1156
KLINICKÁ341804001074588109168189242288347
FARMAKOLOGIE709804001074291138211265312372415474533554598
A13288040010753
FARMACIE1403804001074191138210265316336380
/18298040010732
Klin190680400107446583131
Farmakol2057804001074278105179220258305325
Farm.2402804001074178104179195
2026;40(3):176-1802617804001074487128170185229275299342363377414451491521559598643
/33058040010732
www.klinickafarmakologie.cz4568804001076513320121425327329234035839843647950254457164568672477179183988990895196610061045
1801288020012657111170
PŘEHLEDOVÉ341200012660124182256312369444520587645
ČLÁNKY1008200012660115187259327395
Korelace34136001063372108140172214247279
genotypu63636001063768110151181220256296
a948360010638
fenotypu100236001062860102143173212248288
CYP2C19:130636001063271106139172203233249
fenokonverze,157036001062860102143179217259297329365400432449
populační203436001063273109149180222255297314
specifika23643600106316597131149179197233274
a2654360010638
moderní270836001065292132164200241259
sekvenační29823600106316298138170212252285326344
přístupy33423600106326885118150192226263
v3621360010636
personalizované367336001063264100134175216256287305338377414450492523
farmakoterapii421236001062967102157197233272302334370412446464481
že34362001093985
být45462001095194127
vztah60762001094485118163213
mezi846620010976122162184
genotypem105662001095197148199229275328374451
a1533620010943
skutečným160262001093679130160206248298340417
fenotypem34376001092672122172202247300346422
klinicky7847600109426586136157198240285
závažný.108876001093984126170210260301317
Metodologický483900010975122154205259311334386439462504548596
pokrok1125900010952105150182234278
v1449900010945
oblasti1540900010951105128173210242264
NGS1851900010961122168
a3431040010945
sekvenování416104001093783126173218269319363407458479
exomu923104001094689139216266
tyto1217104001093176110159
limity1404104001092243119141171216
postupně16481040010953105140171222274325371
překonává.343118001095383128171220271315358402421
Nové7911180010961112155200
technologie1018118001093075117167218268290341392413459
umožňují15041180010951128178217267317339360
detekce1890118001095399213862001093074116155199
vzácných236062001094484128168218258297347
variant,272962001094588116137180229258276
CNV3028620010953111161
i3212620010922
přímé325662001095281102177222
fázování350162001092770109158200243293313
haplotypů,213876001095092141162210238281332380397
které255276001094273116144187
konvenčním275676001094289138178221269308356376449
metodám3222760010975119148195245287360
chybí.359876001094189128179199216
Předpokladem213890001094774116165214261302322363411454526
jejich26769000109226584103141188
smysluplného2875900010936108146180199245294313361404451498
zavedení338590001093881120162211254301320
do371790001095097
rutinní2138104001093079107127176225244
praxe2404104001095281123165208
však2634104001094478121162
není2818104001095195144164
jen3004104001092267116
technologická3142104001093073114162211260280329379399438479522
připravenost36861040010952801002138118001095179122162205254302336365
laboratoří,2517118001092163112161189232260307335354371
ale2902118001094463107
i30231180010921
edukace3058118001094595143184227266308
lékařů3380118001092165106149177225
a36191180010943
systémová3676118001093678112393462001093073147195237279
integrace42356200109217097140190218261300343
farmakogenetických46006200109266997171213254301350395443488516536575615659698746
dat536862001095193121
do5510620010951100
elektronické393476001094565109150181209257305325363404446
zdravotní439476001093888115158198245273322341
dokumentace.474976001095099140188261306354382424463506523
Výsledek528576001095092126146190240284325
farmakogenetických39349000109266997171213253300350394442486515534573613657695743
testů469190001093073107136184
je488990001092266
tedy496990001093073123164
třeba514790001093058101151194
vnímat535590001094392111185227255
nikoli3934104001094968108154174192
jako4138104001092263103149
definitivní4298104001095194118140187206234253294342361
diagnózu,4671104001095069110158205253288336352
ale5035104001094362105
jako5152104001092263102148
jeden5312104001092265114157205
ze5529104001093881
vstupních3934118001094377106154204253272311359
parametrů4308118001095294122164237282310338386
klinického471011800109426382131150189229272321369
rozhodování.5094118001093077114162210260308349392440459476
LITERATURA344141001234978134189250318368438498567
1.34315800853750
Zanger41415800833973112153189211
UM,647158008345101115
Schwab78415800833367106159193233
M.103915800835670
Cytochrome11311580083417096134168207230268328365
P450151715800833670104139
enzymes167815800833574105140200237265
in196415800831555
drug3431680083385998137
metabolism:50116800835792115148187226242257283341353
Regulation87516800833570110148163196217233271309
of120516800833757
gene128216800833873112147
expression,144916800833466106127162189215230268307320
enzyme178916800833472102136195230
activities,3431780083326488103136152174189224251264
and62617800833169108
impact75317800831572111144177201
of97217800833857
genetic104717800833873111146169184216
variation.12821780083316485101133155170208246260
Pharmacol156017800833573105126185217249286302
Ther.188017800833372107128139
2013;138:103-141.34318800833468100130141172201236248278309343364395426457466
2.34319800853653
Botton4151980083357598124163202
MR,63719800835592107
Whirl-Carrillo76419800835898114137154178222256279302319336352392
M,117519800835570
Del126419800834683100
Tredici13831980083335287128144178194
AL,15971980083417489
et170619800833458
al.17841980083314863
PharmVar18661980083357410813134320800835996130153
GeneFocus:52020800834583124162198238273314342357
CYP2C19.90120800834181120157199234267280
Clin12052080083415876116
Pharmacol134620800833676111134196231266305323
Ther.169420800833375113136149
2021;186720800833572108142152
109:352-366.34321800833467104118155189224245279315352367
3.34322800853651
Lima41022800833147104137
JJ,5632280083244860
Thomas64022800833272110168201227
CD,8842280083398596
Barbarino9962280083366990129162184199237275
J,128822800832436
et134022800833457
al.14132280083324760
Clinical14902280083405570108123155187203
Pharmacogenetics17092280083357310512618521724928634323800833873112147169185217245
Implementation60923800831473112128163221257295317350372387425464
Consortium109423800834077116142181203227243281339
(CPIC)14532380083195994109150170
Guideline16442380083448298137172188203241276
for19412380083185678
CYP2C1934324800834077114147187219249
and60524800833270109
Proton7272480083355693115152191
Pump93124800833572130169
Inhibitor11132480083155391106145160183220241
Dosing.136724800834684111126164203216
Clin15962480083405570108
Pharmacol171724800833572105126184217249286302
Ther.34325800833372107128138
2021;109:1417-1423.49725800833468101132141171202237250280311342371389420451484519531
4.34326800853651
Lee40826800833166101
CR,5232680083407690
Luzum6272680083326998136194
JA,8362680083246478
Sangkuhl92926800833265103142172210248264
K,120726800833550
et127126800833457
al.13422680083324760
Clinical14172680083405570108123155188203
Pharmacogenetics1635268008335721041261842162492853253603432780083387395110142170
Implementation53427800831572112128163221256294316349370386424462
Consortium101727800834077116142180202227242280338
Guideline13752780083448297136171187202240275
for16702780083195778
CYP2C19176927800834077114147187219250
Genotype34328800834479117155177211251286
and64228800833270109
Clopidogrel7642880083405593132148187225264285319335
Therapy:111228800833272107128161200231244
2022136928800833569101136
Update.151828800834483122154176210222
Clin17532880083405570108
Pharmacol18742880083357210412534329800835790122159175
Ther.53329800833372107128138
2022;112:959-967.68729800833468101136148178206236248283317350373408444477483
5.34330800853651
Beunk40930800833571110149180
L,60430800833146
Nijenhuis6653080083456177113152191229246273
M,95330800835469
Soree10373080083327194129165
B,121830800833549
et128230800833457
al.13543080083324862
Dutch143230800834584107139178
Pharmacogenetics1625308008335741071291882222552933333693433180083377295111144172
Working53031800835693115146163202241
Group78631800834365103141181
(DPWG)98131800831965101159203223
guideline12183180083387692131166183198237272
for15053180083185678
the15983180083216095
gene-drug170831800833773111146170211233271311
interaction3433280083145375109131165198223239277316
between6743280083387498151186222261
CYP2D6,94932800834078115149194230244
CYP2C19120832800833977114148188221252
and147532800833170109
non-SSRI/non-159932800833776115138170203239255282319358396420
-TCA3433380083215292135
antidepressants.4943380083317193110149185226248283311339373412435463478
Eur9883380083327092
J1095338008324
Hum113533800834482141
Genet.129133800834480119155179193
2024;32:1371-1377.150033800833469103136149185218232263294327360380412443476512519
6.34334800853651
Relling4063480083357085100114151190
MV,6083480083549099
Evans7193480083326496134159
WE.89134800835790103
Pharmacogenomics100634800833572104125182214246282321356393431488503535562
in158034800831552
the16453480083215993
clinic.1751348008331466098112144157
Nature.1920348008345763433580083226081115127
2015;526:343-350.48535800833469100130141176209243255291326359381413446480493
7.34336800853747
Shah41136800833373107146
RR,5803680083367489
Smith69136800833493109133173
RL.8863680083367085
Addressing99336800834282123145181209237253292333
phenoconversion:134836800834080117156196230269309342378400428444484524537
The190736800833475111
Achilles’34337800834173112128143159194221235
heel59937800833873109125
of74537800833858
personalized8243780083397597124163202235251266296331371
medicine.121637800835894134149182197236271284
Br152137800833658
J1599378008325
Clin16453780083405671110
Pharmacol.177637800833573106128187220343388008331688497
2015;79:222-240.45538800833469100130141174207220256290325345376408444457
8.34339800853652
Klomp4103980083355290148187
SD,6123980083337889
Manson71639800835487125151189228
ML,95939800835486100
Guchelaar107439800834482114152187203235267288
HJ,13773980083447082
et147439800833456
al.15453980083324760
Phenoconversion1620398008335731081461842172542923243583793434080083264179117
of47540800833857
Cytochrome5474080083406892129162200221258317352
P45091440800833567100134
Metabolism:106340800835489112144184223238253280337349
A1427408008341
Systematic14834080083336390113146204237258274306
Review.180440800833570102118153204215
J343418008324
Clin3824180083405671108
Med.50641800835489129142
2020;9:2890.66341800833469101135148184197232266300336348
9.34342800853649
Petrović4104280083356991112150182197229
J,65742800832437
Pešić7124280083356895110142
V,87242800833644
Lauschke93542800833164102128161199229263
VM.121642800833691105
Frequencies13394280083325286125163198236268283318345
of170242800833757
clinically1777428008331466199114146179194209241
important34343800831573112152173198231270292
CYP2C1965543800834078115149189221252
and92743800833271110
CYP2D6105843800834077114148193229
alleles1308438008332476398114149176
are15054380083325387
graded16134380083386093132168208
across18414380083326586124151178
Europe.3434480083336990128167203215
Eur5734480083336990
J679448008324
Hum71844800834482140
Genet.87344800834479118153175188
2020;28:88-94.107644800833569102136149184217230264300322357393406
10.3434580085367085
Proietti4474580083355693108143165190205
R,67245800833549
Maranho74145800835587109142180218256
Neto101745800834580102139
GA,117645800834485100
Kunzova129645800833472110139176208241
S,155745800833345
et162245800833457
al.16994580083314760
Pharmacogenomic17794580083357210512618421734346800833168108143181219277292324
profile6824680083396097115132147182
of87946800833756
a950468008332
central99646800833265103125146179195
European12054680083336991128167203235273
urban14924680083385998131169
random16764680083215492131169227
population-Czech1918468008339773434780083397792124146161199238260303334368401439
population.79747800833877117155170203224240278316329
PLoS114247800833566103135
One.129347800834785120132
2023;18:e0284386.144147800833468101136147177208220255291323357394426461496509
11.3434880085366678
Sibbing4354880083324786126141179218
D,66848800834556
Koch73848800833572105143
W,89548800835867
Gebhard97748800834379118156189210248
D,123948800834656
et131048800833456
al.13804880083324760
Cytochrome14544880083406893130163201222259317352
2C1917182048800833574106137169198
allelic3434980083324864100116131164
variant,5284980083326688104137176198212
platelet7614980083395689111146162198221
aggregation,100349800833272112134169209242265281320359372
bleeding13964980083405692128169184223263
events,168049800833568103142164193206
and190849800833271111
stent3435080083264983121143
thrombosis5025080083216081118176215254281296322
in84050800831552
clopidogrel-treated9095080083314684124139178216256277311327349371393427459481514554
patients14795080083397293109143181203231
with17265080083506688126
coronary186950800833168891273435180083387091125
stent4835180083265083121143
placement.6415180083395587119153211246284306319
Circulation.9755180083405576107145161193215230268306319
2010;121:512-518.131051800833468100131144174204236244279311340361395426457470
12.3435280085366883
Tašková4395280083326086116153185218
I,67052800831427
Šafářová7105280083326583117137174206239
N.96252800834457
TDM103252800833379134
jako11795280083154676114
nástroj13055280083387096119140177193
pro15115280083385996
farmakogenetické16205280083195273131163193230269304342376343538008322376999133
profilování4925380083396097115132147185217250288303
pacientů:81153800833972104119154192214251264
kazuistika10905380083306493131147173196211241275
fenokonverze.13815380083185290129159197235267301322353387399
Klin17965380083355166104
Farmakol1916538008332628334354800835790120157173
Farm.5325480083326183141154
2025;39:206-212.70254800833468101136146181215228263297333356387419448461
13.3435580085366883
de44555800833873
Jong53855800832462101140
LM,69755800833287101
Boussallami81755800833674112139165198214229261319334
S,117155800833245
Sánchez-López123655800833265103135173208238259292330369405434
E,169055800833346
et175555800833457
al.18315580083324860
The191155800833372107
impact34356800831572111144177201
of56056800833756
CYP2C1963256800834078114148187220250
genotype89856800833873111149171205245280
on119456800833876
phenoconversion128656800833977112150189221258297328362383411426464502
by180456800833970
concomitant18905680083316810734357800833168126142164197235256
medication.61557800835792132147179212233249287325338
Front9695780083325289127149
Pharmacol.113357800833573105126185217249286302315
2023;14:1201906.146357800833469101136148178209221251281315347377412448461
14.3435880085366984
Hakkola44258800834476107138175191224
J,68158800832436
Hukkanen73258800834482112143177215250288
J,103558800832436
Turpeinen10865880083336687127163178216251289
M,139058800835568
et147358800833456
al.15445880083324861
Inhibition16205880083145290105145160183198236274
and190958800833270109
induction3435980083155392129161185201239277
of63459800833757
CYP70559800834077113
enzymes83359800833372101135194229255
in110259800831553
humans:116959800833875133165203230242
an142559800833270
update.150959800833776116148170204216
Arch17395980083416293131
Toxicol.18845980083336797113343608008331688497
2020;94:3671-3722.45560800833469101136148184220232267301334367385418450484519532
15.3436180085366883
Stanke-Labesque4466180083325486124155189212245278318353380419457492
F,95861800833238
Gautier-Veyret101761800834376114136151186207227263296327349383405
E,144361800833246
Chhun150961800834078116153191
S,172161800833245
et178661800833456
al.18636180083324760
Inflammation1943618008315533436280083173467125184217239254293332
is69662800831441
a758628008332
major81162800835790106144166
regulator9986280083215696134149182204241263
of128262800833857
drug13606280083396099139
metabolizing151962800835894116150189229245260290306344384
enzymes19236280083357334363800832963123158185
and54963800833271111
transporters:6816380083214377115142182221243268303324352365
Consequences106763800834077117143179219257293331364398425
for15136380083195779
the16136380083226196
personalization17306380083397597125164203235251266343648008328628399137175
of53364800833857
drug6056480083386098137
treatment.7576480083224377109131189224262284297
Pharmacol106964800833673105126185217249286302
Ther.138764800833271106128138
2020;215:107627.154064800833469101135148183215245256286317350382415448454
16.3436580085366985
Zhou44165800833876114152
S,60765800833245
Skaar6666580083326296128149
DJ,8296580083456779
Jacobson9226580083245689125165192230268
PA,12046580083357387
et130465800833457
al.13746580083324861
Pharmacogenomics144865800833573105126185217249286326361399437495510542570
of213815800833757
Medications221315800835490129144176209231246284323349
Commonly258015800834077136193232270286317
Used291615800834469104144
in307815800831553
the31491580083226095
Intensive32631580083145274108146172187219254
Care35351580083407394128
Unit.36821580083438196119132
Front21381680083325289128149
Pharmacol.230316800833572104126184216249285301314
2018;9:417867.263316800833468100131143178191226256286319354387393
17.21381780085366876
Duthaler223117800834584106144177192227248
U,249617800834454
Bachmann256717800833568101138196229267305
F,288817800833339
Suenderhauf294317800833370105143182217238277309346366
C,332517800834053
et339517800833456
al.34681780083314760
Liver35441780083324780114135
Cirrhosis3696178008340557698213818800833876103117143
Affects23011880083416079113146170198
the25181880083226095
Pharmacokinetics263218800833673105126185217249286317333371406429444476503
of315518800833756
the32311880083215994
Six33451880083324778
Substrates344218800833370109136159181214235269296
of375718800833857
the21381980083226094
Basel22451980083356894129145
Phenotyping240319800833572107144183204238277293331369
Cocktail278519800834077109139163196211226
Differently.3024198008345608099133154188226247263294304
Clin33411980083405570107
Pharmacokinet.34611980083357210412518321624828431533121382080083387395108
2022;61:1039-1055.226120800833569102136149184215223253284318351374405437471503515
18.21382180085366985
van223821800833265103
der23542180083397395
Lee246321800833165101
M,257721800835568
Kriek26592180083355873108138
M,281121800835568
Guchelaar289321800834482114152187202235267288
HJ,31952180083446981
et329021800833456
al.33602180083324760
Technologies34342180083336496134172210226264304319354381
for21382280083185576
Pharmacogenomics:222622800833471102123180211243279317351389426483497529555567
A2805228008341
Review.285822800833569100115149199209
Genes308022800834377114148174
(Basel).32672280083185385111145160178189
2020;11:1456.34682280083346799132144174201209238268300333346
19.21382380085366779
Hippman22362380083445896134191222259
C,251323800833951
Nislow2582238008345588397134184
C.278323800834052
Pharmacogenomic285323800833571102122179210241277315348385422479493524
Testing:33942380083336288110124160198209
Clinical36202380083405468105118149180194
Evidence21382480083326276112145181211242
and239024800833167104
Implementation250324800831570107121153209242278297328347361397433
Challenges.294524800834075105119132165200237270295306
J3261248008324
Pers32942480083356685110
Med.341424800835386124135
2019;9:40.35582480083346696124134168179211245256
20.21382580085367287
Pratt22392580083355689111135
VM,238725800833591104
Del25042580083458196
Tredici26132580083335084124139171186
AL,28122580083417386
Hachad291125800834477109147179218
H,314225800834457
et321225800833457
al.32822580083314760
Recommendations335525800833570103140198256291329368400422437213826800833776102
for22562680083195678
Clinical23502680083405570108123155188203
CYP2C19257026800834077113147187219249
Genotyping283526800834479118156178211251267305344
Allele31952680083415772107122157
Selection:33682680083336883118151175190228267279
A3663268008341
Report37202680083367121382780083387798122
of227327800833756
the23422780083215994
Association24482780083416895133165180211233248285323
for27842780083185677
Molecular287427800835492107142174211226258279
Pathology.31662780083356688125163179217256288297
J3476278008324
Mol351327800835492107
Diagn.36332780083456092131168181
2018;20:269-276.213828800833468100131143178212225261294328352383416447461
21.21382980085367082
Lopes223529800833169108144171
JL,24212980083245670
Harris25062980083447697119135161
K,268229800833550
Karow27472980083356889127178
MB,294029800835490103
et305829800833456
al.31302980083314760
Targeted32052980083326082120155177211250
Genotyping347029800834479118156178211251267305344
in213830800831552
Clinical22033080083405570107122154187202
Pharmacogenomics:241830800833572104125183215247284323358395433491506538566578
What300930800835796128149
Is317130800831541
Missing?32243080083557096122137175213238
J3475308008324
Mol351130800835593109
Diagn.36323080083456193131169182
2022;24:253-261.213831800833468101136148183215227262297330352383417447456
22.21383280085367288
Gaedigk224632800834476111151166205235
A,250132800834155
Ingelman-Sundberg25753280083155392127143200233271293325362400439478514535573
M,316832800835468
Miller32553280083557086101135157
NA,343132800834586100
et355132800833456
al.36273280083324760
The370732800833372107
Pharmacogene213833800833573105127185218250287327362400436
Variation25943380083366789104137158174212251
(PharmVar)28653380083195592125146205239271292310
Consortium:319633800834077116142181202227243280338351
Incorporation356733800831553861231441842232138348008321547591129167
of232034800833756
the23913480083226095
Human250134800834482140172210
Cytochrome27263480083406792129162200221258316352
P450309234800833567100134
(CYP)32413480083195895132149
Allele34053480083415772107122157
Nomenclature35773480083458314117621421383580083314779100138160194
Database.23473580083457899132171204231266278
Clin26403580083405570108
Pharmacol276435800833572104126184216249285301
Ther.308135800833272107128138
2018;103:399-401.323435800833569100131144174205238250285318353377414450481491
23.21383680085357185
Schwarz223536800833263100149181201231
UI,24783680083425769
Gulilat25593680083438094109123154175
M,274636800835366
Kim282436800833450106
RB.29423680083357082
The303636800833270104
Role31523680083357287121
of328536800833655
Next-Generation335236800834377108131150195230267300321353374388425462
Sequencing213837800833268107145179218250265303342
in249437800831553
Pharmacogenetics256237800833572104126184216249286325360398433455471503530
and310737800833270109
Pharmacogenomics.323037800833673105126185217249286326361399437495511543570584
Cold21383880083407793132
Spring22853880083337193109146185
Harb24863880083447697137
Perspect26383880083356990117156192225249
Med.290238800835590129142
2019;9:a033027.306038800833468100130143178191224259293326360393426432
24.21383980085367186
Souche224239800833271109141179214
E,247439800833346
Beltran25383980083357086108130163201
S,275639800833346
Brosens28203980083355694120155193220
E,305839800833245
et312139800833456
al.31953980083324860
Recommendations327339800833671103140199256292330369401423438476514541
for21384080083185678
whole222940800835189128143178
genome242140800833873111149208243
sequencing267740800832661101138173211244259297336
in302640800831553
diagnostics30924080083395486125163201228251266298326
for34314080083195678
rare35234080083205374109
diseases.3645408008338538011514621384180083266188102
Eur22554180083326990
J2360418008325
Hum240041800834482140
Genet.255541800834479117152174188
2022;30.275841800833468101136148183218230
25.21384280085367387
Tafazoli22464280083336180113143180196211
A,247742800834155
Guchelaar255342800834382114152187203235267288
HJ,28624280083446981
Miltyk29634280083557086108142173
W,315642800835767
et324442800833456
al.33204280083324760
Applying340142800834180120136167183221260
Next-Generation36824280083448011121384380083224188123161196218251272288326364
Sequencing252243800833368107145180218250265303342
Platforms28844380083365082104125163185243269
for31744380083185677
Pharmacogenomic327243800833572104126184216249285325360398436495510542
Testing21384480083336390113129166205
in235744800831553
Clinical24244480083405570108123155188203
Practice.26414480083355689121145160192226238
Front28934480083325289128149
Pharmacol.305644800833573105126184217249286302315
2021;12:693453.338544800833468101132140170200213248282315350383416429
26.21384580085367187
Gaedigk224145800834476111151166205235
A,249145800834155
Boone256145800833674113151186
EC,27634580083327386
Scherer286445800833265103138159193214
SE,30934580083336578
et318745800833356
al.32584580083324760
CYP2C8,333345800834078114148187222235
CYP2C9,358345800834077114148187221231
and213846800833373114
CYP2C19228346800834180119155197231263
Characterization257746800834181115138173207233269292309341376400416457497
Using31054680083457289129170
Next-Generation330646800834683116143164213251291328351386410427467508
Sequencing213847800833368107145180219251266304343
and250247800833270109
Haplotype263247800834477116132170192226266302
Analysis:295447800834280112128160187202228241
A3215478008341
GeT-RM327747800834479108127164220
Collaborative3517478008340789410914118122024127421384880083223769104
Project.22574880083355693109143176200213
J2486488008324
Mol252548800835593109
Diagn.26494880083466193132170183
2022;24:337-350.284848800833468101136148183215227262295327346378411445458
27.21384980085377382
Ionova22454980083155594134167201
Y,247149800833644
Ashenhurst254049800834271110146185225263285313337
J,290249800832537
Zhan296449800833978111150
J,313949800832537
et320149800833558
al.32844980083334862
CYP2C19337049800834280118152193227258
Allele36524980083435974110126162
Frequencies21385080083325185123160195232263278312338
in248950800831552
Over255450800834780114134
2.227025080083344681
Million2796508008355698498112150188
Direct-to-Consumer29975080083456080114146169188210246269311347385411447504539559
Genetics356950800834479116151172187218245
Research21385180083356893126157176206242
Participants23905180083356585108122152166203234270290316
and271751800833167104
the28325180083215891
Potential29335180083357090122158178192223237
Implication318051800831570108122136166197217231267304
for34945180083185474
Prescriptions3579518008334548611114216117621321385280083213571108133
in228152800831551
a2342528008331
Large23845280083316282118151
Health254652800834376107121141178
System.27345280083326086107139195207
Clin29515280083405367103
Transl30655280083324779115139153
Sci.3229528008332627688
2020;13:1298-1306.33275280083346697129141169198208236264296330351380408441475487
28.21385380085367288
Samarasinghe224653800833265123156177210236251289328366401
SR,26665380083336882
Gaedigk276753800834476111151166205235
A,302153800834155
Swen309553800833382117155
JJ,32695380083244860
et334953800833356
al.34245380083324760
Long-Read350353800833269107146169206241273312
Sequencing213854800833267106143177215247262299338
Enhances248854800833270107139177208242268
Pharmacogenomic276954800833571103124182214246282321356393431489503535
Profiling33175480083345592109126141155193231
by356154800833869
Resolving3642548008336709713415021385580083324785124
Complex227755800833976135174190225256
Haplotypes,254755800834477116132170192226265301328341
Novel290255800834583115149165
Star30815580083335487108
Alleles,32035580083415671106122157184197
and341455800833270109
Structural35375580083325375113145169207229262277
Variants.21385680083366788104136174195223236
Clin23905680083405570108
Pharmacol251356800833573105126184217249286302
Ther.283056800833372107128139
2026;119:536-545.298456800833468101135147177205235248283316351374408443476488
29.21385780085367184
Gurbel224057800834481102140175190
PA,24485780083357285
Bliden25515780083365165103137175
K,274357800833549
Sherwood281057800833370104124177214252291
M,311957800835467
et320457800833456
al.32775780083324759
Development335457800834580111145160197236294328366386
of375857800833756
a2138588008332
routine21815880083205693114129165199
bedside239158800833973111137150188222
CYP2C19262458800833975111143182213242
genotype287758800833871108145166199237272
assessment31605880083315782116142167224257294315
program34865880083385995133153185241
for37385880083195576
antiplatelet21385980083326990104142158189210243258292313
therapy24635980083215993113145184214
guidance26895980083387489127158195227260
in296059800831552
a3023598008332
community306659800833268125182219256270292325
hospital340259800833875101139154176208222
catheterization363659800833163841211552138608008321547489116149169184220257
laboratory.24066080083154684122142174194230251283292
J2709608008324
Thromb27446080083337191127183221
Thrombolysis.29766080083337191126183221259274304330344369381
2024;57:566-575.33686080083346799129140174206215249282316339372404435446
30.21386180085367287
Ji224561800832439
Y,230461800833543
Skierka23676180083326278113134165198
JM,25856180083247992
Blommel26976180083355189147205240256
JH,29726180083246982
et307461800833356
al.31496180083324760
Preemptive32296180083355690125183222244260292326
Pharmacogenomic357561800833572105126184217213862800833168108143182220279294326
Testing24856280083326390114129167206
for27126280083185678
Precision28116280083355690123138164179217256
Medicine:308862800835490129145177192230265278
A3386628008342
Comprehensive34486280083407713617519723127030534321386380083264174109
Analysis226863800834179112128160187202228
of251763800833857
Five25956380083324880115
Actionable27316380083417397113151190222262278313
Pharmacogenomic306563800833573106127186219251289329364402441500515547
Genes363363800834480118154181
Using21386480083446984122161
Next-Generation231364800834580111136155202237275310332365386402440478
DNA280564800834591132
Sequencing295164800833267107144179217250265302341
and330664800833270109
a3429648008332
Customized347564800834076102126163221236265299339
CYP2D6213865800834077114147192228
Genotyping237965800834379117155177211251266304343
Cascade.273565800834073100132165204239251
J2999658008324
Mol303665800835593109
Diagn.31586580083456193132170183
2016;18:438-445.335465800833469100131144174205217252284319341378415448460
31.39341580085366981
Weitzel403215800835791106128159193209
KW,425715800833495105
Cavallari437815800833972104137152167199221236
LH,46301580083327689
Lesko47351580083316692122160
LJ.49111580083315871
Preemptive49981580083355590125183222244259292326
Panel-Based534015800833567105140156178215248393416800832661101
Pharmacogenetic405016800833573105126185217249286326361399434456471503
Testing:45691680083326390113128166205218
The480216800833372107
Time492516800833249107142
is508216800831541
Now.513916800834483134145
Pharm529916800833573105126185
Res.54991680083367197111
2017;34:1551-1555.393417800833468100129139174210222251282314345364395425457490502
32.39341880085367085
Lanillos403218800833164101116131146183210
J,425418800832436
Carcajona43021880083407293123156171208246278
M,459218800835467
Maietta467218800835486101135157181213
P,489718800833540
et494918800833456
al.50171880083314759
Clinical50891880083395469106121152184199
pharmacogenetic530118800833876108129186218250286393419800833873111146168184216
analysis416619800833270102118150177191217
in440019800831553
5,00144691980083344681117149
individuals46351980083145291106139155194231263279305
with49561980083516789127
diagnostic51001980083385385124162200227250266298
Exome541419800833365103161196
Sequencing393420800833268107145179218250265303342
data.42912080083387092125138
NPJ44452080083448099
Genom456020800834379117155213
Med.478920800835489129142
2022;7:12.494620800833569101136149181192221251264
33.39342180085367186
Wang403621800835789127166
L,421821800833145
Scherer427821800833365103138159193215
SE,45082180083336578
Bielinski46022180083355185101116154180210226
SJ,48442180083335769
et492921800833456
al.50012180083324760
Implementation507721800831572112127162220255293315348369385423461
of555421800833756
preemptive39342280083396094129187226248263296330
DNA427722800834591132
sequence–based442222800832661100137172210242276313353386412447487
pharmacogenomics492122800833977110131189221253290330364402440499514546573
testing5507228008322558239342380083213673111
across40572380083316383119145171
a4240238008331
large42832380083154667104138
academic44332380083316395133167223238269
medical471423800835690129143175207221
center:494723800833164101122155175188
The514723800833271105
Mayo-Baylor526423800835385115152174210242272288325346
RIGHT39342480083355196140175
10K412424800833466102
Study.42412480083325492131163173
Genet442924800834479117152174
Med.461924800835489129142
2022;24:1062-1072.477624800833468101136148183215227257289324358378409440473507520
34.39342580085377693
Klein40522580083365491109149
TE,42252580083337085
Ritchie43342580083365478111152169206
MD.4564258008356104117
PharmCAT:470525800833676111134195239284315326
A5055258008341
Pharmacogenomics512125800833575110133194229264303345382423464393426800835774107136
Clinical40892680083405773112129162196213
Annotation432126800834181120160183217240257297336
Tool.467626800833368108126140
Clin48352680083405773112
Pharmacol496626800833574108130190224258296313
Ther.529826800833373110132144
2018;546126800833470103135149
104:19-22.393427800833467105118149181206238274288
35.39342880085377388
Joynt40432880083256496136158
ACM,422328800834282138152
Axford43972880083427597136158198
MM,4616288008356112126
Chad476328800834180113154
L,493828800833246
et500528800833558
al.50842880083334962
Understanding516828800834483123159181209233267306346362401441
genetic393429800833975115151174190223
variants41792980083326688105138177200229
of442929800833858
uncertain450929800833877111146168193227243282
significance.48132980083274282122138156174207241280314348361
Paediatr519629800833669105146162195218240
Child54582980083408095111152
Health.393430800834479111126149187200
2022;27:10-11.414930800833569102136149184217227256288312343370380
36.39343180085367287
Kratochvíla40343180083355789111147180217248264280312
J,435931800832436
Plzák44073180083355078111141
Z.456131800833750
ČSN462431800834073117
EN475431800833276
ISO48433180083154794
1518949493180083346495125159
(8551213180083185285
5101)52193180083346496127141
Zdravotnické5373318008337759612815919721839343280083375283113147
laboratoře40933280083154685123145177198235256289
–4395328008334
Požadavky44423280083357199132170202233263297
na475132800833769
kvalitu48333280083296396111125147185
a5030328008332
kompetenci.507432800832966124162197219253290322337349
3.543632800833446
vyd.549432800833265103116
Praha:39343380083355689127159171
Česká412133800834073100130164
agentura430033800833271106144165203224257
pro45733380083386097
standardizaci;46863380083264982120159191212250265295328360375387
2023.508833800833569101136149
37.39343480085367079
Češková402634800834073100129167198231
E,427034800833245
Šilhán4328348008332466199131168
MP.45093480083549095
Současnost461734800833270108139172198236274300323
a4953348008331
budoucnost499734800833876115153191223260298325348
farmakogenetického53583480083185172130162192229393435800833873111146168184216246280318356
testování43073580083225682106143174207245260
se458435800832661
zaměřením466235800832962120155175209247262320
na499935800833870
farmakoterapii50863580083185273131163194231253287308341380396411
deprese.55143580083387339343680083396094121156168
Psychiatr41183680083356194125163178210232253
Praxi.43873680083355588120135148
2024;25(2):71-75.455136800833468101133145180214232266284296329362380412444456
38.39343780085367288
Národní40363780083457798135175213228
strategie42783780083264970103125159199214248
elektronického45403780083345084115139161198236251283313348386424
zdravotnictví49783780083286687120152190211250265297321355371
ČR536337800834075
2025203554523780083346810113639343880083346799132
[Internet].4078388008318347192125145183217239256267
Databáze43583880083447697129168200229262
strategií46323880083264970102123156195209224
[cited4868388008318486284117156
2026-04-21].50363880083346799132155192227249280310326337
Available538538800834170103117132164202393439800831550
from:40043980083194178137149
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DiPha:40404280083466197135167180
Komplet424042800833573132171187222245
softwarových45064280083266484109162196217254287321353391
nástrojů49184280083377097120142179195233
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a4300438008332
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účelné456843800833870104119157193
farmakoterapie47814380083195274132165195233255289311344383399434
pomocí523643800833877136175208223
digitalizované547943800833954931083934448008322547085114151183216254289
informace42374480083155271109131189221254287
o4538448008337
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aspektech51854480083325897133163188222254292
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lékových55374480083155039344580083306799133165203
interakcích41514580083155374108129162193224239271309
[Internet].4474458008319357394128149188223245263274
National47634580083457799114152191223238
Electronic50164580083334883115139161198237252284
Tool531445800833367106122
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Available428146800834171103118133164203218253
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A,419748800834054
Müller426348800835491106120155175
P,445148800833438
Vojtěšek45024880083357085107140166200230
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Sequencing).53754980083326610514217621339345080083314684123142153
Klin41025080083355267104
Onkol.422250800834785116153169182
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Ceník402451800834072109123154
vyšetření41895180083316490124145166198235250
[Internet].4450518008318337090123143181215236252263
GHC472551800834387126
Genetics486351800834377114148169184215241
[cited5116518008318476182115154
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Available393452800834171103117132163202217251
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úhradách43175380083387698131171203236274
vyšetření46125380083326794130152174208247262
metodou489553800835894116154194232271
NGS518753800834590124
[Internet].5332538008318347395129151190225248266278
SLG.cz393454800833366110125159191
[cited4149548008319516791126168
2026-05-21].434154800833571105141165204240263296329346359
Available472454800834274109125141175216233270
from:50185480083194281142155
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aktuality/zmeny-v-uhradach-vysetreni-metodou-ngs/.39345580083326286124157172187210243267295353388426457479512534572610632665704736768806829861895922957980100110351073108811111169120412271264130313411379140214411480150615321537
43.39345680085377592
Morris405156800835697121146164192
SA,42685680083337794
Alsaidi43865680083426089125142184201
AT,46125680083427485
Verbyla47215680083377296139173191226
A,497156800834359
et505556800833459
al.51395680083325065
Cost522956800834181110136
Effectiveness53895680083345579116152179196393457800833267107143171199
of415457800833758
Pharmacogenetic423257800833574108130190224257296337373413449473489523
Testing47755780083336593118134174214
for50095780083195881
Drugs511057800834568108149176
with53065780083516892131
Clinical5458578008340567311212839345880083316581
Pharmacogenetics403058800833573107129188221254292332368407443466482515544
Implementation458958800831573113130166225260299322356378395433473
Consortium507758800834077117144183206231247286344
(CPIC)54375880083185894110151173
Guidelines:393459800834586103144182200217258295324339
A4297598008342
Systematic43645980083336595120157218253277294329
Review.471759800833674109127164218231
Clin49735980083415875116
Pharmacol511359800833676111134196231266305324
Ther.546159800833375113136149
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Haidar40386180083447692130163184
CE,42366180083407386
Crews43376180083406195146173
KR,45246180083357286
Hoffman462561800834482102121180212250
JM,48906180083247992
et499761800833456
al.50686180083314760
Advancing514261800834180112145183215230268307
Pharmacogenomics546461800833572105126393462800835891124162203238277316376391424453
from44086280083184179139
Single-Gene45686280083334887127143178202250286325361
to495062800832260
Preemptive50316280083355792128187227250266299334
Testing.53866280083336592116132171210224
Annu393463800834179117155
Rev410463800833570103
Genomics422263800834479117155214229261289
Hum452663800834482139
Genet.468163800834479117152174188
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Slanař40376480083324880118150171
O.422564800834758
Farmakogenomika43006480083326283141174204241281316354392450466496529
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současnost,489764800832664103135167194232270297320333
budoucnost,524764800833876116154192224262300327350364
perspektiva.39346580083397495123162197227252267300333346
Klin42956580083355267105
Farmakol44156580083326283141174204241257
Farm.46886580083326183141154
2012;26:126-130.485865800833468100130142177211223253283316340371401435448