Klin Farmakol Farm. 2014;28(3):120-123

Practical aspects of hormonal therapy for breast cancer

Šárka Lukešová¹, Otakar Kopecký²

¹ Onkologické oddělení Oblastní nemocnice Náchod, a. s., Ústav klinické mikrobiologie FN a LF UK Hradec Králové

² Onkologické oddělení Oblastní nemocnice Náchod, a. s., Stomatologická klinika FN a LF UK, Hradec Králové

Hormonal therapy is the oldest and safest clinically proven therapeutic method used in all stages of breast cancer. It is a targeted, individualized



treatment: Four basic treatment modalities, namely ablative, competitive, inhibitive, and additive, have been included in the clinical

practice. It is the preferred treatment for hormone-dependent breast cancers, including visceral involvement, if there is no high risk or evidence

of hormone resistance or if a therapeutic response needs to be achieved rapidly. The article deals with the currently recommended cascade

of hormonal treatment, including basic studies which the recommendation is based on, the side effects, and the possibility of overcoming

hormone resistance with new medicines coming into clinical practice.

Keywords: breast cancer, hormone receptors, hormone resistance

Published: November 1, 2014  Show citation