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18156558020012657111166
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při34014400298144233297
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CYP1A2151814400298143290428553695828
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klinického826200001335279104164189237288341402462
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MARTA9572510012181140191240293
jsou1271251001212561115168
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cytochromu3329279001214491124175217269299350430482
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mimo26692930012183105186239
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214653070012150
kazuistiky1534307001214694137192215253287310356405
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praxe2346307001215689137183232
na25963070012155102
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na10143350012155104
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interakce2032335001212379112163197246294338388
klozapin-ciprofloxacin2441335001214773129172222280305361394443466524558614644671727774823869893949
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léčiv1613349001212375121145194
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v26063490012148
kombinaci26793490012147101186244269325374420443
s31473490012140
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vyšetřením.6493630012148100141192226260310367391475498
Klíčovým1169363001215480104150204253304389
tématem1581363001213383168217251301385
je1989363001212475
také2087363001213383131181
optimalizace22903630012155113147171256305329353397448493543
antipsychotické28563630012148104138162220260309354410466500524570617667
a35463630012148
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terapie698377001213384118167225249301
u10193770012155
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spolupráci3142377001214097154179235292326376422446
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klinickým34039100121477397153177223270322407
farmaceutem,770391001212979113197246292342399433483567589
psychiatrem1382391001215798147192248272321354388438523
a19283910012148
dalšími20003910012156105129169193277302
specialisty.2325391001213997149196220269293317357391442460
Článek340405001215882131187239287
zdůrazňuje6544050012142100155189238283339395419471
roli1152405001213288113137
klinického131640500121477397153177222270320377433
farmaceuta1776405001212979112197246292342398432482
v22854050012148
mezioborové23604050012184135179204260318375409464513563
komunikaci29504050012146101186242298322370420466490
při3466405001215791116
hodnocení360840500121561121703404190012155112158208265289
lékových658419001212375123177226277322378
interakcí,1065419001212379113163197246294339363384
individualizaci1478419001212379137161210235293348397422446490540586610
farmakoterapie2117419001212979112197246294349382433467516574598650
a27954190012148
prevenci2872419001215791142190240297343367
nežádoucích32684190012155107151202259315372418441487543
účinků.3404330012155101125181229285306
Diskutována669433001216792131179235269324373422478527
je1219433001212476
i13184330012123
potřeba13644330012157114148181232290339
integrace1726433001212480113164221255304350400
farmakogenetiky2149433001212979113198247294349407458515566601625672724
do28954330012157113
klinické303143300121477397153177223270320
praxe3374433001215791140189239
jako3635433001212574121176
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pro708447001215791146
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psychiatrických1667447001215798147192248272320354387412458505556601657
pacientů.23484470012156106152176227284317373394
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slova:690463001244372130182235260
klinická97646400121477295150173218264313
farmacie,1315464001212978111195243288311361381
antipsychotika,17214640012149104136159216255303347402457490513560609630
antibiotika,23774640012148103135159215239294327350396445466
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interakce,3166464001212479111160193242288332381401
cytochrom35934640012145941301843404780012145100132187270
P450,6324780012153100150200220
terapeutické873478001213383115164221272327360383428474523
monitorování14174780012184139195218251305338392440488543566
léčiv.2005478001212373119142190206
Pharmacokinetic3405030012458116169207294347392450504534592646683711757
interactions1117503001242786123176215268313351380438497540
of1678503001245792
clozapine1790503001244574132179233293321380433
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olanzapine:2435503001245886139198245300360387446499525
case340517001244599142196
studies556517001244380139200227281325
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drug1013517001246099157216
modifications12495170012486144205233268297342396432461519578621
due18905170012460119172
to2082517001243795
CYP1A221975170012459122181234294351
inhibition2568517001242786145173233261298326384443
MARTA3405340012180142195246300
antipsychotics6675340012149104136159216255303347402457490513558599
are1292534001214981131
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drugs1838534001215789144201239
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the2210534001213388139
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drug2592548001215689144200
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This33605480012149106129168
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the340576001213386135
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P4501508576001215298146195
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(CYP1891576001212882137189
1A2),20965760012151104155180198
which23105760012173127149192246
may25725760012182129173
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level3265576001212473119167190
changes3471576001214498144198252301340
beyond3405900012157108155209265321
the682590001213389139
therapeutic842590001213388139172220277328383416439484
range.1347590001213382137193243263
Two3406040012150117171
selected538604001213990114164210245294352
case917604001214493132183
reports1127604001213282139195228264304
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clinical168660400121456891146169214263286
practice1999604001215790138183218241286335
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the742618001213491143
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these1675618001213390142183235
interactions1940618001212481115165199250296333357413471511
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solutions.3061618001214198123179213237294352392414
Special35056180012150108161208232282306
emphasis3406320012151136194251300340363403
is772632001212464
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clozapine2630632001214569125168219277301357409
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drug1699646001215789145201
monitoring19216460012184139195218251305338361416473
(TDM),2415646001212881148228255274
potentially27106460012157113146195251283306354377400448
in3179646001212479
combination3279646001214599183239263318366399422477533
with340660001217497130186
pharmacogenetic5456600012157113161194277326370424481531587637671694738
testing.1303660001213383122156179234290311
A16346600012161
key1715660001214796143
theme1878660001213388138222273
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patients14036740012157106138161211267299340
with1770674001217397130185
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pharmacists,10426880012157113161193277325370393431465506527
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The3407020012150106157
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effects.1132730001215079112162208243284305
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patients.33407440012157106138161211267299340361
Key3407610012461111162
words:5197610012475131169229272297
clinical83476100121446790144166211258281
pharmacy,11337610012156111158190273320364413429
antipsychotics,15797610012148102134157213251299342396450483505549589610
antibiotics,22067610012148102134156212235290322344388428449
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P450,4957750012153101150201221
therapeutic737775001213388138171220277328383416439484
drug1242775001215689144200
monitoring.14647750012183138194217250304337361416472493
DECLARATIONS:4068253008648871301662142563043393604124625014570253008514
Declaration406826700874987120141179206244271291333375
of445726700874066
originality:45372670087406888130150192230251271298337356
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1964,528539100853771110150166
with54743910085537297139
subsequent406840200852867107136172213252288328352
amendments,443740200853493130169210269305345369398414
as486840200853462
well494840200855287105122
as508840200853362
with51674020085526993133
the53184020085236298
ICMJE543440200851759116143179
Recommendations406841300853977112153216278317359402439465483525568598
for46974130085226389
the481841300852466104
Conduct,495441300854283125168210245272290
Reporting,527541300853978121163189217236278321338
Editing,40684240085347491115132172212227
and430842400853373113
Publication443442400853776117134151183218242259298338
of478542400853859
Scholarly485742400853467106146163198221239273
Work514242400856097121155
in531042400851656
Medical537842400855693134151183218235
Journals,406843500852666105129169204221249265
updated435343500853980121155179215256
in462943500851656
December470543500854683116151211252289313
2018,503743500853673107140156
including52134350085165689106145186203243283
patient55164350085407540684460085234076116140
consent422244600853270110138174214238
where447544600855191127151187
appropriate.467744600853474115139178219243260295318354369
Conflict406845900874282124149171191223251
of433445900874065
interest44134590087196288126154192224251
and467845900873779122
financial48144590087244587125167200220258279
disclosures:51074590087416293126147188220261289327359378
None.406847100854686126162177
Funding/Support:406848400873777119162183225267291329371414457499526554574
None.406849600854686126162177
Cit.4068714008541588297
zkr:41807140085306489105
Klin42997140086416079120
Farmakol44347140086357095156192229269288
Farm.47367140086367096156174
2025;39(3):181-184492571400863775113151167205242264301321338373409445465499534574
https://doi.org/10.36290/far.2025.063406872500853962881291571721982194284725008641811004385725008514547811714345287250086387390130169206244283307330367393407447485522561577616655693
Článek40687360085415892132168202
přijat4285736008539638198132156
redakcí:445673600852359100134168199216231
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Článek40687470085415892132168202
přijat4285747008539638198132156
k4456747008533
tisku:45047470085234068101141156
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PharmDr.406876600874182120148209259287303
Kateřina438576600874381108146174194236274
Skopalová,467376600873877118161199219261298336356
Ph.D.504376600874082101152170
skopalovak@pnkm.cz406877800852861100141176193232266301335387428468501562577610642