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KLINICKÁ341804001074588109168189242288347
FARMAKOLOGIE709804001074291138211265312372415474533554598
A13288040010753
FARMACIE1403804001074191138210265316336380
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Klin190680400107446583131
Farmakol2057804001074278105179220258305325
Farm.2402804001074178104179195
2025;39(4):218-2222617804001074487128172185229271295337358373417456495524563607650
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www.klinickafarmakologie.cz4568804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
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HLAVNÍ341200012670127198263336370
TÉMA733200012657114204274
Linezolid3413600106294788120154193225243282
a639360010638
terapeutické6923600106306298140175206247279297331367399
monitorování:110736001065292134151183222258299336373414431447
Nastal156836001063979113146182213
čas179736001063274108
pro192136001063268108
rutinní204536001063374107124165207224
TDM?228536001062969123149
topenia343650083225998134172187219
analysis5776500833270103118150177192218
by8106500833970
population8966500833877117155170203224240278316
PKPD12286500833569106151
modeling13956500835796135170186201238277
and16886500833270109
simulations.1813650083264198136151183343750083223775113140153
Eur512750083326990
J61775008324
Pharmacol.6577500833572105126184217249286302314
2025;1002:177777.9877500833468101136147177208244277290319349383418452487493
18.343850085366985
Stalker443850083325486102132166187
DJ,645850083466880
Jungbluth7408500832462100139178194232254293
GL.1048850083447689
Clinical1153850083405570108123155188203
pharmacokinetics13718500833977110131189222254291321338376411433448480508
of18948500833857
linezolid,196685008315303439500833771100136152166204216
a57295008331
novel6159500833774106139154
oxazolidinone781950083376798127164179194232246283321358392
antibacterial.1186950083316889104142174206229262283298329344356
Clin1554950083405469106
Pharmacokinet.167295008334711031231802122432793093253431050083387395108
2003;42(13):1129-1140.46610500833569105138149184217234266296313325354382412446470501528559595608
19.3431150085366881
Liu4361150083314683
J,53211500832435
Pang58011500833566103142
Y,73411500833543
Li79011500833146
W,84811500835767
et92711500833456
al.9951150083324759
Impact106711500831572110143175198
of127811500833756
hepatic134611500833772110143164179211
impairment156911500831572110143158178236271308329
and191111500833169107
renal3431250083215492124139
failure495125008318516681118139172
on68012500833775
the7681250083215994
pharmacokinetics87412500833977109130188220252288318335372407429444475503
of138912500833756
linezolid14581250083152967102131168183198237
and170712500833269108
its18281250083143664
metabolites:1904125008357923431350083225494132148163186220246259
contribution61813500833168107128150165204243265281319357
of99113500833857
hepatic106413500833873112145167182214
metabolism129413500835893115148187226242257283340
and165113500833169108
renal17761350083205593125140
excretion.1933135008334653431450083315285107122160198211
Antimicrob56614500834178100115172186218239276315
Agents89314500834179113151172199
Chemother.110514500833977111168206228265300321331
2025;69(5):e0189224.144814500833468100135145180214233266284295329365396426460493527559571
20.3431550085357185
Gou44015500834381118
J,57015500832436
Li61815500833145
Q,67615500834659
Fan7471550083326198
N,85715500834456
et92515500833455
al.9921550083324759
High10631550083435896133
accumulation12081550083316393130186223238269290305342380
of160015500833655
linezolid16671550083152966100129165181195233
and191215500833169107
its3431650083143663
major41816500835687102139159
metabolite58916500835791112144182220235249271303
in90416500831551
the9671650083215892
serum10711650083266080117174
of125716500833655
patients13231650083387091106139176197224
with15591650083496486123
hepatic169416500833770109141161176207
and191316500833168106
renal3431750083205491123138
dysfunction4931750083387096116154191223246261298336
is84217500831440
significantly8941750083264079116131148165196228266287302333
associated12401750083315783121153168199220253292
with15451750083506587124
thrombocytopenia168217500832159791161732122502823153431850083225998134172187219
and57718500833270109
anemia.70118500833270105163178210224
Microbiol94018500835470102123160200215253269
Spectr.122518500833271106139163185195
2025;13(7):e0249324.143518500833469101136147177207225260279291326361394426459492525556569
21.3431950085367082
Crass4381950083406194120147
RL,5991950083356781
Cojutti6941950083397692129152176192
PG,8991950083358093
Pai10061950083356782
MP,11011950083559195
et121019500833456
al.12801950083314760
Reappraisal135319500833671103142181203236251277310326
of169219500833757
Linezolid17621950083324785120150187203218257
Dosing34320500834584111125163202
in56320500831553
Renal63320500833671109141156
Impairment80720500831573112145160181239274312334
To115920500833266
Improve124320500831572112133170202237
Safety.14972050083336685119141175185
Antimicrob170020500834179100116173189221242279319
Agents34321500834179114152174202
Chemother.56021500834078113170209231269304325335
2019;63(8):e00605-19.91121500833468100130143179212230264282294329364400436472506528559589600
22.2138650085367288
Brier2245650083355772107128
ME,23916500835588101
Stalker2511650083325386101131165187
DJ,2716650083456779
Aronoff2814650083416299138176196215
GR,3047650083438094
et31596500833456
al.3233650083324760
Pharmacokinetics33116500833673105126185217249286317333371406429444476503
of21387500833757
linezolid2215750083153068103133170186201240
in24767500831553
subjects25497500832664103119153186211238
with2808750083516689127
renal2956750083205593125141
dysfunction.3117750083387098118156195227251266305343356
Antimicrob34947500834179101116174190222243280320
Agents21388500834179114152174201
Chemother.23558500834078113170209231269304325335
2003;47(9):2775-2780.27068500833468104137149183215232264282294329362397430452483516549584597
23.2138950085377490
Zhang22499500833877111150190
SH,2460950083337891
Zhu25739500833877115
ZY,2710950083387685
Chen28169500834180116155
Z,29929500833952
et30669500833457
al.3145950083324861
Population32289500833573114153169202225240279319
Pharmacokinetics35689500833674108129189223213810500833270102119158194217233266295
and245510500833271112
Dosage258810500834787114148189225
Optimization283410500834889112128188204234268291307346386
of324210500833858
Linezolid33211050083324888124154193210225265
in360810500831554
Patients3683105008336699210821381150083347293121
with22721150083506688126
Liver24111150083324780114135
Dysfunction.255911500834578105125163201233257273311349362
Antimicrob293411500834179100116173188220241279318
Agents326511500834179114152173201
Chemother.347911500834078113170209230269304325335
2020;64(6):e00133-20.213812500833468101135148184220240273291303338373409441471504526557591604
24.21381350085367186
SanFilippo223713500833265103136151166181220260299
S,254913500833245
Turgeon26071350083326687125160199237
J,285713500832436
Michaud290613500835570102140172210249
V,316813500833544
et322513500833457
al.32951350083314760
The336813500833271106
Association34871350083416996134167182214235251289327
of213814500833756
Serotonin22071450083326788125147183221236274
Toxicity24941450083326696111143158180213
with27201450083506688126
Combination285914500833976134173188226258279294332370
Linezolid-Serotonergic3242145008331468411914818520121625427630734236340042245849753155221381550083385385
Agent223815500834179114152174
Therapy:242715500833272107128161200231245
A2687155008341
Systematic27431550083326289112146204236258273305
Review306315500833671103119153204
and328215500833270109
Meta-Analysis.340615500835590112145167209247279295326353368394408
Pharmacy213816500833573105126184217249282
(Basel).24361650083185487114149164184195
2023;11(6):182.264616500833468101136147177205220253271283313344378390
25.21381750085367388
Höhl224717500834483122138
R,240617500833550
Rasshofer24761750083366996123161200220255276
F,277317500833339
Kinzig28331750083355190120135175
M,302917500835468
et311817500833457
al.31961750083324761
TDM327717500833381136
Study34341750083335493132165
Group.361917500834566104143182195
Underexposure213818500834482121156177211243282321348385406441
of259918500833757
linezolid26761850083153068103133170186201240
in293618500831553
critically3009185008331536891106138171187202234
ill32631850083153045
patients33281850083397294109144182204231
with35801850083516689127
extracorporeal37271850083346621381950083224376109146167207246268302334349
membrane250819500835792151190212245283318
oxygenation284619500833868102140176214246268283321360
(ECMO):32261950083195292148196214226
results34721950083215582119135157185
from36781950083184078136
a2138205008332
monocentric218420500835795134172205238277298319335367
study25652050083264987126158
including27372050083155385100138177192230269
blood30192050083395593132171
samples320420500832660117157172207234
from34522050083184078136
52360220500833467
patients.3683205008339729310921382150083347294121135
Infection.22882150083155372106139163178216255268
2025257121500833569101136
Nov272321500834483115
6.285321500833447
26.3934650085367187
Liu4039650083314784
T,41416500833241
Yuan42006500833570103141
Y,43586500833644
Wang44206500835788126165
Ch,4603650083407891
et47116500833456
al.4785650083324760
Therapeutic48636500833372107128161200236273296311343
drug5224650083385998137
monitoring537865008358961341491722093934750083213674113
of40627500833756
linezolid4133750083153068103132169185200239
and43877500833270109
exploring45107500833466105121159181197234273
optimal4798750083377799114172204220
regimens5032750083215595110167203241267
and53147500833169108
a543775008332
toxicity-related54837500832259891053934850083314567100121143176191223244277315
nomogram42618500833775132170208229261318
in45918500831451
elderly4654850083344987121142157188
patients:4854850083387092106140177198225237
a510385008332
multicentre,51478500835693108130145176209246267288321332
prospective,549185008339609639349500832664100132156171203237248
non-interventional41959500833775113135151188209243264298332369390406443481513528
study.4736950083254886124156166
J491495008324
Antimicrob4951950083407899114171186218239276315
Chemother.52789500834077112169207228266301322332
2024;79(8):1938-1950.393410500833468101133145178211230264282294324354387421444475505539573586
27.39341150085367180
Xu402811500833874
Y,411611500833644
Yang417411500833565103142
X,433011500833851
Liang43961150083314678116156
P,456611500833539
et462011500833456
al.46901150083324760
Linezolid47641150083324785120150187203218257
dose503511500833876103138
adjustment51871150083327186124150173231266305326
according55271150083326439341250083316788126141178217
to416312500832258
therapeutic42341250083215993114146185220257279294326
drug45721250083385996135
monitoring471912500835795133148170206227243280318
helps50501250083377287125151
reach52141250083205485117154
the53811250083215994
goal548712500833875108123
concentration393413500833168107139172211232254286308324362400
in434913500831452
severe44161350083266193128149183
patients,46141350083387193108143181203230243
and487213500833270109
the49961350083215994
oldest51051350083375392127154177
seniors52971350083266199114152174201
benefit55121350083397539341450083387390107129
more.407914500835795117151163
BMC425814500833590131
Infect44041450083155372106139163
Dis.45821450083456187101
2023;23(1):840.469814500833468101136147182217235267281293328364400413
28.39341550085357186
Chen403315500833977111148
X,419315500833851
Yang425615500833564101140
L,440815500833144
Zhang446415500833875106144182
Q,465815500834760
et473015500833455
al.47981550083314658
Population486915500833470109147161193214229266304
pharmacokinetic51851550083387610812818621824928531533136840339341650083213667
model401416500835694132167182
of420816500833755
linezolid42761650083142966100129165181195233
and452216500833168106
its46411650083143663
metabolite471616500835791113145183221237251273306
PNU-142300503416500833578122144174204236270304339
in538516500831552
elderly54491650083344987121142393417500831547
patients.39961750083397293109143181203231244
J4256175008324
Antimicrob429517500834179101116174189221242279319
Chemother.462917500834078113171209231269304325336
2025;80(11):3001-3010.498017500833468101136147182217237269296311323358392428460479511546578609622
29.39341850085367285
Zavřelová403818500833871102124158174212244277
A,433318500834155
Merdita440718500835590111149164187220
S,464518500833346
Žák470918500833871101
P,482918500833540
et488718500833457
al.49621850083324860
Population504118500833572111150165197219234272311
Pharmacokinetic53701850083367310512618521739341950083316899115153188210226258
Model-Based420819500835593133168183206243276302337377
Optimization460219500834786108124181197226259281296334373
of499219500833756
Linezolid50651950083314785120149186202217256
Dosing533819500834584111125163202
in555719500831553
Hematooncological393420500834377133165185221259296327363378415453467498530545
Patients44902050083356586101134171192219
With47202050083577293130
Suspected48622050083326893131165197220253291
or516520500833657
Proven52342050083345490121154191
Gram-54362050083436496152174
-Positive39342150083215894121136158174206241
Sepsis.419021500833267107133148174188
Clin43932150083405570108
Transl45162150083335083121148163
Sci.4694215008333658093
2025;18(9):e70346.480221500833569101136147177208227260278290324357390423458494508