Klin Farmakol Farm. 2009;23(2):71-75

Pharmacological’s medication of the peripheral vascular disease

MUDr. Jarmila Indráková¹, Lucie Kalinová²

¹ I. interní klinika FN a LF UP Olomouc

² II. chirurgická klinika LF UP a FN Olomouc

Peripheral Vascular Disease (PVD), affecting estimatedly up to 20 % of the patients over 70 years, is in its less advanced stages (stage I and

II of the Fontain classification) chiefly a predictor of increased cardiovascular mortality due to a high probability of collateral ischemic

heart and brain disease. The more advanced stages of the disease limit the prognostically ill person significantly and they principally

threaten the quality of life, not only by the possibly amputation of the limb. Atherosclerosis is a generalised disease, the basis of PVD

therapy inheres in an agressive intervention of its risk factors and in the influence of its possible complications. Pharmacologically there

are administered the antiagregants in all stages of the disease, the hypolipidemics, the administration of angiotensin converting enzym

inhibitor is under consideration. Good diabetes compensation is implied. As for the non pharmacologic means intensive rehabilitation is

required. A lot of data we have of naftidrofuryl and cilostazol, still not registered in the Czech Republic. The prostaglandines are reserved

for critical limb ischemia. In the cases of significant manifestations of the disease the revascularisation, e. g. percutaneous transluminal

angioplasty or surgical operations (endarterectomy, bypasses) is unambiguously preferred.

Keywords: ischemic limb disease, atherosclerosis, vasoactive drugs.

Published: July 1, 2009  Show citation