Klin Farmakol Farm. 2009;23(3):138-141

Pharmacokinetics and clinical applications of selected immunosuppressants I.

Mgr. Petra Maršálková
Ústav klinické farmakologie FNsP a ZSF Ostravské univerzity, Ostrava

The currently available immunosuppressive agents have been used for the management of patient with a wide range of medicinal issues,

such as organ transplantation, autoimmune diseases, asthma, and rheumatoid arthritis, among others. All of the agents have relatively

narrow therapeutic ranges with significant dose-limiting toxicities. This review discusses pharmacodynamic properties, biotransformation,

drug interactions, and side effects of corticoids, inhibitors and analogues of DNA bases, polyclonal and monoclonal antibodies.

Keywords: immunosuppressive agents, corticoids, polyclonal antibodies, monoclonal antibodies.

Published: November 6, 2009  Show citation

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Maršálková P. Pharmacokinetics and clinical applications of selected immunosuppressants I. Klin Farmakol Farm. 2009;23(3):138-141.
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    References

    1. Trevillian P. The CARI guidelines. Calcineurin inhibitors in renal transplantation: therapeutic drug monitoring. Nephrology (Carlton) 2007; 12 Suppl 1: S57-S65. Go to original source... Go to PubMed...
    2. Taylor AL, Watson CJ, Bradley JA. Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy. Crit Rev Oncol Hematol 2005; 56(1): 23-46. Go to original source... Go to PubMed...
    3. Legler UF, Benet LZ. Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives Clin Pharmacol Ther 1986; 39(4): 425-429. Go to original source... Go to PubMed...
    4. Kozower M, Veatch L, Kaplan MM. Decreased clearance of prednisolone, a factor in the development of corticosteroid side effects. J Clin Endocrinol Metab 1974; 38(3): 407-412. Go to original source... Go to PubMed...
    5. LaForce CF, Szefler SJ, Miller MF, Ebling W, Brenner M. Inhibition of methylprednisolone elimination in the presence of erythromycin therapy. J Allergy Clin Immunol 1983; 72(1): 34-39. Go to original source... Go to PubMed...
    6. Ged C, Rouillon JM, Pichard L, Combalbert J, Bressot N, Bories P, Michel H, Beaune P, Maurel P. The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction. Br J Clin Pharmacol 1989; 28(4): 373-387. Go to original source... Go to PubMed...
    7. Brooks PM, Buchanan WW, Grove M, Downie WW. Effects of enzyme induction on metabolism of prednisolone. Clinical and laboratory study. Ann Rheum Dis 1986; 35(4): 339-343. Go to original source... Go to PubMed...
    8. Ohnhaus EE, Park BK. Measurement of urinary 6-beta-hydroxycortisol excretion as an in vivo parameter in the clinical assessment of the microsomal enzyme-inducing capacity of antipyrine, phenobarbitone and rifampicin Eur J Clin Pharmacol 1979; 15(2): 139-145. Go to original source... Go to PubMed...
    9. Bartoszek M, Brenner AM, Szefler SJ. Prednisolone and methylprednisolone kinetics in children receiving anticonvulsant therapy Clin Pharmacol Ther 1987; 42(4): 424-432. Go to original source... Go to PubMed...
    10. Petereit LB, Meikle AW. Effectiveness of prednisolone during phenytoin therapy. Clin Pharmacol Ther 1977; 22(6): 912-916. Go to original source... Go to PubMed...
    11. Choi Y, Thrasher K, Werk EE Jr, Sholiton LJ, Olinger C. Effect of diphenylhydantoin on cortisol kinetics in humans J Pharmacol Exp Ther 1971; 176(1): 27-34. Go to PubMed...
    12. Werk EE Jr, Macgee J, Sholiton LJ. Effect of diphenylhydantoin on cortisol metabolism in man J Clin Invest 1964; 43: 1824-1835. Go to original source... Go to PubMed...
    13. Christy NP, Hofmann AD. Effects of diphenylhydantoin upon adrenal cortical function in man. Neurology 1959; 9(4): 245-248. Go to original source... Go to PubMed...
    14. Buffington GA, Dominguez JH, Piering WF, Hebert LA, Kauffman HM Jr, Lemann J Jr. Interaction of rifampin and glucocorticoids. Adverse effect on renal allograft function. Jama 1976; 236(17): 1958-1960. Go to original source... Go to PubMed...
    15. Hendrickse W, McKiernan J, Pickup M, Lowe J. Rifampicininduced non-responsiveness to corticosteroid treatment in nephrotic syndrome. Br Med J 1979; 1(6159): 306. Go to original source... Go to PubMed...
    16. Penzak SR, Formentini E, Alfaro RM, Long M, Natarajan V, Kovacs J. Prednisolone pharmacokinetics in the presence and absence of ritonavir after oral prednisone administration to healthy volunteers. J Acquir Immune Defic Syndr 2005; 40(5): 573-580. Go to original source... Go to PubMed...
    17. Boekenoogen SJ, Szefler SJ, Jusko WJ. Prednisolone disposition and protein binding in oral contraceptive users. J Clin Endocrinol Metab 1983; 56(4): 702-709. Go to original source... Go to PubMed...
    18. Naggar VF, Khalil SA, Gouda MW. Effect of concomitant adninistration of magnesium trisilicate on GI absorption of dexamethasone in humans J Pharm Sci 1978; 67(7): 1029-1030. Go to original source... Go to PubMed...
    19. Uribe M, Casian C, Rojas S, Sierra JG, Go VL. Decreased bioavailability of prednisone due to antacids in patients with chronic active liver disease and in healthy volunteers. Gastroenterology 1981; 80(4): 661-665. Go to original source...
    20. Masri MA. The mosaic of immunosuppressive drugs. Mol Immunol 2003; 39(17-18): 1073-1077. Go to original source... Go to PubMed...
    21. Hobara N, Watanabe A. Impaired metabolism of azathioprine in carbon tetrachloride-injured rats. Hepatogastroenterology 1981; 28(4): 192-194. Go to PubMed...
    22. Merion RM, Howell T, Bromberg JS. Partial T-cell activation and anergy induction by polyclonal antithymocyte globulin Transplant 1998; 65(11): 11481-11489. Go to original source... Go to PubMed...
    23. Hong JC, Kahan BD. Immunosuppressive agents in organ transplantation. Semin Nephrol 2000; 20(2): 108-125. Go to PubMed...
    24. Rommer PS, Stüve O, Goertsches R, Mix E, Zettl UK. Monoclonal antibodies in the therapy of multiple sclerosis, an overview. J Neurol 2008; 255 Suppl 6: 28-35. Go to original source... Go to PubMed...
    25. Suchý D, Komzáková I, Grundmann M. Základní charakteristiky vybraných imunosupresiv Klin Farmakol Farm 2004; 18: 90-95.
    26. Rubbert-Roth A, Finckh A. Treatment options in patient with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review. Arthritis Res Ther 2009; 11 Suppl 11. Go to original source... Go to PubMed...

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