Klin Farmakol Farm. 2005;19(4):239-240

Side effects and interactions of new antiepileptics

doc. MUDr. Vladimír Komárek CSc
Klinika dětské neurologie 2. LF UK a Centrum pro epilepsie FN Motol, Praha

The aim of rational pharmacotherapy of epilepsy is to maximize effectiveness as well as to minimize side effects. In comparison with old antiepileptic drugs (1st and 2nd generation), the side effects and interactions of new „3rd generation“ antiepileptics are less known. The overview of efficacy and tolerability of new antiepileptic drugs (gabapentin, lamotrigine, topiramate, levetiracetam, occarbazepine, tiagabine, zonisamide) is based on a metanalysis of 1 462 publications. In terms of interactions, the slow degradation of lamotrigine due to a combination with valproate is stressed.

Keywords: Kex words: new antiepileptics, side effects, drug interactions, epilepsy.

Published: January 1, 2006  Show citation

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Komárek V. Side effects and interactions of new antiepileptics. Klin Farmakol Farm. 2005;19(4):239-240.
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    References

    1. Efficacy and tolerability of the new antiepileptic drugs, AAN, Neurology, 2004.
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    5. Warner. Lamotrigin induced carbamazepine toxicity, Epilepsy res. 1992.

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