Klin Farmakol Farm. 2014;28(4):142-146
Cytochromes P450 in the main role in a metabolism of cholesterol
- 1 Ústav farmakologie, Lékařská fakulta Univerzity Palackého v Olomouci
- 2 Ústav molekulární a translační medicíny, Lékařská fakulta Univerzity Palackého v Olomouci
Cytochrome P450 (CYPs) are enzymes which are involved in drug metabolism and also in biotransformation of a variety of endogenous
compounds incl. cholesterol, which plays an important role in human body. In the case of malfunction of these CYP enzymes, complications
in the treatment of diseases can take place and/or enzymes can also cause various diseases itself. This paper deals with cholesterol,
disorders of enzymes metabolizing cholesterol and consequences of therapies of enzyme insufficiency. Treatment of diseases of this type
consists mainly in replacement therapy; however, without the early testing of the individual markers, the treatment may not be sufficient.
Keywords: cholesterol, cytochromes P450, enzyme insufficiency, therapy
Published: January 1, 2015 Show citation
