Klin Farmakol Farm. 2004;18(3):181-182

Nefrotoxicita indometacinu u novorozenců

Zdeněk Doležel, Dan Wechsler, Lia Elstnerová
II. dětská klinika LF MU a FN Brno

Keywords: indomethacin, acute renal failure, newborn.

Published: December 31, 2004  Show citation

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Doležel Z, Wechsler D, Elstnerová L. Nefrotoxicita indometacinu u novorozenců. Klin Farmakol Farm. 2004;18(3):181-182.

V klinické studii byl u nedonošených novorozenců hodnocen vztah mezi podávaným indometacinem a rozvojem akutního selhání ledvin. Důvodem k intravenóznímu podávání indometacinu byla snaha o uzavření průchodného ductus arteriosus. U hodnoceného souboru byla incidence akutního poškození ledvin 24 %, ale tento stav byl přechodný. Přesto je třeba velké opatrnosti v podávání indometacinu nedonošeným novorozencům, neboť za přispění některých dalších faktorů může být renální alterace závažnější.

INDOMETHACIN AND RENAL IMPAIRMENT IN NEONATES

The aim of this study was to determine the incidence of renal impairment in infants treated with indomethacin in a single center, to determine whether there is evidence of renal impairment on day 30, and to identify risk factors for renal impairment. Of infants who were less than 30 weeks compled gestation, 24 % had acute but reversible acute renal failure following indomethacin administration.

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    References

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