Klin Farmakol Farm. 2005;19(3):149-151

Statins: from lipidology to cardiology

MUDr. Michal Vrablík Ph.D, doc. MUDr. Richard Češka CSc
III. interní klinika VFN a 1. LF UK, Praha

HMG-CoA reductase inhibitors (statins) represent a common standard in therapy of patients with dyslipidaemia, diabetes mellitus, coronary artery disease and other manifestations of atherosclerosis. There is huge evidence proving their positive effects over a broad range of cholesterol levels in the plasma. Statins have been used in certain novel indications, e.g. acute coronary syndrome, heart failure, aortic stenosis, etc. Large prospective clinical trials are needed to prove the efficacy of statins in these novel indications.

Keywords: Key words: statins, atherosclerosis, acute coronary syndrome, aortic stenosis, heart failure.

Published: January 1, 2006  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Vrablík M, Češka R. Statins: from lipidology to cardiology. Klin Farmakol Farm. 2005;19(3):149-151.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Vrablík M, Štulc T. Statiny nejen v léčbě hyperlipoproteinémií. Causa Subita 2002; 5: 245-246.
    2. Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischemic heart disease and stroke: systematic review and meta-analysis. BMJ 2003; 326: 1-7. Go to original source... Go to PubMed...
    3. Nissen SE, Tuzcu EM, Schoenhagen P, et al. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis. A randomised controlled trial. JAMA 2004; 291: 1071-1080. Go to original source... Go to PubMed...
    4. Cannon CP, Braunwald E, McCabe CH et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 2004; 350: 1495-1504. Go to original source... Go to PubMed...
    5. Češka R, Prokeš M. Lipidy v ordinaci praktického lékaře, PAxCE, Edukapharm, Praha 2004, 134 stran.
    6. Liebson PR. Women's Health Study (Aspirin) and TNT. Prev Cardiol 2005, 8 (3): 181-185.
    7. Grundy SM, Cleeman JI, Bairey Merz CN, et al. Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation 2004; 110: 227-239. Go to original source... Go to PubMed...
    8. Jones PH. Lipid-lowering treatment in coronary artery disease: how low should cholesterol go? Drugs 2000; 59 (5): 1127-1135. Go to original source... Go to PubMed...
    9. Schwartz GC, Olsson AG, Ezekowitz MD, et al. Effects of atorvastatin on early reccurent ischemic events in acute coronary syndromes. The MIRACL study. JAMA 2001; 285: 1711-1718. Go to original source... Go to PubMed...
    10. Ray KK, Cannon CP. Intensive statin therapy in acute coronary syndromes: clinical benefits and vascular biology. Curr Opin Lipidol 2004; 15 (6): 637-643. Go to original source... Go to PubMed...
    11. Mohler ER, Gannon F, Reynolds C, et al. Bone formation and inflammation in cardiac valves. Circulation 2001, 103: 1522-1528. Go to original source... Go to PubMed...
    12. Aronow WS, Ahn C, Kronzon I, Goldman ME. Association of coronary risk factors and use of statins with progression of mild valvular aortic stenosis in older persons. Am J Cardiol 2001; 88: 693-695. Go to original source... Go to PubMed...
    13. Bellamy MF, Pellikka PA, Klarich KW, et al. Association of cholesterol levels, hydroxymethylglutaryl coenzyme-A reductase inhibitor treatment, and progression of aortic stenosis in the community. J Am Coll Cardiol 2002; 40: 1723-1730. Go to original source... Go to PubMed...
    14. Cowell SJ, Newby DE, Prescott RJ, et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 2005; 352: 2389-2397. Go to original source... Go to PubMed...
    15. Widimský J, sen. Statiny v léčbě srdečního selhání. In: J. Widimský a kol. Srdeční selhání. Triton 2001: 394.
    16. Fukuta H, Sane DC, Brucks S, Little WC. Statin therapy may be associated with lower mortality in patients with diastolic heart failure: a preliminary report. Circulation 2005; 112 (3): 357-363. Epub 2005 Jul 11. Go to original source... Go to PubMed...
    17. Ray JG, Gong Y, Sykota K, Tu JV. Statin use and survival outcomes in elderly patients with heart failure. Arch Intern Med 2005; 165 (1): 62-67. Go to original source... Go to PubMed...
    18. Horwich TB, MacLellan WR, Fonarow GC. Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure. J Am Coll Cardiol 2004; 43 (4): 642-648. Go to original source... Go to PubMed...
    19. Horwich TB, Hamilton MA, MacLellan WR, Fonarow GC. Low serum total cholesterol is associated with marked increase in mortality in advanced heart failure. J Card Fail 2002; 8 (4): 216-224. Go to original source... Go to PubMed...
    20. Schuster H, Foc JC. Investigating cardiovascular risk reduction-the Rosuvastatin GALAXY Programme. Expert Opin Pharmacother 2004; 5 (5): 1187-1200. Go to original source... Go to PubMed...

    Return to the content


    Clinical Pharmacology and Pharmacy

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.