573
KLINICKÁ341804001074588109168189242288347
FARMAKOLOGIE709804001074291138211265312372415474533554598
A13288040010753
FARMACIE1403804001074191138210265316336380
/18298040010732
Klin190680400107446583131
Farmakol2057804001074278105179220258305325
Farm.2402804001074178104179195
2025;39(2):122-1292617804001074487128172185229271295338360375412449493518557595638
/33008040010731
www.klinickafarmakologie.cz4568804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
1221318020012657110167
PŘEHLEDOVÉ341200012660124182256312369444520587645
ČLÁNKY1008200012660115187259327395
Retatrutid:3413600106336699135164200240273291330346
Nový70236001063980118156
přístup8743600106336886118151192227
v1117360010636
léčbě11693600106296196132164
obezity,134936001063874106141158190230241
diabetu16053600106375595130163196237
mellitu185836001065284115147165197238
a2112360010638
MASLD216536001065293126157197
(metabolic237836001062275107140177212254285303338
dysfunction-associated273136001063873105135177218253286304345386415453487519559595612652680712752
steatotic34993600106316395137165204235252287
liver38023600106294685117152
disease)39703600106385588119161194226250
Retatrutid:340920029814226735548156765879588294810891148
Nový15379200298165303425556
přístup21429200298143233296398485624766
v29579200298127
léčbě3132920029866191299442568
obezity,37499200298138280406517583669798850
diabetu34011800298143207332474599687826
mellitu121511800298206331397461525611750
a201311800298127
MASLD218911800298203360488609773
(metabolic3010118002987527339848661275489195610201126
dysfunction-associated340144002981432683694505887278339249891126126513431469157116731810191719822107219223172459
steatotic284814400298104191316441526663750815922
liver38181440029866130256377467
disease)433414400298143207309435560662788854
Robert3401840013765129194253295337
Prosecký1,7001840013764105168216274324384445114318500803611781840013729
Klaudia1219184001376899157220286316374
Hálová16161840013775134164228284342
Karoliová2198018400137681261682322622923554124702449185008036
1II.34020000783337120000133265276
interní470200001332686121175210271296
klinika790200001335178103163188239293
FN11062000013354124
u12532000013361
sv.1337200001334397114
Anny,14742000013367128188238255
Brno1752200001336095156216
2Endokrinologický3402150078333732150013354114176236287324350410470496556618643692743798
ústav,11942150013361103140193244261
Praha1478215001335993146206259
Obezita3402660012169126178221244277326
a6892660012148
metabolická7602660012184134168217273329353376421467517
onemocnění13002660012154110161244299345400451506529
jsou1852266001212463118174
globální2049266001215679134191240263319342
výzvou,2413266001214999144195249304325
která2761266001214783132165213
vyžaduje2997266001214899144194250305329379
inovativní3399266001212379134181229262285333389412
terapeutické340280001213382115164220272327360383428474523
přístupy.883280001215790113152186241297344360
Retatrutid12632800012154104138187219252307340363420
(LY3437943)1703280001212874121172223272320370422471496
je2219280001212475
nová23142800012155110157206
farmakoterapeutická2540280001212978111194242289343376425458506563614669703726770817866
možnost,34262800012183139181236291330364385
která340294001214884135169218
kombinuje5872940012148103188246271327383408459
agonistický10752940012149107163220244283318342388435487
účinek15912940012156102125182233282
na19022940012156105
receptory2036294001213485131182240274329363414
GLP-1,24802930012469123182214264287
GIP27952930012469100160
a29832930012453
glukagonu,306429300124608814820425931937843849835632940012121
čímž3613294001214669154198
nabízí3403080012156104161185228252
komplexní6203080012147101185242267317365421444
přístup1093308001215790113152186242299
k14203080012147
léčbě1496308001212374120177228
obezity,17523080012155113164208232265315331
diabetu2112308001215680128185236270325
mellitu24653080012184135159183206239294
2.2788308001215173
typu2889308001213383141197
a31153080012148
metabolických31923080012183134168217274330354378423469520564619
onemocnění3403220012155110160243298343398447502525
jater883322001212471104152185
(MASLD).10853220012129106167217263329355373
Jeho1475322001213787143197
mechanismus16903220012183133178233280335358396479533572
účinku2279322001215599122177223278
spočívá2574322001214096151196219267315
v29063220012148
regulaci2972322001213282138192215263307330
chuti33193220012145100154187209
k35463220012146
jídlu,3610322001212447103126180201
zpomalení340336001214298152234281304353407430
vyprazdňování786336001214897154186233275330384438484531585607
žaludku,1410336001214291113167222267322341
podpoře17683360012156111167222277309357
sekrece2142336001213988134167216260308
inzulinu2467336001212377119173195217271325
a28083360012148
zlepšení2873336001214265114169208257311333
energetického32233360012149104153185239288321343387432480534588
metabolismu.3403500012183133166215271327351373412494549569
Výsledky9273500012155103142165215272319369
klinické131335000121477294149172216262311
studie1642350001213973127183206256
TRIUMPH19163490012455114143211296354422
prokazují2356350001215789143190239282337360383
významné2757350001214898143198246328383433
snížení3208350001213994117160209264287
tělesné3513350001213382105155194249299
hmotnosti3403640012156139194227283338378412435
(až803364001212874117
o9483640012155
24,210323640012151100120173
%12183640012179
po13253640012157114
4814673640012151104
týdnech1600364001213383139194245291346
léčby)1974364001212474120177223250
a22523640012149
zlepšení2329364001214367117174214264320343
metabolických27013640012183134168217274330354377422468519563618
parametrů.33473640012157106139188271322355388444464
Současně3403780012149105160205253292347398
byla7623780012157104128176
potvrzena9623780012157113146197230275325380428
jeho1415378001212475130185
účinnost16253780012155100123178233288328362
na20113780012156104
snížení2139378001214095118161211267290
obsahu24533780012155112152201256311
tuku2788378001213388135190
v30033780012148
játrech3075378001212573105138188233288
a33883780012148
potenciální34613780012157113145195250295318340392001214872127150
renoprotektivní513392001213383138194251284338371420467503526575631654
efekt.1190392001215180130178214235
Přestože1448392001215485135174208262304354
je1826392001212474
retatrutid1924392001213383116165197230285318341398
slibnou234639200121396285142198253308
terapeutickou2678392001213382115164220271327360383428474528583
inovací,3285392001212378133180229274297317
jeho3626392001212474130185
bezpečnostní3404060012157108151208259305360415455488544567
profil928406001215790144173200223
a11724060012148
dlouhodobé1242406001215679134190245300357412470521
účinky17844060012155100123178225275
vyžadují2080406001214899144194250305329352
další24534060012156104128167190
výzkum.2664406001214899144191246329350
Klíčová340422001246190118163220272325
slova:686422001244371129182234260
retatrutid,968423001213382116165197230285318341398419
obezita,14084230012155112163207230263312333
diabetes1762423001215780128184236269318358
mellitus21414230012184134158181204237292331
2.2494423001215172
typu,2588423001213383140196216
MASLD,28264230012180142192238304322
GLP-131704230012164112165195240
agonista,34314230012149105160216239277311360381
GIP340437001216589142
agonista,5044370012148104159215238277310359380
glukagon,906437001215579134180229286341396417
metabolismus,13444370012184134168217273329353376415498553592613
klinické197843700121477295150173218265313
studie.2313437001213973128185208258278
Retatrutide:3404640012459112150204240280338375404464517543
A9034640012465
novel9894640012458116168220248
approach12584640012452112173211269323368427
in1706464001242786
the1812464001243796150
treatment1982464001243776129182219306360419456
of2458464001245792
obesity,25704640012458118172216244281335358
diabetes2948464001246088141201254292345389
mellitus,33574640012486140168196224261320364391
and3404780012453112172
MASLD5324780012484151206257326
(metabolic8784780012432115169206260320379407434480
dysfunction-associated137847800124601131561912493083543934214795385726256697127708168448979349871048
steatotic2446478001244380134187224282319347393
liver2859478001242755108160199
disease)3078478001246088131185238282335364
Obesity3404960012169127179219242275325
and6944960012148104161
metabolic8844960012183134168217274331355378423
diseases1336496001215680119170218258308348
represent1713496001213383140174224263314370403
a21454960012148
global2222496001215679135192242265
challenge25164960012145100149172196246302359410
requiring2954496001213383141196219252276332388
innovative3371496001212379134190237286319342391440
therapeutic340510001213389139172221278330385418441486
approaches.8555100012148105163196251300345400451490512
Retatrutide13955100012154105139188220253309342365422473
(LY3437943)1896510001212975122173225274322372424474499
is2423510001212463
a25145100012149
new25915100012156107180
pharmacological28005100012157113161194278326371425450505562585630679703
option35315100012155113146169224280
that340524001213388136169
combines535524001214599182239263318368408
agonistic9695230012453112170229256300337366411
action1405523001245398137165223282
on17125230012458117
GLP-1,18545230012468120178209258281
GIP,2160523001246898157173
and23595230012452111171
glucagon2555523001245987145191244303361420
receptors,300052300124389213819025128834638542934305240012121
offering3477524001215584117167200223279335
a3405380012148
comprehensive413538001214599182239272322378428484522545594643
approach10815380012148105162195249298343398
to1504538001213387
the1616538001213388139
treatment1780538001213365115163196279329385417
of2222538001215584
obesity,23315380012155112164203226259309325
type2681538001213383141192
228985380012151
diabetes,2974538001215680127184235269318357379
and33785380012148103160
metabolic356353800121831341672163405520012157113137160204
dysfunction-associated5625520012157104143174229284329365388442498530578617656711757780827860909966
steatotic1546552001214074123171203257290313357
liver192155200121244795144177
disease2116552001215679118168216255306
(MASLD).24405520012128106168218264330356375
Its283355200121245797
mechanism29485520012184134180235282338361399482
of3448552001215584
action3550552001214893128151206262
includes340566001212379124147201258308348
appetite7115660012148105162213247270303352
regulation,1086566001213383140195218266298321376432453
delayed15625660012157107131179224274331
gastric19165660012156104143177210233278
emptying,22175660012150134191224274298353409430
enhanced26705660012150106161209264309358416
insulin3109566001212379117172195218273
secretion,3406566001213990135168218251274329385405
and3405800012148103160
improved5255800012124107164197251298347405
energy9555800012150106156189245292
metabolism.12735800012183134167216273329353376415498519
Clinical1817580001215881104159182227276299
trials214158000121336689137161199
TRIUMPH23665790012455114144213298357425
demonstrate28165800012156107190246301340374406455487537
significant3378580001214062118174197226252297346401433
weight3405940012173123146202257289
loss646594001212479118157
(up821594001212879136
to974594001213387
24.21079594001215199119173
%12645940012179
after1361594001214876112161194
4815735940012151103
weeks16945940012173123173220262
of1974594001215584
treatment)2076594001213365114162194277328383415442
and25365940012148103159
improvement27135940012123106162195249296345428479534566
in3297594001212378
metabolic33935940012183133167215272327351374418
parameters.3406080012156104136184266316348397429469490
Additionally,8476080012160115171194226249303358405428450497512
its137760800121235595
efficacy1489608001215079111137180228272321
in1827608001212478
reducing1922608001213382138192236258313368
liver230760800121244694142174
fat2498608001212977109
content2625608001214497152183232286318
and29606080012148103158
a31356080012148
potential32006080012157112144192247279301349371
renoprotective3589608001213281136190340622001215688141173220265299321368415
effect772622001214978109158202237
have10256220012155101146194
been12366220012156105155209
confirmed.1461622001214497151179204235317366422442
Although1919622001216083115168222276330384
retatrutide2319622001213381113161192224277309332387435
is2771622001212360
a28486220012147
promising2912622001215688141222245282304358412
therapeutic3341622001213286135167214269319372404426470
innovation,340636001212379134189236285317340395451472
its83363600121235697
safety951636001214089118168201251
profile1223636001215790145174200223274
and15186360012148103160
long-term1699636001212479134191222256305338422
effects2142636001215080112162208243284
require2447636001213383140195218250300
further2768636001212985118154209259292
investigation.3081636001212479125174214248271327375407430485541562
Key3406520012461113164
words:5246520012476133171231275301
retatrutide,846653001213382116165197230285318341398448468
obesity,13356530012154112163202225258308324
type1679653001213483141192
218926530012151
diabetes1963653001215780128184235269318358
mellitus,23416530012183134158181204237292331352
MASLD,27146530012180141192238304322
GLP-130576530012164112165195240
agonist,33176530012148104160215238277311332
GIP3669653001216589143
agonist,3406670012148104159215238277311332
glucagon,693667001215679134179228284339395415
metabolism,11306670012183134167216273329353376414497518
clinical166966700121456891147170214263286
trials.197666700121346690137161200221
Úvod3407030014780142208279
Epidemie480720001094393113163207281301345
obezity840720001094999144182202231275
celosvětově1130720001093982103152186230273302349391434
a15797200010942
v16367200010942
ČR1693720001095198
zvláště1806720001093782103145179340734001093177
sílí44573400109375984106
a5797340010945
proto651734001095385136168219
všechny898734001094482129173225277320
možnosti,12467340010978130170222274312344366386
jak1660734001092368113
tento1800734001093178130161213
trend340748001093059105155206
zvrátit,564748001093884114159188209239259
jsou840748001092257107157
vítané.101474800109446596140190236254
Po1285748001094897
mnoha13997480010975125175225269
desetiletích168574800109519613217820923025129734076200109294988137
beznaděje491762001095095133182224273317338382
v8887620010942
léčbě944762001092165105155200
obezity1158762001094899143181202231274
se1447762001093579
nyní1540762001094989138158
etabluje1713762001094473116166187235256300
řada340776001092972123165
nových521776001094998140185224273
léků810776001092165107157
s9827760010935
klinicky103277600109426485134155194236280
relevantním132877600109297395139182225274303352373447
dopadem17907760010950991501942140706001095197173
pro2339706001095282132
pacienty2497706001095296137159205256286331
trpící2854706001093060112134175197
obezitou.30767060010950102149189211241291341361
Tyto3463706001094583116166
léky3654706001092268111157
mají21407200010975119140162
příznivý2323720001095181103141192213257303
dopad26477200010950100152197248
i29167200010921
na2958720001095094
komplikace3073720001094291167218240261303348389433
obezity35277200010950102148187209239284
a21407340010943
související2198734001093685134178199234279300321361381
komplikace2595734001094290164215236257299343383426
DM30377340010959131
2.3184734001094564
typu.3264734001092974125175194
K34737340010948
agonistům35377340010943931421922132472140748001093079155
GLP-123147480010958102150177218
receptorů2552748001092975116160212242291321372
nyní2943748001095092143164
nově31267480010950100143188
přicházejí3333748001095281103144193237276322344365
na3718748001095093
scénu2140762001093677121172221
duplicitní23817620010951100152174195236257287337358
a27597620010943
v28227620010943
dalším2885762001095195116151172248
textu3153762001092974117150199
popisovaný33727620010952102154176211261304348398439
triplicitní214077600109305981132154175216237267317339
agonisti.2498776001094394144194215251282303322
DECLARATIONS:4068268008648871301662142563043393604124625014570269008514
Declaration406828200874987120141179206244271291333375
of445728200874066
originality:45372820087406888130150192230251271298337356
The406829300853473109
manuscript418829300855891130168195227249266306329
is452829300851744
original45832930085386178117133172205222
and481629300853472112
has49392930085387299
not50502930085387699
been516129300853975110149
published532229300853977117134150177216251291
or406830400853862
submitted414530400852867108167184208234269310
elsewhere.44703040085355381117169209245269305320
Ethical406831800873764107127160198218
principles43003180087427090132165185228249287319
compliance:463331800873173134177197218256298330368387
The406832900853678116
authors420532900853475100142183208238
attest44643290085356087124153179
that466432900852465101126
their481132900852465103121146
study49783290085295595138173
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approved531232900853577120145186221258301
by406834000854073
the41583400085236399
local42743400085175689124141
Ethical44323400085345898115147182199
Committee464834000854179139198215239265300337
and500234000853373113
is513234000851745
in519434000851656
compliance526734000853169129169187204239278311346
with40683510085537298140
human423635100854081143180221
studies44863510085285596139157195226
and474035100853577119
animal48883510085347695156193212
welfare512835100855391110133170196234
regulations53903510085236110414516420140683620085234080120148
of423536200853960
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authors’44343620085347397136176200229244
institutions46983620085165684109126150189213231270310338
as505636200853462
well513836200855187104122
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World406837300856099124142184
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Association453537300854474104144178196231256273314355
Declaration491137300854785119136172196232257274315356
of528837300853961
Helsinki537037300854684102131149189224243
on406838400853878
Ethical41653840085355898115147182199
Principles43833840085376178117150167207225261290
for46923840085205983
Medical479438400855693134151183218235
Research504838400853874102139173197229268
Involving53353840085175690128146181198238278
Human406839500854685145179219
Subjects430739500853474114132168201227256
adopted458339500853474114155179215256
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in439340600851758
Helsinki,447440600854785104134152193228248264
Finland,47614060085355394113149190232249
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June511540600852667109147
1964,528540600853771110150166
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well494841700855287105122
as508841700853362
with51674170085526993133
the53184170085236298
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Recommendations406842800853977112153216278317359402439465483525568598
for46974280085226389
the481842800852466104
Conduct,495442800854283125168210245272290
Reporting,527542800853978121163189217236278321338
Editing,40684390085347491115132172212227
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Work514243900856097121155
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Journals,406845000852666105129169204221249265
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December470545000854683116151211252289313
2018,503745000853673107140156
including52134500085165689106145186203243283
patient55164500085407540684610085234076116140
consent422246100853270110138174214238
where447546100855191127151187
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Conflict406847500874282124149171191223251
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interest44134750087196288126154192224251
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financial48144750087244587125167200220258279
disclosures:51074750087416293126147188220261289327359378
None.406848600854686126162177
Funding/Support:406850000873777119162183225267291329371414457499526554574
Podpořeno406851100853877119160201225262302343
z4431511008531
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2025;39(2):122-129492571400863775113151167205242264301322338374408446468502536574
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Prosecký,451976600874068109141179212251291308
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