Klin Farmakol Farm. 2005;19(2):116-120

Pharmacogenomics and nutrigenomics: complex gene-environment interactions

Ondřej Šeda^1,2, Lucie Šedová¹

¹ Ústav biologie a lékařské genetiky 1. LF UK a VFN, Praha

² Oddělení metabolismu diabetu, Centrum experimentální medicíny, IKEM Praha

Pharmacogenetics is an interdisciplinary field dealing with the relationships between the genetic disposition of an individual and the effects of the drugs administered at the level of particular gene polymorphisms. Since 1950s pharmacogenetics has evolved from single observations and indirect indices to highly parallel, high-throughput analyses of genetic polymorphisms affecting the action of the drugs administered. Only recently have we witnessed the advent of pharmacogenomic methods that allow to assess the effect of the drug administered on the global expression of the genetic information at levels of transcriptome, proteome and metabolome. Concurrently, the fields of nutrigenetics and nutrigenomics evolve based on the notion that common diet contains a substantial number of biologically active compounds. Their effects on the onset, course and therapy of several complex diseases are, again, partly dependent on the genetic make-up of an individual. The common goal of pharmacogenomics and nutrigenomics is personalized medicine with a possibility to ascertain the adequate type and dose of a drug together with an appropriate dietary regimen for an individual based on predictive genetic testing.

Keywords: Keywords: pharmacogenetics, pharmacogenomics, nutrigenetics.

Published: January 1, 2006  Show citation