1462
KLINICKÁ341804001074588109168189242288347
FARMAKOLOGIE709804001074291138211265312372415474533554598
A13288040010753
FARMACIE1403804001074191138210265316336380
/18298040010732
Klin190680400107446583131
Farmakol2057804001074278105179220258305325
Farm.2402804001074178104179195
2026;40(1):47-552617804001074487128170185229275299339356371414455478520561
/32238040010732
www.klinickafarmakologie.cz4568804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
541838020012657115
PŘEHLEDOVÉ341200012660124182256312369444520587645
ČLÁNKY1008200012660115187259327395
Interval3413600106155688121156195231262
QT,6193600106386981
etiopatogeneze7153600106296381121157193221260300332373405440472
arytmie120236001063874110144198215247
„torsade14643600106255492128163202242274
de175336001063870
pointes“18393600106327391132164196231256
a2110360010638
riziková21633600106345184102137176213250
farmakoterapie242836001062967102157198233272302335370412447464496
rilátoru.3436200109295071114142191220269288
U646620010958
mladých71962001097495138188231270319
nemocných105362001094994169218258308348387436
lze150462001092159104
zvážit162362001093883127165186215
jeho185462001092166116165
subkutánní34376001093685136179229259304354404425
variantu78476001094387117138182232261311
s1111760010935
tím,116376001092950126145
že132476001093884
se142476001093581
sníží152176001093686107146167
budoucí1704760010952102153203253294315
riziko3439000109305292114158207
problémů57790001095283134187209256333384
s988900010936
intravazálně105090001092273103134179222267308354376427474
zavedenými155190001093985128174227274326368446468
elektrodami343104001094567113156188218267319363438459
(4).82410400109267094111
Rozhodování957104001094898136186236288338381425475496
o14751040010950
léčbě1547104001092167108159206
těchto1775104001092974115165195244
vrozených343118001094374123161206257298338388
forem749118001092776106152227
prodloužení994118001095282131183204254305344389439460
QT14731180010962106
patří1597118001095195125154176
do17911180010951101
rukou1910118001092980343132001094291141
odborníků5031320010950101153204234284305349399
na922132001095093
léčbu1034132001092167108160210
arytmií.1263132001094373119152227248269288
V4831460010952
prevenci565146001095385132177224277320342
získaných937146001094063100144191243287329381
forem1348146001092780111159237
syndromu1616146001093682135189220272351403
dlouhého343160001095276129182235283337390
QT7711600010964111
je920160001092371
vhodné1029160001094599152206259308
pacienta13751600010953100144167215268300347
poučit17611600010952106159203225258
a3431740010945
nejlépe417174001095199122145193247295
vybavit741174001094593147194238261293
kartičkou,1063174001094390121155178220264315368388
která1480174001094378125156202
upozorňuje171117400109511051581982502813431880010950100122168
na536188001095194
možná6561880010975126164215259
rizika94018800109305291113155200
(výše1166188001092567114150196
zmíněná13871880010939115136187233283327
stránka174018800109366797141191234279
www.crediblemeds.org).2138620010968140212229271302349404426479503550629677731768789840872924950968
Na3133620010961107
této326762001093178110161
adrese345562001094598129176214262
je374462001092270
možné2138760010975126165215261
stáhnout242576001093667112162212263313344
i2795760010921
aplikaci,284176001094496118139182227268289308
která317576001094275120150195
vypočítává339676001094389142193235256286331373418
rizikové21389000109305292115158208252298
léky246290001092269113160
a2648900010945
kombinace.271990001094393171223246297342384430449
U3194900010960
vysoce328090001094491128180222268
rizikových357590001093052921141582082138104001094388127177
pacientů2330104001095194135155200250279328
je2673104001092267
důležité2755104001095199120165204225254298
vyšetřovat3069104001094388123168198227276318362391
EKG3475104001094492148
před3638104001095180125176
a21381180010943
po21961180010951101
nasazení2313118001094992127170209254303324
léčby.2653118001092166106157198213
Je2881118001093379
možné,29751180010974124161211256274
že3264118001093883
budou33621180010951101151200250
v36271180010943
budoucnu3685118001095110121381320010951101151192242291
dostupná24471320010951101137167217269319363
léčiva,2827132001092267109130173218237
která3081132001094375120150194
zvýší3293132001093884130166187
IKs34981320010921352013800642851
proud3582132001095181131181232
a21381460010943
bude22051460010951101153198
je2427146001092267
tak2518146001092974116
možné26581460010975125163213259
použít29401460010952102152191213243
při3206146001095281103
prevenci3332146001095282127170215265306327
TdP3683146001094385131
u21381600010950
vysoce2212160001094389125175216261
rizikových249716000109295190111154202245291331381
pacientů,2902160001095195136157203253283332351
tento3278160001092974124154203
koncept3505160001094291142182227279309
se2138174001093681
ale2242174001094364110
zatím2374174001093984114135210
nepodařilo2606174001095096147198250294323345366416
potvrdit30441740010951102132178208259280310
na3377174001094993
zvířecím3492174001093985107139184225246322
modelu,21381880010975125177223245294313
další2470188001095195116151172
výzkum2661188001094490131173223299
probíhá2979188001095181130182204256299
(98–100).3297188001092670117164205248296321338
Závěr3934590014768131190250294
Získané407476001094967100139181228271
nebo435676001095093141189
vrozené455776001094270116152194242285
prodloužení485376001095178125173192239287323365413431
intervalu52967600109216895136164207248267314
QT3934900010962104
může4057900010975122160203
vyústit427890001094488137170199219247
v4543900010944
životu460590001093858100147175223
nebezpečnou484790001095094143188226275320360408456504
komorovou5370900010942891632113934104001092977118165214
tachykardii4161104001093072111159199240283311360379398
TdP4573104001094383128
a47141040010943
poté47711040010951100128171
přejít4955104001095179123143162190
k51591040010942
fibrilaci521410400109264898126146166207246265
komor.549310400109428939341180010975123151164
Přestože4111118001094774117151180227263307
je4430118001092265
vztah4508118001094382112155203
mezi47231180010975119156176
délkou4911118001095194114154201249
intervalu517311800109216996139167211253273320
QT55061180010962104
a39341320010943
TdP3994132001094383128
velmi4137132001094386106179199
komplexní4352132001094289163212233277318367386
a47541320010943
frekvence481313200109265598139184227275314357
TdP5186132001094383128
je5329132001092266
velmi5411132001094386106179199
nízká,3934146001095068105145187204
jde4150146001092271114
o42761460010949
potenciálně4337146001095199126169217255274315334382425
maligní47741460010974115135153202249268
arytmii.5054146001094370114144217236255272
Proto5338146001094774121148195
je5545146001092265
nutné3934160001095098126175218
mít4168160001097595123
o43071600010950
těchto4373160001092972112160188235
vztazích4624160001094382113155193212251299
povědomí49391600010951100141184234282356375
a53301600010944
dobře5390160001095099149177220
zvažovat3934174001093881123159206246288315
podání4260174001095199148189236255
léčiv4527174001092164102121162
prodlužujících4701174001095078125174193239276323342361399418456503
interval521517400109216996138165209250269
QT,54961740010961102114
zejména3934188001093982102176220268310
u42601880010949
pacientů4325188001095193132152195244272319
s46601880010936
rizikovými471118800109304986106146193234279353372
faktory.5099188001092669109140187216259273
LITERATURA344211001234978134189250318368438498567
1.34322800853648
Lester4122280083326693116150172
RM,60422800833692105
Paglialunga73022800833567107122137170185223261301333
S,108422800833245
Johnson115022800832463102140166205244
IA.14142280083155771
QT150622800834780
Assessment16062280083427096132159186244279317339
in196622800831453
Early3432380083336687103134
Drug49323800834567105144
Development:65323800834581113147163201241299334372394407
The107623800833272107
Long119823800833269107146
and136023800833270109
the14852380083216095
Short159523800833371109131155
of176623800833757
It.18382380083153751
Int19042380083155375
J1994238008325
Mol34324800835493109
Sci.467248008333658093
2019;20(6):1324.57524800833468100130143178212232265283295325355387419432
2.34325800853651
Yap40725800833564103
YG,5232580083357791
Camm62625800834073130188
AJ.8272580083406780
Drug91925800834667105144
induced10762580083145291128160194233
QT132225800834779
prolongation14132580083396097113151189228260282297335373
and179925800833169108
torsades192025800832158793432680083265998133160
de51826800833873
pointes.6072680083387793130152186213226
Heart.84926800834479111132156170
2003;89(11):1363-1372.103426800833468104137149184218238269297311323353383417451473504534566600613
3.34327800853651
Isbister413278008315418095121145178200
GK.6322780083447995
Risk7462780083355177107
assessment8722780083325985120147174231266304326
of121727800833857
drug-induced12932780083386098137159175213252290322356395
QT170827800834679
prolongation.180627800833960981141521903432880083387092107145184197
Aust55528800834178105128
Prescr.6982880083355690117149170181
2015;38(1):20-24.89428800833468100130141176210229261275287322357380411443456
4.34329800853550
Krahn4052980083345688126163
AD,5802980083408596
Laksman6882980083316493121178209247
Z,94729800833750
Sy100929800833261
RW,108229800833592101
et119529800833456
al.12632980083314658
Congenital133429800833975113151185222237259291306
Long165229800833167105143
QT180729800834778
Syndrome.189729800833261993433080083385996155190202
JACC56030800832464104142
Clin7173080083405570108
Electrophysiol.8403080083334883116140161198238276307334349387403416
2022;8(5):687-706.127130800833468101136148184203236254266302337370389420453489502
5.34331800853650
Hondeghem41331800834482121160195234272307365
LM,79931800833187100
Carlsson9193180083407394110136163201239
L,117931800833145
Duker124431800834584114148169
G.143331800834458
Instability15113180083155379103135175190205220243277
and180831800833270109
triangulation1937318008322435934332800833271111150165198221237275315
of67932800833858
the7583280083226197
action8763280083326590106145184
potential108132800833979102136175197213246262
predict13643280083396196137152185210
serious15953280083276284100139178205
proarrhythmia,1821328008340621001341551783433380083386893131189204236249
but6073380083397799
action7213380083326488104142180
potential9163380083397799133171193208240255
duration11863380083387697130152167205244
prolongation14443380083396198114152190229262284299337375
is183433800831541
antiarrhythmic.189033800833270911063433480083325375113144169207265280312325
Circulation.6833480083405577108145161193215230268306320
2001;103(15):2004-2013.101834800833468104136144174206239257289319337349384418454491514545579611640653
6.34335800853652
Sanguinetti41435800833366104143180195233268290314329
MC,76335800835596108
Tristani-Firouzi891358008333506591114146184199221255270291328366395410
M.132135800835569
hERG140935800833872107151
potassium158035800833978100132159185200237295
channels18953580083316910134336800833774108122147
and50136800833268106
cardiac6183680083316383120134164195
arrhythmia.8253680083315172109138162199255269300312
Nature.11483680083457696133153186197
2006;440(7083):463-469.135636800833467102136148181217251270303335369402418429462497529550586620653663
7.34337800853645
Vandenberg40737800833667105144179217256292313351
JI,7773780083254053
Perry8493780083356990112146
MD,1014378008355101111
Perrin11453780083356890111127165
MJ,13293780083558193
et144137800833456
al.15173780083324760
hERG159637800833871106151
K(+)17663780083355493110
channels:18953780083316910134338800833876111127153166
structure,5293880083275071110142167205226261273
function,8223880083195896128152168206245258
and110038800833270110
clinical12303880083324762100116148181196
significance.14473880083264180119134152169201234272305339351
Physiol181838800833673104132146185201
Rev.34339800833570103113
2012;92(3):1393-1478.47139800833468100130142178211228262279291321351384417438469500532566579
8.34340800853652
Hoffmann41540800834482102121180212250288
P,72440800833540
Warner78440800835789110148183205
B.100940800833549
Are10784080083416296
hERG119540800833771106150
channel136640800833169101139177212228
inhibition16144080083155391106145161183199237275
and190940800833270109
QT34341800834779
interval4404180083155375108130164197213
prolongation6714180083386097113151190229261283298336375
all10644180083324762
there11444180083226095116150
is131341800831440
in137241800831452
drug-induced14434180083385997136158174212251289321355394
torsadogenesis?1856418008321588010714034342800833876116151189224251265292316
A677428008341
review7354280083215587103138189
of94242800833756
emerging101642800833491127148186201239278
trends.13124280083214377115154180194
J1523428008324
Pharmacol156542800833573105126184217249286302
Toxicol188442800833367971133434380083316884
Methods.44243800835590112150189228255268
2006;53(2):87-105.72543800833569105141153188221239273291303338371389420451486498
9.34344800853650
Nogawa41344800834584124156207241
H,67444800834558
Kawai75244800833569121154169
T.94244800833342
hERG100544800833771107152
trafficking1177448008322447796114132164194211249289
inhibition14864480083155392107146162185200239278
in178444800831553
drug-18584480083386098138160
-induced3434580083213980122162196232275
lethal6524580083155377118153170
cardiac8564580083336891132149183218
arrhythmia.11084580083335680121154181222283300334349
Eur14924580083347396
J1622458008325
Pharmacol.168245800833676111134195230265304322337
2014;741:336-339.34346800833468100131143176206237245280313348371404437470481
10.3434780085367085
van44747800833265103
der5694780083397395
Heyden68347800834580111150184223
MA,92547800835597111
Smits105647800833290105127155
ME,123147800835488101
Vos13524780083357198
MA.147047800835496111
Drugs160147800834567105144170
and179147800833270109
trafficking19204780083214376343488008318365386116132170209
of56648800833756
ion6364880083155391
channels:74148800833169102140178213228254267
a1022488008331
new106748800833873124
pro-arrhythmic12054880083396097121153174196234265290328386401433
threat16524880083226081115147169
on183448800833876
the19244880083226095
horizon?3434980083387697113142179218242
Br60149800833556
J673498008324
Pharmacol.71249800833573105126185217249286302315
2008;153(3):406-409.104249800833468105140152182212245264297314326361397432456492528563574
11.3435080085366678
Han43750800834476114
S,56850800833245
Zhang62950800833876108146185
Y,83050800833644
Chen89050800834078113151
Q,105750800834761
et113450800833456
al.12065080083324860
Fluconazole12835080083324784116153192224254291307342
inhibits16415080083145290105145160183210
hERG186850800833770106150
K(+)3435180083355393109
channel46451800833269101139177212227
by70451800833869
direct7865180083385374108140164
block9635180083385492124154
and113051800833269108
disruption12515180083385379100138176198213251289
of155351800833756
protein16225180083396097119152167205
trafficking.18405180083214275931111291613435280083304684123136
Eur4945280083336991
J600528008324
Pharmacol.63952800833673105126185217249286302315
2011;650(1):138-144.96952800833569100128136172206240260291306318347377412434465496533546
12.3435380085366884
Mladěnka44553800835470102141176214244278
P,74153800833640
Applová80053800834180119135174206238
L,105753800833145
Patočka11215380083356788125158188221
J,136153800832436
et141653800833456
al.14915380083314760
Comprehensive156953800834077136175196230269304342368383415450
review3435480083215486102136187
of54254800833756
cardiovascular6115480083316484122137175206239265297334349381402
toxicity10265480083215888103135149172205
of124454800833756
drugs13125480083385997136161
and148654800833269108
related16075480083205469101122156195
agents.181554800833170104142163191204
Med34355800835490129
Res4875580083367198
Rev.60055800833570103112
2018;38(4):1332-1403.72855800833468100131143178212231264282294324353386419439470501537570583
13.3435680085377086
Shah45056800833373106146
RR.6175680083377490
Drug-induced72856800834770109150173190229270309342377418
QT116856800834882
interval12715680083155577112134171205221
prolongation:151456800833962100117157197237271294310349389402
regulatory1937568008322573435780083397894127149187210245
perspectives6095780083397698126166203237261277311346374
and100457800833372112
drug113757800833961100141
development.129957800833975108143160199240299335375397411
Ann173157800834281120
Med.187357800835591132146
2004;36(Suppl34358800833468104141152187222241273310349389405
1):47-52.763588008334496095127145179213225
14.3435980085366782
Milon4355980083546882119157
D,60359800834454
Daubert66859800834576113151185205228
JC,9085980083236375
Saint-Marc9945980083326478115135154208240260290
C,129559800833951
et135759800833455
al.14235980083324658
Torsade14925980083326585111143181215
de171859800833871
pointes.18005980083397691127148180206218
Apropos34360800834179100137175213239
of59460800833755
5466160800833468
cases.7416080083316389123149162
Ann91460800834178116
Fr104160800833251
Anesth110460800834078112138160198
Reanim.131360800833670101138152209222
1982;1(5):513-520.15466080083346398130142171186218236247281312341362395427461472
15.3436180085356781
Hondeghem43661800834481119157192230268302359
LM.80761800833186100
Drug-Induced91961800834566104142164180217255292324357396
QT132761800834678
Prolongation14176180083355592107145182221252274289326364
and179361800833169107
Torsades191261800833366873436280083265997132158
de51462800833772
Pointes:5986280083357187124145178205217
An82862800834078
All-Exclusive918628008341567193127159190205242268282314348
Relationship12796280083356985116138153190228254292306345
or163662800833759
Time170762800833249106141
for18606280083185677
an194962800833269
Amicable34363800834199114146179218234269
Separation?62763800833368107140161194216231269308332
Drug97463800834667106145
Saf.1134638008333658496
2017.124563800833468100130136
16.3436480085377188
Tsuji4526480083335695111127
Y,60064800833645
Yamazaki66664800833667127160191225257274
M,96164800835670
Shimojo10536480083337288147187203242
M,131764800835670
et140864800833558
al.14886480083324862
Mechanisms157164800835692126166199238254281341368
of196064800833959
torsades3436580083226184113148189225254
de62265800834076
pointes:7246580083408097137160195224237
an98765800833272
update.108565800833879121155178213227
Front13376580083345594134157
Cardiovasc15206580083417598138154194228262290324
Med.187065800835693134149
2024;11:1363848.34366800833468101133145175203211241271305339373410446459
17.3436780085366775
Thomas43167800833271109166198224
SH,6686780083327588
Behr76867800833570108129
ER.9096780083326782
Pharmacological100367800833572104124182214246282298336375389421453468
treatment14846780083214276107129186221258280
of177667800833756
acquired1844678008332641011381533436880083215594
QT45268800834779
prolongation5456880083396098114152190229261283298336375
and93468800833270109
torsades10576880083225981108141180215242
de131368800833873
pointes.14016880083387792130152186212226
Br164168800833657
J1712688008325
Clin17516880083405570108
Pharmacol.18736880083357310512634369800835790122159175188
2016;81(3):420-427.54669800833468100131143179211226259276288323355389413450482515521
18.3437080085366985
Chan44770800834078110148
A,61470800834155
Isbister688708008315418095121144178199
GK,9067080083448094
Kirkpatrick10197080083355172103143176198220235267297
CM,133570800834095109
et146270800833457
al.15387080083314760
Drug-induced161670800834667106145167183221260298330363403
QT34371800834779
prolongation4357180083386097113150189228260281297334373
and82071800833270109
torsades9427180083215879106139178213240
de119571800833872
pointes:12807180083397793130152185212224
evaluation15177180083346699114151184205220258296
of182671800833757
a1895718008332
QT194071800834779
nomogram.34372800833876134172212233266324337
QJM.69672800834770125139
2007;100(10):609-615.85172800833468104137146176208244264295327345357392428463487524554584596
19.3437380085366982
Cyr4427380083406890
S,54973800833345
Abdelaziz61273800834180120155170203232248277
L,90773800833145
Minichiello96973800835570108123155193208243258273311
A,129873800834155
et137173800833456
al.14457380083314760
Impact152273800831573112145177201
of174173800833756
antidepressant181573800833270911071451803437480083396094121148181219240
and59674800833270109
antipsychotic7187480083327091107146172205236274313335350382
use11137480083376398
in122474800831553
the12907480083216095
occurence139874800833769100138159193231263297
of170874800833757
torsades17787480083215880107140179214241
de34375800833873
pointes4327580083397893131153186213
arrhythmia:6627580083315374113143168207264279311324
a1002758008332
case-control10507580083316491126149183219258279301338354
study.14207580083275088127159169
Gen160575800834479117
Hosp173975800834482109148
Psychiatry.190375800833562943437680083316984116138159193204
2025;94:16-23.56276800833468101136147182218230260291314345380393
20.3437780085367288
Varro4517780083366789111148
A,62077800834155
Baczko69677800833568101132163200
I.91777800831528
Cardiac9667780083407394133148180213
ventricular119977800833266105127148164196234250282303
repolarization15237780083215595134150182203219249282304320358397
reserve:19407780083215521382280083276385121156169
a2329228008332
principle23832280083396278117150166206223259
for26632280083195881
understanding276522800833877118154176204228262301341357396436
drug-related322322800833961100141164187222238271294329370
proarrhythmic36142280083406210013515717921382380083386893131189204236
risk.2389238008321376393107
Br251223800833556
J2584238008324
Pharmacol.262323800833573105126185217249286302315
2011;164(1):14-36.295323800833468100128136166197234253285299311341372395428462475
21.21382480085367082
Obreztchikova223524800834787108142172197227265280310348380413
MN,2662248008355100113
Sosunov27902480083327097134172211243
EA,30472480083337690
Plotnikov31512480083365088110149164194231263
A,342924800834155
et349824800833457
al.35692480083324760
Developmental36442480083458111314721382580083155393151186224245278294
changes245025800833169101139178213240
in270825800831552
IKr27782580083155173
and286925800833270109
IKs29962580083155079
contribute309325800833168106128149165204242265299
to341025800832158
age-related348625800833271106129151185201233255288328
expression213826800833466106127161188215230268307
of246626800833756
dofetilide25432680083387696131153168184199238273
effects28362680083355473108141165193
on304926800833876
repolarization31462680083215594133149182203219248282304319357396
and356226800833271110
proarrhythmia.3692268008339619821382780083325375113144169207265280312325
Cardiovasc24782780083407394132148186217250277309
Res.28032780083357097110
2003;59(2):339-350.292927800833468104137149184216235269287299334367400424456489523536
22.21382880085367389
Yokohara224828800833670101139178210232265
S,253428800833346
Hashiguchi260128800834477104142157197235267306321
M,294328800835568
Shiga30322880083337186126158
T.321128800833343
Psychotherapeutic32742880083366295127166204227265301322355395431469492508540
drug-induced21382980083385998137159175213252289322355395
life-threatening2551298008315304984107129167189223254276310348363401440
arrhythmias:30092980083325375114144169207265280312339351
A3379298008341
retrospective3438298008321557798136162201237270294309342376
analysis213830800833270102117149176191217
using23753080083376378116155
the25493080083226095
Japanese26643080083245695128166201228263
adverse294630800833271104138159187222
drug31873080083385998137
event334330800833466101139160
report35233080083205494132154179
database.37213080083387021383180083225494127153188200
J2354318008324
Arrhythm.23933180083416284123153178216274287
2023;39(6):928-936.269631800833468101136147182215234268286298333366400422457490525538
23.21383280085367287
Choy224032800834078116147
AM,240232800834196110
Lang252632800833265103142
CC,26833280083407891
Chomsky278832800834078116175201231265
DM,3067328008346101114
et319632800833456
al.32663280083324860
Normalization334132800834583105163195211226255288310325363402
of375732800833857
acquired213833800833163100137152173206245
QT239633800834678
prolongation24873380083385996111149187225257278293331369
in286833800831552
humans293233800833875132164201227
by317133800833969
intravenous3253338008314527394126157191229266304330
potassium.35953380083387798131157183197213834800833795108
Circulation.22623480083405576107145160192214229267306319
1997;96(7):2149-2154.259634800833465100133143178213232267286298334365396429453484515545580593
24.21383580085356984
Shaffer223535800833269100119138171192
D,243935800834555
Singer25063580083324683121155176
S,269435800833244
Korvick27503580083357192126141172202
J,296435800832335
et301135800833355
al.30783580083314659
Concomitant314935800833975113144180237252273305342363
risk3524358008321366190
factors36263580083185182106142162189
in213836800831554
reports22133680083215696136158183212
of244636800833858
torsades25253680083226082110144184220247
de279336800833975
pointes28893680083397995134156190218
associated31283680083336087126160175208231265306
with34553680083516790130
macrolide36063680083589112414618421383780083153069104
use:22603780083376398111
review23893780083215587103138189
of259737800833756
the26723780083215994
United27853780083448196119153192
States29963780083325386108142168
Food318337800833270108148
and334937800833270109
Drug347737800834567105144
Administration36393780083418013815321383880083385379102123156178193231270
Adverse242838800834179112146168195230
Event26783880083336599137158
Reporting285738800833570109148170195210248287
System.31643880083336289113146204217
Clin34023880083405570108
Infect35303880083155372106139163
Dis.37133880083466187101
2002;35(2):197-200.213839800833468104137150185218235269287299329359392410441475512524
25.21384080085367287
Orlandi22404080083476985117155194209
C.246440800833953
A2531408008341
case25874080083316490125
of272740800833757
torsade27984080083225980107141180215
de302740800833873
pointes31154080083387793131152186213
caused334240800833164102128163203
by355940800833970
hypomagnesemia.364440800833768108147213841800835790129167202229264322337369382
G2535418008344
Ital2594418008315377086
Cardiol.26954180083407394132147185201214
1986;16(12):1062-1065.29244180083346499135147177208227259289307319349380416449469500532567601613
26.21384280085377491
Pasławska22514280083366997114148201229260295
U,256842800834557
Noszczyk-Nowak264742800834686114145177209245277298347386440474505
A,317442800834257
Kungl325342800833675115155172
K,344642800833652
et352042800833558
al.36004280083334963
Thyroid36854280083337410621384380083215873112
hormones22684380083377597155194232267294
concentrations257943800833269107139173211233254287309324362400427
and302343800833270109
ECG315043800833272114
picture32824380083385486110148169203
in350343800831452
the35734380083215994
dog.368543800833876116129
Pol21384480083357288
J2241448008324
Vet22814480083356890
Sci.2387448008332647992
2006;9(4):253-257.249544800833468104140152188207240257269304339372394425460493499
27.21384580085367180
Corović22334580083407798136168183215
N,246345800834558
Duraković253645800834584105138168205237253285
Z,283645800833851
Misigoj-Duraković29024580083547096111150188203225272311332365395433465480512
M.342945800835569
Dispersion35134580083456187126161182210224262301
of213846800833756
the22074680083226095
corrected23154680083316890111145178202236275
QT260346800834779
and269546800833270109
JT281746800832458
interval28884680083155374108129164197212
in311346800831552
the31784680083226095
electrocardiogram32864680083344984117141162199232265286324339377416438471528
of213847800833756
alcoholic22064780083314678114151189204219250
patients.24684780083397192107141178199226239
Alcohol27204780083405587123161198214
Clin29464780083395468106
Exp306447800833264103
Res.31794780083356995109
2006;30(1):150-154.330047800833467102137149183217236267281293322351385408438467502514
28.21384880085367288
Cunha224348800834076114152185
DF,24444880083457985
Cunha254548800834076114152185
SF,27464880083326470
Ferreira28334880083326687109143158179212
TP,30624880083326973
et315248800833456
al.32244880083324860
Prolonged33014880083355693109147185224259299
QTc361648800834779107
intervals37404880083145221384980083225577111144160186
on234449800833775
the24404980083215994
electrocardiograms25544980083345085118142163200233266287325340378418439472530556
of313049800833857
hospitalized320749800833776102141157179212228243272306345
malnourished35724980083589010514318222021385080083213662100135175
adults.232850800833271108124146174187
Nutrition.253150800834482105126142164180218256269
2001;17(5):370-372.281650800833468104136144174203220253272284319351384408440472507519
29.21385180085377489
Astrom-Lilja22495180083427195118157217240275291307323357
C,262751800834155
Odeberg270451800834889125166203225265
JM,29915180083248195
Ekman310851800833465126160199
E,332951800833347
et339851800833558
al.34785180083324862
Drug-induced356251800834669109149173190229213852800833876109143182
torsades23415280083225981108142181216243
de260552800833873
pointes:26995280083397894132154188215227
a2947528008332
review30005280083205587103138190
of321052800833857
the32885280083226096
Swedish340452800833383118158173199237
pharmacovigilance366252800833978110132213853800835993127166199216257273290324363397433
database.25965380083397396131172207235271285
Pharmacoepidemiol290653800833675109132193227261299337378395435472532549588606
Drug353753800834670110151
Saf.37135380083336888101
2008;17(6):587-592.213854800833468104140152182212228261279291326361394412446478512524
30.21385580085377591
Darpö225355800834780103144185
B.246155800833751
Spectrum253555800833474111146171194234294
of285255800833859
drugs293455800833962102143170
prolonging312755800834063102119159199240256295336
QT348655800834983
interval35925580083155577113135172206222
and213856800833270109
the22645680083226095
incidence23775680083145284100138173211244277
of267256800833756
torsade27465680083225980107140180214
de297856800833873
pointes.30695680083387792130152186212226
Eur33135680083326990
Heart342156800834479111132156
J3595568008324
Suppl.363756800833269109148164177
2001;3(Suppl213857800833468104136144179197229267306345361
K):K70-80.25155780083345668103138171195231267279
31.21385880085366981
Roden223958800833574113148186
DM.2445588008345100114
Long257958800833168107146
QT274458800834780
syndrome:28435880083265998137158195253288301
reduced31635880083215595132164198238
repolarization34205880083215594133149181202218247280302317355394
reserve21385980083215581116137172206
and235759800833270109
the24785980083226095
genetic258659800833873111145168183215
link.2814598008314296797112
J2938598008325
Intern29755980083155374108129168
Med.315659800835489128141
2006;259(1):59-69.331059800833468104140152187222254273305319331366398422459493503
32.21386080085367186
Roden224160800833574113148186
DM.2444608008345100114
Drug-induced257560800834567105144166182220259297329363402
prolongation29946080083386097113151190229261283298336374
of338560800833756
the34586080083226095
QT356960800834780
interval.366560800831553741081292138618008332658093
N2246618008345
Engl230661800833371110125
J2446618008324
Med.248661800835489129142
2004;350(10):1013-1022.264361800833468105141153188221255274306337356368398429461491513543575608643655
33.21386280085367186
Warner224462800835789110148183205
B,246862800833648
Hoffmann253662800834483102121180212250288
P.284462800833540
Investigation29046280083155384118145168184222255277292330368
of329262800833756
the33686280083226095
potential34836280083387799133171192208240255
of375862800833756
clozapine21386380083314785113146185201239274
to242963800832158
cause250463800833164102128163
torsade26846380083215880107140179214
de291563800833873
pointes.30056380083387792130152186212226
Adverse324863800834179112146167194229
Drug349463800834667106145
React365563800833671102135159
Toxicol21386480083336797112144181197
Rev.235164800833570102112
2002;21(4):189-203.247864800833569105138150185216232264282294324355389412443478511523
34.21386580085367489
Liu22486580083324785
Y,235465800833544
Xue241965800833874110
Y,254965800833644
Wu261465800835895
S,273065800833346
et279665800833557
al.28746580083324861
Effect29556580083335372106139164
of314065800833757
verapamil32186580083316688121161194252268283
in352265800831553
the35966580083226096
treatment37126580083224478213866800833254112147185207
of236566800833857
type24426680083225696132
22594668008334
long26496680083155391130
QT280066800834779
syndrome29006680083265897137158195253289
is320966800831541
not32706680083387698
a3389668008331
dose-dependent344166800833876103138161202237276312350213867800833873111133
pattern:22876780083397293118151173211223
a2527678008332
study25756780083264987126158
from27506780083184077136
bedside290267800833974114140155194229
to314767800832258
bench,322267800833874112144182195
and343367800833270109
back.355967800833871103133148
Eur37236780083337091
Heart213868800834479111132157
J2310688008324
Suppl.235068800833269109148164177
2016;18(suppl_A):A37-A46.254268800833469100131144174205224250287326365381418463482493536571604622663698734748
35.21386980085367186
Milberg22416980083547085124160181219
P,247769800833540
Reinsch25346980083357085123150182220
N,277169800834457
Osada284569800834774108147179
N,304169800834558
et311669800833456
al.31896980083324760
Verapamil32666980083366990123162195253268283
prevents35666980083396094127161199221248
torsade21387080083225981109143183218
de237770800833874
pointes24727080083397894132154189216
by270970800833971
reduction28017080083215595134166191206245284
of310670800833857
transmural31847080083224477116143201240261295310
dispersion35157080083395481120156178206221260299
of213871800833757
repolarization22157180083215595134150182203219248282304319358396
and263271800833270109
suppression276271800832663103142164198225252267305344
of312671800833857
early32047180083346687103135
afterdepolarizations3360718008332517611013116920424428329933135336839843121387280083223877116143
in230372800831453
an237772800833372
intact24707280083155476110143167
heart265972800833874107128154
model283472800835898138174190
of304572800833858
LQT3.312472800833279112149162
Basic33077280083367097113145
Res34747280083367199
Cardiol.35947280083417596136151190207220
2005;100(4):365-371.213873800833468104138149179211247267299317329364398432454487519551561
36.21387480085367389
Taglialatela224974800833361101117132165181213235270286319
M,258974800835569
Castaldo267874800834174101125158174214253
P,295274800833540
Pannaccione301374800833568107145178211242258296336371
A,340574800834256
et348274800833457
al.35607480083324861
Cardiac36427480083417496134150213875800833264
ion22237580083155392
channels233575800833270103141179215231257
and261275800833271110
antihistamines:27437580083327092107145161187210244302317355391418430
possible319475800833978105132147186202237
mechanisms345275800835893126164197235251277335362
of213876800833757
cardiotoxicity.22107680083316485123138176198235266281313328351384394
Clin26207680083395570108
Exp274376800833265105
Allergy.28637680083415671106127166198208
1999;29(Suppl308676800833464100135148183217236268305344384400
3):182-189.3501768008334516393124158178209240274285
37.21387780085367079
Olasinska-Wisniewska22357780083476395122137175201231264287344361387425440474525552582616
A,286877800834155
Olasinski29407780083476396122137175201231247
J,320577800832436
Grajek32587780083446598114148179
S.345477800833245
Cardiovascular3517778008339729313214718521725027639342280083327187120142
safety40972280083276181116139174
of429222800833858
antihistamines.43722280083327194110149164191215249309324363399427441
Postepy483522800833673101125160200232
Dermatol508922800834682104164198220258275
Alergol.53852280083425894116155195211225
2014;31(3):182-186.393423800833468100131143178209224258275287316347381401432463499512
38.39342480085367288
Hagiwara404224800834476116131182215236269
T,433024800833341
Satoh43912480083326587124162
S,457224800833346
Kasai46372480083356895128143
Y,479924800833644
et486224800833456
al.49372480083324860
A5017248008341
comparative507724800833168126165198219252274289322356
study54522480083275088127159
of393425800833857
the40122580083226096
fluoroquinolone41292580083173472110132170210248264302341357395434470
antibacterial46192580083337193108148181214238273294310342358
agents499825800833271107145167195
on521425800833876
the53112580083226196
action54282580083326589105143182
potential39342680083397799133171193208240255
duration42072680083387597130151167205243
in446826800831452
guinea45382680083387590128163195
pig47512680083385493
ventricular486126800833266104126147163195232248280301
myocardia.517926800835888126159192213251266298311
Jpn550826800832463102
J3934278008324
Pharmacol.397327800833673105126185217249286302315
2001;87(3):231-234.430427800833468104136144179212229262279291326361392411442477512524
39.39342880085367185
Briasoulis40382880083355772104131169207223238264
A,432028800834156
Agarwal439428800834180112133186219235
V,464828800833544
Pierce47112880083354984105136170
WJ.49002880083577991
QT501028800834779
prolongation51082880083396098114152190229261283298336375
and550228800833270109
torsade39342980083225880107140179213
de416029800833873
pointes42462980083387792130151185211
induced44702980083155291129161194233
by471629800833970
fluoroquinolones:47992980083163371109130167206244259297335350388427461488500
infrequent5312298008315537193127166204238276298
side39343080083264180115
effects40663080083345372106139163191
from42743080083184078136
commonly442730800833168126184222261276308
used47523080083376398138
medications.490730800835792132147179212233249287325351365
Cardiology.52893080083407394132147185201239279311321
2011;120(2):103-110.393431800833468100128136166196230250284301313343375408430460488519532
40.39343280085367489
Abo-Salem404132800834180119143174207222257315
E,437432800833346
Fowler443932800833269120136171192
JC,46503280083246578
Attari47463280083416287120141156
M,492132800835468
et500732800833456
al.50823280083324760
Antibiotic-induced516032800834180101116155171209231246278297313351390427393433800833165104
cardiac40543380083316485123138170202
arrhythmias.42723380083325374113144168207264279311338352
Cardiovasc46393380083407394132147185217250277309
Ther.496333800833372107128138
2014;32(1):19-25.511733800833468100131143178210228259274286315346369400435447
41.39343480085366981
Brunetti40363480083355795133169191215231
L,428734800833245
Lee435334800833166101
SM,447534800833287100
Nahass459634800834577115148174201
RG,48173480083368094
et493134800833457
al.50083480083324861
The508934800833372107
risk5217348008321366292
of533034800833757
cardiac54073480083316486124139171203
events393435800833466101139161189
in414335800831553
patients42173580083387193109144182204231
who446935800835189128
received46173580083215588122137170204244
concomitant488235800833168107139176235250272305344365
levofloxacin52683580083155082120138155193223256289304342
and393436800833270109
amiodarone.405836800833290105143182215236273312347359
Int44323680083155374
J4522368008324
Infect45613680083155372106139163
Dis.47393680083466187101
2019;78:50-56.485536800833469100131143176210222257291315349383397
42.39343780085377389
Volberg40453780083377491132169191231
WA,4297378008359100115
Koci443337800833675109125
BJ,45803780083376275
Su467737800833372
W,477137800835969
et486237800833558
al.49423780083334963
Blockade50263780083375393127158193234270
of531837800833859
human539837800833978138172211
cardiac39343880083326587126142174207
potassium416238800833979102135162190205243302
channel448538800833271104142181217233
human473938800833877136169207
ether-a-go-go-related49683880083345796132153174207230271310334375414438461496512545567601642
gene393439800833873111146
(HERG)40933980083186396131175194
by430039800833970
macrolide438339800835790122143180196211250285
antibiotics.46813980083316991106145161199220236268295309
J5003398008324
Pharmacol504039800833572105126184216249285301
Exp535439800833365105
Ther.547239800833272107128138
2002;302(1):320-327.393440800833468104137150185219252269301315327363395429453485518551557
43.39344180085367186
Hancox404041800834476114147184214
JC,42744180083246578
Hasnain437141800834477103141173188226
M,461741800835468
Vieweg47054180083355286138172212
WV,493641800835897106
et506241800833356
al.51374180083324860
Azithromycin,52174180083417288110148169207265296327342380393
cardiovascular39344280083316383120135172203235261292329343375395
risks,4341428008321366190118130
QTc448342800834778105
interval46004280083155272105126160192206
prolongation,48184280083385996111148185223255276291328365377
torsade52074280083215778105137175209
de542842800833771
pointes,55114280083387639344380083155374108135148
and409643800833169108
regulatory42184380083215594132147180201238260294
issues:45264380083144167104139166179
A4718438008341
narrative47734380083387091113146168183215250
review50374380083205487102137188
based52394380083397298133173
on542643800833775
the55154380083226095
study39344480083264987126158
of410844800833756
case41794480083326591126
reports.43204480083215594133155179207221
Ther455644800833372107128
Adv469944800834180112
Infect48274480083145271106138163
Dis.50054480083456187100
2013;1(5):155-165.512144800833468100130141171186220238250280310342364395426460472
44.39344580085377793
Albert40504580083425999136159185
RK,42574580083377490
Schuller436945800833468107147163179215238
JL.46294580083255973
Macrolide472545800835690124146185202218258295
antibiotics50424580083337396112153169209232248282311
and537545800833373113
the55114580083226299
risk3934468008321386697
of405846800833859
cardiac41434680083326790130146180214
arrhythmias.43834680083335579119152178218278295329357371
Am4781468008342103
J4910468008325
Respir496146800833673102143160182
Crit51694680083416481105
Care53004680083417698134
Med.546146800835693134149
2014;189(10):1173-1180.393447800833468100131143173204238258289321339351381408438472494525552583619631
45.39344880085367186
Gysel403548800834475102137152
M,420248800835568
Vieweg42854880083365287138173212
WV,451248800835897106
Hasnain463348800834477103141173188226
M,487448800835568
et495748800833457
al.50294880083324760
Torsades51044880083336788115149188222249
de536848800833973
pointes5457488008338779213039344980083225582
following4037498008318567287125176191229268
clarithromycin43264980083314678100115138176197234293323355370408
treatment.47544980083224377109131189224262284297
Expert507249800833265104140161186
Rev527849800833570103
Cardiovasc5401498008340739413214718539345080083326591123
Ther.407350800833272106128138
2013;11(11):1485-1493.422650800833569100130142172200215246274288300330361397431453484515548581593
46.39345180085367489
Brown40415180083355794145184
SM,424251800833287100
Peltan43605180083356884106139177
I,455451800831528
Kumar459951800833572130162184
N,480051800834558
et487551800833456
al.49495180083314760
Hydroxychloroquine502651800834476114135173203237268306322360381419458496511549584
versus39345280083316586113150176
Azithromycin41225280083417287109147168205262293324339376
for45115280083185576
Hospitalized460052800834482108147162184216232246275309348
Patients49605280083356788103138175196224
with51965280083516688126
COVID-19.533552800833984119135181204235264275
Results39345380083357097134150172200
of415353800833757
a4229538008331
Randomized,428053800833568106145183241256286320359372
Active46715380083417297112144179
Comparator486953800834077135174207228261283320342
Trial.5230538008332496597112125
Ann537553800834179117
Am551153800834199
Thorac393454800833372110132165197
Soc.414654800833371104117
2021;18(4):590-597.427854800833469101133141171202221254272284319351387411445477510516
47.39345580085367079
Farmakis40305580083326283141174204220246
IT,42935580083154958
Minopoulou436755800835570108147186225263278317355
I,473855800831528
Giannakoulas47825580083446092130168200230267306321353380
G,517855800834457
et525255800833456
al.53255580083324760
Cardiotoxicity5402558008340739413214718539345680083225989104136151174208
of416156800833757
azithromycin42375680083326277100138159196255285317332370
in462656800831553
COVID-19:469856800834086121138183207238268281
an499956800833270
overall508856800833769104125158173188
proportion52965680083396097137176197222237275314
meta-analysis.393457800835792115147170202240273288320347362388401
Adv435157800834179112
Respir44785780083357097136152173
Med.466657800835489129142
2022;90(3).482357800833569102136149184220239273290301
48.39345880085367490
Sung403958800833270108147
DJ,42015880083456880
Kim429658800833551109
JG,44205880083246983
Won451858800835794132
KJ,46655880083356375
et475658800833456
al.48275880083324760
Blockade49035880083355189121152185224259
of517758800833757
K+524958800833574
and533958800833169108
Ca2+546358800834072107147
channels393459800833169101138176211226252
by419859800833970
azole42805980083326198114148
antifungal44415980083316990105124163200239271286
agents474059800833170105142164191
in494459800831452
neonatal500859800833872111149181202235250
rat52715980083205374
ventricular53585980083316510312414516119223039346080083154768
myocytes.401860800835788125158191216250277290
Biol43246080083355088104
Pharm444460800833572104126184
Bull.46436080083367489104117
2012;35(9):1469-1475.477560800833468100130142177210228261279291320351387421445476507539572584
49.39346180085367285
von403461800833269108
Heeren415661800834580115136170208
F,437961800833339
Tanner44326180083336199137172193
R,464061800833549
Theurillat470461800833372107145166181197212244266
R,498561800833549
et504961800833456
al.51206180083324760
Determination519561800834580103136158216231269301323338376415
of393462800833757
fluconazole40116280083173472104141180212242280296330
in436262800831553
human443562800833876134166204
plasma46606280083395587114172204
by488562800833870
micellar497562800835873105139155170202223
electrokinetic52196280083345085118142163201232248286321344359391
capillary393463800833164104119135150182204238
chromatography41926380083327091129187220242279319340373412451482
with46956380083506689127
detection48436380083387395129162187202240279
at514263800833254
190521763800833464100
nm.533863800833896109
Journal54686380083246210112239346480083387085
of403564800833756
Chromatography41066480083407899137195227249286325347380419457488
A.460964800834156
1996;745(1):165-172.468064800833464100135147180211244261293307319349380414436467496531543
50.39346580085367287
Santos403465800833265103125161188
SR,42356580083326781
Campos432965800834072130169208234
EV,45766580083337079
Sanches466865800833265103135173208235
C,491565800834053
et498165800833456
al.50506580083324760
Fluconazole51236580083324684116153191223252290305340
plasma54766580083395486113393466800835790
concentration404066800833168107139172210232253286308323361400
measurement445666800835793124151188209243301336374396
by486866800833970
liquid49546680083153069107122160
chromatography51316680083316990127186218240277316337370409448479
for39346780083195780
drug403567800833961100140
monitoring419667800835998138153176214237253292332
of454967800833858
burn462867800834079101141
patients.47906780083397396112147186209237251
Clinics50636780083405672111126159188
(Sao52726780083195185124
Paulo).541867800833668107123162180192
2010;65(2):237-243.393468800833468100131144180214232266283295330365397416447479511524
51.39346980085367082
Salem40296980083326581116174
M,421669800835468
Reichlin42976980083357085117155171186224
T,453469800833241
Fasel45886980083336289124139
D,474169800834556
et481069800833456
al.48806980083314760
Torsade49536980083326688115148187222
de518969800833873
pointes52756980083387793131152186213
and550169800833270109
systemic39347080083265986109143200216248
azole41967080083326299115150
antifungal43607080083327092107126165203242274289
agents:466470800833271106144165193206
Analysis488470800834179112127159186201227
of512570800833857
global51977080083385391131164179
spontaneous539170800832665104142164196393471800833873111149176
safety41257180083265978113135169
reports.43097180083215594133154179207220
Glob45457180083435997137
Cardiol46977180083407394132147185201
Sci49147180083326480
Pract.50097180083355689121145158
2017;2017(2):11.518371800833468100129139174208240269285319337349379407416
52.39347280085367288
Haeusler404072800834477113151178194230252
IL,43097280083154761
Chan438872800834078111150
XHS,455572800833883116130
Guérin470272800834483118140156195
PJ,49147280083355568
et499972800833457
al.50737280083324862
The515272800833373108
arrhythmogenic52787280083315376115146172211269308393473800833874114130163
cardiotoxicity41197380083326688127143182205243275291325341364399
of454073800833858
the46207380083226198
quinoline47407380083387793132172189205244280
and504273800833271111
structurally51767380083265073112146171210232266283299332
related55307380083215639347480083154972107149
antimalarial41057480083337295112171205222256278295329345
drugs:447374800833961101142170183
a4679748008332
systematic47347480083276189114149209243266283316
review.50737480083215690107144197209
BMC530474800833693136
Med.546274800835692134148
2018;16(1):200.393475800833469101133146177209228261276288324359396409
53.39347680085367185
Funck-Brentano403276800833268106138168188225246280318339372410448
C,449376800834052
Ouologuem455876800834785123139177216254288346
N,491776800834457
Duparc498776800834583122155176207
S,520776800833245
et526576800833356
al.53337680083324760
Evaluation5406768008332649711214918139347780083223775113
of406277800833857
the41347780083226095
effects42447780083345372107139163191
on445077800833776
the45417780083216095
QT-interval46507780083478098114152174207229263296312
of497777800833756
45048778008334
artemisinin-based50977780083325378112169185211226263278316339379412438473513