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Farm.3211804001074178104179195
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KLINICKÁ4183804001074588109168189243289347
FARMAKOLOGIE4547804001074191138210265311372414474533554597
A51618040010753
FARMACIE5231804001074291138210265317337380
15356558020012657110166
HLAVNÍ4945200012671127198263336370
TÉMA5337200012657114204274
Glifloziny42533600106376886116148187218236277314
v4583360010636
léčbě46353600106296196132164
diabetu48153600106375595130163196237
a5068360010638
jeho51223600106225495136
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Glifloziny34092002981642302943754435806907568941013
v14029200298127
léčbě1577920029866192300442568
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a30699200298126
jeho3244920029870195335472
komplikací3764920029813026446861067573986799310991164
Petr3401320013764120161204
Žák1,566132001376412218274613300803651
2,8101330080368481320013729
Karolína8991320013767126167231261291356414
Kvíčalová1,13351320013767121152201259289353410468179513300803651
2,185913300803618971320013729
Eliška1948132001375990120167227286
Ambrožová1,22561320013772166232274338389453510567281613300803651
22880133008036
12.340148007833370148001335679
interní473148001332586121175210271296
klinika,792148001335279104164189240294316
Lékařská11321480013351106157211246290340394
fakulta,1550148001333285136196222258311333
Masarykova19071480013388141184237272327379438489542
univerzita,24721480013361121146199253288337362398451474
Brno2969148001336096157217
2Diabetologické340163007833373163001337399151213269305364390450512537586637690
centrum10861630013350103164199234295386
2.1495163001335780
interní1598163001332686121175210271296
kliniky,1918163001335178103163188239294311
Fakultní22521630013354102153214239275335360
nemocnice26351630013361116208268318378403452505
u31641630013360
sv.3248163001334397113
Anny33851630013367127188237
v36461630013353
Brně3722163001335995156211
Léková340214001214796142195241289
skupina650214001214085139195218272319
gliflozinů991214001215578100128154208249271325379
(SGLT-21391214001212974138184226252297
inh.)1710214001212378132152178
byla19102140012157102125172
v21042140012148
počátcích21732140012157112157204236278300344398
svého2592214001214088136191245
klinického285921400121467192147169212258306361415
využití3295214001214898153195217249271
představena3588214001215788137193340228001214072120166214269316
jako675228001212471117170
antidiabetika8642280012148103134156211234280336386419441486535
s14182280012140
nízkým1477228001215678120165215298
rizikem179422800121335698120166213296
hypoglykemie.21092280012156101157212268290337383431514536585604
Až27332280012161105
následně28582280012155102140162212268322372
nám32492280012156103185
výsledky3453228001214898137159208264310359
randomizovaných340242001213279132187240321343384437482529582626668721
klinických107624200121466991144166208253301343396
studií1488242001213971124178200221
ukázaly,17242420012155100147189237258304318
že2058242001214290
rozsah2163242001213285125164211265
jejich244324200121247294116159212
účinku2670242001215497119172217270
je2955242001212473
mnohem30432420012182135189243291372
širší,343024200121406192130152170
s36152420012140
potvrzeným36702420012156110340256001213383115159208262307390
přínosem749256001215688111165219257307390
pro1157256001215789142
snížení1318256001214094116158207261283
kardiovaskulární1620256001214795126182204258304351389435489512559590645667
morbidity,23052560012184138170226249304326358407422
mortality27462560012183137169204252275296329377
i31422560012123
jejich318425600121247396118162216
nefroprotektivním34192560012155105133166219276308361340270001213381126161182229284305387
potenciálem.7422700012157111142190244288309355377426508528
Srdeční1285270001214980135183227281303
selhání1603270001213988111164211264286
se1905270001213988
zachovalou2008270001214391134188241287334356409463
ejekční2486270001215073121167209263284
frakcí2786270001212961108153195217
(HFpEF)3018270001212891138191239286313
je3346270001212473
nejčastěji34352700012155104126169216254286334356378
uváděným3402840012155103150206255309354437
fenotypem795284001212978133187219268324375457
selhání1270284001214089112166213267289
u15772840012155
diabetu1650284001215779126181232264318
2.1986284001215171
typu2075284001213382139193
(DM2).2286284001212993172222247265
Toto2569284001214997129182
onemocnění27692840012155109159241295340394444498520
je3307284001212474
však3399284001214886134179
často3596284001214593131164217
poddiagnostikované3402980012157112168224246293348402456494527549595648694741796845
i12022980012124
nedostatečně12432980012155105161215254286334366414459513562
léčené,1822298001212473118166220270289
a21282980012148
to2194298001213386
navzdory22972980012156103148192247301333383
prokázané2697298001215789142189237279328382432
účinnosti3146298001215599121175229283322355377
SGLT-235402980012149112159201227272
inh.340312001212378132152
v5133120012148
léčbě581312001212473118173223
HFpEF.8253120012165113166215262273
V11183120012156
současnosti1194312001214094149192240278332386425457479
tak1694312001213381126
SGLT-218413120012149113159201227272
inh.2134312001212378132152
patří23063120012157105137168190
k25173120012147
základním2584312001214392138162209264318341423
pilířům3027312001215780102124158213295
léčby3342312001212473118173219
nejen35813120012156105128177232
diabetu,340326001215779127183234266321341
ale708326001214871121
i8553260012124
srdečního906326001213971127177222276299355410
selhání1343326001214090113168215270292
a16623260012148
diabetického1737326001215779127183234267289333379427483537
onemocnění23013260012155111161244299344399448504526
ledvin.2854326001212373130178201256276
V31573260012156
léčbě3240326001212474119175225
diabetu3492326001215779126183233266321
jejich34034000121247395117161214
účinek570340001215498119173222268
významně853340001214897141195241323376425
přesahuje1294340001215688136174222275328351400
kontrolu1709340001214799153184215268291344
glykemie,2069340001215577123169217298320369388
zahrnuje2472340001214391145176230283306354
i28423400012123
modulaci28813400012183136192245267314357379
metabolismu32753400012183132164212267321344365403484537
nebo3403540012155104160214
snížení569354001214093115157205259281
oxidačního865354001215598121176222266319341396450
stresu.1330354001214072103152190243262
V16083540012155
recentních1679354001213280124172226257311332376429
experimentálních2124354001214995151200232254335384439470517539592614657711
pracích2850354001215788135179200243297
byl31623540012157102125
prezentován3302354001215788136178227281312364410457511
možný3403680012182135175229272
účinek627368001215497118171220265
SGLT-29063680012149111157198222267
inh.1188368001212376129148
na13513680012155101
diabetickou1467368001215577122177226257279321366417470
retinopatii1952368001213280112133186239294341371392414
a23813680012147
neuropatii,24433680012155103156187239294341371393414433
pozoruhodná28903680012157110150203234287340393448501547
jsou3452368001212460113167
data36333680012156102133179
sledující340382001213961110165218241262305327
možné6823820012183136177230279
ovlivnění9763820012155100123144191245294348370
progrese1361382001215688140195226275312361
neurodegenerativních17373820012156104158189242297346401449503552583630661683729784805848902
onemocnění.26543820012154108157239292336390438492514533
Jistě320238200121375996128176
bude33933820012156110165214
ještě3622382001212473110143190
třeba340396001213364113169216
doplnění5723960012157111167190244293347369
klinických95739600121477193147169212258307350404
studií1376396001214073126182204226
na16183960012155102
větší1736396001214896128168190
pacientské19423960012156104148170219273304344389437
populaci,23953960012157111167222244291335356376
ale2787396001214870119
možná29223960012184138179233280
se3218396001213989
v33233960012148
budoucnu33863960012157112167221275319373427
dočkáme3404100012156110155200249331380
dalšího7394100012157104126164186242296
rozšíření1054410001213387128168190224273327349
indikací1423410001212377133155200249292314
pro1757410001215788142
léčbu1918410001212473118173228
SGLT-221654100012149112159201227272
inh.2456410001212478132152
Klíčová340426001246190118163220272326
slova:686426001244371129181234260
SGLT-29664270012149114161204231277
inh.,1265427001212378134155176
HFpEF,14624270012166115169219267278
CKD,17614270012158112179197
retinopatie,1980427001213282115138194249306355387410460480
neuropatie.24824270012155106161193248305354386409459480
Gliflozins340454001246897125160189247294322381425
in785454001242886
the892454001243696149
treatment1061454001243776130183220307360420456
of1537454001245893
diabetes1650454001246087141201254292345389
and20594540012453112172
its2251454001242764109
complications23804540012445102189249277305350404440469527586629
The3404720012150106157
drug517472001215689144200
group737472001215689143198255
gliflozins1012472001215680103132158213255279334373
(SGLT-21405472001212875139187230256303
inh.)1728472001212379134155182
was19304720012174122161
introduced2112472001212378111143198255309355404461
at2593472001214881
the2694472001213388138
beginning28524720012157109165189244299322377433
of3305472001215584
its341047200121235697
clinical352747200121446891146169213262286
use340486001215594145
as510486001214887
antidiabetic6224860012149104136159216239287343395428451496
drugs1143486001215689144200239
with1408486001217397130185
a16184860012149
low1692486001212479152
risk186948600121335695141
of2036486001215584
hypoglycemia.21454860012155101159215271295342386435519542590611
Only27814860012169125149196
later3002486001212472104154186
did3214486001215679136
the3375486001213388139
results3539486001213383122176200233273
of340500001215584
randomized449500001213382137193249332355398448506
clinical98050000121456891146169214262286
trials129150000121336689137161199
show1516500001213994150222
us1764500001215594
that1883500001213389137169
the2077500001213489139
scope2242500001213984138195246
of2514500001215484
their2623500001213388139162195
effect2843500001215080112163208244
is3112500001212362
much32005000012183138183238
broader,3463500001215790145193250300333349
with340514001217497130186
a5505140012148
confirmed622514001214599154183209242326376433
benefit10805140012157108163214243270303
for1407514001212984117
reducing1548514001213383140195240263318374
cardiovascular1946514001214594126182205260307356395440495518566599
morbidity,25695140012183139171229252309332365415431
mortality30245140012183139172208256280303336386
and34345140012148103160
their3618514001213388139162195
nephroprotective3405280012155106163219251306363396450483533578614637685734
potential.10955280012157113146195251283306354378398
Heart15155280012165116164196232
failure1769528001212978101124179211261
with2052528001217397130185
preserved2258528001215790140180230263314363421
ejection2700528001215074124170205228283339
fraction3060528001213063112156192215270325
(HFpEF)3407528001212892141196245293322
is3751528001212362
the340542001213388139
most5005420012183139178212
frequently733542001212963112169224275330363386433
reported1187542001213383140196229265314371
failure1580542001212978101124179211261
phenotype18625420012157113164219274307357415466
in2349542001212379
type2449542001213383140192
226625420012151
DM.27345420012167147170
However,29255420012165121193243290340372388
this3335542001213388111150
disease3506542001215679118169217256306
is340556001212362
often421556001215584121170226
underdiagnosed6665560012155110167217250306329377433488544583633691
and13765560012148103160
inadequately1555556001212378126183233291345393426475499547
treated,2121556001213365115163196245302323
despite24635560012156107146203226259309
the2791556001213388138
proven2948556001215790145192241297
effectiveness3264556001215080112163208244267315364420470510549
of340570001215584
SGLT-24495700012149113161204231277
inh.751570001212378134155
in931570001212378
the1034570001213388139
treatment1197570001213366116164196279330386418
of1640570001215584
HFpEF.17485700012166115169219267279
Currently,20515700012158111144177227282315338385401
SGLT-224775700012149114162205231278
inh.2779570001212479134155
are2959570001214881130
among31145700012148132187242299
the3437570001213388139
basic36015700012157105144167212
pillars340584001215781105128176209250
of618584001215585
the731584001213489140
treatment899584001213467117165198282333389421
not13495840012156111144
only15225840012155111135183
of1733584001215585
diabetes,1846584001215780128186237271320360382
but22565840012157113147
also2431584001214972111167
of2626584001215685
heart27405840012155106155187223
failure2992584001212979102126181213264
and32845840012149104161
diabetic3474584001215780128185237270294339
kidney340598001214772130185236284
disease.652598001215781120171219259310330
In1011598001212480
the1120598001213389140
treatment1289598001213366116165198282333389422
of1740598001215584
diabetes,1853598001215780129186238272321361383
their2265598001213389140163196
effect2490598001215081114164211246
significantly2765598001214063120176199229255300350405438462510
exceeds3303598001215199143192244302341
the3673598001213389140
control340612001214599155188221276300
of669612001215584
glycemia,782612001215680127172221305329377398
also1209612001214872111167
includes1404612001212479125148203260311351
the1783612001213489140
modulation19526120012184139197252276324357380435492
of2472612001215585
metabolism25856120012184135169218275332356379418502
or3115612001215689
the3232612001213489140
reduction3401612001213383141196241277300355411
of340626001215584
oxidative4486260012155100124180228261284332381
stress.853626001214074106156196235256
In1133626001212479
recent1236626001213383129178233266
experimental1526626001215097154205238262345396451484532556
studies,2106626001213973128185208258298319
the2449626001213388138
possible26116260012157113152192214271295346
effect2981626001215079112162208243
of3248626001215584
SGLT-233566260012149114162205231278
inh.3658626001212378134155
on3406400012155111
diabetic471640001215680127184235269292337
retinopathy828640001213382116139194249306355388443488
and13376400012148103160
neuropathy,15176400012156106161194249306354387442488504
the2041640001213388139
data22006400012157105137186
monitoring24066400012184139195218251305338361417473
the2899640001213388139
possible30586400012157113152191214271295345
influence3424640001212379107134188239294339388
on3406540012155111
the469654001213389139
progression627654001215790144201233283323362385440495
of1141654001215584
neurodegenerative12446540012155106161193248305356412463518569602650683706754803
diseases2066654001215679118169217256306346
are2430654001214981131
remarkable.2580654001213282166214246293342399423474494
Of30926540012169100
course,3211654001214598154186227277297
clinical352765400121446891146169214262286
studies340668001214073128185208258298
on6606680012155111
a7936680012149
larger864668001212472104160210243
patient11296680012157106139162212267300
population14516680012157113170226249297330353408463
will1937668001217397120144
still210366800121407497120143
be22696680012156108
needed,23996680012156106157214265322343
but27646680012157112146
perhaps29326680012157108141197245301341
in3295668001212479
the3396668001213389139
future3557668001213085119174206256
we3406820012174123
will484682001217498121144
see649682001214090141
a8116820012149
further881682001212985117153209259292
expansion1194682001215097155203259297320375431
of1646682001215584
indications1751682001212479136159203252285308363418457
for2229682001213084117
the2368682001213388138
treatment2528682001213365115163195279329385417
of2966682001215584
SGLT-230726820012149113161204231277
inh.3370682001212479134155
Key3406980012461113164
words:5256980012476133171231275301
SGLT-28476990012149114161204231277
inh.,1146699001212378134155176
HFpEF,13436990012166115169219267278
CKD,16426990012158112179197
retinopathy,1861699001213282115138194249306355387442488504
neuropathy.23866990012156106161194248305354387442487504
Circulus3407310014771101144199267299367418
vitiosus785731001476192135166234284352403
–12157310014760
inzulinová13027310014731100154223254285354422482544
rezistence,3407450014743105160191241285346416470532560
zánět,9287450014754117186248291321
oxidační12777450014767126157227289343412444
stres1748745001475093136198249
Kardiometabolický480762001094892121171192241315361390434485534556576616658702
syndrom1198762001093578128179208256331
(CMS)1544762001092675147190215
vzniká1774762001094383133153195239
v3407760010943
důsledku3997760010951101136157203255297347
dysfunkce763776001095093129157207257300339384
tukové1163776001093080122171214258
tkáně,1437776001093072117167213231
významného16847760010943891301802242992140734001095096146196
zvýšení2356734001093884130166212262283
masy26597340010975118154198
tukové2876734001093079122171213258
tkáně,3153734001093072117167213231
nebo3403734001095096148198
spíše3621734001093587108146191
kombinací2140748001094189163213234282325364384
obojího.2539748001094999149169190240289306
Dysfunkce28607480010959102136163212261302341384
tukové3259748001092977119166208251
tkáně3525748001092970113162207
je3746748001092266
charakterizována2140762001094090134163207250282327357378417467510554604647
aktivací2803762001094486119140184228268289
patologických3108762001095296125174196246298319360402447487537
metabolických366176200109751212140776001093074126176198219260302348388438
drah,2602776001095180125175194
rozvojem2820776001093079117163212234279355
inzulinové3200776001092171110160181202252302345390
rezisDECLARATIONS:36147760010930751141361714070216008648871301662142563043393604124625014571216008514
Declaration406923000874987120141179206244271291333375
of445823000874066
originality:45382300087406888130150192230251271298337356
The406924100853473109
manuscript418924100855891130168195227249266306329
is452924100851744
original45842410085386178117133172205222
and481724100853472112
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