724
www.klinickafarmakologie.cz340804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/26878040010732
Klin276480400107446583131
Farmakol2915804001074279105179220258305325
Farm.3260804001074178105179195
2025;39(1):34-433475804001074487128172185229271295335352367411456485531572
/40928040010732
KLINICKÁ4170804001074588109168189242288346
FARMAKOLOGIE4538804001074191138210265312372415474533554598
A51578040010753
FARMACIE5231804001074292139211266317337381
4356558020012657115
HLAVNÍ4945200012671127198263336370
TÉMA5337200012657114204274
Lékové41053600106296197136173205
interakce43263600106155688121156198234266298
DOAC464036001063879117151
a4806360010638
protizáchvatových486036001063368109139157190231264306344381409448485524556598
léků54733600106296197138
24.343660085356984
Chin439670083397691128
PKL,5796700833468100113
Wright704670083577792130167187
DFB,9046700834476111123
Zhang10396700833774105142181
M,12326700835366
et13106700833455
al.1377670083324659
Correlation1448670083397596117150166197218233270307
between1767670083387395147180215252
trough343770083224380118157195
plasma556770083385486113171203
dabigatran7767700833871110125164196218240273311
concentrations11047700833168106139172210232253286308323361400426
and15477700833270109
estimates1673770083346184100157190211245272
of19627700833857
glomerular343870083385391149184206244259291312
filtration6688700831734497193126147163201239
rate920870083215375109
based1042870083387198133172
on12278700833776
creatinine1316870083315286118140155193208245280
and16098700833270109
cystatin1731870083316491115147169184222
C.19668700834053
Drugs3439700834567105144170
R52997008335
D.5799700834657
2014;14(2):113-123.6519700833469100131143173204224258276288317345375397428458492505
25.3431060085367287
King4481070083355189128
PK,5941070083357085
Stump6971070083325391149188
TA,9031070083337084
Walkama100510700835789104134167225257
AM,128010700834197110
et140810700833457
al.14831070083314760
Management156110700835487125157196231289324362383
of196210700833857
Phenobarbital34311700833573109147186226259280320336359392408
and77111700833271110
Apixaban9021170083418197128161201234272
Interaction11951170083155375109131164196221236275314
in152911700831553
Recurrent160311700833671104142164186220258280
Cardioembolic190411700834073953431270083385391127185224263279294326
Stroke.6841270083325375112143177189
Ann88812700834180118
Pharmacother.102112700833572105126184217249286308346381402412
2018;52(6):605-606.144912700833468100131143178211229262280292327363397419456492527541
26.3431360085367187
Dagan44713700834578117149187
G,65113700834457
Perlman7261370083356889105163195233
A,97713700834155
Hochberg-Klein104913700834482115153192228249287309346363397413451
S,151713700833245
et157913700833457
al.16531370083324760
Managing173013700835587125158197212250289
Direct3431470083456081115147171
Oral52614700834768101116
Anticoagulants65414700834179100115146183215254291306338375397424
in109014700831552
Patients11551470083356688103137174196223
With13901470083577395133
Antiepileptic153514700834179100115149188203218253291313328360
Medication.1907147008354893431570083385385118140155193232245
Can60315700834073111
J729157008324
Cardiol.7691570083407294132147185201214
2018;34(11):153.4e1-1534.e3.99815700833468100131143178214233265292307319349379412424459494524543574604637672685719754766
27.3431660085367180
Eyal4371670083336497112
S,56416700833245
Lamb62416700833165122162
JG,8001670083256983
Smith-Yockman89716700833390106128166189221255288318377410448
M,135916700835568
et144216700833456
al.15131670083324760
The158816700833272107
antiepileptic170916700833270921071421811972122472863431770083223769
and42817700833270109
anticancer5531770083316991106138171209241275296
agent,86517700833271106144165179
valproic10591770083326580119141178194226
acid,13001770083326479118131
induces14471770083155291129161195222
P-glycoprotein168517700833556961121431752122512733103431870083225571108
in46718700831552
human53518700833875133165203
tumour75418700832159117156194215
cell984187008332658196
lines10961870083142967102129
and124118700833169108
in136518700831553
rat14331870083215475
liver.1524187008315306297118128
Br166818700833556
J1740187008324
Pharmacol.178018700833572105126184216343197008331688497
2006;149(3):250-260.45519700833469105140153183214247266300317329364399433457488521557569
28.3432060085367288
Červený4492070083407495130164202233
L,70020700833145
Švecová7632070083326397130167199231
L,101320700833145
Anzenbacherová107620700834179108142180219252285323358379416448481
E,157520700833346
et163920700833456
al.17132070083324760
Valproic17912070083366782121143180196228
acid3432170083326479118
induces4762170083155392130162195222
CYP3A471421700834077113147187222
and95121700833270109
MDR11075217008355101137170
gene126021700833873111146
expression142221700833365105126160187214228266305
by174221700833970
activation182821700833164881031361693432270083223775113
of46922700833857
constitutive53922700833168106133156171194232254269302336
androstane88822700833270109130167194217250288323
receptor12242270083215587121160182219241
and147822700833270109
pregnane16002270083386094133171204242277
X1890227008338
receptor19412270083215534323700833165104126163185
pathways.5422370083387193131182214245272286
Drug84223700834567105144
Metab100023700835489112145184
Dispos.11982370083456087125164191205
2007;35(7):141723700833468104137146181214232267286298
1032-1041.17292370083346599131151182214250280290
29.3432460085357082
Olaizola4362470083466192106133169184215
I,66124700831526
Brodde6982470083355591129166200
MF,9082470083548690
Kehrel100924700833567104124156171
BE,11902470083356779
Evers12802470083326295115141
S.143224700833244
The148624700833270104
Impact160024700831571109140171193
of180424700833755
Levetiracetam18702470083316394127343257008321365687118151172204260
and61425700833168106
Valproate7312570083356580117138174206226259
on100125700833774
Platelet10862570083354879100133147181202
Functions-A129925700833267104135158172209246271291331
Double-Blind,164125700834582119157172205227263278292328366378
Placebo-Controlled3432670083354879110142180218240281317354374394430445459492530
Crossover8842670083406095121146183214247267
Study.11612670083335289127157166
J1338267008324
Clin13732670083395367104
Med.148826700835387125137
2023;12(3):933.16362670083346798132142171199216248264275308340371383
30.3432760085367287
Langenbruch44827700833165103142177215254276314346384
L,85027700833145
Meuth91327700835489127150188
SG,11192770083327790
Wiendl122727700835774108146185201
H,144627700834457
et152027700833457
al.15952770083314760
Clinically16732770083405570108123155187203218250
relevant1941277008320543432870083155082115153174
interaction5342870083155274108129162194218234271310
of86028700833857
rivaroxaban9332870083213769102123161191224263296334
and128328700833270109
valproic14092870083316479118140177193225
acid16502870083326479118
–1784287008335
A1836287008341
case18932870083316491126
report.3432970083215594133154179192
Seizure.5512970083326782111150171205217
2020;80:46-47.78329700833569102136148184219232266303326363395401
31.3433060085366982
SPC44530700833368108
ČR:5743070083407689
Depakine68430700834581120153183200238273
Chrono®97830700834078991361752131191306008529
(kyselina12413070083194983111146161176214247
valproová),15093070083316480119141178217249282301312
Sanofi184230700833265103142160177
s.r.o.,343317008326406273111124137
7/2024.5013170083345490124157189202
[Internet].724317008319357395129150189225247265277
Available102231700834172105121136169208224260
from:13023170083194179138150
https://sukl.gov.cz/14733170083385984124151164191211236274304321334373412444454486517546
verejnost/leciva/.3433270083326687121136174213239263290306341374389422454481487
32.3433360085377389
SPC45333700833369111
ČR:5853370083417892
Xarelto®6983370083397395130146169207236
(rivaroxaban),955337008319395689123145184215249289323362380392
Bayer136933700833670102137159
Pharma,155033700833674107129190223237
9/2024.18083370083355995130164197210
[Internet].343347008319347394128149188223246263275
Available63934700834171104120135167207223258
from:9173470083184178137149
https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_cs.pdf.10863470083386084124150163190210262315369380415473505518553591613650690723736771809835871909343357008331701281632022242522783163383754154534865105305475856046426647237567787938328708979289619821017103310551093111611531193122612471267130813301367140714451478150215221538157715961634165634336700835790111127165203240273301314354394413425
33.3433760085377489
SPC45437700833370112
ČR:5883770083417892
Keppra70237700833672113154176211
(levetiracetam),9353770083193672106141165181203238271306330364424442454
UCB141137700834588125
Pharma155837700833675108131191225
1/2025.18053770083355894130164201214
[Internet].343387008319357395129151190225248266278
Available64238700834172105120136169208224260
from:9223870083194179138150
https://www.ema.europa.eu/cs/10933870083386085124152164191212264318372383418477509523558596618655695729742778816842872900926
documents/product-information/keppra-epar-product-information_cs.pdf.3433970083387711014820624128030132935539341545249253056258760762366168071874079883185386890794597210031037107711171139117211941231127113041325134513851407144514841522155515791599161516533434070083185678136168190205243282319352380393433473492503
34.2138660085367388
Mavri22406700835487118140156
A,24096700834155
Ilc2477670083153062
S.25526700833246
The26116700833271106
efficacy273067008334537188120153185219
of29626700833756
direct3031670083395475109141166
oral3210670083375891107
anticoagulants3330670083316991106138175208247285300332370392419
in37626700831553
patients2138770083397293109143181203231
on23887700833776
concomitant24837700833168106139176234249271304342364
treatment2866770083224377109131189224262284
with3169770083506688127
levetiracetam.3315770083155082116138154175208240274296329387400
Sci3734770083336580
Rep.21388700833570110122
2023;13(1):9257.22758700833569102136148178208226258272284319352387420427
35.2138960085367186
Giner-Soriano2245970083445998133154174206244266282314352391
M,26569700835569
Marsal27459700835588109136170185
JR,2951970083246074
Gomez-Lumbreras30469700834483142177207228262299357397418453474507534
A,36019700834155
et36779700833456
al.3754970083324760
Risk21381070083355177107
of225910700833857
ischaemic23311070083144073111143178236251283
stroke26281070083265071108139173
associated28161070083315884123155171203224258298
with31281070083516689127
antiepileptic32691070083327092107142181197212247286308323355
drugs:36391070083385997136162175
a2138117008332
population-based219111700833979119158174207229245284323346387420447483523
case-control27351170083326593128152186224263285307345361
study31171170083275189129162
in330011700831453
Catalonia.33741170083417496130146184224239272285
BMC368011700833692134
Neurol.213812700834580117139176192205
2021;21(1):208.235812700833468101133141176207222254268280315350385398
36.21381360085367288
Sáez-Torres224313700833265100130152182216237259293320
de257913700833873
Vicente26681370083365284118156178211
M,289613700835467
Puig29801370083357287126
PM,312213700833589102
Toresano32411370083326688122149182220258
LV,35151370083326473
et360413700833456
al.36771370083314760
Ischemic375313700831541213814700833271107166182215
stroke23741470083275073111142177
due257314700833877113
to270714700832260
possible278814700834080107135150190207242
interaction30521470083155376110132166199224240279319
of339214700833858
rivaroxaban34711470083213771105126165196229270304343
with21381570083516689127
primidone22831570083386076133148187225264299
in260015700831552
a2670157008332
patient27201570083397294109144182203
with29411570083516689127
atrial3086157008332537590122138
fibrillation.3242157008317347394110125140172194209247286299
Med355915700835590129
Clin37061570083405570108
(Barc)21381670083195487108140158
2021;156(5):255-256.231116700833569101133141171201236255288307318354388421443474509543556
37.21381760085367078
Manis222917700835486124138164
MM,2406177008354108121
Petersen25401770083356890123144171205243
K,279517700833549
Roberts285717700833573112147168192219
MZ,308917700835492105
Kyle32061770083356479114
JA.33321770083246478
Managing342317700835486123155194208246284
the37201770083215994
Drug-Drug213818700834566104142164210231269307
Interaction24571870083155273107127160191215230267305
With27741870083577395132
Apixaban29181870083417995125157196228265
and319618700833169107
Primidone:33151870083355570127142180217255290302
A3629187008341
Case36821870083397298132
report.21381970083215594133154179192
Hosp234619700834482109148
Pharm.250919700833573105126184198
2023;58(4):345-349.272219700833468101136147183217236269286298333369401423456491524535
38.21382060085367288
Andreasen224420700834179118139173205232267305
A,256620700834156
Brosen26392070083355794121156194
K,285020700833550
Damkier291820700834577135165181216237
P.317320700833540
A3231207008341
comparative328920700833268127166199220253275290323357
pharmacokinetic366320700833978110131213821700835790122159189206244279301316348
study25012170083264987126158
in267321700831553
healthy274021700833873105120142181211
volunteers29662170083316985122160182216251272299
of328021700833756
the33512170083216095
effect34602170083345473107140164
of363821700833757
carbamazepine37092170083316485213822700833972129162191225265280318353
and250722700833169109
oxcarbazepine26312270083376899132153192225255289328344382417
on306322700833876
cyp3a4.315522700833164104138170205218
Epilepsia.33882270083337287103137177203218250264
2007;366722700833468104137147
48(3):490-496.21382370083347089123140152186219255279316349384397
39.21382460085357083
Serra22342470083326687108140
W,238724700835665
Calzi24652470083397186114129
ML,26072470083538598
Coruzzi27172470083397697134163193208
P.293824700833439
Left29892470083316583107
Atrial3109247008340618297128143
Appendage326424700834079118152190228259298332
Thrombosis36082470083327191128185213825700833876103117143
During229325700834583104119156194
Therapy250025700833271105126158197228
with27402570083506587125
Rivaroxaban28772570083355183115136172202234273305343
in323225700831552
Elective32962570083334782114138152184218
Cardioversion3527257008339719213014418221324726821382670083264178116
for22672670083185577
Permanent23562670083356889147179217251289310
Atrial2679267008341618398130145
Fibrillation.28362670083334786107123138152184206221258296309
Clin31582670083405569107
Pract.32772670083355688120144157
2015;5(3):788.34472670083346799128139174191224241253286319354367
40.21382760085367590
Robinson225027700833675115131170196235275
ZS,25462770083387285
Arvin26522770083426499115154
JP,28272770083246165
Madding291327700835689128168184222262
KL,31962770083356983
et330027700833457
al.33782770083324861
Rivaroxaban34602770083365285119140178209243282316355
Failure2138287008333627893131152187
in234528700831553
a2419287008332
Patient24712870083366890105140179201
Taking26922870083336192108146186
Oxcarbazepine.289828700834880111144166206239269303343358397432444
Ann336328700834180118
Pharmacother.35022870083357310512718621825128821382970083226095116126
2021;55(10):1302-1303.228029700833468101132141176208226257289307319349379413446467497527562595608
41.21383060085366880
SPC223230700833267107
ČR:23523070083407589
Diacomit®245330700834661931251612192342572711306008529
(spiripentol),2753307008318448398119135173209247268305321340351
Biocodex,31173070083355088121157197231263276
7/202434063070083345489123155187
https://36063070083375983122149161188208
www.ema.europa.eu/cs/documents/product-information/213831700835110415816920426229530834338140244047951352656159962565468270874478281585391194798510071034106010981120115711971235126712911311132713661385142214441503153515571573161116501676
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42.21383360085367086
Kerr22423370083356990112
BM,237233700833590103
Martinez-Lage249333700835487108133148186221250272305339378412
JM,29233370083247992
Viteri30333370083355274108129145
C,319533700834053
et326633700833456
al.33393370083324860
Carbamazepine34173370083407394133166224257286320359375213834700833874
dose223334700833877104140
requirements23943470083215595134149171205264300339361389
during28043470083387798114153192
stiripentol3017347008327506688104143179218240278294
therapy:33323470083226196118152191223237
influence3590347008315537189127162201213835700833267
of222635700833859
cytochrome23063570083326792131164204226264324360
P-45026883570083365896130165
inhibition28743570083155494109150166189206245284
by318035700834072
stiripentol.3273357008327516789106146183222244283299313
Epilepsia.360735700833474901061421832138367008326417386
1991;32(2):267-274.22403670083346499131139175207224258276288323357390408439472503515
43.21383760085366982
SPC223137700833265104
ČR:23453770083397385
Fycompa24393770083326191126182220251
(perampanel),26993770083195690110141197234265301334348366375
Eisai30843770083334670102115
5/2023.32093770083345689121152185196
[Internet].3415377008318326888120139176209230245256
Available36803770083417010111421383870083154785100135
from:22913870083194077135146
https://www.ema.europa.eu/cs/documents/product-information/fycompa-epar-product-information_cs.pdf.2455387008338598312214815918520525630936237240646449550854257960063667570872075479281784587289793297010021039109711311169119012171242127913001336213839700833874105128146161197215251271328359379393430467491509542572608665703734755790828860879898936956992103010671097112011381153118912071243126313201351137213861422145914951526155315651603164216601670
44.21384060085357184
SPC223240700833264102
ČR:23434070083407384
Inovelon®243640700831550861151471611962322666406008529
(rufinamid),2704407008318357187104139169224237273291300
Eisai3013407008332456899112
GmbH,313440700834399135178189
12/2023.33324070083336185118149180212223
[Internet].3564407008318326786118137173205226241251
Available3934670083406899112125155191205238
from:4181670083183872128138
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C,43988700834155
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Schneider48408700833367108148185201243280302
B.51728700833651
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drugs4579970083396098137163
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direct4884970083385374109141165
oral5066970083375992107
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prevention.49151070083396195127162200221237275313327
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Opin546910700834787103141
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SA,42581270083337488
Kwak436012700833484117147
C,452112700834053
Kamin458712700833569126142179
M,478012700835468
et486112700833457
al.49311270083324760
Effect50051270083335271105138162
of518012700833857
cenobamate525012700833265103142181214272304326360
on393413700833776
the40251370083226095
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pharmacokinetics448313700833877109130189221253290321337375410432447479507
of500613700833756
multiple507813700835795110132148187203237
cytochrome53311370083316589126159197218255393414700835792
P450404714700833567100134
probes42011470083396098137173199
using44211470083376378116155
a4596147008332
cocktail464814700833268101131156189204219
approach488714700833271111132170203235273
in518014700831553
healthy525314700833772104120142180211
subjects.54841470083266310339341570083155082107134148
Clin40971570083405570108
Transl42201570083335083121147163
Sci.4398157008333658093
2022;15(4):899-911.450615700833468101136148179209226259277289323358393417451483511521
47.39341660085366978
SPC402516700833266107
ČR:41441670083407588
Ontozry®4244167008347851061421701912254471166008529
(cenobamát),45121670083184881119156195228285317338357368
Angelini489216700834178117151166181218233
Pharma,513816700833471103124182213226
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from:45131770083194179138150
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48.39342060085367490
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S,424620700833245
Zamarripa431120700833871129161183204220259292
CA,46242070083398296
Spindle47412070083327187125164179214
TR,49752070083337084
et507920700833456
al.51562070083324760
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of555320700833756
Cytochrome39342170083416995132166205227265324360
P450-Mediated431621700833568102137161218254295311343366400441
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Ther.531122700833372107128138
2023;546322700833468101136147
114(3):693-703.39342370083346293112146163175210244277299330363397409
49.39342460085367184
SPC403124700833267107
ČR:41512470083397588
Epidyolex®425224700833271861241561932092442754529246008529
(kanabidiol),45712470083184982120152191206244259297313332343
9/2024.49272470083345791125158189202
Jazz51412470083245686117
Pharmaceuticals52702470083357210412518321524728131839342570083213668100115141
Ireland.4087257008315356984116153192204
[Internet].4304257008318347192125146184219240257269
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from:48512570083183976134145
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Martin404028700835487108133148186
P,424428700833540
Czerwinski430228700834071105126179195233259289305
M,462628700835468
Limaye471228700833147104137167202
PB,49322870083357083
et503328700833456
al.51082870083314760
In518628700831553
vitro5257287008331477091128
evaluation5404287008334669911415218439342970083223775113
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fenfluramine43332970083185290108125162184217274289327362
and471129700833270109
norfenfluramine48352970083387698119154192209226264285318376391429464
are53142970083325387
unlikely54172970083377590105135170393430700831547
to399530700832158
act40673070083326489
as417030700833158
perpetrators42423070083397496135171193215248269306328355
of461130700833857
drug46823070083385997136
interactions.48333070083145274107129162194218233271310336350
Pharmacol519730700833572105126184217249286302
Res55133070083357097
Perspect.39343170083356990117156192224248262
2022;10(3):e00959.421131700833468101136148178210229263280292327362398433468500511
51.39343260085377285
SPC404232700833370112
ČR:41773270083417892
Fintepla®429232700833449891121471882052394531326008530
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UCB499932700834588125
Pharma514632700833776109132193226
8/2024.53953270083356298134168202215
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from:45133370083194179138150
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M,440136700835467
Carnoy44813670083407293131169200
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drugs48793770083375895132158
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