Klin Farmakol Farm. 2005;19(1):67-71

Infliximab in clinical treatment

MUDr. Vladimír Zbořil CSc
III. interní klinika gastroenterologická, FN Brno-Bohunice

Infliximab belongs to the group of so name biological therapy. It is human monoclonal antibody against tumor necrosis factor alpha. It consist of 25% mice a and 75% human sequention. The main contemporary indication´s for its clinical use are rheumatoid arthritis, rheumatoid spondylitis (ancylosing spondylitis) and Crohn´s disease.

Keywords: Key words: TNF – tumor necrosis factor, Crohn´s disease, rheumathoid arthritis, rheumathoid spondylitis, IL – interleukin´s.

Published: January 1, 2006  Show citation

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Zbořil V. Infliximab in clinical treatment. Klin Farmakol Farm. 2005;19(1):67-71.
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References

  1. Sands BE. Biologic therapy for inflammatory bowel disease. Inflammatory bowel disease, 1997; 3: 95-113. Go to original source... Go to PubMed...
  2. Ardizzone S, Bianchi Porro G. Inflammatory bowel disease: new insights into pathogenesis and treatment. Journal of J Int Med, 2002; 252: 475-496. Go to original source... Go to PubMed...
  3. Terr AI. Mechanismy zánětu. In: Stites DP, Terr AI. Základní a klinická imunologie. Victoria Publishing, 1991: 122-129.
  4. Maini R, ST Calir, EW, Breedweld F, et al. for the ATTRACT Study Group: Infliximab (chimeric anti-tumor necrosis factor a monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant medication methotrexate: a randomised phase III trial. Lancet, 1999; 354: 1932-1939. Go to original source... Go to PubMed...
  5. Braun J, Brandt J, Listing J, et al. Treatment of active ankylosing spondylitis with infliximab: randomised controlled multicentre trial. Lancet, 2002; 359: 1187-1193. Go to original source... Go to PubMed...
  6. Hanauer SB. Maintanance infliximab for Crohn´s disease. The ACCENT I randomized trial. Lancet, 2002; 359, 4: 1541-1549. Go to original source... Go to PubMed...
  7. Sands B. Infliximab maintanance therapy for fistulating Crohn´s disease (ACCENT II). N Engl J Med, 2004; 350, 9: 876-885. Go to original source... Go to PubMed...
  8. Rutgeerts P. Comparison of Schedule and episodic treatment stategies of schedule infliximab in Crohn´s disease. Gastroenterology, 2004; 126: 402-413. Go to original source... Go to PubMed...
  9. Ryan BM, Russel GMVM, Schurgers L, et al. Effect of antitumor necrosis factor-alpha therapy on bone turnover in patiens with active Crohn´s disease: a prospective study. Aliment Pharmacol Ther, 2004; 20: 851-857. Go to original source... Go to PubMed...
  10. Marshal L, Haens GD, Van Asshe G, et al. The risk of post-operative complications associated with infliximab therapy for Crohn´s disease: a controlled cohort study. Aliment Pharmacol Ther, 2004; 19: 749-754. Go to original source... Go to PubMed...
  11. Colomobel JF, Loftus Event, Tremaine WJ. Perioperative infliximab and/or immunomodulatory therapy is not associated with increased postoperative complications in Crohn´s disease. Gastroenterology, 2002; 124:A521 (abstract). Go to original source...




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