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KLINICKÁ341804001074588109168189242288347
FARMAKOLOGIE709804001074291138211265312372415474533554598
A13288040010753
FARMACIE1403804001074191138210265316336380
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Klin190680400107446583131
Farmakol2057804001074278105179220258305325
Farm.2402804001074178104179195
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HLAVNÍ341200012670127198263336370
TÉMA733200012657114204274
TDM34136001063070123
jako4803600106226197136
nástroj63136001063979113146182222245
pro89236001063368109
farmakogenetické101636001062967102157197233272312343385417450468503538571
profilování160236001063368109140158189228265302343360
pacientů:197836001063269102120152193225267282
kazuistika227536001063475110151168201233251286328
fenokonverze261936001062860102143179218259298329365400432
11.343650085356475
Světlík428650083326194115129143173
S,6116500833244
Hronová666650083436399135172203234
K,9116500833447
Slanař969650083324677113144164
O.11446500834656
Fenotypizace12116500833264101137158190229243270302333365
enzymů1587650083337098130187223
podílejících1821650083387511312714217534375008315296074105142
se4967500832660
na5677500833769
metabolismu6477500835791112144182220235249274331367
léčiv.102575008315498195126135
Čes1171750083407399
slov1281750083264077108
Farm.1401750083326080138150
2012;61(3):115-26.1562750083346798127138173202217249265276305332361382412444457
12.343850085366884
Bousman4478500833574112138196229267
ChA,7348500834078120134
Stevenson888850083335488120154192219257296
JM,1204850083247993
Ramsey13178500833668126153188219
LB,1557850083316780
et16578500833457
al.1734850083324760
Clinical1815850083405570108123155188203
Pharmacogenetics3439500833573105126184217249286325360398433456471503531
Implementation8889500831573112128163221256294315348370385423462
Consortium13649500834077116142180202227242279337
(CPIC)1716950083195893108148169
Guideline19009500834381973431050083387287101138173
for5281050083185576
CYP2D6,61610500833976111144188223235
CYP2C19,86310500834076112145184215245254
CYP2B6,113010500833975111144178213225
SLC6A4,136710500833262100133173207219
and159810500833169107
HTR2A171710500834477113148189
Genotypes1918105008344783431150083387698131171207234
and59211500833270109
Serotonin7161150083336889126148185224239277
Reuptake100811500833570108147169202232266
Inhibitor12901150083155391106145160183220241
Antidepressants.154711500834179100116155189229250284311338371409430458472
Clinical3431250083405570108123155188203
Pharmacology56212500833572104126184216249285301339379411
and98812500833270109
Therapeutics.111312500833271106128161200235273296311343371384
2023;114(1):51-68.151212500833569102136148178206237256288302314349380399436472485
13.3431350085366782
Porcelli4371350083357192123156171186200
S,65013500833244
Fabbri7071350083326199138160175
Ch,8941350083407789
Serretti9961350083326787109142164188203
A.121113500834155
Meta-Analysis127913500835488110142164205243274289321347362387
of167913500833756
Serotonin17471350083326787124146182220235272
Transporter3431450083324982119145184222244268301322
Gene67814500834378116151
Promoter8411450083355692150188210243264
Polymorphism11181450083347186118176214235274313327353410
(5-HTTLPR)15411450083185173119152189222257292310
Association18641450083406894132343155008331457798112149187
with5421550083506587124
Antidepressant6781550083417899114151186224245278304330362399420
Efficacy.1111155008332496684115147179211221
European13441550083326888125163198229266
Neuropsychopharmacology:16231550083447811513517121023626829933637334316500833977109130188220252289305343382414427
The78316500833372106
Journal90216500832462100121160192207
of112216500833756
the11911650083226094
European12981650083336990127166202233271
College15821650083407792107142181216
of181116500833756
Neuropsychopharmacology.1880165008344791173431750083215897124157188226265304343375396455487519556572610650682692
2012;22(4):239-258.105017500833468100130142177212229262280292327362395418449484518532
14.3431850085366984
Hahn44318500834476115153
M,61118500835568
Müller69518500835492107123157179
DJ,8891850083466880
Roll9851850083357389104
SC.11051850083327386
Frequencies12071850083325286125163198236268283318345
of156818500833756
Genetic164018500834379117152174190222
Polymorphisms1877185008335728812034319500835796117157196211237294321
of68219500833757
Clinically7571950083405570108123155188203218250
Relevant10251950083367186121153186224246
Gene-Drug128919500834479117152176223244283322
Pairs16291950083356782103130
in177819500831452
a1849195008331
German18991950083437910034320500835790128
Psychiatric4902050083356294126164179211232254270302
Inpatient8112050083155392125147162197235256
Population.108720500833572111150165197219234272311324
Pharmacopsychiatry.143020500833673105126185217249286326353385417455470502523545579589
2021;54(2):81-89.34321500833468101133141176211231264282294329361380416450461
15.3432250085366780
Sládková4342250083324677115144180210242
Kavínová6872250083346797112148185216247
H,94522500834456
Dorofeev101222500834482102138156189223254
A.127722500834154
Farmakogenetické13422250083326080137168197233271305342375396411441470503
vyšetření185622500833164901231443432350083215491106
v462235008332
psychiatrické5072350083396597128165179211232252267299328361
praxi8822350083396092123138
v1033235008332
ČR.10782350083407589
Acta11802350083417296128
Medicinae.132123500835589128142174188225257291303
2023;16:36-39.163723500833468100134145174204216251284307339372382
16.3432450085366984
Tašková4392450083326086115152184216
I.66824500831427
Terapeutické7082450083326283116154189226249264295325358
monitorování107924500835794132147169206227264295327365380
psychofarmak14712450083386597128165203222255276333365395
z1878245008328
pohledu1919245008338763432550083385388127165
klinického527255008329466199114146176210248287
farmaceuta:8332550083185172131163195229267289322334
doporučení118625500833877116155177215247281319334
versus15392550083316687114151178
praxe.17362550083386093124158170
Remedia.19252550083367134326500835792132147179192
2020;30:650-656.55126500833468101135148183217230266300334358395429463476
17.3432750085366776
Scherf-Clavel43227500833265102137158180200243258290322356371
M,81627500835568
Frantz8972750083325285122144175
A,108427500834155
Eckert11522750083336494128149174
A,133827500834155
et140627500833456
al.14752750083324760
Effect15482750083325170105137161
of172227500833756
CYP2D6179127500834077114147192227
pharmacogenetic34328500833977109131189221254291330365403438460476508
phenotype86628500833977112150189211244284320
and120128500833270109
phenoconversion132628500833877112150188221258296328362383410425463502
on184328500833876
serum19342850083276234329500832159117
concentrations47929500833168107139172211232254286308324362400426
of92529500833756
antidepressants10002950083327092107146181220241276302329362400422449
and146929500833169108
antipsychotics:15972950083327091106145172205236274313334350382409422
a343305008332
retrospective3973050083215679101139166206243276301317350386
cohort80430500833270109148171196
study.10213050083275190130162173
Int12153050083155476
J1313305008324
Clin13583050083415772111
Pharm.149030500833675108130189203
2023;45(5):171430500833570104140152187221239274293305
1107-1117.3433150083346293126144175203231260266
18.2138650085366985
European2236650083326990127166201233271
Medicines25196500835589129144175190228263289
Agency.28216500834179113151183216226
Guideline3060650083438196135169185200237272
on33456500833775
the3433650083215994
investigation35406500831452831171441661822202522138750083223775113
of22707500833757
drug2345750083386098137
interactions2501750083145274107129162194218233271310336
[online].2856750083185493108123161196213225
201231007500833468100130
[cit.324875008319496486100
17.3366750083356470
4.34557500833447
2025].35207500833468101136156168
Dostupné370675008346842138850083264987126165200
z:23538500832842
https://www.ema.europa.eu/.2411850083375983122149162188209260313367378412470503516551588610647686719733767805831837
19.2138950085366982
The22399500833372107
Flockhart2365950083324785117148187219240265
Cytochrome2649950083406792129162200221258317352
P45030199500833668100134
Drug-Drug31729500834667106145167214236274313
Interaction3504950083155374108129162194218234272310
Table.21381050083326099115150162
Updated231310500834482122154176209249
2021.257510500833468100132141
[online].27291050083185493108123161195213224
Dostupné296610500834584111134171210249284
z:326310500832842
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20.21381250085367287
Center224012500834074112133167188
for24431250083185677
Drug253512500834567105144
Evaluation,26941250083326497112150182204219257296308
and301712500833270109
Research.31401250083367197132164185216254268
2025.342212500833468101136148
“For35851250083205491113
Healthcare37121250083447921381350083334972111144178200236
Professionals.”23951350083365896116152179207223262301335351378392412
U.S.28281350083455792106
Food295613500833371111152
and313013500833271112
Drug326313500834669109149
Administration.34331350083428214115719621223926328531934235821381450083377689
FDA.224814500833277117132
[online].24011450083185493108123161197214226
June264714500832563101136
27,28031450083356873
2025.289714500833468101136149
Dostupné306614500834584111134172212250285
z:337214500832842
https://www.34351450083375983123150162189210261314368379
fda.gov/drugs/drug-interactions-labeling/healthcare-professionals-fdas-examples-drugs-interact-cyp-enzymes-and-transporter-systems.2138155008319589110514418321624027629833737740343046648852756758960664566770172375778981483086990893595697310061046108210981114115211921219125912941327134313661405143714711493152715511592161416522138165008318538110812316120023324827529631635538841543647350553859663665268771473677779883787690392494197910011035105610901122114711671201123512751299133613741404143914981533156015821614165321381750083386083104137175202241279301326359381400427460487510544602628642
21.21381850085367082
University22411850083448297130164186213228251284
of254618500833757
Florida26231850083334886108123162195
Health.283918500834479111127149187201
CYP2D6306018500834078114148193229
phenoconversion331018500833877112151189222259298329364385412427466504
calculator21381950083316480112150165198220257278
[online].24371950083195593109124162197214226
Přístup2684195008335567198121159198
31.29031950083346575
3.299819500833547
2025.306619500833468101136148
Dostupné323519500834584111134172211250285
z:354119500832842
https://36041950083375983123150162189210
precisionmedicine.ufhealth.org/.21382050083396094127142168183221259317352392407439454492527539577596637672704719741780793831852891917923
22.21382150085367287
Cicali22382150083405586119134149
EJ,23992150083335971
Elchynski24832150083324779116147185211241257
AL,27522150083417386
Cook285121500833976114145
KJ,30082150083356375
et309521500833456
al.31642150083314759
How323621500834482132
to338121500832258
Integrate34522150083155273107146167200221254
CYP2D6371921500834077213822500833568112147
Phenoconversion229722500833571106143181213249287317351372398413450488
Into27972250083155273109
Clinical29182250083405569106121152184199
Pharmacogenetics:313022500833471103123181213244280319353391425447462493520532
A3674225008341
Tutorial.3727225008332652138235008322598096128143156
Clin23092350083405570108
Pharmacol243323500833572104126184216249286301
Ther.275023500833272107128138
2021;110(3):677-687.290423500833468101132140170198230249283300312347380415433470506539545
23.21382450085377794
Bloch22652450083365596131172
MH,2470245008356104119
McGuire262224500835692140181198222259
J,291424500832539
Landeros-Weisenberger298624500833269110152190213254283307368404422451489530572610634675713737
A,375624500834258
et213825500833458
al.22182550083324963
Meta-analysis230325500835592115149173206246279296329357373400
of272525500833858
the28062550083226197
dose-response292625500833878106142166190225253293333373401437
relationship33852550083215773107130146185225253292308348
of375625500833758
SSRI213826500833368106123
in228726500831555
obsessive-compulsive236826500833981110147176205222256293318354394455497538555583600635671
disorder.30652650083395684125149190227250262
Mol335326500835697115
Psychiatry.34942650083366499133173190225248272308320
2010;15(8):850-855.213827500833469101134147178209227261280293328363398422459494527540
24.21382850085367186
Schulz223828500833265103140156185
M,243628500835568
Schmoldt251828500833264102160199215253276
A,280828500834155
Andresen-Streichert287628500834179118140174200235274296327348370404419451489524545570
H,346028500834456
et353028500833456
al.36002850083324760
Revisited:3674285008335701021182138295008326416397137149
Therapeutic230629500833372107128161200236273296311343
and266829500833270109
toxic27962950083225989105137
blood29522950083385492131171
concentrations314229500833168106138172210232253286308323361400426
of358729500833756
more366229500835896118152
than21383050083215991128
110022793050083346192127
drugs24193050083385896134160
and259230500833169107
other27113050083375996131152
xenobiotics.287530500833063101139178193230252267298325339
Crit3226305008340607597
Care.33363050083397293126138
2020;24:195.348630500833468100134146181212224253283316328
25.21383150085367287
Chen223831500834077112150
R,240131500833549
Shen246331500833270105143
K,261931500833549
Hu268131500834482
P.277531500833540
Single-28283150083334785124139174197
and303831500833169108
multiple-dose315931500835795110132147186202237260300338365399
pharmacokinetics3571315008339771091301892213934650083316898115152187209225256284
and42316500833169108
tolerability4352650083225874109130163202217232247270303
of46686500833756
a473765008332
paroxetine4782650083387192129159193215230268303
controlled-release50986500833168106127149186202217251291313335369384419450477512
tablet3934750083225494110144167
in41147500831553
healthy41807500833873104120142180211
Chinese4404750083407893131166193228
subjects.46457500832764103118153186210238251
Int4910750083145274
J499775008325
Clin5035750083405570108
Pharmacol51567500833673105126185217249286302
Ther.54727500833271106128138
2017;55(3):231-236.39348500833468100129139174207224258275287322357388407438472507520
26.3934950085367186
DrugBank40329500834566104142177210247277
Online.43219500834785100114152186198
Paroxetin4531950083356787124154187209224261
[online].4805950083185391106121158192209221
Edmonton50389500833370127165203224260298
(AB):5348950083195995112124
DrugBank;54849500834566104393410500833772104141171184
202441301050083346799130
[cit.427210500831847628396
19.43801050083346373
4.446510500833446
2025].45231050083336698132151162
Dostupné469710500834583108131168206243277
z:498610500832841
https://go.drugbank.50391050083375881120146158184203238275287325345383421459491528557571
com/drugs/DB00715.393411500833168126152188209248287313339385421457493526558588600
27.39341250085367180
Remood403112500833570128167205245
20429312500833468
mg437912500835796
tablety.44921250083225594110145167201211
Souhrn472012500833271109147168206
údajů494412500833776108124161
o5122125008337
přípravku51771250083386075114136169200231269
(SPC)54641250083185085125146
[online].39341350083195593108123161196214225
Praha:41771350083355588127159171
Medicom436513500835590129145177213272
International;46541350083155374108129168200222237275314346361373
[cit.5044135008319496487100
19.51611350083346575
4.525413500833446
2025].531813500833468101136155167
Dostupné55021350083468439341450083264987126165200
z:414914500832842
https://www.sukl.cz/.42071450083375983122149162188209260313367377405442472489502534564592598
28.39341550085367389
Paroxetine:40451550083366890127158193216231270305318
Drug438415500834668107147
information45521550083155372111133192225247263301340
[online].49131550083195695111126165200218230
UpToDate.516415500834484114148195228250285297
Waltham54821550083589010639341650083226092150
(MA):410316500831972114133145
UpToDate,426716500834483112146193225247280292
Inc.;4578165008315538598111
2024470816500833468101133
[cit.4860165008319496486100
19.49791650083346475
4.507316500833447
2025].513916500833468101136155167
Dostupné532516500834684111134172211250285
z:393417500832842
https://www.uptodate.com/.39911750083385984123150162189210261314368378416455477514554586608641654686722781807813
29.39341850085377591
Hilleret4049185008345628097134158194219
H,429218500834560
Voirol43771850083367592116156174
P,457518500833642
Bovier464218500833677111129166190
P,485618500833643
et492318500833559
al.50061850083335065
Very50961850083367195132
long52521850083155697139
half-life54151850083387391112135153170393419500831956
of401719500833961
paroxetine41051950083407699140173210235253294332
following4464195008319607996137192210251294
intoxication47851950083155680120153171206242267285326368
in518019500831556
an526319500833274
extensive53641950083356996133174204221393420500833268
cytochrome40252050083326793132167206229268328365
P4502D6441420500833569103139174220258
metabolizer.469520500835894118153194235252269299335358370
Ther508920500833273110133
Drug524520500834669109150
Monit.541920500835595135152176191
2002;24(4):567-569.393421500833470107141155192225246280299312349385419439474510545558
30.39342250085367388
Bertelsen40432250083367193118152168194230268
KM,433222500833593106
Venkatakrishnan445922500833669108138172194227258281297323361400433471
K,495122500833550
Von502222500833672111
Moltke515422500835594110132163198
LL,53732250083316477
et547122500833457
al.55492250083324861
Apparent393423500834181121154175210248270
mechanism-based422523500835793126164197235250277335358398431458493533
inhibition47792350083155391107146162184200238277
of507723500833757
human515423500833876134167205
CYP2D6538023500834078115149194230
in393424500831553
vitro4004245008331476991128
by414924500833970
paroxetine:42362450083397293130161194217232270305317
comparison457124500833168126165198219235261299338
with49262450083506688126
fluoxetine50702450083173371109139173196211249284
and537124500833270109
quinidine.5497245008338759139342550083385391107144179192
Drug414125500834567105144
Metab430125500835489111144183
Dispos.45002550083456187126164191205
2003;31(3):289-293.472025500833468105138149184215230264281293328362396419450485517530
31.39342650085366981
Saito40282650083326580102139
M,418026500835468
Yasui-Furukori42602650083356591128143165199235256294324361383398
N,467126500834557
Nakagami474126500834577107140179211269284
T,503826500833241
et509226500833356
al.51602650083324760
Dose-dependent523326500834584110145168208243282317355393427500833874112134
interaction40892750083155375110131165197222237276315
of442527500833757
paroxetine45032750083397294132162197219235273309
with48332750083516790128
risperidone49822750083213763103139160176216254293329
in533227500831553
schizophrenic5406275008326599711314218039342850083387697130167182213
patients.41602850083387091106140177198226239
J4411285008324
Clin44472850083405469106
Psychopharmacol.45652850083356193123161198237275306327385416448484499512
2005;25(6):527-532.508928500833467103136147181215232265282294328361393411445477509521
32.39342950085377389
Hahn404529500834578118157
M,422329500835670
Roll43142950083377693108
SC.44442950083337589
The455429500833374110
role46852950083216076112
of481929500833858
phenoconversion489829500834079116155194228266306338373395424439478518
in543729500831554
the55132950083226197
pharmacogenetics393430500833977109131189221254290330365403438460476508535
of448330500833857
psychiatric45543050083396698130168183215236258273305
medication.487430500835792132147179212233249287325338
Pharmacogenomics.522630500833673105126185217249286326361393431500833876134149181209222
2023;24(9):485-487.417231500833468101136147182214233266284296330366400422459495528534