213872700834081104131
and229872700833373114
the244172700832363100
Pharmacokinetic/Pharmacodynamic257072700833776110133195229263302335353393430454471505534572612646669730765799838880914955989105010661100
Disposition37007270083466391213873700834081109125149165205245
of240873700833959
Dabigatran.249273700834781122139180213237259294334348
Antimicrob286573700834383106122182198232255294335
Agents322573700834383119159182211
Chemother.346273700834180117177218241281318340352
2017;61(11):e01201-e01217.213874700833468100129139175205220252280294306340376408438472504522559594626656687717723
48.21387570085367389
Brooks22407570083355693132162191
KM,244375700833591104
Gordon256075700834482103141179217
LA,27907570083317488
Penzak289175700833568105135168198
S,310175700833345
et315975700833456
al.32277570083324760
Cobicistat,330075700833976115131162177203226258280293
but36067570083387698
not37177570083377597
Ritonavir,21387670083365174111150182214230252262
Increases24207670083155386107142174200236263
Dabigatran270376700834678118134173205227249282321
Exposure.304476700833366106145172209231265277
Poster33427670083357299123157178
409.354176700833470106117
Conf367876700834178117136
Retroviruses21387770083357093114151183199220258285320347
Opportun250277700834787126165187211249287
Infect,28077770083155371106139163176
Seattle,300077700833368100121146161196208
WA,322677700835796110
13335377700833565
to343577700832259
16351177700833465
February35947770083326610512716519739345700832156
2017.40115700833469102132138
[Internet].417057008319357496131152192228250268281
Available44725700834172106122137170210227262
from:4755570083194280139151
https://www.croiconference.org/wp-content/uploads/sites/2/posters/2017/409_492857008338608512515216519321426632037438641844047849452756460462365839346700832156941271611742132352733003523924164514885275495846226446727097497658048388779049309559709931028105510811117114411821222124912731307132913571383141814531485151515361568160416401676
Brooks.pdf.3934770083355794133163192206246285305316
49.3934870085357083
Cox40308700833976105
D,41488700834555
Rehman42158700833570107164196233
M,44608700835467
Khan45408700833473104142
T,46948700833241
et47478700833455
al.4815870083314658
Effects4886870083325169103135159186
of50848700833756
nirmatrelvir/ritonavir515287008337527213016218320423725228429932034336237739943539349700833769100116137
on40839700833775
midazolam41719700835772110142171208224256313
and44969700833270108
dabigatran46179700833870108124162194215237269307
pharmacokinetics49369700833977109130187219251288318334372406428443475502
in54519700831452
healthy5515970083387239341070083324769107137
participants.40841070083387192116131163177216249286308335348
Br444510700833556
J4514107008324
Clin45511070083395469106
Pharmacol.467010700833572104125183215247283299312
2023;89(11):3352-3363.499410700833468101135146181215234265293307318353386419451471503536570604616
50.39341170085367287
Wang404111700835789127166
N,422611700834558
Chen430311700834078113151
L,447411700833145
Li453911700833146
N,460511700834557
et468211700833456
al.47581170083324760
Predicted48381170083355589129144176200234274
effect51311170083345473107140164
of531411700833857
ticagrelor5391117008321366810114016119639341270083155375
on403012700833876
the41271270083226196
pharmacokinetics424412700833977110132191223256293324341379414437452485513
of477712700833857
dabigatran485512700833971111127166198221242276314
etexilate51901270083345691122138154186208242
using54531270083376479117157
physiologically393413700833977108135150188204242282297329362378393425
based43791370083397299134173
pharmacokinetic457313700833977110131190222254291322338376412434449481
modeling.507513700835796135170186201239278291
Sci53871370083326580
Rep.548713700833671110123
2020;10(1):9717.393414700833468101135148178210229261275287322355388417423
51.39341570085367082
Härtter40311570083447698122147180202
S,424715700833345
Koenen-Bergmann430715700833572108146181219241278314335373431463501539
M,486115700835468
Sharma494315700833371103124182215
A,517215700834155
et524215700833456
al.53131570083324760
Decrease538715700834681114135169201393416700832661
in401016700831553
the40781670083226095
oral41881670083385992108
bioavailability43111670083395492125157190205220252291307322337360393
of472016700833756
dabigatran479116700833871110126164197218240273311
etexilate51171670083345690122137152185206240
after53721670083325176110131
co-55191670083316891
-medication393417700832180115154169201234256271309348
with42971770083516789127
rifampicin.4440177008321365689147186201233249286300
Br475517700833657
J4828177008324
Clin48681770083405570108
Pharmacol.499217700833572105126184216249286301314
2012;74(3):532217700833468100130143175206225259276288
490-500.393418700833467103127161195231244
52.39341970085367288
Wang404319700835890128167
Y,423119700833644
Chen429619700834078114152
M,446919700835569
Chen455919700834078113152
H,473219700834457
Wang481019700835890128168
F.499819700833340
Influence5058197008315547189126162200233267
of534619700833757
ABCB1542419700834177118154187
Gene393420700834479118153
Polymorphism41072070083367288120179218239279318333359417
on454520700833776
Rivaroxaban46412070083365184117138176206239278311349
Blood50112070083355190128168
Concentration520020700834077115148181220241263296318333371410
and393421700833270109
Hemorrhagic406221700834479137175197219257289328344376
Events44572170083326498136158186
in466221700831452
Patients47332170083356789104139177199226
With49782170083587496134
Atrial5132217008340628399131146
Fibrillation.52972170083324787108124139154186208223261300313
Front39342270083325289128149
Pharmacol.409922700833572104126184216249285301314
2021;12:639854.442922700833468101132140171200213248282315350384420432
53.39342370085367084
Wu403123700835793
T,413623700833341
Wu418923700835793
A,429523700834054
Li436123700833247
L,442023700833144
et447723700833355
al.45442370083324759
The461623700833271105
impact473323700831572110143174198
of494323700833756
ABCB1,501123700834176116151182191
CYP3A4/5521423700834076112145184219243276
and550323700833168107
ABCG2393424700834176116157191
gene413824700833872109144
polymorphisms42942470083397793124182219241280318332358415441
on474724700833775
rivaroxaban48352470083203567100121157187219258290328
trough51752470083224380117156193
concentrations5380247008331681061371702083934257008322437698113151190216
and417025700833270109
bleeding42992570083385489124164179217256
events457525700833466100139160188
in478325700831452
patients48552570083397294109144182203231
with51062570083506688127
non-valvular525325700833775114136169202217250288304336357
atrial3934267008332547591123138
fibrillation.4087267008317347395110126141173195210248286300
Hum440226700834482140
Genomics.455726700834479117155214229261288302
2023;17(1):59.487426700833569101136148178207224255270282317349360
54.39342770085367388
Villapalos-García4038277008336526782115154187202240267288334367388419434466
G,452027700834457
Zubiaur459327700833874114129161199220
P,482927700833539
Ochoa488427700834780118156189
D,508927700834556
et516027700833457
al.52322770083324861
NAT2530827700834586115151
phenotype54752770083387711239342870083377596130169204
alters41512870083314668101122149
pharmacokinetics431228700833977108129187219250287317333370405427442473500
of482528700833756
rivaroxaban48932870083213668100121158188220259291328
in523428700831452
healthy529828700833772103118140178208
volunteers.55192870083316839342970083155290112146181202230243
Biomed41922970083365189147182222
Pharmacother.442929700833573105126185217249286308346381403413
2023;165:115058.485729700833468101136148178209243254283311341375409443457
55.39343070085367185
Campos-Staffico403830700834073131170209235256288309342360378396428465
AM,452130700834197110
Dorsch464930700834684106133165203
MP,48713070083549095
Barnes49843070083356890128163190
GD,519230700834490101
et531130700833457
al.53863070083324760
Eight54653070083324786124145
pharmacokinetic393431700833876108128186218249285315331368403424439471
genetic441731700833872109144165180211
variants4641317008331638499130168189216
are48693170083325286
not49673170083377596
associated50753170083325884121153168199221254292
with53803170083506587124
the55173170083215893
risk3934327008320366191
of403732700833756
bleeding41063270083385488123162177214253
from43713270083194077135
direct45183270083385374107139163
oral46943270083375890105
anticoagulants48123270083316990105137173206244281296328366387414
in523832700831552
non-valvular53033270083377511313516720021524728539343370083154666
atrial4012337008331527388119134
fibrillation4158337008317337192107121136167188203240277
patients.44473370083387091106139177197224237
Front46963370083325187124145
Pharmacol.485333700833571103123180211243279294306
2022;13:1007113.51713370083346799132144173202213242273308339371398427439
56.39343470085367288
Zhao404034700833876108146
T,420434700833241
Li426334700833146
X,432734700833851
Chen439634700834078113151
Y,456434700833644
et462534700833457
al.46993470083324760
Risk47773470083355177107
assessment49013470083325985120147174231266305326
and524534700833169108
molecular53713470083579611214617921739343570083154768
mechanism401835700835792125163195233248275332
study43663570083264987126158
of454035700833757
drug-drug46123570083386098137159200221259298
interactions49263570083155274108129162194218234272310336
between52783570083397497150184220258
rivaroxaban55513570083213739343670083326586124154187227260298
and425336700833270110
tyrosine43833670083225678116143158196231
kinase46353670083294684117143179
inhibitors48343670083155392107146162185222244271
mediated512636700835793132148180202236276
by542236700833971
CYP2J2/3A455133670083417839343770083356995128155190230265
and421437700833270109
BCRP/P-gp.433837700833676112148169205227267306319
Front46723770083325289128149
Pharmacol.483737700833572104126184216249285301314
2022;13:914842.516737700833468101136148178208219254286318353390422435
57.39343870085367180
Lee403038700833166101
E,414738700833346
Wu420938700835794
Z,431938700833851
Shon438638700833371109147
JC,45503870083246578
Liu46443870083314784
KH.47443870083358194
Danazol485438700834678116148178215231
Inhibits51013870083155391106145161183211
Cytochrome53283870083406893129162200221258393439700835893
P450404839700833568101135
2J242043970083346094
Activity43193970083417397113146162184218
in455839700831553
a4632397008332
Substrate-independent468439700833371110137161182216238272295312350389424464500538578613652673
Manner.537839700835588126164200221232
Drug393440700834567105144
Metab409440700835489111144183
Dispos.42934070083456187126165191205
2015;43(8):1250-1253.451340700833468100130141176208226260278290320350385419443473503538571584
58.39344170085357186
Wang403341700835787124163
Z,420841700833750
Li427041700833146
X,432841700833750
Zou439041700833874111
Y,451341700833543
et456841700833355
al.46354170083314659
Combination470641700833975132171186223254276290328365
of508341700833756
Rivaroxaban51514170083355082114134171200232271303340
and550341700833169107
Amiodarone393442700834199114152192224245282321356
Increases43044270083155385106140172199234261
Bleeding45794270083365186122161176214253
in484742700831452
Patients49144270083356788104138176198226
With51544270083587496134
Atrial5303427008341628399131146
Fibrillation.54644270083324786108124393443700831530628499137176189
Ann413843700834179117
Pharmacother.427143700833572104126184216249285307346381402412
2024;58(8):761-770.469843700833569102133145180215234267285297330362393411443477510523
59.39344470085367286
Evangelista40414470083336699138178214230245272296329
EA,43924470083337691
Kaspera45044470083367097137173195229
R,475444700833650
Mokadam482644700835594126160200233292
NA,513944700834587102
et526244700833558
al.53414470083324861
Activity,5423447008342749911514816439344570083225868
inhibition,40264570083155494110151168191208247288301
and435145700833272113
induction44874570083155596135169194210250290
of480145700833859
cytochrome48834570083326793132166206228267328364
P450527145700833670104140
2J254344570083356397
in555545700831555
adult393446700833271108124146
human409746700833875133166204
primary43184670083396076134166187221
cardiomyocytes.45564670083326486124139177235266303336370394428455469
Drug504246700834567105144
Metab520446700835489111144183
Dispos.54054670083456087126164191205
2013;41(12):2087-2094.393447700833468100130141176206222253283301313348382418451469500534569605618
60.39344870085367388
Leow404148700833166104155
JWH,421548700832482128140
Ang437448700834179118
XJ,45114870083386577
Chan460648700834078111149
ECY.477348700833373110119
Development491148700834580113147163201240299334372393
and532348700833270109
verification5450487008332668710312113839344970083316486101139178
of412549700833756
a4194497008332
physiologically423949700833977108135150188204242281297329361377392424
based46764970083387198133172
pharmacokinetic486149700833978110131190222254291322338376411433448480
model535549700835795135170185
of555349700833857
dronedarone39345070083396098137173213246268306345380
and433550700833371111
its44675070083153866
active45545070083326590105138173
metabolite474850700835894117150190230246261284319
N-desbutyldronedarone:50885070083456810914517221225127430832436438642346349839345170083387192130168204216
Application417151700834180120136152184217239254292331
to452351700832159
prospective46025170083396198125164200233257273306340
simulation49635170083264199137152185207222260299
of528351700833757
complex536051700833269127167183218250
drug-drug39345270083386099138161202223262302
interaction42575270083145375109130164197221237275314
with45925270083516790128
rivaroxaban.47415270083213770103125163193227266300338352
Br511452700833557
J5192527008324
Clin52375270083405671110
Pharmacol.5367527008336741071281872203934537008331688497
2023;89(6):1873-1890.404653700833469101136148183217236270288299329360393428449480511546581594
61.39345470085366880
Leow402754700833165103154
JWH,419454700832481126139
Gu434654700834381
Y,443954700833544
Chan449554700834077109147
ECY.465554700833272109117
Investigating47855470083155283117144167182220252274289326365
the51635470083215994
relevance52695470083215570105136169207239272
of555454700833756
CYP2J2393455700834077114147173207
inhibition41555570083145290105144160183198236274
for44435570083195678
drugs45355570083385997136163
known471255700832969107158197
to492355700832158
cause499555700833164102128163
intermediate51725570083155374108129188223262278310331365
to555155700832259
high39345670083375189126
risk4072567008320356089
torsades41735670083215778104136174208234
de441956700833871
pointes.45025670083387691128148181207220
Eur47345670083326788
J4834567008323
Pharm486956700833571102123180
Sci.5061567008332637790
2023;187:106475.51635670083336698132143172202234243272303337373404436447
62.39345770085367187
Hügl403857700834482121136
B,419057700833648
Morlitz425457700835593115130145168199
M,446957700835468
Fischer45535770083324773105143178199
K,476857700833550
Kreutz48345770083355791129152182
R.503257700833650
Clinical50985770083405570108123155188204
significance53185770083264179117132150167199232270393458700833164
of401158700833655
the40795870083215993
rivaroxaban-dronedarone41855870083203668100121157187219258291328350390411447485520559590611648686720
interaction:49185870083145273106127159191215230267305317
insights5247587008315527892131168189216
from54765870083184076134
physiologically393459700833877107134148186201239278293325357373387419
based43665970083387197131171
pharmacokinetic454959700833977109130188220252288318335372407429444475
modelling.503759700835795134169184199214251290303
Eur53525970083336990
Heart545459700834479110131156
J3934607008324
Open.397360700834787123161174
2023;3(1):oead004.416260700833569102136148183201233247259297332364403439475511524
63.39346170085367287
Tang40396170083336199138
LWT,419461700833287123132
Wu434461700835794
G,445661700834357
Chan453061700834078110148
ECY.469661700833373110119
Identification48336170083145488127148163181198230263285300338376
of522761700833757
Infigratinib5301617008315537187126148181202218255271310
as393462700833258
a4011627008331
Potent40616270083357193127165187
Reversible426662700833570103137158185200239255290
Inhibitor45746270083155391106145161183220242
and483462700833270109
Mechanism-Based496162700835590122160193231246272329352389422449484523
Inactivator5502627008315538539346370083315571103136158195216
of416863700833857
CYP2J2:424363700834077114147173207219
Nascent448063700834577104136170208229
Evidence47286370083326480119153192224257
for50036370083195678
a5099637008332
Potential51496370083357294127166187202234250
In541763700831553
Vivo54886370083355284122
Metabolic393464700835490112145184223239254286
Drug-Drug423864700834567105144166213235273312
Interaction45696470083145274108129162194218234272310
with48976470083516689127
Rivaroxaban.50426470083365184117138175205238277310348362
J5422647008324
Pharmacol546464700833573105126393465700835790122159175
Exp412465700833365105
Ther.424465700833372107128138
2022;382(2):123-134.439865700833468101136148183217251268302320332362392427448479509545557
64.39346670085367489
Tian40366670083324981119
X,416866700833851
Zheng423266700833775110147186
H,443166700834457
Zhou450066700833876114152
X,466466700833852
et472866700833456
al.47976670083324760
The487066700833271106
development498966700833872104138154192231289324362383
of538566700833756
novel545466700833775107141157
cytochrome39346770083316590126159197218255314349
P450429767700833567100134
2J244466770083346093
(CYP2J2)45546770083185895131165191224242
inhibitor48116770083145290105145160183220241
and506767700833169108
the51906770083226095
underlying529967700833775114149171186218234272311
interaction39346870083155374108129162194218234272310
between42646870083397597150184220258
inhibitor45426870083155391106145161183220242
and480468700833270109
CYP2J2.493368700834077114148173207219
J5173687008324
Enzyme521768700833371100134193228
Inhib54656870083155391106145
Med393469700835490129
Chem.407869700834078113171184
2021;36(1):737-748.427869700833468101132140175210229261275287320354387405436467503516
65.39347070085367286
Mikus404070700835470100138164
G,422470700834457
Foerster430170700833269105126153176210231
KI,45527070083355164
Schaumaeker463570700833365103136173231263298329363384
M,503870700835568
et512670700833456
al.52027070083314760
Application528170700834181120136151183216238253291329
of393471700833757
a4005717008331
microdosed405171700835772104125163202240267302342
cocktail440771700833168100131155188203218
of463971700833857
34710717008334
oral47587170083385992108
factor48807170083185184108145166
Xa506071700833971
inhibitors51457170083155391106145160183220241268
to542871700832158
study55007170083265088393472700833870
drug-drug40217270083385997136158199220258297
interactions43357270083155274108129162194218234272310336
with46887270083506688127
different4831727008338537392127148182220241
perpetrator50897270083397495135171193215248269306328
drugs.54337270083386098137163177
Br393473700833557
J4006737008324
Clin40467370083395570107
Pharmacol.416973700833572105126184217249286302314
2020;86(8):1632-1641.449973700833468101135148183218237271289301331362396428449480511547577587
66.39347470085367388
Hodin403574700834482121136173
S,422174700833245
Basset42797470083356794120155177
T,446874700833341
Jacqueroux45227470083245688125162197218255292323
E,485874700833345
et491674700833456
al.49857470083314659
In505774700831452
Vitro5122747008335517395132
Comparison526674700834076134173206227242268306344
of393475700833757
the40087570083226095
Role41207570083367490125
of426275700833857
P-Glycoprotein433775700833556102118150182219258280317339373388426
and478075700833270109
Breast49077570083355690122149172
Cancer509775700833972110142176197
Resistance53127570083357097112138161194232264298
Protein39347670083355592114147162200
on414676700833776
Direct42347670083456181115148171
Oral441876700834768101116
Anticoagulants454776700834178100115146183216254292307339376398425
Disposition.49857670083456086124163189204226241279317330
Eur53287670083326889
J5430767008324
Drug546776700834566104143
Metab393477700835490112145184
Pharmacokinet.413377700833573105126185217249286317333371406428442
2018;43(2):183-191.459077700833468100131143178210229262280292322353387409440470502511