Problematika rezistence Helicobacter pylori k antimikrobním léčivům

Klin Farmakol Farm. 2004;18(3):142-143

Problematika rezistence Helicobacter pylori k antimikrobním léčivům

MUDr. Jindra Lochmannová jr¹, doc. MUDr. Milan Kolář PhD², doc. MUDr. Otto Lochmann CSc³: ¹ Interní klinika fakultní nemocnice Motol a 2. lékařské fakulty Univerzity Karlovy v Praze; ² Ústav mikrobiologie FN a LF UP v Olomouci; ³ emeritní docent Ústavu mikrobiologie 2. LF UK, Praha

Klíčová slova: Helicobacter pylori, antibiotika, rezistence, terapie.

Keywords: Helicobacter pylori, antibiotics, resistance, therapy.

Zveřejněno: 31. prosinec 2004 Zobrazit citaci

Lochmannová J, Kolář M, Lochmann O. Problematika rezistence Helicobacter pylori k antimikrobním léčivům. Klin Farmakol Farm. 2004;18(3):142-143.

Práce je věnována problematice rezistence Helicobacter pylori k antibiotikům. Je diskutován způsob testování rezistence na antibiotika (E-test, fluorescenční metoda, molekulárně genetické postupy) a možnosti antibiotické léčby.

V našem souboru byly zjištěny značné rozdíly v rezistenci ke klaritromycinu (< 5 %) a metronidazolu, kde rezistence činila více než 40 %. Na základě výsledků lze jako léčbu I. volby u infekcí způsobených H. pylori doporučit spíše kombinaci klaritromycinu s amoxicilinem a omeprazolem.

RESISTANCE OF HELICOBACTER PYLORI TO ANTIBIOTICS

The paper deals with resistance of Helicobacter pylori to antibiotics. Special attention is paid to H. pylori resistance testing to antibiotics (E-test, fluorescence method, molecular-genetic procedures) and possibilities of antibiotic treatment.

Our experimental set demonstrated significant differences in resistance to clarithromycin (< 5 %) and metronidazole (above 40 %). Based on the results of our study it may be recommended to use the combination of clarithromycin with amoxicillin and omeprazol as the first option therapy.

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