554
www.klinickafarmakologie.cz340804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/26478040010732
Klin272480400107446583131
Farmakol2871804001074279105179220258305325
Farm.3212804001074178104179195
2025;39(4):213-2173423804001074487128172185229271295336358372417456494521560599636
/41048040010732
KLINICKÁ4182804001074488109168189242288346
FARMAKOLOGIE4546804001074191138210265312372414474533554598
A51618040010753
FARMACIE5231804001074291138211266317337381
21356558020012657111164
HLAVNÍ4945200012671127198263336370
TÉMA5337200012657114204274
Navození266936001063979114153184216258275
indukce29603600106155696137172205237
CYP3A4321336001063271106139177210
metamizolem343836001065284117154208225258297328361415
potvrzené386936001063374104145180215247288320
metodou420536001065283117156196237278
TDM:449936001062969123139
případová46533600106336886121158197238275312
studie498136001063063104144161193
s5190360010630
kvetiapinem523636001063474106139157197231248290321376
Navození3409200298166292412545655781921984
indukce1373920029866205346484612715839
CYP3A422609200298143290429555706836
metamizolem314492002982063324195467508149261063112712531458
potvrzené340118002981442813684985887018269661091
metodou148011800298206331419556698835973
TDM:250211800298131296497558
případová340144002981442332974385647058429641088
studie147714400298104191329471536660
s218614400298104
kvetiapinem233814400298131263384471537662803867100611311337
Ivana340184001373190147212269
Tašková6321840013760111159218280337395
Oddělení3402000013376139200255281336397422
klinické785200001335279103164189237288341
farmacie,1150200001333285120212265313338393414
Psychiatrická15882000013358100153201261286338373408434482533587
nemocnice21982000013361116208268318378403452505
Bohnice,27262000013360120181242267315369390
Praha3140200001335892145206258
Katedra3402150013360113149202265300353
sociální7172150013343103153178230255315340
a10812150013353
klinické1157215001335279103164189237288341
farmacie,1522215001333285120212265313338393414
Farmaceutická19602150013353102137228281330383444480504553604657
fakulta2641215001333285136197222258311
Univerzity29752150013372131156209263298347372408463
Karlovy34612150013360113149174234286341
v38262150013352
Hradci39022150013371107160222271296
Králové4221215001336097150175235287340
Metamizol3402520012180131164213296319362416440
je798252001212474
analgetikum8902520012148103151175231281314337383439522
a14302520012148
antipyretikum14952520012149104136159215262295345378401447503586
s20982520012140
dlouhou2156252001215679134189245300355
historií2529252001215578117150204237260283
klinického283025200121477295150173217264312368423
využití,3271252001214898154197220253276296
jehož3585252001212575130185227
některé3402660012155105152187236268318
farmakologické675266001212978110193241287340364418475498542588636
vlastnosti,1329266001214871119157191246300339373395415
včetně1762266001214891139172227277
bezpečnostního20572660012156107150206257302357411450483538561618672
profilu,2747266001215689143172198221275295
však3060266001214786135181
dosud32582660012156111150204260
nejsou35352660012156106129168222277
plně340280001215781136186
objasněny.5482800012155112136183222278328383429445
Novější3402940012166121168217241280303
studie668294001213973128185208258
ukazují,9502940012156102152195250274297317
že1292294001214393
metamizol14092940012184134168216300323366420444
působí18782940012157112151206263287
jako2190294001212472118172
středně2387294001213973106155213268318
silný273029400121396286141186
induktor2941294001212378135190236272326359
enzymů33252940012150106149199283337
cytochromu3687294001214594340308001213387133188220275358413
P4507773080012154101151201
(CYP),1002308001212984140194220239
zejména1265308001214393116200250306354
CYP3A416433080012158114168217276327
a19943080012149
CYP2B6,20673080012158114168217270322343
což2434308001214599141
může25993080012184138181231
vést2854308001214898137171
ke3049308001214796
změně31693080012143127177232283
plazmatických3476308001215781129172256304340322001213356101147198241296
koncentrací6583220012147100156201250306338371419464487
současně1166322001214095150195244283338388
podávaných15753220012157113170218265313369414458513
léčiv2109322001212474120143191
z23213220012143
řad2385322001213381138
jejich254432200121247599122166221
substrátů.2787322001213994150190224256305337392412
V3403360012156
rámci417336001213381164209232
tohoto670336001213488143199231285
článku976336001214568116172218274
je1271336001212474
prezentována1366336001215790140183233289321375422471526574
kazuistika1961336001214796140195218257291314360410
pacientky,23923360012157105150173223279311358408424
u28373360012155
které2913336001214783132165215
při3149336001215790113
pravidelném3283336001215790139185209266316340395446529
podávání3403500012156111167213259306360382
metamizolu7393500012182132164212293316357411434487
došlo12433500012156109148170224
k14843500012146
výraznému1547350001214797129176219273322404457
poklesu20213500012156111157181230269322
plazmatické2360350001215679126168250297328350394439487
koncentrace2864350001214698153197245299330362409453501
kvetiapinu3381350001214796144177199246301324378431
(přibližně340364001212884116138194217240282336385
o7423640012155
75814364001215097
%),9233640012178103121
což1061364001214497138
odpovídá12163640012154110166221267290346393
středně1626364001213972103152208263312
silné195536400121396184138187
indukci2159364001212478133187233275298
CYP3A4.24743640012157112165213271321341
Po28323640012152104
vysazení2953364001214898136184227276330353
metamizolu33233640012182132164212294317359412436489
se340378001213989
hladiny447378001215578126182205260305
kvetiapinu769378001214797146179202249306329384438
vrátily1224378001214881129161184207254
zpět1496378001214299149182
do16963780012156110
terapeutického1824378001213382114162219269324357380424470518574628
rozmezí.2470378001213286128211261304327347
Význam28353780012155103147202250333
tohoto3185378001213386142196229283
poklesu34853780012157112159184234273327
byl3403920012157104129
potvrzen4973920012157114147198232277327383
metodou9093920012184135169223281336392
terapeutického1330392001213383116165222273329363386431478527583639
monitorování19983920012183139195219252306340395442491547570
lékových2597392001212374122176224275319374
hladin3000392001215680128185208264
(TDM),3293392001212881149230257276
která3597392001214783133166215
umožnila3404060012155138194236291314337385
správnou747406001213996129177224280335390
interpretaci1158406001212479111161193251284334367416461484
této1663406001213382116170
lékové1854406001212374121175222271
interakce.2146406001212479111160193242288332381401
Tato340420001215193127182
kazuistika,551420001214898142199223262297321369419441
spolu1021420001214098155180236
s12864200012140
doplněním13554200012158114172197254305362386471
teoretických1855420001213384141175226260284330377429473530
poznatků24144200012158115158215264297345401
o28444200012156
indukčním2929420001212481139194242287343367452
působení34104200012158115155211269322379402
metamizolu,3404340012183133167215298321363418442496516
podtrhuje8744340012157112169202235290344368418
klinickou130943400121477295150172217263316371
relevanci1698434001213382106156203251306351374
jeho2090434001212474129184
interakčního2292434001212378110159192240286329384407464519
potenciálu28284340012157113145194250294317365388442
a32884340012148
zdůrazňuje3354434001214298152185233276331385409459
nutnost3404480012155109142197252291324
zvýšené682448001214393143182232288338
opatrnosti10374480012155112160192225280335374407430
při1485448001215689112
jeho1615448001212474129184
souběžném1816448001214095149206256299354404487
podávání23214480012157112169217263311366388
s27274480012140
léčivy2784448001212474119141189240
metabolizovanými30414480012183133167215271327351373416470517565620665749772
prostřednictvím340462001215790144184218250300357412435480515566590673
CYP3A410344620012158114168217276327
a13824620012148
CYP2B6.14524620012158114167217270322343
Klíčová340478001246190118163220272325
slova:683478001244371129181234260
metamizol,9614790012183134167216299323365420444465
kvetiapin,1444479001214798147180203251308331387407
léková1870479001212373121174222270
interakce,2158479001212479111160193242288332381401
indukce2577479001212479135190237280329
CYP3A4,29244790012159115168217276327347
terapeutické3290479001213382115163220271326359382427474523
monitorování3404930012183139194217250304337392439488543566
léčiv.927493001212474119142191206
Induction340516001242888148206252291319377436
of796516001245893
CYP3A49095160012459122180234298354
by12835160012460111
metamizole14145160012486140177231317345392451479532
confirmed19665160012445103162196225264350403464
by24505160012460111
TDM:25815160012455125210236
a3405300012453
case413530001244599142196
study629530001244380139200253
with9025300012476104141200
quetiapine11235300012459118171209237290350378437490
Metamizole3405480012180130163211294317359413437486
is844548001212362
an9235480012148103
analgesic10435480012148103150173229278317340384
and14455480012147102158
antipyretic16215480012148102134157213259292341374397441
with2079548001217397129184
a22805480012148
long2346548001212378133188
history2552548001215578116149203235285
of2855548001215483
clinical295554800121456790145167212260283
use,3255548001215593143163
although3435548001214871104158213268323378
some340562001214095179229
of598562001215584
its71056200121235797
pharmacological8355620012157113161194278326371425449504561584629678701
properties,1564562001215790145202253286322345396435456
including2049562001212378123147201258281337393
its247056200121235797
safety2595562001214089118168202252
profile,2875562001215790145174200224274294
remain3197562001213383166215238293
incompletely3518562001212479124178262340576001215781131165214238285
understood.6475760012155110167217250290324378434491512
Recent3405900012154104149198253284
studies651590001214073127184206256295
indicate972590001212478135157201249281330
that1328590001213488136167
metamizole15225900012184134167215298320363417440490
is2038590001212462
a21275900012148
moderate22025900012184138195245277325357405
inducer2634590001212478134189233281314
of2974590001215684
cytochrome3084590001214695130184229283315369452502
P45036135900012154101149199
enzymes3406040012150105147196279329367
(CYP),733604001212883138191215233
particularly9926040012157105136171193237290313360391414460
CYP3A414786040012158113166214272322
and18266040012148102158
CYP2B6,20106040012158113165214266317337
which23736040012173128150194248
may26476040012183130175
result2848604001213281120173195227
in3101604001212478
altered3205604001214870102150182231287
plasma3518604001215780127165247294
concentrations340618001214496149193240293324354401432453506560596
of951618001215582
concurrently1048618001214496149193245276307355409439461506
administered15696180012148102183205258279316348395426474529
drugs2113618001215687140194231
that2359618001213386132162
are2536618001214879127
substrates2678618001213991146183215246292323370408
of3101618001215482
these3198618001213285134171220
enzymes.34336180012149103144192274322360380
This3406320012150106129168
article527632001214881116139184207258
presents804632001215790139179229285317358
a11816320012148
case1248632001214594133183
report1450632001213383140196229265
of1734632001215484
a18376320012148
patient19046320012157106138161211267299
whose22226320012174130185224275
regular2516632001213282139194217265298
administration28336320012148104188211266289328362394443475498553609
of3461632001215584
metamizole356463200121841341682163406460012185109153209233285
led654646001212476134
to817646001213489
a9366460012149
marked10146460012185134167215266324
decrease13676460012158109156189240290330381
(approximately1777646001212975133192226281328352437487520570595644
75%)24506460012152101180206
in2685646001212481
quetiapine27956460012157113165199223272330354411462
plasma3287646001215782131171256305
concentration,36226460012145100157340660001214594149182214263295318373429450
consistent817660001214599155193216255289338394426
with1270660001217498131186
the1484660001213388138
moderate16506600012183138196246279327360409
induction2087660001212378135189234270293348404
of2518660001215584
CYP3A4.26296600012158115168217276327348
After3004660001216290126176209
discontinuing3240660001215680118163217273305328383438461517573
metamizole,3406740012183134167216299323366420444494514
quetiapine8746740012157111162195218266323346402452
levels1346674001212374121170194233
returned1599674001213382116171203259310367
to1986674001213387
the2093674001213388138
therapeutic2251674001213388139172220277328383417440484
range.2755674001213381137193243263
The30386740012150106156
significance3214674001214063119174197226253297346401446495
of3729674001215584
this340688001213389112151
decline5196880012157107153176199255305
was8536880012174122161
confirmed1043688001214599154183210242326377435
by15066880012157104
therapeutic1638688001213389139172221278329385418441486
drug2152688001215790145202
monitoring23826880012184139195218251305339362418474
(TDM),2884688001212981149230256275
which31876880012174130153198253
enabled34696880012150106154211235286343
an3407020012148103
accurate465702001214893137191224272305354
interpretation841702001212378111160193250283333366415448471526581
of1444702001215584
this1550702001213388111150
drug1721702001215789144201
interaction.1943702001212479111160193242287322345400456477
This24417020012150106129168
case2631702001214593132183
report,2835702001213383140196229265286
alongside3142702001214872127183239278300357407
a35717020012148
theoretical3641702001213388138340716001215588138171194239287311
discussion678716001215780118164218257296319374430
on11357160012155111
the1273716001213388139
inductive1439716001212479136190235270294342391
effects1857716001215080113163209244284
of2169716001215584
metamizole,22807160012183134167216299323365420444494514
underscores28227160012155110167217250290335389422472511
the3361716001213388138
clinical352771600121446790146169213262285
relevance340730001213382106157204253308353402
of769730001215484
its87973000121235697
interaction1002730001212479111161193242287322345400456
potential14847300012157113146195251283306354377
and18887300012148103160
highlights2074730001215679135190214236292348380421
the2521730001213388139
need26867300012156106157214
for2927730001212984117
increased3070730001212479124156206254293344401
caution3497730001214594148181205259315
when3407440012174129180236
co-administering597744001214598132180236320343398421460494543576599655711
it1329744001212356
with1407744001217397130185
drugs1613744001215789145201240
metabolised18747440012183134167216273329353376415465522
by24177440012157104
CYP3A425427440012158114168217276327
and28907440012148103160
CYP2B6.30717440012158114168218271322344
Key3407600012461112163
words:5207600012475132170230273299
metamizole,8367610012183133166215297320362416440490510
quetiapine,13637610012156110160193216264320343398448467
drug1848761001215688143199
interaction,2064761001212378110159191239284319341396451471
CYP3A425537610012158113166215273324
induction,2895761001212378134188232267290345400420
therapeutic3333761001213387137170218274325379412435479
drug340775001215689144200
monitoring.5627750012183138194217250304337360416472493
DECLARATIONS:4070254008648871301662142563043393604124625014571255008514
Declaration406926800874987120141179206244271291333375
of445826800874066
originality:45382680087406888130150192230251271298337356
The406927900853473109
manuscript418927900855891130168195227249266306329
is452927900851744
original45842790085386178117133172205222
and481727900853472112
has49402790085387299
not50512790085387699
been516227900853975110149
published532327900853977117134150177216251291
or406929000853862
submitted414629000852867108167184208234269310
elsewhere.44712900085355381117169209245269305320
Ethical406930400873764107127160198218
principles43013040087427090132165185228249287319
compliance:463430400873173134177197218256298330368387
The406931500853678116
authors420631500853475100142183208238
attest44653150085356087124153179
that466531500852465101126
their481231500852465103121146
study49793150085295595138173
was517331500855490119
approved531331500853577120145186221258301
by406932600854073
the41593260085236399
local42753260085175689124141
Ethical44333260085345898115147182199
Committee464932600854179139198215239265300337
and500332600853373113
is513332600851745
in519532600851656
compliance526832600853169129169187204239278311346
with40693370085537298140
human423733700854081143180221
studies44873370085285596139157195226
and474133700853577119
animal48893370085347695156193212
welfare512933700855391110133170196234
regulations53913370085236110414516420140693480085234080120148
of423634800853960
the43163480085236399
authors’44353480085347397136176200229244
institutions46993480085165684109126150189213231270310338
as505734800853462
well513934800855187104122
as528034800853462
with53623480085526993133
the55153480085236299
World406935900856099124142184
Medical427435900855795137155188224242
Association453635900854474104144178196231256273314355
Declaration491235900854785119136172196232257274315356
of528935900853961
Helsinki537135900854684102131149189224243
on406937000853878
Ethical41663700085355898115147182199
Principles43843700085376178117150167207225261290
for46933700085205983
Medical479537000855693134151183218235
Research504937000853874102139173197229268
Involving53363700085175690128146181198238278
Human406938100854685145179219
Subjects430838100853474114132168201227256
adopted458438100853474114155179215256
by485938100854074
the49533810085236399
18th507238100853669514338200501437
WMA5199381008559116160
General537938100854582122158182217235
Assembly406939200854475105143204247266302
in439439200851758
Helsinki,447539200854785104134152193228248264
Finland,47623920085355394113149190232249
in503439200851758
June511639200852667109147
1964,528639200853771110150166
with54753920085537297139
subsequent406940300852867107136172213252288328352
amendments,443840300853493130169210269305345369398414
as486940300853462
well494940300855287105122
as508940300853362
with51684030085526993133
the53194030085236298
ICMJE543540300851759116143179
Recommendations406941400853977112153216278317359402439465483525568598
for46984140085226389
the481941400852466104
Conduct,495541400854283125168210245272290
Reporting,527641400853978121163189217236278321338
Editing,40694250085347491115132172212227
and430942500853373113
Publication443542500853776117134151183218242259298338
of478642500853859
Scholarly485842500853467106146163198221239273
Work514342500856097121155
in531142500851656
Medical537942500855693134151183218235
Journals,406943600852666105129169204221249265
updated435443600853980121155179215256
in463043600851656
December470643600854683116151211252289313
2018,503843600853673107140156
including52144360085165689106145186203243283
patient55174360085407540694470085234076116140
consent422344700853270110138174214238
where447644700855191127151187
appropriate.467844700853474115139178219243260295318354369
Conflict406946100874282124149171191223251
of433546100874065
interest44144610087196288126154192224251
and467946100873779122
financial48154610087244587125167200220258279
disclosures:51084610087416293126147188220261289327359378
None.406947200854686126162177
Funding/Support:406948600873777119162183225267291329371414457499526554574
NETPHARM406949700854680116153197239276332
project441649700854063101117151183207
(CZ.02.01.01/00/22_008/0004607),46384970085205998113148182196232264275311343363397434456492527562599635671694728765802838874910944963976
co-funded40695080085317094116156195236272313
by439750800854073
the44855080085236399
European45995080085347396135176213247287
Union.490150800854584101141181196
Cit.4069714008541588297
zkr:41817140085306489105
Klin43017140086416079120
Farmakol44367140086357095156192229269288
Farm.47387140086367096156174
2025;39(4):213-217492771400863775113151167205242264300321338376412446470505541574
https://doi.org/10.36290/far.2025.071406972500853962881291571721982194286725008641811004387725008514547811714345297250086387390130169206244283307330367393407447485522561577616653690
Článek40697360085415892132168202
přijat4286736008539638198132156
redakcí:445773600852359100134168199216231
16.47027360085367085
9.480273600853650
2025486673600853672107144
Článek40697470085415892132168202
přijat4286747008539638198132156
k4457747008533
tisku:45057470085234068101141156
10.46767470085366984
12.47757470085366884
2025487474700853672107143
PharmDr.406976600874182120148209259287303
Ivana43867660087205896138176
Tašková,457676600873972104143184221259279
Ph.D.486976600874182102153170
ivana.taskova@bohnice.cz40697780085165186126160176199234262296334368403456496537576616633665700715748780