Klin Farmakol Farm. 2005;19(1):61-63
ADEFOVIR DIPIVOXIL TREATMENT IN CHRONIC HEPATITIS B
- I. interní klinika FN Královské Vinohrady 3. LF UK, Praha
We report a 46-yars-old woman with chronic HBeAg positive hepatitis B which during ten-years period was successively treated with glucocorticoids and azathioprine, famciclovir, interferon alfa-2a, alfa-2b and natural interferon, lamivudine alone and in combination with natural interferon, but only normal ALT level and HBV DNA negativity in serum were observed after treatment and in no treatment schedule seroconversion of HBeAg to anti-HBe occurred. After long-term lamivudine treatment, a mutant resistant to lamivudine developed with a relapse of hepatitis after therapy cessation. Finally, we used adefovir dipivoxil 10 mg/day for nine months but again no HBeAg seroconversion occurred. Sustained biochemical and virological response was observed during therapy. However, after treatment cessation both biochemical and virological relapse recurred.
Keywords: Key words: chronic hepatitis B, treatment, adefovir dipivoxil.
Published: January 1, 2006 Show citation
References
- Farrell GC, Liaw YF, McCaughan GW. JGH and Asia-Pacific consensus on prevention and management of gastrointestinal and liver diseases. J Gastroenterol Hepatol 2000; 15: 815-818.
Go to original source... 
Go to PubMed... - Stránský J. Virová hepatitida B a její klinický význam. Grada Publishing 2001: 107-109.
- Lok ASF. Hepatitis B infection: pathogenesis and management. J Hepatol 2000; 32 (Suppl 1): 89-97. Go to original source... Go to PubMed...
- Hadziyannis SJ, Papatheodoridis GV, Dimou E, et al. Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B. Hepatology 2000; 32: 847-851. Go to original source... Go to PubMed...
- Chayama K, Suzuki Y, Kobayasi M, et al. Emergence and take over of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-take over by wild type after cessation of therapy. Hepatology 1998; 27: 1711-1716. Go to original source... Go to PubMed...
- Stránský J, Burešová H, Stříteský J, Hejná M. Dlouhodobá léčba chronické hepatitidy B lamivudinem nebo v kombinaci s interferonem. Prakt Lék 2003; 83: 461-466.
- Trépo C, Ježek P, Atkinson GE, Boon RJ. Efficacy of famciclovir in chronic hepatitis B: results of a dose finding study. Hepatology 1996; 24: 188A.
- Lam KC, Lai CL, Ng RP, et al. Deleterious effect of prednisolone in HBsAg-positive chronic active hepatitis. N Engl J Med 1981; 304: 380-386. Go to original source... Go to PubMed...
- www.hepsera.com
- Stránský J. Adefovir dipivoxil je nový lék na chronickou hepatitidu B. Vnitř Lék 2004; 50: 222-224. Go to PubMed...
- Marcelin P, Chang TT, Lim SG, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med 2003; 348: 808-816. Go to original source... Go to PubMed...
- Hadziyannis SJ, Tassopoulos NC, Heatcote EJ, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B. N Engl J Med 2003; 348: 800-807. Go to original source... Go to PubMed...
- Peters M, Hann HW, Martin P, et al. Adefovir dipivoxil (ADV) alone and in combination with lamivudine (LAM) suppresses YMDD mutant hepatitis B virus replication: 48 week preliminary analysis. Hepatology 2002; 36, No 4, Part 2: 374A. Go to original source...
- Schiff E, Lai CL, Neuhaus SP, et al. Adefovir dipivoxil (ADV) for the treatment of chronic hepatitis B patients preand post-liver transplantation (OLT) with lamivudin-resistant (LAM-R) hepatitis B virus (HBV) patients. Hepatology 2002; 36, No 4, Part 2: 371A. Go to original source...
- Westland CH, Delaney IV W, Yang H, et al. Hepatitis B virus genotypes and virologic response in 694 patients in phase III. studies of adefovir dipivoxil. Gastroenterology 2003; 125: 107-116. Go to original source... Go to PubMed...
- Westland CE, Yang H, Delaney IV WE, et al. Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B. Hepatology 2003; 38: 96-103. Go to original source... Go to PubMed...
- Husa P. Adefovir dipivoxil-další krok ke zvládnutí chronické infekce virem hepatitidy B. Před námi však stále dlouhá cesta. Vnitř Lék 2004; 50: 177-180. Go to PubMed...
- Liaw YF, Sung JJY, Chow WC, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med 2004; 351: 1521-1531. Go to original source... Go to PubMed...
- Perrillo R, Hann HW, Mutimer D, et al. Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus. Gastroenterology 2004; 126: 81-90. Go to original source... Go to PubMed...