Klin Farmakol Farm. 2026;40(2):97-101 | DOI: 10.36290/far.2026.024

Innovative clinical trial designs

Adriána Papiež^{1, 2}, Lenka Součková^{1, 2}, Jitka Rychlíčková^{1, 2, 3}

¹ Farmakologický ústav, Lékařská fakulta, Masarykova univerzita Brno

² Centrum excelence CREATIC, Lékařská fakulta, Masarykova univerzita Brno

³ Fakultní nemocnice u sv. Anny v Brně

Innovative clinical trial designs represent an important shift in the methodology of clinical research, reflecting the growing complexity of diseases, the development of personalized medicine, and the emergence of advanced therapy medicinal products. In addition to traditional randomized controlled trials, approaches such as adaptive designs, master protocols or single-arm studies are increasingly being used, enabling more flexible and targeted evaluation of new therapeutic interventions. They may accelerate the identification of effective therapies and improve the efficiency of resource utilization; however, they also introduce methodological and organizational challenges, particularly in relation to statistical planning, control of bias, and interpretation of results. In the Czech Republic, the implementation of innovative trial designs remains limi­ted, mainly due to insufficient methodological expertise, limited funding in the academic sector, and the lack of systematic education in clinical trial methodology. Capacity-building initiatives may help strengthen the methodological background and support a more active involvement of Czech institutions in the international research landscape. Innovative trial designs represent a key tool of modern clinical research, and their further development will depend on systematic methodological support and interdisciplinary collaboration.

Keywords: innovative designs, clinical research, adaptive designs, clinical trial methodology.

Received: April 16, 2026; Revised: June 3, 2026; Accepted: June 11, 2026; Published: July 1, 2026  Show citation