Klin Farmakol Farm. 2004;18(3):146-148
Klinicky významné interakce léčiv gastrointestinálního traktu
- Ústav farmakologie LF UP a FN Olomouc
Keywords: drug interactions, gastrointestinal tract, absorption, metabolism.
Published: December 31, 2004 Show citation
Práce shrnuje nejvýznamnější lékové interakce běžně používaných léčiv gastrointestinálního traktu. Většina z nich interaguje ve fázi absorpce a může ovlivnit účinnost perorálně podávaných léčiv (antacida, prokinetika, sukralfát). Některé léky gastrointestinálního traktu, metabolizované cytochromem P450 (cisaprid, omeprazol), interagují ve fázi metabolizmu. U látek se systémovým účinkem mohou být závažné i farmakodynamické interakce (spazmolytika, opioidní antidiarrhoika).
CLINICALLY IMPORTANT INTERACTIONS OF THE GASTROINTESTINAL DRUGS
This article summarizes the most important drug interactions of commonly used drugs of the gastrointestinal tract. The majority of them interacts in the absorption phase and possibly influences effectivity of orally administered drugs (antacids, prokinetics, sucralfate). Some of the gastrointestinal agents, metabolized by cytochrome P450 (cisapride, omeprazole) interact in the phase of metabolism. In the drugs with systemic effects the pharmacodynamic interactions may be also important (spasmolytics, opioid antidiarrhoeals).
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