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měchýře534736001065283118159197233265
LITERATURA34457001234978134189250318368438498567
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Broďák402740083355692131162192
M.6067400835467
Léčiva686740083306496110142174
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2018:677-690.10679400833468100131144179212246265302336372384
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Oefelein41510400834783102136152187202240
MG.Safety67610400835499113147180199234256290
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profiles14421040083396198116133148183210
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agents53811400833271105144165193
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Drug34312400834567105144
Saf5031240083326584
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M,61713400835467
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J.99413400832537
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a1691134008332
kumulace174213400833068126163179211243277
jejich343144008315506580112150
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účinků8971440083387085123153191
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Med.140414400835590129142
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2020;17(3):173214400833468101135148178208224258275287
182-189.3431540083346599119150181215226
4.34316400853651
Boustani40616400833573111137160193230245
MA,66416400835496110
Campbell78616400834073130169208243259274
NL,10721640083457690
Munger117516400835491129168202223
S,141116400833245
et146916400833355
al.15371640083324760
Impact160916400831572111144176200
of182116400833756
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a714174008332
review7591740083215587103137188
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Aging16861740083417994132171
Health.1870174008344791111273431840083226073
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Richardson4041940083355081117149169206232269306
K,72219400833448
Fox7821940083326898
C,89219400833951
Maidment95519400835485100137194228265285
I,125219400831527
et129119400833355
al.13581940083314658
Anticholinergic14281940083407798113143180218233247284318338375390421
drugs18611940083375795133158
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of56720400833655
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case-control9292040083316389124146180216254275296333349
study.12902040083264986125156166
BMJ.146920400833589114127
2018;361:k1315.16082040083346899130141176210240248278309339369399411
6.34321400853550
Kay4052140083346797
G,51321400834356
Crook5812140083395995133163
T,75621400833140
Rekeda8082140083346898131169200
L,102021400833144
et107621400833354
al.11422140083324658
Differential1212214008345607997130151184221242256287302
effects15262140083335270104135158185
of172321400833755
the17902140083215892
antimuscarinic1894214008331688910334322400835794120152184205220257272304
agents65922400833270105142163191
darifenacin8622240083387091106125159196228260275312
and118722400833169107
oxybutynin130722400833766100139177199232270285323
ER164222400833267
on172222400833775
memory18092240083579214918734323400832155
in41323400831553
older4812340083375392127148
subjects.64423400832664103118153186210238251
Eur9112340083326990
Urol101623400834465102118
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Coupland40724400834077115154170202240279
CA,7062440083398296
Trevor-Hill,8212440083335084117154176195241256272287299
Dening113924400834681119134172211
T,136924400833342
et143024400833456
al.15052440083324760
Anticholinergic158424400834180101116148186225241256293328350388403435
drug3432540083385998137
exposure49325400833466105144171208229263
and77025400833170109
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dementia.117625400833973131166205226241273287
A1476254008341
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JAMA63826400832464120162
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Med.99826400835590129142
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Rube41227400833573112148
TE,5782740083326679
Scorcheville67527400833365102123155192227260276291306341
A,103327400834155
Londos110627400833269107146185211
E,133527400833346
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the3432840083226095
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scale13672840083265891106141
(Swe-ABS).152328400831950100135158199235267286297
Drugs.183528400834567105144170184
2023;83(4):315-340.34329400833468101136147183217235268285297332363393415447483519531
9.34330400853751
Bishara4153040083365279118151173207
D,64430400834657
Perera7233040083367092127149183
G,92730400834559
Harwood100830400834578100155194233274
D,130430400834657
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Acting182430400834275100115154195
Anticholinergic34331400834281104120153192231248264303339361400416449
Drugs81331400834769109149176
Used101131400834471107148
for11803140083195880
Urinary12823140083446682122155177212
Conditions151531400834179119159175198214254293321
Associated185731400834271981383433240083324780102137177
with5423240083516790129
Worse69232400835996118146182
Outcomes89532400834887110142179239275302
in121832400831554
Dementia.129332400834682141177216238254287301
J1615324008324
Am1661324008341100
Med178332400835591131
Dir19353240083466284
Assoc.3433340083416995134166180
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10.3433440085367085
Matta44634400835487109133166
R,63134400833549
Gomes69934400834482141176203
T,92034400833342
Juurlink9813440083246299121136151189219
D,121934400834656
et129434400833457
al.13693440083324861
Receipt144834400833671103137152191213
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Overactive17563440083478011513616920122524034335400833266
Bladder4263540083355183122161196217
Drugs66035400834567105144170
and84735400833270109
Incident9733540083155385100139174212233
Dementia:122335400834581139174212233249281293
A1533354008341
Population-based15903540083367211215016519821923527331133337340634336400832661101
Case-control4593640083407299134157191228266288309346362
Study.8363640083335492131163173
Eur10243640083326990
Urol112936400834465102118
Focus.126236400833269102140166180
2022;8(5):1433-1440.145736400833468101136148183202236254266296327360393414445476513549562
11.3433740085376982
Özmen44837400834879140177217
N,68937400834660
Yiginer7733740083365394110150186209
Ö,100637400834860
Ün109037400834585
H,119937400834559
Bicakci12823740083365386121152185201
B.150737400833751
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occurring1926374008338723433840083316990112128165204
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de82138400833873
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patient16203840083397294109144182203
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solifenacin193138400832665343394008315305084123155188203241
therapy6053940083226095117150190221
and84739400833270109
management97739400835890129161201236294330368390
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Anatol165139400834180112134172188
J1859394008325
Cardiol.190439400834073953434040083385391107120
2015;15(4):342-3.47840400833569100130141171201219252269281316352384405437450
12.3434140085366883
Asajima43941400834169102117132190222
H,67441400834457
Sekiguchi7444140083326797114152190222260275
Y,103241400833543
Matsushima108841400835587109136174200238253310342
S,144341400833346
et150241400833356
al.15714140083314760
QT164441400834679
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and46842400833269108
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de81442400833873
pointes8994240083397793130152185212
associated11234240083325884122155170201223256296
with14314240083516688126
solifenacin1570424008326647994113147185217249264302
in188442400831552
an194942400833269
81-year-old3434340083346685117151183204224263279318
woman.67543400835088146179217230
Br91843400833657
J989434008324
Clin10264340083405570108
Pharmacol.114843400833572104126184216249286301314
2008;66(6):896-897.147643400833468104140152188223242275294305340375410434469504537543
13.3434440085366883
DrugBank®.43944400834567105144180213251281722444008529749444008312
DB0670277444400834582117153186219252
[Internet].1039444008318347293127148187222244262273
[cited1325444008319496487120160
2025149844400833468101136
Feb164744400833266105
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RL,7044640083356881
Heise8034640083448095121156
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CredibleMeds®;4924740083416398138154194211247303339380407899474008530929474008312
Tucson,96347400833367100129168208221
AZ,12054740083428397
AZCERT;132347400834283122155192227235
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www.CredibleMeds.org343484008351104157168208229263302317357372407462498537563577615637675
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Suchopár43849400833269101139177216249270
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17.3435440085377079
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DB,6155440083478498
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MB,97454400835694107
Bedigian110354400833673114130171187220260
MP,13845440083569499
et150454400833559
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QT166954400834882
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muscarinic68956400835998126159194216232272288321
M3103256400835692
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J1581574008325
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18.3435940085366985
Breuel4405940083355790128163178
HP,6315940083448084
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G,90959400834457
Bondy97959400833573112151182
S,117459400833345
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1993;43(4):461-464.23777400833565100133144179211230263280292326362393411448484520533
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F,24898400833340
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M,27828400835570
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C.31068400834155
The31828400833474111
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J,254612400832537
et260412400833558
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J,235813400832436
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B.265414400833548
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K,309515400833550
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PJ.34771540083355567
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Eur37241740083326990
J2138184008324
Clin21771840083405671108
Pharmacol.230118400833572105126184217249286302314
1997;52(5):403-406.26311840083346499132142177210228261280291326362395417453489525538
22.21381940085367288
Swart223919400833282114135160
PJ,24121940083355466
Krauwinkel24901940083355790127178194231261295311
WJJ,281419400835778102114
Smulders294019400833390127142181216237264
RA,32171940083357791
et332119400833456
al.33901940083324759
Pharmacokinetic34621940083357210412518421624828431533121382040083387395110142
effect22932040083345473107140164
of247020400833757
ketoconazole25402040083306486123156193231263293330346381
on293420400833776
solifenacin3023204008326648095115149187219252267305
in334120400831452
healthy340720400833772104119142180211
volunteers.3631204008331698512216021382140083225591112139153
Basic23062140083366995110142
Clin24632140083405570108
Pharmacol258621400833673105126185217249286302
Toxicol29042140083326696112144181197
2006;99(1):33-36.311621400833468104140153188223242274289300336369390423457471
23.21382240085367287
Abebe224222400834180116155191
BT,24492240083356877
Weiss254222400835891106132159
M,271622400835568
Modess280022400835593133168194221
C,303722400834053
et310622400833456
al.31782240083324760
Effects32542240083325170105137161189
of345922400833757
the35312240083226095
P-Glycoprotein364222400833556103119151213823400833168108129167188222237275
Inhibitor24272340083155391106145161183220241
Clarithromycin26822340083405588109124147185206243302332364379417
on311323400833775
the32022340083226095
Pharmacokinetics331123400833572104126184216249286316333370405428443475503
of213824400833757
Intravenous2208244008315537496129160195233271309335
and255724400833270109
Oral267924400834769102118
Trospium28102440083335087114153168206264
Chloride:30872440083407893132153169208242255
A3356244008340
4-Way341024400833457115146177
Crossover3601244008340619812515118921382540083326687
Drug-Drug224325400834567105144167214235274313
Interaction25742540083155374108129162194218234272310
Study29022540083335492131163
in308325400831452
Healthy315325400834479111126149187218
Subjects.338925400833269109124159192216243257
J3664254008324
Clin37062540083405570108
Pharmacol.213826400833573105126184217249286302315
2019;59(10):1319-1330.246826400833468100130143178210230261293311323353383414444468498528561596608
24.21382740085377390
Astellas22502740083427196131147163197225
Pharma249727400833675109131192225
US,27442740083457992
Inc.28582740083155589103
Vesicare®298327400833670991141481822042403223274008530
(solifenacin)32752740083194686103119139175215248282298337356
–3653274008336
Full37112740083337187103
prescribing21382840083406398126160182199240256296336
information24962840083155575114137197231254270310350
[Internet].2868284008319367598133155196232256274287
2020317728400833571105141
May334028400835690122
[cited3484284008319506690125166
2025367228400833571105142
Feb213829400833368108
25].22672940083357191104
Available239229400834273107123138171212228264
from:26772940083194280140152
https://www.accessdata.fda.gov/28512940083386085125153166194215267322376388422456487522549577617650673706720740780813827867906939963
drugsatfda_docs/label/2020/021518s017lbl.pdf.213830400833859981371631962182392773103473874254584855115275605996346506767117457788128368709039349649951026105210871119114811631202121812311271131013301341
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AbbVie224431400834180120155171206
Inc.2468314008315538598
Enablex®2585314008332701021421581922242811314008529
(darifenacin)28583140083195688109125144178216249281296334351
–3228314008335
Full3281314008332698499
prescribing33993140083386094121153174190229244282321
information37393140083145221383240083185678137169191206245283
[Internet].2442324008318347294128149188223246263275
2021273832400833468101133
Jul28913240083256378
[cited2989324008319496487121161
2025317032400833469102137
Feb332732400833367106
25.34543240083346981
Available355632400834171105120135167207223258
from:21383340083194281141154
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a2981344008333
Clinical30343440083415672110125158191207
Pharmacology326234400833573106128187220252290306345385417
Biopharmaceutics37003440083365290213835400834080114136197230264299338362378412441
Review260035400833773107124160213
https://www.accessdata.fda.gov/28353540083396187128156169197219272327383394429463495530559586627661684718732753793827841881921954979
drugsatfda_docs/nda/2004/21-513_Enablex_biopharmr.pdf.2138364008338589513415919121223327030233837741544647349853457260462966369773276779282685687590893896710031037107411051143115911931223126013001315135213911429146014811538155915681607164616651676
26.21383740085377491
Malhotra225537400835690107147187210233268
B,254837400833751
Sachse262437400833468102142170207
R,285637400833752
Wood293437400835997138179
N.313937400834660
Evaluation322537400833467102119158192215232271312
of356237400833959
drug-364737400833962102143167
-drug21383840083216486126167
interactions23273840083155477112135169203228244284324352
with27013840083526892132
fesoterodine.28553840083195583123146181204243284300339376389
Eur32663840083347294
J3382384008325
Clin34293840083425874113
Pharmacol.3564384008337761091321922262138394008331688497
2009;65(6):551-560.225039400833469105140153188222240273291303338371402421455489524537
27.21384040085367180
Salahudeen22394040083336681113151189228263299337
MS,259640400835588101
Duffull271740400834684104123162177192
SB,29294040083336881
Nishtala30304040083456086124146179194226
PS.32774040083356881
Anticholinergic337940400834179101116148186225240255293329350388403435
burden21384140083397798136171209
quantified236641400833876108146167183200217252292
by267641400833970
anticholinergic27654140083327092107139177215231246284319340378393425
risk3209414008321366392
scales33204140083265991107142169
and350741400833270109
adverse363541400833271104138159213842400832661
outcomes22154240083387698129166224259286
in251742400831553
older25864240083375392127148
people:275042400833975113153169204216
a2982424008332
systematic30304240083275986109143201233255270302
review.33494240083205487102137188199
BMC356442400833691131
Geriatr.3711424008344802138434008321366991112123
2015;15:31.228143400833469101131142172202213249280289
https://bmcgeriatr.biomedcentral.com/259143400833859841231501631902102513093423804154364524845065275385785946326917267667988328708929139479629751007104411031129
articles/10.1186/s12877–015–0029–9.3741434008332532138444008322376984119146172205236249280307338374399423453483517550584617654686716752789825858892930964975
28.21384540085357186
Rosa22374540083357299131
GM,238045400834397110
Ferrero25034540083326586107140161197
S,271345400833244
Nitti27694540083445981105120
VW,290145400833595105
et301845400833355
al.30854540083324759
Cardiovascular31564540083407293130145182213246271303340355386407
Safety35754540083326583117139172
of375945400833755
β3-adrenoceptor21384640083387193125164184218256294326360398420457478
Agonists262946400834078116154169195218245
for28874640083185577
the29764640083226094
Treatment30834640083324983115136194228266287
of338346400833756
Patients34524640083356688103137175196224
with36884640083506688126
Overactive213847400834780115136169201225241273307
Bladder24614740083355183122161196217
Syndrome.269447400833262101140161198256291304
Eur30134740083326990
Urol.311847400834465102118131
2016;69(2):311-323.326547400833468100131143179213232266284296331362389408441473508520
29.21384840085367285
Park22434840083356788119
JS,23814840083245668
Choi246848400834078116132
SB,26184840083336881
Jang27174840083245795134
WS,286948400835891104
et299248400833356
al.30674840083314760
Risks31454840083365177107136
of330048400833756
Dementia337548400834681139174212233249281
After36754840083405984118139
Treatment21384940083335084116137196231269290
with24444940083516689127
an258749400833270
Anticholinergic,267249400834180101116148186225241256293328350388403435448
Beta-331364940083357093125148180
Agonist,333249400834179118156171197220234
or358149400833859
Combination36564940083407713521385040083385391122144159196234
of238450400833756
Both24525040083357394132
for25965040083185576
an268550400833169
Overactive276650400834679113134166198221236268302
Bladder:30805040083355182121159193214227
A3320504008340
Korean33735040083347192126157194
National35805040083447697112149187219234
Cohort213851400834077115154175200
Study.23535140083335492131163173
Eur25415140083336990
Urol264751400834464102118
Focus.278051400833270102140166180
2024;10(2):306-314.297551400833469101133145175207226260278290325360395419451482513526
30.21385240085367287
Malik224652400835487102117147
M,241452400835467
van250252400833164102
Gelderen26255240083437994133168189223261
EM,290752400833287101
Lee302852400833266101
JH,31495240083246982
et325152400833457
al.33285240083324760
Proarrhythmic34085240083355693126147169208238263301359374406
safety21385340083266080115138172
of233153400833857
repeat24095340083215696132165187
doses261753400833877105140168
of280653400833757
mirabegron28845340083587495129169205245267305344
in324953400831553
healthy332353400833874106122145184215
subjects:355953400832765104120156189214242255
a2138544008331
randomized,21825440083205390129166224238267301340352
double-blind,254654400833876113152167202224264279294331369382
placebo-,29405440083395486117150189227250262
and321454400833269108
active-controlled33345440083326387102134168190223260298319340376392407441480
thorough21385540083226098119157195234272
QT242355400834779
study.25155540083264987126158168
Clin26965540083405570107
Pharmacol281655400833673105126185217249286302
Ther.313155400833271106128138
2012;92(6):696-706.328255400833468100130142177210228261279291326360395419450483519532
31.21385640085366879
Yamaguchi222956400833564120152190227258295309
O,255056400834657
Kakizaki26185640083356797112140173202218
H,284756400834456
Homma291556400834481138195226
Y,315356400833542
et320756400833455
al.32735640083324759
Safety33435640083326482116137170
and352556400833168106
efficacy3643564008334516987118150213857400833164
of221557400833755
mirabegron22835740083577292124163198237257294331
as262757400833258
‚add-on‘26975740083124684123144183221232
therapy29425740083215993114146184215
in317057400831451
patients32345740083397192107141178199226
with34725740083516688125
overactive36105740083376810212215518621385840083223668102
bladder22515840083395486124162196217
treated24805840083214275106127160199
with26915840083506587124
solifenacin:2827584008326647993112145183214246260297309
a3148584008331
post-marketing,319158400833977103125144202234254284317339354391429441
open-364458400833776111148170
-label21385940083213667105140154
study23045940083264885123153
in246959400831451
Japan25315940083245593125162
(MILAI27045940083197186117159173
study).28885940083264885123154171181
BJU308159400833558101
Int.3194594008314517284
2015;116(4):612-622.32895940083346798127137166192222240272289300334363392412448480514525
32.21386040085367186
Katoh22386040083356890127165
T,241660400833342
Igawa24716040083155486136169
Y,265360400833544
Yamaguchi271060400833564122154193231263301316
O,303960400834758
et311060400833456
al.31796040083324760
Cardiovascular32526040083407394132147185217249276308346361393414
safety3679604008326607811339347400832255
of40027400833757
antimuscarinic4072740083316991106164201228260293314329367382414
add-on44997400833271110132171210
therapy4722740083216094116149188219
in49547400831552
patients5019740083397294109143181203231
with5263740083506688126
overactive540274008337691031251581903934840083223769104
bladder4051840083385486126165199221
who42858400835089127
had44258400833870109
a454784008332
suboptimal45928400832663102141181203218276308323
response4928840083215582121160198225259
to52018400832158
mirabegron5272840083577394127166201241262299338
monotherapy:39349400835795133170192230264285317356387400
A434794008340
post44009400833876103125
hoc45389400833775107
analysis46589400833169101116147174188214
from4884940083184077134
the5031940083215994
Japanese5137940083245694127164199225260
MILAI54099400835470101144159
II55809400831530
study.39341040083264987126158168
Low411810400833168119
Urin42531040083436480118
Tract43861040083335083115139
Symptoms.454110400833262120160182219277303317
2020;12(1):68-80.487310400833468101135148178208226257272284319355377413448461
33.39341140085367083
Lee40351140083316498
J,415111400832435
Moy420311400835592122
S,434211400833344
Meijer440411400835488102116149169
J,459011400832535
et464311400833455
al.47151140083324658
Role47901140083367387121
of492811400833856
cytochrome50011140083316487123154191210246303337
p450535611400833873105138
isoenzymes55111140083154076393412400833573102135194229255
3A420812400833575
and430212400833270109
2D6442912400833580115
in456312400831553
the46341240083226095
in474812400831552
vivo48191240083324780117
metabolism495512400835893115147186225240254280338
of531212400833856
mirabegron,5387124008359739312616520139341340083385894131142
a4087134008332
β3-adrenoceptor41301340083387191122160179212249286317349387408443464
agonist.460513400833269106143157181203215
Clin48311340083405467104
Drug494613400834566103140
Investig.50971340083155282115140162176213225
2013;33(6):53331340083346797126136169201218250266277
429-440.39341440083346598120155191226237
34.39341540085357389
Konishi403915400833473112128154193209
K,426315400833450
Minematsu432815400835470108144202235258286324
T,466715400833242
Nagasaka472415400834477117150177211242276
Y,501515400833544
Tabata507415400833261101134157190
K.527915400833551
Physiologically-based53451540083357310413214718620324139341640083385487121138154187211252286314350390
pharmacokinetic434016400833878112134193227260298330348387423447463496
modeling485216400835796137173190206245285
for51531640083185780
mirabegron:52481640083577496130171207248270309348362
a3934174008332
multi-elimination399017400835999116140158182221238255316333373407431449489530
pathway45441740083397498139192227260
mediated482817400835896138155189213249291
by514317400833973
cytochrome52401740083316794133168209232272333370
P450393418400833569103138
3A4,409018400833576112126
uridine42341840083376077117134173209
5‘-diphosphate-glucuronosyltransferase4461184008335476911112716820824727531635638941244847251453157060364266570474378381184586388690994498310111032106810911125393419400832662
2B7,401119400833470104110
and413719400833170110
butyrylcholinesterase.426219400833877101136159193211243282321338354393429457481516538572599635648
Xenobiotica.492619400833771110150190207245268285317351366
2019;49(8):530719400833469101132146182216236271290303
912-921.39342040083346899121157192224235
35.39342140085367186
Konishi404021400833572111126152190205
K,426521400833550
Minematsu433521400835570108143201233255283320
T,467521400833342
Nagasaka473721400834577116149175208239272
Y,503021400833543
Tabata509321400833361100133155188
K.530121400833550
Application53722140083418011913515018221539342240083223775113
of406722400833756
a4142224008332
physiologically419322400833978108135150188204242282297329362377392424
based46362240083397298133173
pharmacokinetic482822400833977110131189222254291321338376411433448480
model532722400835896136170186
for55322240083195678
the39342340083215993
prediction40402340083385993132147178202217254292
of434423400833756
mirabegron44132340083577192124163198237258294332
plasma47582340083385485111168200
concentrations497123400833067105136169207228249282303318355393419
in540223400831552
a5467234008331
population55112340083387639342440083397792124146161199238
with41882440083506688126
severe43302440083266193128149183
renal45292440083205492125140
impairment.468524400831472111144159180239274312334347
Biopharm50482440083355088128166199220278
Drug534224400834567105144
Dispos.55022440083456187393425400833977104118
2019;40(5-6):176-187.406725400833468100130143178214233267289326344356386415447471502533566572
36.39342640085367288
Krauwinkel40412640083355790128179195233263297313
W,437326400835767
et445926400833456
al.45342640083324760
The461326400833272107
effect47392640083345372107139163
of492126400833857
mirabegron,49972640083577293126166201241262299338350
a5366264008332
potent54172640083397899133171193
and393427400833270109
selective40562740083266177111144168184216250
β3-adrenoceptor43202740083387193126165186220258296329363402424461482
agonist,481627400833170109147162188211225
on505427400833775
the51422740083226095
pharmacokinetics52502740083397711013118922225429132133839342840083377193107139166
of411228400833655
CYP2D6417928400834076112144188223
substrates441428400832662100126149170202223256282
desipramine47082840083387298112150171203260275312346
and506628400833168107
metoprolol.518528400835690112148187208244259297312324
Eur55222840083326788
J3934294008324
Drug397329400834667106145
Metab413329400835590112145184
Pharmacokinet.433229400833573105126185217249286317333371406428442
2014;39(1):43-52.478929400833468100131143178211230262276288323355377411444457
37.39343040085367079
Groen-Wijnberg403230400834465103138176199256273288326365400422460
M,451030400835468
van459630400833265103
Dijk47173040083456176106
J,484130400832436
Krauwinkel48963040083345790127179194232262297312
W,522630400835868
et531230400833456
al.53863040083324760
Pharmacokinetic546530400833572104126393431400835790122159189206244279301316348
Interactions42983140083155375108130163195219234272311337
Between46513140083367193146181216254
Mirabegron49213140083557091124164199239260297336
and527331400833270109
Metformin,539831400835489112133170192393432400835772109122
Warfarin,406832400835788109130163184199237249
Digoxin43303240083456098136166181219
or456132400833759
Combined463232400834076134173188226260299
Oral494432400834768101116
Contraceptives.507232400834077115136157189221255293315330362396423436
Eur55213240083326889
J3934334008324
Drug397333400834667106145
Metab413333400835590112145184
Pharmacokinet.433233400833573105126185217249286317333371406428442
2017;42(3):417-429.478933400833468100129139174206224257275286321351381399436468502513
38.39343440085367288
Lin40393440083314785
J,414034400832436
Goosen419234400834482121148183221
TC,44293440083327284
Tse45293440083335590
S,463534400833245
et469634400833457
al.47693440083314760
Physiologically484534400833572103130145183199237276291323356372387418
Based52793440083366995130170
Pharmacokinetic546534400833572105126393435400835688119155184200237270292307337
Modeling428335400835491129163178192229267
Suggests456235400833268106144177203226252
Limited482635400833146102116138171209
Drug-Drug504735400834465102140162207228265303
Interaction53623540083155272105125157188212226393436400833775
for40213640083185576
Fesoterodine41093640083326692130151184205241280295332367
When448836400835795129167
Coadministered466736400833976108146203218255270295318351372405444
With51243640083567294131
Mirabegron.52683640083546989122160195234254291329342
J3934374008324
Clin39733740083405671108
Pharmacol.409737400833572105126184217249286302314
2019;59(11):1505-1518.442737400833468100130143178210229261289303315345375409443465496526557588601
39.39343840085367084
U.403038400834355
S.409738400833245
Food415538400833269107146
and431338400833269108
Drug443338400834567104143
Administration.458838400834179136151188203229251272305326341379417430
Gemtesa®5030384008343781361571902172495279384008529
(vibegron)53203840083184964103138177198235273290
–3934394008336
clinical39913940083324864103118151185201
pharmacology421439400833979112134194228261299316355396429
and466439400833372112
biopharmaceutics47983940083395594135175208230290324357392431454470503532
review(s)53513940083215690106142194214241259
[Internet].3934404008319357395129151190225248265277
Urovant;423240400834465103135169207229242
2020449540400833569102137
Dec465240400834682115
[cited4788404008318496487121161
2025497040400833469102137
Feb512840400833267106
25].52554040083357090102
Available537840400834172105120136168208393441400831550
from:40004140083184078136148
https://www.accessdata.fda.gov/drugsatfda_docs/4164414008338598312315016218920926031436737841244447550953556260163365568870172175979280584488291493797399410321071109711311152117312121244128213211360139214201446
nda/2020/213006Orig1s000ClinPharmR.pdf.39344240083387710913517020423727129633136239242746349854756958462365367571074678282483985489292796599710181077111311271167120712261238
40.39344340085367590
Ritchey40454340083365275106145180212
ME,427843400835589103
Wang440243400835890128168
J,459143400832437
Young464943400833570109147187
JC,48574340083256679
et495743400833558
al.50364340083324761
CYP2D6511843400834078115149195231
Substrate537043400833371111138162183217393444400832256
Dispensing40104440083466288127163201228243281320
Among4351444008341100138177216
Patients45884440083356789105140178200228
Dispensed48364440083466188127163201228263303
Mirabegron:51604440083547091124164200240261298337349
An553044400834180
Administrative393445400834282141157196212239263285319342358392427
Claims43834540083405690106165192
Analysis.459745400834281115131164192207234249
Drugs486745400834669108149176
Real506445400833773106122
World520745400835997119136176
Outcomes.540545400834887111143181393446400835792119133
2023;10(1):119-129.408246400833468101136147178209229260275287316344374398429459493504
41.39344740085366880
Welk402647400835789105134
B,417247400833548
McArthur423247400835486128149173210247268
E.451247400833345
Increased45704740083145283104138169195229268
risk4851474008320356190
of495447400833655
dementia502247400833772129163201222237268
among530247400833289127164203
patients55174740083387139344840083213670107128155
with41014840083506587124
overactive423748400833768102122155186210224256290
bladder45394840083385385123161195216
treated47674840083214275106127160199
with49784840083506587124
an511448400833269
anticholinergic51954840083316989104135173210225240277311332369383415
medication393449400835792132147179212234249287325
compared427249400833269127166199220254294
to457949400832158
a4651494008331
beta-346954940083397597130152185
agonist:489349400833170109147162188211225
a5131494008332
population-based517649400833877117155170203224240278316339379412393450400832661101
cohort405050400833168107145167191
study.42565040083275088127159169
BJU444050400833560104
Int.4560504008314527487
2020;126(1):183-190.466350400833468101135148178208241260292306318348379413435466496532544
42.39345140085367086
Okita40375140083477894117149
Y,420351400833644
Shimomura42645140083327085143181240277298331
Y,461251400833644
Komukai467351400833572130168198232247
S,493751400833245
et499951400833456
al.50725140083324860
Risks51495140083365177107136
of530251400833757
Dementia53765140083458013817321139345240083223972
Associated402852400834272100139174190223246281323
With437352400835976100140
Anticholinergic453552400834282105121154194234251267306343365405421454
Medication501252400835692134150183217240257296336
Compared53715240083417914018121539345340083215595
to404953400832259
Beta-341285340083367194126149182
Agonist433053400834180118157172198221
Among457253400834199137176215
Older480853400834763102137158
Patients49875340083356789104139177199227
With52345340083587497135
Overactive53905340083478011513616920139345440083223769104
Bladder40575440083355183122161196217
in429354400831553
Japan:43655440083245696129167179
The456354400833272107
LIFE46895440083314679112
Study.48205440083325391130162172
Int50115440083155375
J5105544008324
Geriatr514854400834479100116148170191
Psychiatry.5358544008335629412616417921123239345540083215565
2025;40(1):e70036.401455400833468101136147181217237269283295329362395431464499512
43.39345640085367186
Trbovich40365640083335089128160176208246
M,429756400835568
Romo438056400833674132171
T,456656400833241
Polk46235640083357187117
M,475556400835568
et483956400833456
al.49105640083324760
The498556400833372107
treatment51085640083214377109130188223262283
of540656400833857
neurogenic54785640083387311039345740083215897132170185217
lower416657400831553104139160
urinary43415740083375873111144165199
tract45555740083214376108132
dysfunction47025740083387097117155193226250265303341
in505857400831553
persons51255740083397496123161200226
with53665740083506688126
spinal5507574008326658139345840083387085
cord40355840083316890128
injury:41785840083155368105127161174
An436858400834179
open446258400833877113151
label,46295840083144786121137149
pilot47945840083395469107129
study49395840083264987126158
of511358400833756
anticholinergic51855840083327091107139177215231246284319340378393425
agent393459400833271106144165
vs.41145940083325972
mirabegron42015940083577293126166201241262299338
to455359400832259
evaluate462659400833467100115152185206240
cognitive488159400833168107146161183198231265
impact516159400831472111144176201
and537659400833270109
efficacy.550059400833452708839346040083316496130140
Spinal40896040083337187125157173
Cord42776040083407798136
Ser44296040083326789
Cases.45336040083407399134161175
2021;7(1):50.472360400833468101132141174190222236248283317330