Klin Farmakol Farm. 2007;21(2):79-83

Therapeutic drug monitoring by means of electrophoresis methods

Lucie Pavlíková2,1, Hana Brozmanová2, František Kvasnička3, Milan Grundmann2
1 Farmakologický ústav LF UP, Olomouc
2 Ústav klinické farmakologie FNsP a ZSF Ostravské univerzity, Ostrava
3 Ústav konzervace potravin a technologie masa, Vysoká škola chemicko-technologická, Praha

The review of the electrophoresis methods for the terapeutic drug monitoring (TDM) is presented. In clinical analysis, usually the drugs must be analyzed in a complex matrix. For this reason, attention will be paid to sample pretreament procedures used for TDM since it is a critical step in the analysis of biological samples. The method used for the preparation of sample solid-phase extraction or liquid-liquid extraction. For some determinations direct sample injection can be used, which is one of advantages of electrophoresis methods compared with some others separative analytical methods (chromatographic). This overview describes the principle of the capillary electrophoresis and their particular modes. The determinations of some drugs in the biological materials are presented.

Keywords: TDM, capillary electrophoresis, capillary zone electrophoresis, non-aqueous capillary electrophoresis, micellar electrokinetic capillary chromatography, elektrokinetic capillary chromatography, isotachophoresis

Published: October 1, 2007  Show citation

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Pavlíková L, Brozmanová H, Kvasnička F, Grundmann M. Therapeutic drug monitoring by means of electrophoresis methods. Klin Farmakol Farm. 2007;21(2):79-83.
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