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FARMAKOLOGIE4538804001074291138211266312372415474534555598
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HLAVNÍ4945200012671127198263336370
TÉMA5337200012657114204274
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non351936001063980122
nocere:365736001063979115147182215232
Jak39043600106226196
bezpečná401636001063466100135167202243283
je431536001062254
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roztroušené489836001063374105139175216257289320362394
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Jak2523920029899223351
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je3995920029869195
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terapie3401180029888213304427569633758
roztroušené11461180029891229339429520657796899102411641289
sklerózy?248311800298105233301426517654764893992
Dominika3401580013777140235265329359419477
Šťastná1,840158001375998156204244309367120015900803651
2,126415900803613021580013729
Dana13531580013776134199256
Horáková1,16321580013775139181239298360417475209915900803651
22163159008036
1Neurologická3401740078333711740013372128188223283309369431456505555609
klinika1003174001335279104164189240294
a13201740013353
Centrum13961740013364117178213249309400
klinických1819174001335279104164189238288343391451
neurověd22941740013361116176211271322376438
1.2755174001335774
LF28521740013352105
UK29801740013371131
a31341740013353
VFN32101740013362116186
v34191740013353
Praze3495174001335993146193248
2Registr3401890078333731890013359114176201244280316
ReMuS,7121890013359114203263316338
ReMuS,10741890013359114202263315338
nadační14351890013361114175228276337362
fond,1820189001333292153215237
Praha2080189001335993146207259
Roztroušená3402400012154111154191225281338378430487536
skleróza907240001214088114166200256299351
je1288240001212576
chronické13952400012145102135191249273319367417
autoimunitní18432400012148104139195219304360417441476533557
onemocnění24312400012155112164249306353410462519543
centrálního3005240001214595152186220270295351376434491
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systému,586254001214090132167218304361384
které1001254001214785136171222
bez12552540012157110156
léčby1442254001212476124182230
vede1704254001214899159211
k19462540012148
významnému20252540012149101148206256341399451537594
neurologickému26502540012156109166200257283340399423470518569655712
postižení.33932540012158116157193217262314371396418
Časné3402680012159109150207259
nasazení6302680012157106147198243295353377
vysoce10382680012149102143200248299
účinné13682680012155102127184241293
chorobu-modifikující16922680012146103160194251310367401488545604629660688736793819844890915
terapie2638268001213384119169228253305
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a11892820012148
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je2000296001212577
však2108296001214889139188
spojena2326296001214099156181233291340
s26972960012140
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mírou30052960012185109143199256
rizik,3292296001213358103127176200
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a23163100012148
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zůstávají1441324001214399139174225272322347372
infekce,1843324001212480110162210255306327
jejichž2200324001212576102126172228273
riziko2503324001213358102126174229
je2763324001212476
akcentováno2870324001214896141191248282337386436492549
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u3403380012155
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monoklonálních8693380012184140197253301327383440489513569593639695
protilátek.1589338001215791147180204229278311361410433
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shrnuje2360338001213995129185241266317
hlavní2702338001215680129177234258
bezpečnostní29853380012157109154211264310366422463498554578
rizika3588338001213357101126173223
spojená340352001214097154179230286335
s6953520012140
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přípravky1313352001215791115173207256304352403
a17363520012149
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dostupné23293520012156112152187243301357409
strategie2758352001213974108157190241298323374
jejich3152352001212475100124170226
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vakcinaci,340366001214898145190214270319365389410
laboratorní772366001212473131188221271305360393450474
a12693660012148
klinický133936600121477397153177223270322
screening,1683366001213985119170222278302359416437
úpravy21433660012155112146196243295
dávkování24603660012157106153202256304354410434
i29163660012124
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substituci.340380001214095153193228252286342388412434
Významnou8013800012156105151208257341397453510
roli1338380001213388114137
sehrávají1503380001214091148181231278328353377
data19073800012157106139189
z21243800012143
reálné2194380001213384133157213265
klinické248638000121477397154178223271321
praxe2834380001215791141189239
–31013800012150
v31783800012148
ČR32543800012158112
byl33933800012157105130
v35513800012148
roce3626380001213389135185
20243403940012151102152201
spuštěn565394001214097154193228278335
systematický923394001214089130164215299348382406452499550
sběr1497394001213997149183
bezpečnostních17033940012157109153211264310366422463497554578623679
dat24063940012156105139
v25683940012148
rámci2640394001213382166213236
registru2900394001213383141165205240274330
ReMuS,32533940012154106188244293315
který3592394001214683134167219
během3404080012157109166217302
prvního662408001215791143201225283339
roku1022408001213288136193
zachytil1235408001214394140196242280304328
přes1584408001215791141182
517874080012151
00018524080012152106160
událostí.20324080012156113162187243283318342364
Pozornost24164080012154108151206240297353393428
je2865408001212476
věnována2961408001214999155211259309365414
i33964080012123
perspektivním34404080012157109143184242294342340422001213357106163187271
přístupům631422001215790115154189245302358442
s10934220012140
potenciálně11524220012157114148198254300324373397453504
příznivějším1676422001215790115158214238288337362402426510
bezpečnostním22054220012157109153211263310366421462496552576660
profilem.2885422001215791146176203227279363385
Primum3290422001215386110194250334
non36434220012156112168
nocere3404360012155111157206240290
dnes6504360012156111162202
neznamená8724360012155106150206254338389445493
léčbu1385436001212374120177233
omezovat,16374360012155139190234289337386419440
ale2097436001214872123
aktivně2239436001214895132155204261312
a25704360012148
individualizovaně2638436001212378136159208233290345393417441484539587636692743
řídit3400436001213357113137171
rizika3590436001213357100124171221
v3404500012148
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moderní8184500012183139197249283339363
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péče.20634500012157109156206227
Klíčová340466001246190118163220272325
slova:690466001244472130182235261
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skleróza,1503467001214086111162194249291341362
chorobu-modifikující18914670012145100155188242299355387471526584607636662709764788811856879
terapie,2796467001213382115164220244294314
bezpečnost,31364670012157108152209260305360416455489510
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události,6894810012155111159183238277311334355
komorbidity.10654810012147100184239272329353409433466515532
Primum340503001245896123210268355
non7155030012458116175
nocere:9115030012458116162215254307333
How12645030012469127203
safe1487503001244397131185
is1692503001242771
modern17835030012486144205258297356
therapy2159503001243796149188241301352
for2532503001243492130
multiple26825030012486145173210239299327380
sclerosis?3083503001244389117170209267311339382424
Multiple3405200012181137161195219276301352
sclerosis721520001214086110161194250290313353
is1103520001212363
a11955200012149
chronic12735200012145101134189246270315
autoimmune16175200012149104138193217301386442498549
disease2195520001215781120172221260312
of2536520001215585
the2650520001213389141
central2820520001214595152185218267291
nervous31405200012156108141193248304344
system3513520001214089129164214299
which,3405340012173129152197252272
if630534001212353
left701534001212373103139
untreated,8585340012155110142175225272305354411432
leads1308534001212373121178217
to1542534001213487
significant1647534001214063118174197226252296345400432
neurological20975340012156106161193248272327383406451499523
disability.2638534001215679118167223247270293326375392
The30485340012149106156
early3222534001215098130154201
initiation3441534001212378101134157205237260315371
of340548001215686
high-efficacy455548001215680138194227281312345372418468514565
disease-modifying1049548001215781121173222262314348434491549573603655680737794
therapy1872548001213491142176226284331
has22335480012156105145
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patient35045480012158108142165217274307
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effectively783562001215079111160205240262310358382428
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inflammatory1741562001212377105131178260342390421475507556
activity2315562001214791126148196219252301
and26335620012147102157
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disease3145562001215679117167214252302
progression.3464562001215689142198230279318340576001213962117172193
However,5505760012165120192241289337370386
higher953576001215578134188238271
efficacy1241576001215080112138182230275324
comes1582576001214598181231270
with1870576001217397129184
an20715760012148103
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risk260657600121335695141
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events,3517576001214997145200232273293
including340590001212378123145200256279333389
infections,747590001212378106156201236259313369407428
autoimmune11925900012148102135189212294377431486536
complications,1745590001214598181237261284328376408431486541579600
and23635900012147102158
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malignancies.30005900012183130154176232287334389433456506545566
Infections3583590001212479108157203340604001213356111167206
remain566604001213382166214237292
the879604001213388138
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pronounced3294604001215790144200255310366411460517
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therapies439618001213388138171220276300350390
involving849618001212378125178202251275330386
anti-CD2012556180012148103136159190252318365416
monoclonal16916180012183138194249295318373429477500
antibodies.22116180012148103136159215271329352402441463
This26946180012149106129167
article2881618001214981117140185208258
summarises3159618001214094177260309341365403454493
the3672618001213388139
key340632001214897145
safety514632001214090120171205256
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individual1903632001212480138162211235293348397421
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preventive340646001215790140187236292324347396445
strategies,809646001214074106155188237294317367406428
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vaccination,1678646001214997142185208264312344367422478498
laboratory2201646001212472128184217266298352385436
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immunoglobulin10966600012123106189244300355411435490547603626649704
substitution.1828660001214094151190224247280335368391446502523
Real-world23796600012154105153176208282336369393450
data28576600012156104137185
play3071660001215681129174
a32736600012149
crucial3350660001214477132177200248271
role3650660001213287111161
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–9686740012150
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monitoring17926740012183138194217250304337361416472
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the3000674001213388139
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20244496880012152103152201
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the1056688001213389140
ReMuS12256880012155106188244293
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recording1916688001213384130185218275299355412
over23576880012155103153187
5,0002573688001215271124178232
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in3142688001212480
the3251688001213389141
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year.3615688001214797146179196
The3407020012150106157
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also807702001214872110166
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emerging14467020012150133184217272296351407
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non18077160012155111166
nocere20007160012155110156205238288
today2314716001213387144192238
does25797160012156111162201
not28077160012155111143
mean29777160012183134182237
limiting3241716001212346129153186209264320
treatment35877160012134661161641963407300012183134190222
but5857300012157113146
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managing17887300012184132187235291314370426
risks223773000121335695141184
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modern34767300012184139196247279335
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care.1240744001214594126176196
Key3407610012462114167
words:5347610012477135174236280307
multiple8707610012184140164198221279304355
sclerosis,1254761001214086109161194250290313353374
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comorbidities.340775001214598182237270327351407431464487537576598
DECLARATIONS:4068242008648871301662142563043393604124625014570242008514
Declaration406825600874987120141179206244271291333375
of445725600874066
originality:45372560087406888130150192230251271298337356
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principles43002920087427090132165185228249287319
compliance:463329200873173134177197218256298330368387
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