Klin Farmakol Farm. 2011;25(4):188-191

Interactions of proton pump inhibitors

Jan Gregar1, Ivona Šimková1, Karel Urbánek2
1 2. Interní klinika &ndash, gastroenterologická a hepatologická LF UP a FN Olomouc
2 Ústav farmakologie LF UP a FN Olomouc

Pharmacokinetic interactions of proton pump inhibitors (PPIs) can occur mainly during absorption and metabolisation. Important interactions

of PPIs are decreased absorption of azole antimycotics, inhibition of metabolism of diazepam and moclobemide, and clopidogrel

activation by cytochrome P450 2C19. Inhibition of CYP3A4 can cause an increase in plasma concentrations of tacrolimus. The lowest risk

of interactions during metabolism has been found in pantoprazole. During the elimination phase, the excretion of methotrexate can be

decreased by inhibition of the proton pump in the renal tubules.

Keywords: proton pump inhibitors, drug interactions, pharmacokinetics, omeprazole, pantoprazole

Published: December 18, 2011  Show citation

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Gregar J, Šimková I, Urbánek K. Interactions of proton pump inhibitors. Klin Farmakol Farm. 2011;25(4):188-191.
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