Klin Farmakol Farm. 2004;18(2):108-110

Interakcie nesteroidových antiflogistík a analgetík

Milan Kriška1,2, Ivan Rybár3, Jozef Rovenský3
1 Farmakologický ústav Lekárskej fakulty UK, Bratislava
2 Nemocnica s poliklinikou Považská Bystrica
3 Národný ústav reumatických chorôb, Piešťany

Keywords: interactions, NSAIDs, paracetamol, adverse drug reactions, ADR.

Published: December 31, 2004  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Kriška M, Rybár I, Rovenský J. Interakcie nesteroidových antiflogistík a analgetík. Klin Farmakol Farm. 2004;18(2):108-110.

Interakcie liekov a prevencia ich nežiaducich účinkov nadobúdajú stále väčší význam pri intenzívnejšom používaní kombinácií liekov. Cieľom práce bolo v stručnom prehľade upozorniť na klinicky významné liekové interakcie jednej z najčastejšie používaných liekových skupín - nesteroidových antiflogistík, analgetík. Autori sa sústredili na interakcie s liečivami kardiovaskulárneho systému. Samostatne sa venovali aspirínu a neopioidovému analgetiku paracetamolu.

Kľúčové slová

interakcie, nesteroidové antiflogistiká, paracetamol, nežiaduce reakcie liečiv.

NON-STEROIDAL ANTIINFLAMMATORIES AND ANALGESICS INTERACTIONS

Drugs interactions and prevention of their adverse effects gains steadily greater importance with more intensive use of drug combinations. Aim of the review article is to warn before clinically important drugs interactions of the most widely used group o remedies - non-steroidal antiinflammatories, analgesics. Authors focused on interactions with the drugs for cardiovascular system. Aspirin and non-opioid analgesic paracetamol are presented separately.

Download citation

References

  1. Seymor MR, Routledge PA. Important Drug-Drug Interactions in the Elderly. Clin Pharmacol 1998; 12: 485-494. Go to original source... Go to PubMed...
  2. Lincová D, Farghali H a kol. Základní a aplikovaná farmakologie, Galén, 2002: 601.
  3. Kriška M a spol. Riziko liekov v medicínskej praxi. Bratislava SAP, 2000: 474.
  4. Perlík F, Martínková J. Lékové interakce, www.postgradmed.cz.
  5. Tatro DS. Drug interaction facts. Facts and Comparisons. Wolters Kluwer Company 2002: 1499.
  6. MacKichan JJ. Protein binding drug displacement interactions fact or fiction? Clin Pharmacokin 1989; 16: 67-73. Go to original source... Go to PubMed...
  7. Silberbauer K a spol. Acute hypotensive effect of captopril in man modified by prostaglandin synthesis inhibition. Br J Clin Pharmacol. 1982; 14 Suppl 2: 87-93. Go to original source... Go to PubMed...
  8. Doležal T. Lékové interakce salicylátu. NOVA MEDICINA PORTÁL, 2002.
  9. Chandrasekharan NY a spol. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/ antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA, 2002; 10: 1073. Go to original source... Go to PubMed...
  10. Epstein MM a spol. Inhibition of the metabolism of paracetamol by isoniazid.Br J Clin Pharmacol 1991: 113, 799. Go to original source... Go to PubMed...
  11. Oral I. Léky znižující účinnost antihypertenziv. Klin Farmakol Farm 2004; 1, 18: 22-26.
  12. Brook RD, Kramer MB, et al. Nonsteroidal Anti - Inflammatory Drugs and Hypertension, Journal of Clinical Hypertens 2000; 2(5): 319-323.
  13. Polonia J. Interactions of antihypertensive drugs with anti-inflamatory drugs. Cardiology 1997; 88 (suppl 3): 47-51. Go to original source... Go to PubMed...
  14. Magulová L, Božeková L, Kriška M: Interakcie v klinickej praxi. Bratislava SAP, 2003: 328.




Clinical Pharmacology and Pharmacy

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.