717
KLINICKÁ341804001074588109168189242288347
FARMAKOLOGIE709804001074291138211265312372415474533554598
A13288040010753
FARMACIE1403804001074191138210265316336380
/18298040010732
Klin190680400107446583131
Farmakol2057804001074278105179220258305325
Farm.2402804001074178104179195
2025;39(3):160-1642617804001074487128172185229271295337359373410449494524563602648
/33108040010732
www.klinickafarmakologie.cz4568804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
1641288020012657111170
HLAVNÍ341200012670127198263336370
TÉMA733200012657114204274
Betablokátory3413600106346699136171203242278320348387423459
v816360010636
léčbě8683600106296196132164
srdečního104836001063166106138172214231272313
selhání13773600106316293135175216233
U483620010960
nemocných57462001095199178230274326370412464
doposud1069620010952104159212249301355
betablokátory1455620010952101133180234257309354401433484516564
neléčených34376001095096118163205249300341381431
má797760010975118
být93876001095193127
léčba108776001092267109160204
zahájena131476001093884134177199245295339
ihned167576001092171121167219
po1917760010951102
stabilizaci.34390001093666111162184205226265310351372391
Závěr3431150014768131190250294
Betablokátory483132001095098131177231254307352398430481513561
jsou1074132001092260112164
v12691320010944
kardiologii1344132001094390121174197249273325379401424
jedny1798132001092371125177221
z3431460010940
nejpoužívanějších4181460010951100123177231284325348395441494542566603626669722
léků1175146001092270115168
s13781460010937
velmi1450146001094592116194217
širokým170214600109376092144189237317
spektrem343160001093586131173205234279353
indikací.712160001092070120141182226266287305
Zcela1033160001094988132153196
jednoznačné1245160001092166117166215253302345385434479
je1740160001092166
jejich182116000109226788109149198
doporučení2138620010952104158211243295337384436459
u2624620010951
pacientů270262001095399141164211264295346
se307562001093785
srdečním318762001093767120168211263286364
selháním357862001093784108160205213876001095072148
se231176001093682
sníženou241976001093686108147193244294345
ejekční279076001094567113156196247268
frakcí.308476001092657102144184206225
V3335760010950
doporučených3411760010951101154205235286327372213890001095091131181
postupech2338900010951102138168218270316357407
jsou276490001092257108158
v2940900010944
této300390001092974105154
indikaci317590001092171123144186231272293
uvedeny348690001095094139191236287328
bisoprolol,2138104001095376112165218250301325377400420
carvedilol,2585104001094187118167213267289312364387407
metoprolol30191040010977125157208262294345368420443
sukcinát3490104001093688132173195247293324
a21381180010943
nebivolol.2197118001095095146168211260282331353372
U25851180010958
HFmrEF26591180010958102175204248292
mohou29671180010974124174224274
být3256118001095193126
BB3398118001094897
zváženy3511118001093984128167212262303
na2138132001095196
základě2261132001094087130154200253300
metaanlýz25881320010977124156202247299321366409
z30231320010940
velkých3090132001094490113157204246297
studií,3414132001093769120174196218238
pro3679132001095283135
podávání21381460010951100151194235278327348
betablokátorů2501146001095196126169220241290332376405453482531
u30481460010949
pacientů3112146001095094134154199248277326
s34531460010935
a35191460010943
HFpEF35771460010958102150194237
zatím2138160001093984113134210
nemáme2367160001095096171215290336
dostatek27221600010951101136167212241286329
důkazů.30701600010951100142187226276295
V4074620010950
léčbě413962001092165105154198
akutního435262001094384132161209228278327
srdečního469362001093663113156196244264314362
selhání506962001093680100148190238258
mohou5341620010975124172220269
být393476001095192123
betablokátory407776001095196124167216237285326369397444472516
použity4613760010951100148186205233277
ke491076001094285
zvládnutí501576001093882103144194242290318338
některých537376001095094134165208393490001092973111159
tachyarytmií,411590001093072111159199241269313344417437456473
nebo461090001095094144192
k4824900010942
úpravě4887900010950100128170211253
srdeční516290001093563112156196244263
frekvence.544790001092654981393934104001094487136176219236
Pozornost4192104001094996132181209259308342371
je4586104001092266
třeba4674104001093059102153196
věnovat4892104001094487136185227269298
pacientům5212104001095195134153198247275324398
s39341180010935
akutní3980118001094282128156202221
dekompenzací,4212118001095092132177249297340387423465502521537
kteří4760118001094171112139158
již492911800109214075
byli5015118001095089109127
betablokátory51531180010950931211622102292763163573844293934132001092973
léčeni.4020132001092165105147196215233
Zde4265132001095099143
se4421132001093579
snažíme4513132001093684126163183256300
v48261320010943
léčbě4882132001092265105154199
betablokátory5094132001095196124167216237285326369397444472516
pokračovat,39341460010951100141170213252298339382409427
pokud43771460010951100141189239
je4631146001092266
nutné4713146001095098126174218
jejich494714600109226686105144192
vysazení,5155146001094387121164202245294313330
zavádíme55011460010938823934160001094384132151223266
je4211160001092265
zpět4287160001093887130158
do4456160001095097
medikace45651600010974117166184224265303345
ihned4921160001092168115158207
po5139160001095199
stabilizaci.5249160001093563105153172191210246288326344361
LITERATURA344183001234978134189250318368438498567
1.34320000853649
Waagstein41220000835890122162188212246261299
F,73220000833339
Hjalmarson7912000083456093108167199221248287326
A,113820000834155
Varnauskas12142000083366889128161199225256289316
E,155120000833346
et161820000833457
al.16962000083324760
Effect17772000083335271106139164
of196120000833857
chronic3432100083327092130169185217
beta-adrenergic5812100083397699132155188228249284323359380419435467
receptor10692100083215690124164186224246
blockade13362100083395695128159193233268
in162521000831554
congestive170021000833169108148184211235250284319
cardiomyopathy.3432200083316485123139177235265303343376397436466476
Br83522000833556
Heart90722000834479111132156
J.107922000832436
1975;37(10):1022-1036.11312200083346497130140175207224256287305317347379411446467497529562596610
2.34323000853651
Swedberg40623000833281115154193228248286
K,70423000833549
Hjalmarson7662300083435890105161193214241278316
A,109523000834054
Waagstein116123000835788120158184206240254292
F,146523000833238
et151523000833456
al.15832300083314759
Prolongation16542300083355692108145183221253274289327365
of34324000833757
survival4182400083266384119135167200215
in65124000831553
congestive72224000833168107146180207230246278312
cardiomyopathy10532400083316485123138176234265303342375397435466
by153724000833870
beta-receptor16252400083387496129151173207240274313335372394
blockade.3432500083395593125155189228263275
Lancet.63325000833265103135169191205
1979;1(8131):1374-1376.8532500083346497131143174189222254284315329341371401433464487517547579611625
3.34326000853651
Packer4102600083356799129163185
M,61126000835568
Bristow696260008335577299122159210
MR,92326000835490104
Cohn104426000834077115153
JN,12142600083247082
et131326000833456
al.13862600083324760
The146326000833372107
effect15872600083345372107139163
of176726000833757
carvedilol184126000833164851201543432700083385368106122
on47827000833775
morbidity56627000835795116156171210225247281
and86027000833169108
mortality98127000835795116141173189203226259
in125327000831552
patients13182700083397293108143181202230
with15602700083516688126
chronic16992700083316990127165180212
heart1924270008337723432800083325378
failure.438280008318526782119141175187
U.S.6422800083445589103
Carvedilol7622800083407394129163202218233271287
Heart106628000834479111132157
Failure1240280008333627792130151185
Study14432800083325391130162
Group.162228000834466103141180193
N1832280008345
Engl189428000833370109125
J343290008324
Med.38229000835590130143
1996;334(21):1349-1355.54029000833464100135147182215251270304336350362392422457490514545574607640652
4.34330000853651
The40630000833271105
Cardiac5243000083397292130145176208
Insufficiency7443000083155278115133151169200215249287318351
Bisoprolol11083000083355075113152173210225263278
Study13993000083325390129160
II157130000831530
(CIBIS-II):16133000083195772107123154176192207226237
a1863300008331
randomised1907300008320539034331000833876135150176211250
trial.609310008321435890106119
Lancet.74331000833165103135169191204
1999;353(9146):9-13.9633100083346499135147182215248266299331362398416428463487518548560
5.34332000853651
Hjalmarson4153200083456093108167199221249287326
A,76232000834256
Goldstein8393200083448399139166189223239277
S,113732000833346
Fagerberg120432000833262102137159199235256295
B,152032000833649
et158932000833557
al.16673200083324861
Effects17493200083335271106139164192
of196232000833757
controlled-release34333000833269108130152190206222257297320342377393429461488524
metoprolol88833000835893116153194216254270309325
on123433000833877
total13323300083225981115131
mortality,148333000835897119145178194209232266276
hospitalizations,178033000833877104144160183216343340008315305993115130168207234247
and61034000833271110
well-being74034000835186102117139179215231269308
in106934000831452
patients11423400083397294109144182204232
with13953400083506689127
heart154334000833773105126151
failure:1714340008319526883121142176189
the19243400083216095
Metoprolol34335000835490112149188210247263301317
CR/XL67435000833975102143175
Randomized86235000833668106145184242257286320360
Intervention12353500083155374108129164198237258273311350
Trial1598350008333506698113
in172435000831553
congestive1790350008332681071461812083433600083223769104
heart46536000833772104125150
failure633360008319526782120141175
(MERIT-HF).82636000831972106141157191209255288308319
MERIT-HF116336000835588123139173192237270
Study14513600083335492131163
Group.163236000834465103141180192
JAMA.184336000832464119161176
2000;283(10):1295-1302.34337000833468104141153188222256274306337356368397427461496518548578613646658
6.34338000853650
Packer4043800083356696125158178
M,59338000835466
Fowler67138000833268118132165185
MB,86838000835489100
Roecker97938000833672107138167199219
EB,12093800083336778
et129938000833454
al.13653800083324657
Effect14333800083335069102134156
of160138000833755
carvedilol16673800083316383116149187201214251266
on194438000833774
the3433900083225892
morbidity45039000835794115153167204218239272
of73739000833755
patients8073900083397091104138174195221
with10433900083506586123
severe11813900083265990123143176
chronic13723900083316887123160174204
heart159139000833872102122145
failure:1751390008318506478114134167178
results194439000832053343400008326617495120
of47340000833754
the5364000083225891
carvedilol6364000083316281113146183196210246260
prospective9054000083385893118154188218241254284317
randomized12314000083205187124160216229256288325
cumulative156640000833166122157171201221234264297
survival187240000832661801131273434100083326377
(COPERNICUS)43341000831856100135166200244258297340370388
study.8334100083274885123153162
Circulation.10074100083405474103140154184205219255292304
2002;106(17):2194-2199.132441000833467101133144172202237254285313331341375405434468490519550578612622
7.34342000853645
Flather4024200083324779101139174195
MD,612420008355101112
Shibata7394200083327085124157179212
MC,96642000835495108
Coats108942000834077110132159
AJS,126342000834168100113
et139142000833456
al.14624200083324860
Randomized153842000833568106145183241256285319359
trial1912420008322435991106
to34343000832158
determine4134300083387395128149206221259293
the7194300083215993
effect8254300083345372106138162
of99943000833756
nebivolol106743000833872111126158195211249264
on134443000833775
mortality143143000835795116140173188202224258
and170143000833269108
cardiovascular182143000833164851221371753434400083316490122160175207228
hospital58444000833775101140155178210225
admission82244000833270128143169195210247286
in112044000831552
elderly11854400083344988123144159191
patients13884400083397293108143180202229
with16304400083506688126
heart176844000833872104125149
failure1930440008318516621382000083155273108
(SENIORS).22612000083185082127143190227261280291
Eur25672000083336990
Heart267320000834479110132156
J.284520000832436
2005;26(3):215-225.289720000833468104138149184217236270287299334366396418449483518530
8.213821000853651
Dargie22022100083457797135149183
HJ.23972100083446981
Effect24902100083335170103135159
of266121000833756
carvedilol27292100083316484118152190205219257272
on301321000833875
outcome31012100083377496126162220254
after33672100083325175108128
myocardial350821000835787124156188209246260292306
infarction21382200083155169101122152175189226263
in241322000831451
patients24752200083397091106139176197223
with27102200083506486123
left-ventricular2844220008315496791109141174211232252267298334349380400
dysfunction:32552200083386995114152188220243257294331342
the36092200083215892
CAPRICORN37122200083408221382300083357085125169205250
randomised24022300083215390129166224238263298337
trial.2753230008321425788103115
Lancet.288223000833164101133166187200
2001;357(9266):1385-1390.309623000833468103134142176208241256288321354389406417446476509543564594623656691703
9.213824000853649
McDonagh220324000835487132171210242281319
TA,25372400083326984
Metra263524000835590112134167
M,281724000835468
Adamo290024000834079111169207
M,312224000835568
et320524000833456
al.32762400083324760
2021335124000833468101133
ESC349924000833266107
Guidelines3621240008343829713617021382500083153068103130
for22872500083195678
the23842500083226095
diagnosis24992500083385385124162200227242268
and278725000833270109
treatment29152500083224377109131189224262284
of321925000833756
acute329525000833264102124158
and347225000833270109
chronic36012500083316990128166181213
heart213826000833873104126150
failure.2304260008318516682119140174186
Eur25062600083326990
Heart261126000834580111133157
J.278426000832436
2021;42(36):3599-3726.283526000833569102133141176209226260294312324359392424460483516548582616629
10.21382700085367186
Málek224527000835588104139170
F,243627000833339
Veselý24962700083366996132148180
J,269727000832437
Pudil275527000833573113128144
R,292027000833550
et299127000833457
al.30682700083334862
Souhrn315027000833372111149171210
Doporučených338127000834685125165187226258292331362394433
postupů213828000833978105129167207246
Evropské24042800083336688126166193223258
kardiologické26822800083306486124140178195233273289321351386
společnosti308928000832666105121157190228267294317333
pro34432800083396198
diagnostiku3562280008339548712616520323021382900083223970110
a2272290008333
léčbu23292900083155286127167
srdečního25202900083274989126160200216257297
selhání28412900083276481120154194210
z3075290008329
roku31282900083226193133
2021.328529000833571105138149
Cor345829000834180103
et358529000833558
Vasa.36672900083377098133147
2022;64(2):121-162.213830000833468101136148184220240274292304334363395414444476509521
11.21383100085366678
Martínez-Sellés222931000835486107132147185219249270301336351366401427
M,266931000835468
Grodzicki274931000834465102141170186218247264
T.302531000833342
Modification307931000835593132147165181213246267282320358
of345031000833756
Cardiovascular3519310008340729313114618421524827421383200083316984117138
Drugs229632000834567105144170
in248632000831553
Advanced255932000834179112145183215248288
Heart286732000834479111132157
Failure:3044320008332627792129151185197
A3261320008341
Narrative33223200083457798120153175190223257
Review.359932000833570102118153204215
Front21383300083325289128149
Cardiovasc23033300083407294132147185217250276308
Med.262733000835489129142
2022;9:883669.278433000833569101136149184197232267301336371405416
12.21383400085366681
Mebazaa223434000835488126158186218249
A,249834000834154
Davison256734000834576106120145182219
B,280134000833647
Chioncel28633400083407690127164194227241
O,311934000834757
et319134000833455
al.32613400083324657
Safety,33333400083336482115136168177
tolerability35253400083215772105125156194208222236257289
and213835000833168105
efficacy2252350008334516886116147178209
of247135000833754
up-titration25353500083377496116130151170201221235271308
of285235000833755
guideline-directed29163500083387487124157171184220253275313327346378409431463501
medical342635000835790128141171202216
therapies3652350008321589111014121383600083395386111
for22593600083195575
acute23443600083326298120152
heart250636000833771101121144
failure2660360008318506478113133166
(STRONG-HF):28363600083184981117163207250272316348366377
a3223360008331
multinational,326436000835894108129142179210230244280317348362373
open-364736000833775109145167
-label,21383700083213667104139153164
randomised,23143700083215389127164220234259292331342
trial.2668370008322425687101112
Lancet.279337000833163100131163184196
2022;30013700083356799132143
400(10367):1938-1952.315737000833468103121151181213246278296306335364395428449479507540572583
13.21383800085366883
Lábr223638000833165104126
K,237638000833550
Špinar24413800083327187124157178
J,263438000832436
Pařenica26853800083356788122160175207240
J,294038000832436
et299138000833456
al.30623800083324760
Betablokátory31373800083357093125165181219249283305341363397
v3549380008332
registru35953800083215595110136159181219
chronického21383900083316990127166181213243277315353
srdečního25043900083264785120152190205245283
selhání28003900083266177114146184199
FAR301239000833371106
NHL.313139000834590121135
2017327939000833468100129
[citován3421390008319496486123155188226
1.366039000833443
duben371639000833876213840000833974112
2025];19(1).226340000833469101136156168198228247279294305
Dostupné258140000834583110133171210249284
z:287840000832842
https://www.muni.cz/vyzkum/29334000083385983123150162189209260314367378436474512527540572603631663697728759797855881
publikace/1394274.213841000833977116132147177210243276302335365399434467500530543
14.21384200085366984
McDonagh224142000835487132171210242281319
TA,25784200083337084
Metra268142000835489112133166
M,286642000835468
Adamo295242000834180112170208
M,317942000835468
et326542000833456
al.33404200083324760
2023341942000833468101136
Focused357342000833370103140167202241
Update213843000834482122154176209
of236043000833757
the24294300083226095
2021253743000833468101132
ESC268243000833266107
Guidelines28014300083448297136171186201239274300
for31144300083195678
the32044300083226095
diagnosis33124300083385385124162200226241267
and359243000833270109
treatment37134300083224377213844000833254112147185207
of236544000833757
acute244244000833264102125159
and262144000833270109
chronic27504400083327091128167182214
heart298444000833873105126151
failure.3155440008319526782120141175188
European33634400083336990128167203235273
Heart365744000834479111132157
Journal.393420000832462101122160193208221
2023;44(37):3627-3639.417020000833469101136148182219239272304324336371406439472490523557591624635
15.39342100085366881
Arnold40322100083416299137152191
SV,42382100083336977
Silverman4331210008333476193127147205236274
DN,462121000834590102
Gosch473921000834482108139176
K,493121000833549
et499621000833456
al.50672100083324759
Beta-Blocker51422100083357091124145182197234266296329349
Use550721000834469103
and393422000833269107
Heart405322000834478109130154
Failure4218220008333617690127148181
Outcomes441122000834684106136172230264290
in471322000831452
Mildly47762200083556984122137168
Reduced495522000833670109145177210249
and521522000833269108
Preserved53342200083355589115149170204237276
Ejection39342300083324680111134148184222
Fraction.41662300083325183113136150187224236
JACC:441323000832462100137149
Heart457323000834477108128151
Failure.4735230008332607488124144177188
2023;11(8,49342300083346698131142171197211243255
Part52002300083356585108
1):893-900.5319230008334475892125156177210245279291
16.39342400085356882
Ettehad40272400083325275107144175213
D,425124000834454
Emdin431624000833288126140176
CA,45032400083408194
Kiran46082400083344969101137
A,475624000834154
et482124000833354
al.48862400083324657
Blood49542400083355087124162
pressure51272400083385891117142178197230
lowering536824000831551101134154168205242
for39342500083185575
prevention40212500083385992123156193214228265302
of433525000833755
cardiovascular44012500083316383120135172202234260291328342373394
disease48062500083385277111142167201
and501925000833168106
death:513625000833872103124161172
a5319250008332
systematic5362250008326578410613819522639342600083223667
review40132600083205385100134184
and420826000833269107
meta-analysis.432726000835791113145166198235266281312338352377390
Lancet.472926000833164101132165186199
2016;387(10022):957-967.49392600083346899129140175208240256287317353385419436447481514547565599633665671
17.39342700085366876
Law402627000833165116
MR,415727000835490104
Morris427727000835492114136151177
JK,44702700083245974
Wald455927000835889104143
NJ.47182700083446982
Use481527000834470105
of493527000833756
blood50072700083385492131171
pressure51932700083386094121148185206240
lowering54482700083155310413939342800083213674113
drugs40652800083385997136163
in424528000831553
the43162800083215994
prevention44282800083396094127161199221236274312
of475828000833757
cardiovascular48322800083316485124139177209242268300338354386407
disease:52572800083385379114146172207220
meta-analysis54952800083579239342900083225680113152186202235263279306
of426129000833859
147434129000833567101
randomised44632900083215695135175235251278314355
trials4840290008322446194110137
in499829000831555
the50742900083226298
context519429000833270110132167200225
of544129000833858
expectations552129000833467393430000833974107131164186201239277304
from42563000083184078136
prospective44103000083396097124163199231255271303338
epidemiological47663000083347389127162220235273289327367382414447462
studies.52463000083275088127142177203217
BMJ.548130000833691116129
2009;338:b1665.393431000833468104140152187220255267306336367403437449
18.39343200085366985
Whelton403232000835796131146169206244
PK,42893200083357084
Carey43863200083407394128159
RM,455832000833591104
Aronow46753200083416299138176227
WS,491532000835790103
et503132000833456
al.51003200083324760
201751733200083346899129
ACC/AHA/531532000834180118145182226267295
AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA3934330008341831191561832202562963233603994344875135505936266506877237608018288658999429681005103910731113114011861240128213091345138614301471
Guideline5418330008343819613416939343400083153068103
for40523400083195678
the41463400083216095
Prevention,42563400083355690122157195216232270308321
Detection,459334000834580102136169193208246285297
Evaluation,49063400083336598113150183204220258296309
and523134000833169108
Management535534000835587125158197231393435000835792130152
of410135000833757
High41733500083445998136
Blood43243500083355189127167
Pressure45063500083355690117143181202236
in475735000831452
Adults:482435000834180117132155182195
Executive50343500083336599132170192207240274
Summary:532335000833370128186218239273287
A3934360008341
Report399536000833570109148170194
of420936000833756
the42853600083226095
American439936000834199134156171203236274
College46933600083407792108142182217
of492936000833857
Cardiology/American50063600083397293132147185201239278310334371429464485501533566604
Heart393437000834479111132157
Association41053700083416995134166181213235250288327
Task44463700083336187117
Force45773700083337092123156
on474837000833775
Clinical48373700083405670108123155188204
Practice50553700083355689121145160192226
Guidelines.52953700083448297136171186201239274301315
Hypertension.393438000834476116151173197231269295310348387400
2018;71(6):1269-1324.434938000833468100131143176209224257275287317347380414438469499531563576
19.39343900085356780
Hjalmarson40263900083435889104160192212238276313
A,435139000834054
Elmfeldt441739000833246103121154169207229
D,465839000834555
Herlitz47253900083437798113127149179
J,491639000832435
et496339000833355
al.50303900083314658
Effect51003900083325169103134158
on527039000833674
mortality535639000835693114138170185199221254
of393440000833756
metoprolol400340000835791114150189211248263301317
in433240000831552
acute439740000833264101123157
myocardial456640000835788125157190211249264295310
infarction.48894000083155271104125155179194232270283
A5185400008340
double-blind523840000833876114152168203225265281295333372
randomised39344100083215492131169227242268303343
trial.4292410008322435991106119
Lancet.442741000833164102135168191204
1981;2(8251):823-827.464641000833465100131140175192226259294325340351386420455476512546579585
20.39344200085367287
Kjekshus40344200083355186116145183220247
JK.42944200083245974
Importance438142000831573112151172197230268300333
of472742000833857
heart479742000833772104125150
rate49604200083205375109
in508242000831452
determining51474200083387395129150208224261276314353
beta-blocker55134200083397439344300083225477117133171203233268289
efficacy4236430008334527088120153185218
in446743000831553
acute453343000833164101124157
and470343000833270109
long-term48254300083155392131153175209230288
acute512643000833264102125158
myocardial529743000835888126159191212251266298313
infarction39344400083145169102122152175190227264
intervention42104400083145172104125158192228249264301338
trials.4560440008321425787102127140
Am471244000834097
J4821440008323
Cardiol.48564400083397191128143180195207
1986;57(12):43F-49F.50754400083346397131143177209225255284301313346377409429465497529535